DrugBaron

FEBRUARY 7, 2022

Finding small molecule drugs is much harder than finding a needle in a haystack – discovering the right arrangement of atoms to bind precisely to a protein target to elicit a particular response is a problem of vast dimensionality. Yet the situation with small molecules is even worse.

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NIH Director's Blog: Drug Discovery

MARCH 8, 2016

Instead of the black, printed stripes of the Universal Product Codes (UPCs) that we see on everything from package deliveries to clothing tags, they used short, unique snippets of DNA to label cells. DNA barcoding has already empowered single-cell analysis, including for nerve cells in the brain.

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The Pharma Data

NOVEMBER 18, 2020

Presentations to highlight the OBI-833 Phase 1 clinical study results in non-small cell lung cancer (NSCLC) and the dose escalation cohort. These results will be presented by the lead investigators of OBI Pharma’s novel anti-Globo H therapeutic cancer vaccine, OBI-833. ” Presentation number: 397P / Poster: ID 680.

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The Pharma Data

APRIL 11, 2023

The presentation highlights the synergistic anti-cancer effects of a PSMA (prostate-specific membrane antigen)-actinium-225 conjugate in combination with darolutamide in preclinical prostate cancer models. Data from all three areas of scientific focus will be showcased during this year’s meeting.

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The Premier Consulting Blog

JULY 9, 2023

During the development of new small molecule drug products, developers must conduct impurity and degradant evaluation at several points in the program and to varying degrees. Sometimes a degradant presents unexpectedly after GLP toxicology studies are completed or are underway. Global regulatory agencies, including the U.S.

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LifeSciVC

DECEMBER 6, 2022

These hair clip-like molecules clamp onto DNA, thereby turning many genes on and off. As Darnell observed, the prospect of being able to regulate Transcription Factor function holds the potential to reframe the way we treat disease but achieving that goal with traditional small molecule screening approaches is impossible.

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The Pharma Data

DECEMBER 13, 2020

Senhwa was invited to present positive topline results from their global phase II trial, evaluating the combination of Silmitasertib plus Gemcitabine/Cisplatin compared to Gemcitabine/Cisplatin alone in the frontline treatment of patients with Cholangiocarcinoma. . Due to the COVID -19 pandemic, the event will be hosted virtually.

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LifeSciVC

MARCH 1, 2023

Importantly, they also pointed to something that we at HotSpot Therapeutics and a small group of other researchers and companies recognized several years ago – that scientific advances have made this attractive, but once considered ‘undruggable,’ target druggable.

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Molecule Blog

AUGUST 13, 2021

This program focuses on testing and developing three of these small molecules as possible interventions in ageing. These molecules target the longevity field with the aim of letting everyone live healthier, happier and longer lives. Additionally, there is a database of compounds that could be pursued.

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The Pharma Data

MARCH 18, 2022

By manipulating the microbes’ DNA, they programmed gene circuits that control the bacteria surface, building a molecular “cloak” that encapsulates the bacteria. They control the iCAP system by giving it an external cue – a small molecule called IPTG – that allows for programmable and dynamic alteration of the E.

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The Pharma Data

OCTOBER 14, 2020

Assistant Professor of Medical Sciences at Columbia University Vagelos College of Physicians and Surgeons, is designed to generate DNA aptamer-based anti-idiotypes to selected monoclonal antibodies identified in Dr. Ilya Trakht’s study. The study led by Dr. Sergei Rudchenko, Ph.D., 1 Noyce RS, et al. 2018) PLoS One. 13(1):e0188453.

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Alta Sciences

APRIL 17, 2024

Several viral vectors are being used currently, in addition to non-viral vectors, such as oligonucleotides, naked DNA, and lipoplexes and polyplexes. They work by binding to specific sequences of nucleotides present within the mRNA structure and can induce mechanisms that either decrease, restore, or modify protein expression.

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KIF1A

MAY 31, 2024

Dr. Kaur now oversees 5 KAND research projects that utilize our patient-derived cell lines to screen for small molecule therapeutics and test potential gene therapies. Dr. Sosa presented information about this during our 2023 conference. John Christodolou, has leveraged this funding into a 3-year, $750,000 federal grant.

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Vial

FEBRUARY 19, 2024

We can link small molecule drugs to a payload that would enter in the cell and kill it. We have the capability of different types of targets, whether small molecules or antibodies. Basically because linkers cleave non-specifically, usually by cathepsin, which is present in every cell.

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The Pharma Data

DECEMBER 27, 2020

Notably, we never modify the DNA of these cells, which avoids some of the safety concerns that have been reported with certain gene-editing technologies. From these cells we apply proprietary methods to manufacture pure populations of only the cell types which we wish to use in patients.

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Agency IQ

JULY 26, 2024

in equipment) for products that are more complex or aren’t as well-characterized, such as antibody drug conjugates or recombinant DNA products, will be considered higher risk than they would if the change was made to the production of standard, small molecule products. Any CMC changes (e.g.,

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Agency IQ

AUGUST 11, 2023

In a study of more than 12,000 small molecule drugs , researchers found 40.4% This latter category is “not predicted to be metabolically activated via an α-hydroxylation pathway,” or would not be predicted to react with DNA. of the APIs analyzed were nitrosamine precursors.

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Drug Target Review

AUGUST 2, 2024

This observation prompted us to search for small molecules that might de-repress TERT, restore physiological levels, and potentially impact hallmarks of ageing. How did the researchers identify the small molecule compound that could restore TERT levels?

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New Drug Approvals

SEPTEMBER 29, 2024

link] 01 Aug 2022 Cortexyme is now called Quince Therapeutics You need to be a logged in or subscribed to view this content This small molecule is an orally available protease inhibitor targeting the lysine proteases of the periodontal pathogen Porphyromonas gingivalis. gingivalis DNA fragments in their CSF at baseline.

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Drug Target Review

APRIL 16, 2024

By delivering radiation directly to the tumour cells, RLT can induce DNA damage, leading to cell death and tumour regression. For naïve patients who have not undergone prior cancer treatment, RLT presents a promising option as an initial treatment modality. In contrast, development of mAbs is typically resource intensive.

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Codon

APRIL 2, 2023

But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression. Read Switchable hydrophobic pockets in DNA protocells enhance chemical conversion. Nature Microbiology. Meeussen J.V.W.

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Codon

MARCH 19, 2024

It is against this backdrop that a new explanation for the phenomenon of aging, called the “information theory,” presents itself. Most cells (excluding T-cells and B cells after V(D)J recombination) in our body contain the same DNA but appear and behave in distinct ways: A neuron looks and acts very differently from a hepatocyte.

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The Pharma Data

OCTOBER 14, 2020

Results will be presented at the virtual CHEST Annual Meeting this weekend. has expanded its product portfolio to include Blueprint, a self-service, scientific visualization and analytics application for small molecule discovery. adults age 65 and older. Dolmatics – U.K.-based based Dotmatics Ltd.

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PLOS: DNA Science

JUNE 22, 2023

In contrast, targeted drugs interrogate specific molecules that cause or drive a cancer by recognizing molecules that are more abundant on, or more active in, or function differently in, cancer cells, properties that arise from mutation. Inherited cancers, in which one mutation is present from fertilization, are rare. (I

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The Pharma Data

AUGUST 3, 2021

Certain financial information for 2021 and 2020 is presented on both a reported and a non-GAAP basis. The non-GAAP measures are presented to provide additional insights into the underlying trends in the company’s business. 30% Non-GAAP guidance reflects adjustments presented in the earnings per share table above.

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Codon

APRIL 30, 2023

Yeast die for two reasons: Either their nucleolus (where the DNA is kept) degrades and dies, or their mitochondria whimpers out and they stop making energy. The vaccine printer can make lots of different types of vaccines, including protein, DNA, and mRNA ones, but I’m sure this is all quite expensive right now. From Zhang et al.

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Codon

APRIL 30, 2023

Yeast die for two reasons: Either their nucleolus (where the DNA is kept) degrades and dies, or their mitochondria whimpers out and they stop making energy. The vaccine printer can make lots of different types of vaccines, including protein, DNA, and mRNA ones, but I’m sure this is all quite expensive right now. From Zhang et al.

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The Pharma Data

DECEMBER 21, 2020

The results from the ADAURA trial were presented during the plenary session of the American Society of Clinical Oncology ASCO20 Virtual Scientific Program in May 2020 and were recently published in The New England Journal of Medicine. 5 Lung cancer is broadly split into NSCLC and small cell lung cancer, with 80-85% classified as NSCLC.

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KIF1A

AUGUST 20, 2024

Susannah is being treated with an Antisense Oligonucleotide (ASO) : To break down the term, this is a molecule designed with a sequence of 20 (oligo, “few”) letters of DNA (nucleotide) that match a sequence on the mutant KIF1A RNA (Antisense) and knock it down.

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Agency IQ

APRIL 19, 2024

Note: Both analyses focused only on studies of small molecules, antibodies and biologics; studies of CAR T therapies were not included. This is of particular note considering that the meta-analyses presented to the committee found the strongest correlation between MRD and PFS, as opposed to OS.

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Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

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Drug Target Review

OCTOBER 4, 2023

2 In response, DNA-damaging agents that could target the entire cell cycle received renewed attention as ADC payloads. Groundbreaking strategies like proteolysis-targeting chimeric molecules (PROTACs) are also being explored. DNA damaging agent-based antibody-drug conjugates for cancer therapy. Florian S, Mitchison TJ.

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Drug Target Review

DECEMBER 13, 2024

1 Lung cancer is primarily classified into two types based on histological examination: Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC). These types differ in their etiology, natural history, and present distinct challenges in disease management. percent of total cancer fatalities.

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The Pharma Data

OCTOBER 26, 2020

Merck presented results from the pivotal Phase 3 KEYNOTE-590 trial for the first-line treatment of patients with locally advanced or metastatic esophageal and gastroesophageal junction (GEJ) cancer at the European Society for Medical Oncology (ESMO) Virtual Congress 2020.

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PLOS: DNA Science

AUGUST 8, 2024

The maternal copy remains, but is silenced, as it typically is if the father’s gene is present and active. This part of chromosome 15 is especially unstable because highly repetitive DNA sequences bracket the genes associated with the symptoms. Repeats can cause slippage as DNA replicates. The clever mechanism?

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Codon

DECEMBER 12, 2024

It’s important to note that the 300-page report, while presenting detailed evidence for the potential harms of mirrored life, uses painstakingly speculative language. DNA and RNA molecules are also built from exclusively right-handed nucleic acids. It gives humanity time to steer away. This is one of them.

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Codon

APRIL 16, 2023

This was no small feat, because moths respond to a complex mixture of two or three different molecules that must be present at specific ratios. Short DNA strands were discovered that can specifically and tightly bind to zinc and cadmium ions. It costs about $15 to sequence a DNA plasmid (if you use Plasmidsaurus ).

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