Covalent Modifiers

MARCH 1, 2024

CHANG Science 2023 382, 6670 DOI: 10.1126/science.abp9201 INTRODUCTION One-carbon metabolism manages cellular carbon pools by detoxifying highly reactive carbon species, such as aldehydes, and diverting their carbon toward the biosynthesis of useful products, including amino acids and nucleotides.

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The Premier Consulting Blog

MARCH 7, 2024

The analytical package, consisting of release, stability, and characterization tests, includes data generated throughout the product development and manufacturing process. For gene therapy vectors, this testing encompasses production cell lines, master and working cell banks (MCB, WCB), and virus banks.

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addgene Blog

AUGUST 13, 2024

Since recombinant antibodies conveniently allow for unlimited production, reliable expression, and easy distribution as DNA (Trimmer, 2020), you may be interested in using them in your own experiments. It is possible to produce your own recombinant antibodies with some molecular biology and cell culture experience.

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Molecular Biology DNA Production 98

ASPET

MARCH 20, 2024

DNA topoisomerase IIβ (TOP2β/180; 180 kDa) is a nuclear enzyme that regulates DNA topology by generation of short-lived DNA double-strand breaks primarily during transcription. TOP2β/180 can be a target for DNA damage-stabilizing anticancer drugs, whose efficacy is often limited by chemoresistance.

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NIH Director's Blog: Drug Development

MARCH 11, 2014

Credit: Jane Ades, National Human Genome Research Institute, NIH Type 2 diabetes (T2D) tends to run in families, and over the last five years the application of genomic technologies has led to discovery of more than 60 specific DNA variants that contribute to risk.

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NIH Director's Blog: Drug Discovery

MARCH 8, 2016

Instead of the black, printed stripes of the Universal Product Codes (UPCs) that we see on everything from package deliveries to clothing tags, they used short, unique snippets of DNA to label cells. DNA barcoding has already empowered single-cell analysis, including for nerve cells in the brain.

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Drug Target Review

JULY 7, 2023

The reasons for this are multifaceted, including concerns over the safety of directly altering DNA sequences and subsequent regulatory restrictions that have arisen as a result. The epigenome (meaning ‘above the genome’) is a system of reversible marks regulating how the DNA is read, translated and used. What is epigenetic editing?

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Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

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The Premier Consulting Blog

APRIL 13, 2025

This pathway allows novel drug products to leverage data from other approved drugs (in the US and abroad), greatly reducing and sometimes altogether avoiding animal testing for approval. from approved products in other countries) to inform doses and development. Focus Areas: Model-Informed Product Development. link] [7] H.R.2565

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DrugBaron

JANUARY 8, 2021

Sarepta is no stranger to controversy, following the decision of the US regulator to approve the company’s earlier product, eteplirsen, which induces exon-skipping to improve expression of dystrophin protein in individuals who carry the mutant gene, as Exondys 51 back in 2016.

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PLOS: DNA Science

FEBRUARY 8, 2024

They write: “Genome engineering of probiotics, including the editing of the genome to introduce, remove, or modify phenotypes, will improve their tolerance to stress during food production, promote their survival in the gastrointestinal tract, or enhance their probiotic function. appeared first on DNA Science. CRISPR Hubris?

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The Pharma Data

DECEMBER 23, 2020

” Dr. Stanley Plotkin , Professor Emeritus at The Wistar Institute, said, “INOVIO’s DNA vaccine appeared to be quite safe with few significant reactions but yet induced both antibody and T cell responses to SARS-CoV-2.” About INOVIO’s DNA Medicines Platform. mg and 2.0

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Drug Target Review

JANUARY 8, 2024

With cellular rejuvenation, our goal is to improve healthspan so as to maximise the number of healthy and productive years one has in their lifetime, not just their total number of years. Jerry began his career at Merck and was extensively involved in multiple blockbuster product launches. acquired by Teva Pharmaceuticals in 2014.

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DrugBank

MARCH 28, 2024

Astronauts face a myriad of ongoing and long-term risks that include reduced muscle mass and bone density loss, accelerated cancer cell metastasizing, and DNA damage. Their focus spans a wide range of potential solutions, from drug repurposing to the creation of nutrient-dense products tailored to counteract the omics-level changes. 

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FDA Law Blog: Biosimilars

APRIL 4, 2023

Innovative medical devices; Innovative and essential pharmaceuticals; Digital health care; Advanced regenerative medicine and advanced bio-pharmaceuticals; DNA tests; Brain-machine interface; Infrastructure” We are excited to hear that South Korea is investing in the growth of the biohealth industry and promoting digital healthcare.

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Drug Target Review

DECEMBER 21, 2023

Jinhyeok Jeong from Samsung Biologics takes us on a journey from cell cultures to drug products, providing insights into the intricacies of bioprocessing. Drug Target Review explores the potential of stem cells in personalised regenerative medicine.

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Drug Target Review

JULY 5, 2023

A good introduction to the use of CHO cells for biotherapeutics production can be found in an article commemorating the 20th anniversary of the approval of a product produced using CHO cells. Over time, there may also be a cost benefit with developing a proprietary system if there is a pipeline of multiple products to produce.

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Drug Target Review

JUNE 9, 2023

This research has resulted in the first TCR-based therapeutic product candidate from the partnership to advance into clinical development. Looking ahead, Genentech has responsibility for clinical, regulatory and commercialisation efforts for any T-cell therapy product candidate.

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LifeSciVC

AUGUST 5, 2024

We are constantly reminded how we are in the midst of an artificial intelligence revolution of the drug development process which promises to completely transform how we develop drugs with increases in productivity of an order of magnitude or more. a company with the strongest pipeline in the entire industry.”

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SCIENMAG: Medicine & Health

MARCH 25, 2024

Nucleus Genomics, the next-generation genetic testing and analysis company, today announced the launch of its DNA analysis product to bring the benefits of personalized medicine to everyone. DNA and health are inextricably linked, but profound insights into how DNA can shape health are missing from healthcare.

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Broad Institute

APRIL 2, 2024

They combined shotgun metagenomic sequencing, which profiles all of the microbial DNA in a sample, with metabolomics, which measures the levels of hundreds of known and thousands of unknown metabolites. In the new study, the Broad team gained a more complete and detailed picture of the impact of gut microbes on metabolism.

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Drug Target Review

OCTOBER 23, 2024

Limitations of DNA-encoded chemical libraries in drug discovery DNA-encoded chemical libraries (DEL) are widely used in the pharmaceutical industry for drug discovery of small molecules. Figure 1: Synthesis process of self-purified DNA-encoded chemical libraries by dual-linker solid phase synthesis.

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sptlabtech

JUNE 9, 2023

firefly delivers a robust, user-friendly and space-economical solution to overcome the productivity challenges associated with manual library preparation, so you can unlock the full potential of NGS and drive transformative discoveries to shape the future of biology and medicine. This further translates to reduced amount of plastic waste.

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DrugBank

JUNE 13, 2024

This approach targets the fundamental instructions within a cell's DNA, either by correcting faulty genes or introducing entirely new ones to combat disease. These viral vectors act as microscopic shuttles, carrying the therapeutic DNA into the host cell's nucleus, where it can integrate into the genome.

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Codon

OCTOBER 13, 2024

.” From their first intrepid steps into the fields, GM crops have become a scapegoat for distrust in science and its overextension into formerly “unadulterated” products. Genetic engineering in the medicine cabinet is one thing; allowing it at the dinner table is another.

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Fierce BioTech

OCTOBER 26, 2023

The company has developed a disruptive DNA synthesis platform that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip. Listing Image oracle Listing Introduction Twist Bioscience’s DNA-based products are powering research to improve the lives of millions of people.

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Drug Target Review

DECEMBER 7, 2023

In an infected animal, cGAS senses viral DNA in cytoplasm whilst in an uninfected organism, DNA is confined in the nucleus. Bacteria must take a different approach as they do not have nuclei and if CBASS reacted to the presence of DNA, it would cause autoimmunity or the bacterium to attack itself, Banh said.

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Codon

DECEMBER 10, 2023

Predictive Models A “ sequence-to-function ” predictive model – an algorithm that determines a protein’s likely function solely by looking at the DNA sequence encoding it – is the natural successor to AlphaFold2. The biggest challenge will be to acquire DNA that encodes millions of different proteins.

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DrugBank

MARCH 12, 2025

This approach can be personalized for each patient by sequencing the tumor's DNA and RNA to identify unique mutations. Unlike gene-editing techniques such as CRISPR-Cas9, which involve permanent alterations to DNA, mRNA provides a transient yet effective means of addressing genetic deficiencies.

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Drug Target Review

DECEMBER 5, 2024

2 Structure and function of AAV capsids in gene therapy Wild-type AAV is composed of a protein shell (capsid) that contains a single-stranded DNA genome encoding proteins involved in viral replication, structure and assembly. Therefore, vectors based on these serotypes may enable targeted gene delivery and optimal transduction efficiency.

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Drug Target Review

APRIL 17, 2024

HLA-II presents peptides to CD4 T cells thought to be important for indirectly helping immune responses and facilitating antibody production. HLA-I molecules present peptides to CD8 T cells and are thought to be responsible for direct recognition and killing of cells with foreign viruses, bacteria, or oncogenic cancer cells.

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DrugBank

JANUARY 29, 2025

Gene Therapy Gene therapy operates on the principle of modulating the DNA blueprint of cells to induce a therapeutic response. In sickle cell disease, for instance, a missense mutation in the HBB gene , encoding the beta-globin subunit of hemoglobin, leads to the production of abnormal hemoglobin S.

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The Premier Consulting Blog

JULY 9, 2023

During the development of new small molecule drug products, developers must conduct impurity and degradant evaluation at several points in the program and to varying degrees. These evaluations include the active pharmaceutical ingredient (API), also known as the drug substance, and the drug product (formulated product).

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The Pharma Data

SEPTEMBER 11, 2021

By leveraging our unique ability to manufacture DNA at scale, we can construct proprietary antibody libraries precisely designed to match sequences that occur in the human body. The core of the platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip.

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Drug Target Review

MAY 28, 2024

Telomere damage, epigenetic dysregulation, DNA damage and mitochondrial dysfunction are primary drivers of damage in aging. It’s a product of the foetal genotype and has a unique tissue type that the mother accepts for nine months without rejecting, even though she’s imperfectly matched to it.

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FDA Law Blog: Biosimilars

MARCH 5, 2024

Gaulkin & Riëtte van Laack — As readers of this blog know, there is a lot of contention about the naming of alternative protein products (APPs), including both plant-based and cell-cultured alternatives for (traditional) animal products. We’ve previously blogged about this ongoing battle here , here , here , and here.

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Broad Institute

SEPTEMBER 11, 2024

Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA. Ultrasensitive measurement of hotspot mutations in tumor DNA in blood using error-suppressed multiplexed deep sequencing. Clin Cancer Res. 2018;24(8):1872-1880. doi:10.1158/1078-0432.CCR-17-1341 CCR-17-1341 Narayan A, Bommakanti A, Patel AA. Nat Methods.

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