DrugBank

JANUARY 29, 2025

Gene Therapy Gene therapy operates on the principle of modulating the DNA blueprint of cells to induce a therapeutic response. In sickle cell disease, for instance, a missense mutation in the HBB gene , encoding the beta-globin subunit of hemoglobin, leads to the production of abnormal hemoglobin S.

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Broad Institute

SEPTEMBER 11, 2024

Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA. High-throughput RNA profiling via up-front sample parallelization. Ultrasensitive measurement of hotspot mutations in tumor DNA in blood using error-suppressed multiplexed deep sequencing. Clin Cancer Res. 2018;24(8):1872-1880. Nat Methods.

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DNA RNA Research Production 52

The Pharma Data

OCTOBER 19, 2020

Spectrum’s self-contained saliva collection kit provides critical sample consistency while suspending and neutralizing viral RNA transcripts completely inactivating the live virus. Qualified commercial RNA extraction chemistries include Perkin Elmer, Thermo Fisher, Roche, and Qiagen. ABOUT SPECTRUM SOLUTIONS AND SPECTRUM DNA.

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RNA DNA Engineering Virus 52

DrugBank

JULY 24, 2024

The success of PARP inhibitors in BRCA-mutant ovarian and breast cancers validates this approach, and similar strategies are being tested for other DNA repair enzymes. By inhibiting "passenger" gene products like PRMT5 in MTAP-null cells, researchers can selectively target cancer cells while minimizing harm to healthy cells.

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Small Molecule Drugs Clinical Trials Therapies 98

Sygnature Discovery

SEPTEMBER 12, 2024

Structures solved of many different protein classes, including membrane proteins, protein complexes and recently RNA. With capabilities across X-ray Crystallography Crystallisation/co-crystallisation screening of proteins, DNA, and RNA using in-house and commercial screens at various temperature.

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Fragment Screening RNA Protein Production DNA 52

Broad Institute

JULY 11, 2024

IDH1 normally facilitates the activity of enzymes called demethylases, which remove chemical flags called methylation marks from DNA, allowing genes to be transcribed into RNA. In cells with mutant IDH1, this gene is silenced due to the buildup of 2HG, but mIDH1 inhibitors allow demethylases to facilitate cGAS expression.

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Treatment Immune Response Drugs Virus 72

DrugBank

MAY 15, 2024

Another promising avenue is the use of technologies like RNA interference and gene editing, which allow scientists to turn off the production of certain proteins altogether. These methods could bypass the need to directly target these proteins with traditional drugs.

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Small Molecule Molecular Biology Drugs Disease 98

New Drug Approvals

SEPTEMBER 6, 2024

TLR7-9 are among the set that are endosomally located and respond to single-stranded RNA (TLR7and TLR8) or unmethylated single-stranded DNA containing cytosine-phosphate-guanine (CpG) motifs (TLR9). In the case of autoimmune disorders, the aberrant sustained activation of TLR7/8/9 leads to worsening of disease states.

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RNA Clinical Trials Disease DNA 62

Dark Matter Blog

JULY 16, 2021

As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. Last stops at RNA My last roles in biotech were where my original passion began: DNA and RNA. My last stop at Arrakis Therapeutics is with a company targeting RNA with small molecules. Arrakis is the capstone of my career.

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The Pharma Data

NOVEMBER 22, 2020

The product is the most advanced gene-editing approach in development for transfusion-dependent beta thalassemia (TDT) and severe sickle cell disease. Cas-9 represents the Cas9 protein, an enzyme that cuts foreign DNA. Once the DNA has been cut, the cell’s natural repair mechanisms kick in.

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DNA Medical Schools Treatment Science 52

Broad Institute

AUGUST 24, 2022

Data from standard DNA and RNA sequencing approaches were integrated with mass spectrometry-based proteomics and phosphoproteomic analyses to derive more complete molecular portraits of treatment-responsive versus treatment-resistant tumors. "The These data suggest a multi-omics predictor for chemotherapy response is within reach.

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DNA Protein Expression Treatment Protein Production 52

Drug Target Review

AUGUST 16, 2024

Here, I oversee the medical strategy for both existing products and those in our development pipeline, including outcomes research. Additionally, she develops and fosters relationships with external organisations and experts to ensure that products continue to meet market needs and yield desired patient outcomes.

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Sygnature Discovery

JUNE 17, 2024

Our skilled protein science team can provide in-house production of proteins to support all these assay formats if needed. MST is notably effective for DNA binding proteins, where it outperforms flow-based systems in multi-component assay setups. Explore this page to learn about the technologies we use and their key benefits.

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Small Molecule Fragment Screening DNA Science 52

Drug Target Review

SEPTEMBER 18, 2024

Because they are mostly personalised medicines today, production is limited to one patient dose at a time and slowed by cumbersome and largely manual processes. AI can vastly improve cell culture, a critical step in cell therapy production. The cell and gene therapy (CGT) space provides a great example of the potential of AI.

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sptlabtech

JUNE 27, 2022

Like many other CLIA labs seeking to improve productivity and save on reagent costs, Aperture was on the lookout for an automation and miniaturization solution. Making the move to automation When Aperture first started using its RT-qPCR for testing saliva specimens, the protocol involved lots of time-consuming manual pipetting.

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Laboratories FDA Approval RNA FDA 52

Broad Institute

MARCH 27, 2025

Her research grew out of a project helmed by Andersson, Jones, Jesse Engreitz, and their collaborators at the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease (NNFC) at Broad: building computational models to predict which specific stretches of DNA called enhancers regulate which genesand in which cell types.

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Research DNA Regulations Disease 52

Drug Target Review

JUNE 11, 2024

My PhD work was focused on understanding how different helicases – small machines that unwind DNA and RNA – work and characterise them using biochemistry and biophysics tools. While I no longer perform experimental work, I participate in designing our roadmap to move our technology forward into a product.

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Engineering Science Molecular Biology Doctors 64

LifeSciVC

JULY 1, 2024

The central dogma of molecular biology is that information generally (with few exceptions) flows from DNA to RNA to Protein. This heterodimer will bring more meaning to your work, enhance your productivity, and open doors over time. Remember life’s Central Dogma. Don’t differentiate too quickly.

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Science Immune Response Molecular Biology RNA 90

The Pharma Data

NOVEMBER 5, 2020

In August, the company announced that it had entered a clinical collaboration agreement with Arbutus Biopharma Corporation to evaluate the product, in combination with Arbutus’ proprietary GalNAc delivered RNAi therapeutic AB-729 and NrtI therapy, for the treatment of chronic hepatitis B virus infection.

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The Pharma Data

JANUARY 13, 2021

” The Johnson & Johnson vaccine also would be hardier than either of the already approved vaccines because it relies on DNA technology rather than messenger RNA to prompt an immune system response. If you only have to give one dose, that would be great.” © 2021 HealthDay. All rights reserved.

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The Pharma Data

OCTOBER 21, 2020

The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency’s (EMA) recently issued a positive opinion recommending marketing authorisation for long-acting cabotegravir and rilpivirine in both injectable and tablet formulations.

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Clinical Development Therapies Clinical Trials Treatment 52

New Drug Approvals

JANUARY 9, 2024

CDK7 also plays a role in transcription and possibly in DNA repair. The trimeric Cak complex CDK7/CyclinH/MATl is also a component of TFIIH, the general transcription/DNA repair factor IIH (Morgan, DO., As a TFIIH subunit, CDK7 phosphorylates the CTD (Carboxy-Terminal-Domain) of the largest subunit of RNA polymerase II (pol II).

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Production DNA RNA Regulations 62

Alta Sciences

APRIL 17, 2024

Several viral vectors are being used currently, in addition to non-viral vectors, such as oligonucleotides, naked DNA, and lipoplexes and polyplexes. Our preclinical and bioanalytical experts have extensive experience in leading-edge technologies to support sponsors in the advancement of their gene therapy products.

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Drug Development Treatment FDA Approval Drugs 52

The Pharma Data

SEPTEMBER 1, 2020

In general, antigen tests have a high specificity, though are not as sensitive as molecular tests that amplify the target viral DNA or RNA sequence in order to generate a quantifiable signal to indicate the presence of the virus in a sample.

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Virus Laboratories Clinical Trials Treatment 52

The Pharma Data

SEPTEMBER 6, 2021

Roche’s Chief Medical Officer and Head of Global Product Development. Fusion and rearrangement (RE) detection using DNA and RNA-based comprehensive genomic profiling (CGP) of sarcomas. Baseline mutational profiles of patients (pts) with carcinoma-of-unknown-primary-origin (CUP) enrolled onto CUPISCO.

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Treatment Therapies DNA Trials 52

The Pharma Data

APRIL 30, 2021

“Our new products are delivering impressive performance and we are on the cusp of potential commercial approvals for more than a dozen new products or indications over the next two years – including five expected approvals in 2021.” Refer to the Key Product Revenues schedules for further details. to $7.47.

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Codon

JUNE 25, 2024

However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide. Most medicines, including insulin and semaglutide (the weight loss drug), are made using DNA cloning. However, E.

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DNA RNA Laboratories Research 90

Drug Target Review

JANUARY 24, 2024

Scientists from Northwestern Medicine have demonstrated that RNA interference could have a crucial role in the onset and development of Alzheimer’s disease (AD). sRNAs Cellular functions rely on numerous protein-coding and noncoding RNAs and the RNA-binding proteins associated with them, which form ribonucleoprotein complexes (RNPs).

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RNA Disease DNA Engineering 64

Drug Target Review

JULY 24, 2023

Through phylogenetic analysis and microscopy techniques, they identified a nuclear-encoded apicoplast RNA polymerase σ subunit called ApSigma. The initial subject of my research carrier was RNA polymerase principal sigma factors in bacteria. The first identification was based on a bioinformatic analysis.

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RNA Regulations Bioinformatics Laboratories 98

Codon

APRIL 14, 2025

DNA sequencing and synthesis costs have dropped precipitously, in part, because maintaining Carlson curves became a rallying point for the field. Leveraging transparency to drive competition has worked well in other fields, such as consumer products , economic policy , and cloud services.

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Protein Expression Engineering Research RNA 87

Drug Target Review

SEPTEMBER 4, 2023

Studies have shown that targeting some expression gene sites could lead to the production of new drugs as indicated. I had earlier proposed the use of Palmatine and Silver Nitrate in the efficacy against the RNA structure of the COVID-19 virus. We discovered it is highly effective and environmentally friendly.

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Drugs RNA DNA Disease 111

Drug Target Review

FEBRUARY 6, 2024

Advances in DNA and RNA-focused molecular diagnostic methods have made blood-based multi-cancer early detection (MCED) tests a reality, but not for all patients. About the author Bob Rochelle Chief Commercial Officer Bob Rochelle is a proven expert in launch, strategy, and marketing for novel healthcare products.

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DNA RNA Science Laboratories 105

BMG Labtech

DECEMBER 20, 2024

Whether it is determining concentrations of molecules like proteins or DNA, looking at enzyme kinetics for crucial reactions, or measuring something as fundamental as cell growth, you will find references to absorbance or optical density measurements. Optical density is also widely used for many scientific applications.

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DNA Science Laboratories RNA 52

The Pharma Data

JANUARY 21, 2021

In the ATLAS study, CABENUVA met the primary endpoint for noninferiority (the proportion of participants with plasma HIV-1 RNA ?50 50 copies per milliliter [c/mL] at Week 48), with a comparable number of patients receiving either CABENUVA or their daily current antiretroviral regimen (CAR) having an HIV-1 RNA level ?50

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New Drug Approvals

SEPTEMBER 23, 2024

Target: DNA/RNA Synthesis Pathway: Cell Cycle/DNA Damage Huntington’s disease (HD) is a progressive, autosomal dominant neurodegenerative disorder of the brain, having symptoms characterized by involuntary movements, cognitive impairment, and mental deterioration. SCHEME PATENT PTC Therapeutics Inc., 2020-01-02.

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Small Molecule RNA DNA Disease 57

PLOS: DNA Science

JUNE 13, 2024

Experiments at the Wuhan facility were done at the lowest two of the four standard biosafety levels, which were established at the dawn of recombinant DNA research in the 1970s. And a change to one specific part of the virus enabled it to locate and glom onto our cells, then slip inside and take over the protein production line.

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Virus RNA DNA Science 52

Drug Target Review

OCTOBER 2, 2024

RNA-based therapies, including mRNA and RNA interference (RNAi), are being explored to modulate gene expression in heart cells. For instance, mRNA therapies can promote the production of specific proteins required for heart tissue repair, while RNAi can silence harmful gene expression, such as those driving fibrosis in heart failure.

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