PLOS: DNA Science

MARCH 28, 2024

A Scant Protein with Outsize Importance Slowing the muscle decline of DMD presents two huge challenges: the ubiquity of muscle and a giant gene. million DNA bases. The gene presents a complex landscape. The gene presents a complex landscape. It delivers a shortened dystrophin gene, just 4,558 DNA bases.

FDA Approval 97

FDA Approval Treatment FDA DNA 97

Broad Institute

OCTOBER 4, 2023

Related links Merkin Prize Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The inaugural Richard N. Caruthers was announced as the winner in June for his development, in 1981, of an efficient, automated technology for synthesizing DNA.

DNA 52

DNA RNA Science Protein Expression 52

Drug Target Review

JULY 5, 2023

In the study presented at ASGCT, what were the specific findings regarding the synergistic killing of SKOV3 ovarian tumour cells by the iPSC-derived lymphoid and myeloid cells? What are the key advancements in nucleic-acid delivery and targeted gene insertion that Eterna and Factor Bioscience presented at the ASGCT?

Therapies 103

Therapies DNA Engineering Virus 103

Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

DNA 97

DNA Laboratories Hospitals Virus 97

Drug Target Review

SEPTEMBER 28, 2023

After some time in that role and launching several products, I received a call from Bill Banyai and Bill Peck, or ‘The Bills’ as we call them, who were building a company around technology that creates DNA by ‘writing’ it on a silicon chip. Researchers were able to use our synthetic RNA controls as a reference to verify and validate assays.

DNA 116

DNA Organic Chemistry Science Virus 116

PLOS: DNA Science

APRIL 20, 2023

DNA is a sleek double helix, with “rungs” consisting of a purine base paired with a smaller pyrimidine base: adenine (A) with thymine (T) and guanine (G) with cytosine (C). . ” DNA encodes amino acid sequences comprising proteins, which impart traits. Watson and F.

DNA 52

DNA Virus Science RNA 52

Drug Target Review

NOVEMBER 13, 2023

The instructions to form a cell are encoded in DNA strands, wrapped in proteins and RNA, and wound together into a 3D structure called chromatin. When the researchers compared the architecture of regulatory and effector T cells, they found there were many unique Foxp3 binding regions only present in regulatory T cells.

Government 104

Government DNA RNA Regulations 104

DrugBank

MARCH 12, 2025

Introduction Messenger RNA (mRNA) technology has emerged as one of the most significant medical breakthroughs. Once delivered into the body, the mRNA instructs cells to produce these antigens, which are then presented to the immune system.

Vaccine 97

Vaccine Treatment Clinical Trials Therapies 97

Codon

JUNE 25, 2024

However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide. Most medicines, including insulin and semaglutide (the weight loss drug), are made using DNA cloning. However, E.

DNA 80

DNA RNA Laboratories Research 80

Codon

NOVEMBER 3, 2024

If present before vaccination, memory immune cells primed to destroy the environmental relatives might cross-react with and neutralize the BCG strain before it has a chance to set up an immune response against itself and M. Some fluoroquinolones — a class of antibiotics that inhibits DNA replication — may even cause psychosis.

Vaccine 96

Vaccine Trials Therapies Treatment 96

The Pharma Data

SEPTEMBER 6, 2021

First data to be presented from the phase II coopERA Breast Cancer study evaluating neoadjuvant giredestrant treatment for oestrogen receptor (ER)-positive, HER2-negative breast cancer. Breast Cancer Highlights. Lung Cancer Highlights.

Treatment 52

Treatment Therapies DNA Trials 52

PLOS: DNA Science

MAY 25, 2023

In these 50 or so conditions, symptoms may appear earlier and worsen from generation to generation, as the mutant gene grows, adding copies of a 3- or 4-base DNA sequence. Now Avidity Biosciences has developed a candidate drug that weds a monoclonal antibody (MAb) to a short piece of RNA – a small interfering RNA (siRNA).

Treatment 52

Treatment DNA RNA Clinical Trials 52

BMG Labtech

DECEMBER 20, 2024

Whether it is determining concentrations of molecules like proteins or DNA, looking at enzyme kinetics for crucial reactions, or measuring something as fundamental as cell growth, you will find references to absorbance or optical density measurements. Optical density is also widely used for many scientific applications.

DNA 52

DNA Science Laboratories RNA 52

Drug Target Review

AUGUST 9, 2023

FTD is a neurodegenerative disease characterised by the progressive death of Glutamatergic and GABAergic neurons in the frontal and temporal lobes, with some evidence pointing to decreases in neurotransmitters like GABA contributing to disease presentation. Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis.”

RNA 98

RNA Regulations Disease DNA 98

Drug Target Review

APRIL 9, 2024

Our approach to investigate the toxicity driven by nucleolar stress was to induce it with certain arginine-rich peptides, present in patients of ALS, which were known to accumulate at nucleoli and cause this type of stress. However, our study was first to show that inducing nucleolar stress in an adult mammal accelerates aging.

RNA 64

RNA Cell Biology Clinical Development Disease 64

PLOS: DNA Science

JUNE 13, 2024

Experiments at the Wuhan facility were done at the lowest two of the four standard biosafety levels, which were established at the dawn of recombinant DNA research in the 1970s. The Likely Predecessor of SARS-CoV-2 – From my Past Blog Posts I wrote 100+ DNA Science blog posts during the pandemic about the virus.

Virus 52

Virus RNA DNA Science 52

Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context. DNA vectors in mouse models?

Therapies 59

Therapies RNA Protein Expression DNA 59

Broad Institute

OCTOBER 11, 2023

His mother had a presentation of the disease that suggested her immune system was already on the job. Using CRISPR screening in mice presented additional challenges. Kayla Colvin (back) and Kelly Heo (front) isolate genomic DNA from melanoma tumors treated with immune checkpoint inhibitors and check the concentration of their samples.

Research 137

Research Immune Response Clinical Trials Therapies 137

PLOS: DNA Science

MARCH 7, 2024

When the primate lineage split from the evolutionary tree some 65 million years ago, tails were still present, but by the time apes split off 25 million years ago, only tailbones remained. The researchers searched the DNA of humans and other primates for clues to how we lost our tails. Did a Genetic Harpoon Lead to Tail Loss?

DNA 52

DNA RNA Research Science 52

Codon

APRIL 2, 2023

But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression. Read Switchable hydrophobic pockets in DNA protocells enhance chemical conversion. Nature Microbiology. Meeussen J.V.W.

DNA 52

DNA RNA Engineering Licensing 52

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52

DrugBank

JANUARY 29, 2025

Gene Therapy Gene therapy operates on the principle of modulating the DNA blueprint of cells to induce a therapeutic response. These disorders, often characterized by a loss-of-function mutation in a crucial gene, can manifest with a wide range of clinical presentations, depending on the specific gene and its role in cellular physiology.

Therapies 52

Therapies DNA RNA Disease 52

DrugBank

JULY 24, 2024

Additionally, while small molecules can target well-defined pockets on enzymes or receptors, targeting PPIs presents a unique challenge due to their flat, featureless interfaces and large interaction areas. Despite these challenges, the progress in PPI-modulating drugs is noteworthy.

Small Molecule 98

Small Molecule Drugs Clinical Trials Therapies 98

The Pharma Data

DECEMBER 3, 2020

Consequently, performing an immunoassay in the early stages of an infection will be negative because the antibodies cannot be produced yet, even though the disease is present. The amount of DNA produced is much higher, and a positive test result can be viewed visually without the need for an additional analysis step,” the study reported.

RNA 52

RNA Virus DNA Disease 52

Drug Target Review

OCTOBER 2, 2024

RNA-based therapies, including mRNA and RNA interference (RNAi), are being explored to modulate gene expression in heart cells. For example, integrating gene therapies that alter the DNA of cardiac cells pose risks of unintended genetic modifications, which could lead to tumorigenesis.

Therapies 98

Therapies Disease Engineering RNA 98

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. “The first printout of the human genome to be presented as a series of books, displayed in the 'Medicine Now' room at the Wellcome Collection, London. It fills up an entire bookcase !

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. “The first printout of the human genome to be presented as a series of books, displayed in the 'Medicine Now' room at the Wellcome Collection, London. It fills up an entire bookcase !

Therapies 52

Therapies RNA DNA Engineering 52

PerkinElmer

JANUARY 19, 2020

Here are ten key tutorials, presentations and posters designed to help you achieve fast, accurate and reproducible results in precision medicine, next generation sequencing, homogenous assays and more. Presenter: Thomas Rawlins, Automation Expert, PerkinElmer. Time away from the lab is limited and valuable.

International 52

International RNA DNA Science 52

Drug Target Review

APRIL 3, 2024

Everything started in school with an experiment on isolating DNA from bananas. Making a little tangle of DNA visible to the eye and understanding that this is the basis of complex organisms, which might be altered in disease, was the defining moment for my future path in life sciences. in North America) in late 2017.

Science 105

Science Clinical Development Treatment DNA 105

Drug Target Review

JUNE 6, 2023

In the context of a tumour microenvironment, Tregs are often present in high numbers, preventing an effective immune response to the tumour. 2 After activation by an antigen presenting cell, a T helper cell segregates the cytokines. Some approaches have already reached the clinical trial stage, with others not far behind.

Engineering 98

Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

New Drug Approvals

SEPTEMBER 6, 2024

TLR7-9 are among the set that are endosomally located and respond to single-stranded RNA (TLR7and TLR8) or unmethylated single-stranded DNA containing cytosine-phosphate-guanine (CpG) motifs (TLR9). A total of 13 TLR family members have been identified, 10 in human, that span either the cell surface or the endosomal compartment.

RNA 62

RNA Clinical Trials Disease DNA 62

Codon

SEPTEMBER 29, 2024

But, regardless of which was first, they all operated with the same core data as their mechanism for understanding life: messenger RNA ( mRNA ). Simple ones, but still… This presented the student with a tantalizing future: the ability to fully model how a cell reacted to genetic perturbations.

Engineering 141

Engineering Virus DNA Therapies 141

New Drug Approvals

SEPTEMBER 29, 2024

gingivalis DNA was detected in postmortem cortices from people with AD and healthy controls, and in CSF of AD patients ( Jan 2019 news on Dominy et al., gingivalis infection led to the appearance of bacterial DNA in the brain, increased brain Aβ42 production, neuroinflammation, and hippocampal degeneration. and Europe.

Small Molecule 62

Small Molecule DNA Disease Trials 62

The Pharma Data

SEPTEMBER 28, 2021

Acute respiratory infections are one of the leading causes of death and disability globally, presenting substantial health challenges especially for infants, the elderly and the immunocompromised. TaqMan® DNA probes that hybridise with the target strand are labeled with a fluorescein allowing real-time measurements during the PCR process.

Marketing 52

Marketing Virus DNA Disease 52

Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito.

DNA 52

DNA Engineering Therapies RNA 52

Codon

APRIL 30, 2023

Yeast die for two reasons: Either their nucleolus (where the DNA is kept) degrades and dies, or their mitochondria whimpers out and they stop making energy. The vaccine printer can make lots of different types of vaccines, including protein, DNA, and mRNA ones, but I’m sure this is all quite expensive right now. From Zhang et al.

Vaccine 52

Vaccine DNA Engineering RNA 52