PLOS: DNA Science

APRIL 20, 2023

DNA is a sleek double helix, with “rungs” consisting of a purine base paired with a smaller pyrimidine base: adenine (A) with thymine (T) and guanine (G) with cytosine (C). . ” DNA encodes amino acid sequences comprising proteins, which impart traits. Watson and F.

DNA 52

DNA Virus Science RNA 52

Codon

FEBRUARY 13, 2024

doi: 10.2210/rcsb_pdb/goodsell-gallery-048 The Virus that Cures It’s been over 25 years since the science magazine Discover first ran an extraordinary article about how a long-forgotten medical treatment, used in the former Soviet country of Georgia, could save us from the growing threat of untreatable, drug-resistant infections.

Therapies 131

Therapies Virus DNA Clinical Trials 131

Drug Target Review

DECEMBER 28, 2023

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell. These mutations are called clonal mutations or clonal neoantigens.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

NIH Director's Blog: Drug Discovery

MARCH 8, 2016

Instead of the black, printed stripes of the Universal Product Codes (UPCs) that we see on everything from package deliveries to clothing tags, they used short, unique snippets of DNA to label cells. DNA barcoding has already empowered single-cell analysis, including for nerve cells in the brain.

DNA 52

DNA Drugs Small Molecule FDA Approval 52

Codon

DECEMBER 12, 2024

It’s important to note that the 300-page report, while presenting detailed evidence for the potential harms of mirrored life, uses painstakingly speculative language. DNA and RNA molecules are also built from exclusively right-handed nucleic acids. It would also be undetectable by key parts of the human immune system.

RNA 104

RNA DNA Vaccine Virus 104

Drug Target Review

APRIL 17, 2024

HLA are the critical molecules that our immune systems use to present peptides to T cells and facilitate recognition and killing in immune responses to pathogens. HLA-II presents peptides to CD4 T cells thought to be important for indirectly helping immune responses and facilitating antibody production.

Immune Response 105

Immune Response Laboratories DNA Virus 105

PLOS: DNA Science

AUGUST 22, 2024

The Genetic Explanation Doesn’t Work The narrative returns to the present. ” The explanation continues, and here’s where it ceases to make sense, to anyone who knows anything about DNA, genes, and genomes. A plant genome consists of DNA, and NOT pieces of 2,4-D, which is a completely unrelated organic acid.

DNA 68

DNA Virus Organic Chemistry Science 68

Codon

SEPTEMBER 29, 2024

mRNA was the intermediate stage between DNA and protein, a dynamic entity that shifted depending on the second-to-second needs of the cell, able to point out if a cell was cancerous or stressed, what kind of cell it was, and so on. Collections of mRNA have been understood as a proxy for cell states for decades.

Engineering 142

Engineering Virus DNA Therapies 142

PLOS: DNA Science

JUNE 13, 2024

The virus SARS-CoV-2 emerged in Wuhan, home of a premiere research institute that focuses on viruses. Experiments at the Wuhan facility were done at the lowest two of the four standard biosafety levels, which were established at the dawn of recombinant DNA research in the 1970s. An altered virus could have escaped. Coincidence?

Virus 52

Virus RNA DNA Science 52

Codon

JUNE 25, 2024

However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide. Most medicines, including insulin and semaglutide (the weight loss drug), are made using DNA cloning. However, E.

DNA 82

DNA RNA Laboratories Research 82

PLOS: DNA Science

OCTOBER 12, 2023

million DNA bases. The DMD gene therapy delivers a shortened version of the dystrophin gene, just 4,558 DNA bases. First, adeno-associated virus (AAV) delivers the genes, rather than the adenovirus (AV) that had entered cells in Jesse’s liver that weren’t the targets. Two other design strategies add precision.

Therapies 69

Therapies Immune Response DNA Virus 69

DrugBank

MARCH 12, 2025

Once delivered into the body, the mRNA instructs cells to produce these antigens, which are then presented to the immune system. This approach can be personalized for each patient by sequencing the tumor's DNA and RNA to identify unique mutations.

Vaccine 97

Vaccine Treatment Clinical Trials Therapies 97

The Pharma Data

SEPTEMBER 28, 2021

Acute respiratory infections are one of the leading causes of death and disability globally, presenting substantial health challenges especially for infants, the elderly and the immunocompromised. TaqMan® DNA probes that hybridise with the target strand are labeled with a fluorescein allowing real-time measurements during the PCR process.

Marketing 52

Marketing Virus DNA Disease 52

PLOS: DNA Science

FEBRUARY 15, 2024

A Five-Generation Saga The tale alternates between ancestors and the present generation farming the same land. The narrative is a bit confusing because Aki is the only ancestor named, and there’s no family tree to link present-day Jake to the past. But dirt is dead, depleted of life. The soil microbiome and gut microbiome?”

Science 96

Science DNA Laboratories Virus 96

Drug Target Review

SEPTEMBER 8, 2023

The cell’s nucleus, containing compacted DNA, is centrally positioned within the cell. It didn’t have the tools that are important for nuclear receptors, namely the ability to interact with DNA and the ability to translocate from the cytoplasm to the nucleus,” says Cheroutre.

Regulations 98

Regulations Research DNA Immune Response 98

DrugBank

NOVEMBER 4, 2024

  The erosion of existing antibiotic efficacy due to resistance presents a challenge — an urgent public health crisis and a potential market opportunity. The World Bank' s projection of a potential $3.4 trillion loss in GDP by 2030 shows the urgency of this crisis. 

Pharmaceutical Companies 98

Pharmaceutical Companies Pharmaceuticals Government DNA 98

The Pharma Data

MARCH 22, 2022

The findings were presented during an oral session at the European Society for Blood and Marrow Transplantation (EBMT) 48th Annual Meeting (Abstract #OS04-07). PREVYMIS is fully active against viral populations with substitutions conferring resistance to CMV DNA polymerase inhibitors. See additional results below.

Disease 52

Disease Virus DNA Therapies 52

The Pharma Data

DECEMBER 3, 2020

Consequently, performing an immunoassay in the early stages of an infection will be negative because the antibodies cannot be produced yet, even though the disease is present. The amount of DNA produced is much higher, and a positive test result can be viewed visually without the need for an additional analysis step,” the study reported.

RNA 52

RNA Virus DNA Disease 52

Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? DNA vectors in mouse models? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context.

Therapies 59

Therapies RNA Protein Expression DNA 59

DrugBank

JANUARY 29, 2025

Gene Therapy Gene therapy operates on the principle of modulating the DNA blueprint of cells to induce a therapeutic response. These disorders, often characterized by a loss-of-function mutation in a crucial gene, can manifest with a wide range of clinical presentations, depending on the specific gene and its role in cellular physiology.

Therapies 52

Therapies DNA RNA Disease 52

New Drug Approvals

SEPTEMBER 6, 2024

TLR7-9 are among the set that are endosomally located and respond to single-stranded RNA (TLR7and TLR8) or unmethylated single-stranded DNA containing cytosine-phosphate-guanine (CpG) motifs (TLR9). Toll/IL-1 receptor family members are important regulators of inflammation and host resistance. Nature Immunol., 11:373-384 (2010)).

RNA 62

RNA Clinical Trials Disease DNA 62

Advarra

JUNE 13, 2024

Recombinant DNA technologies and genetically modified biological agents are being adapted for a wide scope of therapeutic applications, and their use is becoming increasingly common in clinical trials. The SOP should list these symptoms and any available prophylaxis for post-exposure treatment.

Clinical Trials 52

Clinical Trials Engineering Trials Virus 52

Advarra

MARCH 31, 2023

This trend came to the forefront during the COVID-19 pandemic, as the three most popular vaccines developed in response to the coronavirus contained engineered genetic materials in the form of mRNA or a genetically engineered virus. Either way, occupational exposure to these gene delivery systems bears potential risks to the research staff.

Engineering 52

Engineering Clinical Research Research Virus 52

Codon

APRIL 2, 2023

But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression. Read Switchable hydrophobic pockets in DNA protocells enhance chemical conversion. Nature Microbiology. Meeussen J.V.W.

DNA 52

DNA RNA Engineering Licensing 52

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. “The first printout of the human genome to be presented as a series of books, displayed in the 'Medicine Now' room at the Wellcome Collection, London. It fills up an entire bookcase ! From Ling B et al.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. “The first printout of the human genome to be presented as a series of books, displayed in the 'Medicine Now' room at the Wellcome Collection, London. It fills up an entire bookcase ! From Ling B et al.

Therapies 52

Therapies RNA DNA Engineering 52

Drug Target Review

OCTOBER 2, 2024

For example, integrating gene therapies that alter the DNA of cardiac cells pose risks of unintended genetic modifications, which could lead to tumorigenesis. Still, the high cost of CGTs, driven by their complexity and individualised nature, presents barriers to widespread adoption in cardiology, limiting patient access.

Therapies 98

Therapies Disease Engineering RNA 98

The Pharma Data

MARCH 20, 2021

presented the. DNA biomarker services in an accredited environment. Ghent University Hospital for SARS-CoV-2 virus screening. study RNA virus replication and virus-host interactions and in particular the use of single-cell proteomics to aid in this research. In his webinar, Neil discussed the use of the MANTIS.

Laboratories 52

Laboratories Virus RNA Bioinformatics 52

Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito.

DNA 52

DNA Engineering Therapies RNA 52

Codon

JULY 21, 2024

” One way that this dispassionate review system could be improved, Weary suggests, is to find a way of making the animals present to the committee—maybe even by having a live rodent in the room. So rather than walk away, as the objectors do in Omelas, we can take the actions presently available to us.

Research 124

Research Engineering Disease Science 124

The Pharma Data

OCTOBER 21, 2020

These findings were presented today at the 2020 Infectious Diseases Society of America (IDSA) IDWeek. Participants identified as impacted by COVID-19 will continue to be followed and data collected from that group is expected to be presented at a future medical meeting. Kimberly Smith, M.D.,

Clinical Development 52

Clinical Development Therapies Clinical Trials Treatment 52

The Pharma Data

DECEMBER 5, 2020

The first of the new therapies, developed at Harvard Medical School by a team led by Dr. David Williams, uses a virus to introduce RNA into the extracted bone marrow that turns off BCL11A. The CRISPR gene editing method won the 2020 Nobel Prize in Chemistry, and uses chemicals to open up and directly edit DNA sequences, Hsu said.

Therapies 52

Therapies Disease Medical Schools Virus 52

The Pharma Data

SEPTEMBER 1, 2020

This can help healthcare professionals identify a SARS-CoV-2 infection in people suspected to carry the virus with results typically ready in 15 minutes. The SARS-CoV-2 Rapid Antigen Test is for use in point of care settings for both symptomatic and asymptomatic people.

Virus 52

Virus Laboratories Clinical Trials Treatment 52

The Pharma Data

OCTOBER 14, 2020

The research is part of an ongoing collaboration between Columbia University and Tonix that focuses on T cell and antibody responses to SARS-CoV-2 (CoV-2), the virus that causes COVID-19. The research encompasses two projects. The study led by Dr. Ilya Trakht, Ph.D., The study led by Dr. Sergei Rudchenko, Ph.D., About TNX-1800.

Vaccine 40

Vaccine Pharmaceuticals Small Molecule Virus 40

Codon

APRIL 30, 2023

Yeast die for two reasons: Either their nucleolus (where the DNA is kept) degrades and dies, or their mitochondria whimpers out and they stop making energy. The vaccine printer can make lots of different types of vaccines, including protein, DNA, and mRNA ones, but I’m sure this is all quite expensive right now. From Zhang et al.

Vaccine 52

Vaccine DNA Engineering RNA 52