Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

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DNA Engineering RNA Small Molecule 91

The Pharma Data

JANUARY 5, 2021

Durham, North Carolina-based Ribometrix announced a strategic collaboration deal with Genentech , a Roche company, to identify and advance novel RNA-targeted small molecule therapeutics. This is because many proteins do not have small-molecule binding sites. This is not the first deal for RNA therapeutics for Genentech.

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RNA Small Molecule DNA Licensing 52

Sygnature Discovery

JUNE 17, 2024

Our skilled protein science team can provide in-house production of proteins to support all these assay formats if needed. Microscale Thermophoresis (MST) Microscale Thermophoresis (MST) is a technology that uses fluorescently labelled proteins to analyse small molecule binding in solution.

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The Premier Consulting Blog

JULY 9, 2023

During the development of new small molecule drug products, developers must conduct impurity and degradant evaluation at several points in the program and to varying degrees. These evaluations include the active pharmaceutical ingredient (API), also known as the drug substance, and the drug product (formulated product).

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Drug Target Review

DECEMBER 7, 2023

In an infected animal, cGAS senses viral DNA in cytoplasm whilst in an uninfected organism, DNA is confined in the nucleus. Bacteria must take a different approach as they do not have nuclei and if CBASS reacted to the presence of DNA, it would cause autoimmunity or the bacterium to attack itself, Banh said. But what, exactly?”

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Drug Target Review

JUNE 19, 2024

The other powerful benefit is that our cell lines can become any of the cell types of the human body – these cells have within their DNA the capability to become any of the more than 200 human cell types which you might want to manufacture. Just like small molecules and antibodies, cell therapies are changing how we treat patients.

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Dark Matter Blog

AUGUST 31, 2020

The majority of small molecule drugs induce their therapeutic effects by seeking out and binding to their intended target while avoiding most other molecules in the dense milieu of the cell interior. Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA.

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Nvidia Developer: Drug Discovery

MARCH 21, 2023

New supercomputing-scale large language models (LLMs) that understand biology and chemistry text are helping scientists understand proteins, small molecules, DNA, and biomedical text. These state-of-the-art AI models help generate de novo proteins and molecules and predict the 3D structures of proteins.

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Dark Matter Blog

JULY 16, 2021

As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. Last stops at RNA My last roles in biotech were where my original passion began: DNA and RNA. My last stop at Arrakis Therapeutics is with a company targeting RNA with small molecules. I wanted to use molecular biology to create drugs.

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The Pharma Data

JUNE 28, 2021

Broadens company’s oncology platform of Targeted Alpha Therapies / Acquisition includes actinium-225 labeled differentiated PSMA small molecule for the treatment of prostate cancer. It has been demonstrated to inflict difficult to repair damage to tumor cells by inducing DNA double strand breaks.

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The Pharma Data

DECEMBER 14, 2020

. The current standard of care for GBM consists of de-bulking surgery followed by combined treatments with fractionated ionizing radiation (IR) and the DNA alkylating agent temozolomide (TMZ). Over the period of treatment, tumors can evolve and begin to overexpress MGMT and therefore become largely resistant to TMZ.

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The Pharma Data

DECEMBER 13, 2020

Silmitasertib is a first-in-class small molecule drug that targets CK2 and acts as a CK2-inhibitor. Development is currently focused on two lead products: Silmitasertib (CX-4945) and Pidnarulex (CX-5461), both with novel mechanisms of action and for multiple indications. TAIPEI and SAN DIEGO , Dec. About Silmitasertib.

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The Pharma Data

OCTOBER 14, 2020

Assistant Professor of Medical Sciences at Columbia University Vagelos College of Physicians and Surgeons, is designed to generate DNA aptamer-based anti-idiotypes to selected monoclonal antibodies identified in Dr. Ilya Trakht’s study. Tonix’s portfolio is primarily composed of central nervous system (CNS) and immunology product candidates.

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The Pharma Data

JANUARY 21, 2021

Silmitasertib is a first-in-class small molecule drug that targets CK2 and acts as a CK2-inhibitor. Development is currently focused on two lead products: Silmitasertib (CX-4945) and Pidnarulex (CX-5461), both with novel mechanisms of action and for multiple indications. TAIPEI and SAN DIEGO , Jan. About Silmitasertib.

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Drug Target Review

MAY 4, 2023

Using GWAS, scientists identified areas of the genome important for producing fetal haemoglobin, a target based on its promise for reversing sickle cell anaemia, but they did not know which exact variant drives its production.

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The Pharma Data

APRIL 11, 2023

Both small molecule inhibitors in Immuno-Oncology are being jointly developed in a strategic research alliance with the German Cancer Research Center (DKFZ) in Heidelberg, Germany. The oncology franchise at Bayer includes six marketed products across various indications and several compounds in different stages of clinical development.

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Alta Sciences

APRIL 17, 2024

Several viral vectors are being used currently, in addition to non-viral vectors, such as oligonucleotides, naked DNA, and lipoplexes and polyplexes. Our preclinical and bioanalytical experts have extensive experience in leading-edge technologies to support sponsors in the advancement of their gene therapy products.

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Agency IQ

JULY 26, 2024

FDA’s new guidance on postapproval manufacturing changes for biosimilars focuses on current practice, new dosage forms Meeting a biosimilar user fee commitment, the FDA is expanding on its recommendations for biosimilar and interchangeable product applicants asking the FDA for post-approval manufacturing changes. switching studies).

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The Pharma Data

DECEMBER 27, 2020

This year has been difficult, but it has reinforced the importance of our mission: to treat and potentially even reverse the effects of serious diseases and conditions by advancing our novel cell therapy product candidates through clinical trials and into the hands of physicians.

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Agency IQ

AUGUST 11, 2023

BY KARI OAKES AUG 7, 2023 10:20 PM CDT Quick background on nitrosamines in pharmaceutical products Nitrosamines are a large and diverse class of chemicals, with more than 300 different structurally distinct species known today. This was eventually expanded to include biological products as well. To ensure the safety of the U.S.

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New Drug Approvals

APRIL 18, 2023

H]Cl.NCCCCN(CC1=NC2=CC=CC=C2N1)[C@@H]3C4=NC=CC=C4CCC3 AMD-070 is a small molecule drug candidate that belongs to a new investigational class of anti-HIV drugs known as entry (fusion) inhibitors. At the end of the distillation the product is expected to have precipitated. Molecular Weight 349.47 2309699-17-8 SMILES [H]Cl.[H]Cl.[H]Cl.NCCCCN(CC1=NC2=CC=CC=C2N1)[C@@H]3C4=NC=CC=C4CCC3

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New Drug Approvals

SEPTEMBER 23, 2024

Target: DNA/RNA Synthesis Pathway: Cell Cycle/DNA Damage Huntington’s disease (HD) is a progressive, autosomal dominant neurodegenerative disorder of the brain, having symptoms characterized by involuntary movements, cognitive impairment, and mental deterioration. SCHEME PATENT PTC Therapeutics Inc.,

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Drug Target Review

APRIL 16, 2024

By delivering radiation directly to the tumour cells, RLT can induce DNA damage, leading to cell death and tumour regression. Peptides are relatively small molecules compared to mAbs, making them easier and less costly to produce and modulate. In contrast, development of mAbs is typically resource intensive.

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New Drug Approvals

SEPTEMBER 29, 2024

link] 01 Aug 2022 Cortexyme is now called Quince Therapeutics You need to be a logged in or subscribed to view this content This small molecule is an orally available protease inhibitor targeting the lysine proteases of the periodontal pathogen Porphyromonas gingivalis. gingivalis DNA fragments in their CSF at baseline.

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Small Molecule DNA Disease Trials 62

Codon

APRIL 2, 2023

But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression. Read Switchable hydrophobic pockets in DNA protocells enhance chemical conversion. Nature Microbiology. Meeussen J.V.W.

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The Pharma Data

AUGUST 3, 2021

– Revenue from all key products grew in the quarter and 2021 year-to-date. announced an exclusive collaboration focused on the discovery, development and commercialization of potential novel small molecules that stimulate tumor-specific immune responses. Loxo Oncology at Lilly and Kumquat Biosciences Inc.

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The Premier Consulting Blog

APRIL 25, 2023

In the US, new small molecule drugs are developed under the requirements of Sections 505(b)(1) and 505(b)(2) of the FFDCA. Due to concerns over manufacturing consistency and stability, the FDA required all oral levothyroxine manufacturers to obtain NDAs to continue marketing their products lawfully.

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The Pharma Data

OCTOBER 14, 2020

has expanded its product portfolio to include Blueprint, a self-service, scientific visualization and analytics application for small molecule discovery. Talking Medicine uses advanced AI to provide pharmaceutical companies with real-time data intelligence. Dolmatics – U.K.-based based Dotmatics Ltd.

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PLOS: DNA Science

JUNE 22, 2023

A “DNA damage checkpoint” rests the cell cycle while special proteins repair damaged DNA. Throughout the cell cycle, cyclin and kinase proteins pair and part in ways that activate the genes whose products carry out mitosis. The candidate drug, vorasidenib, is a small molecule that inhibits survivin.

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Drugs Small Molecule DNA Clinical Trials 52

Codon

MARCH 20, 2023

Point-of-care peptide hormone production enabled by cell-free protein synthesis. Marine biofilm engineered to produce current in response to small molecules. Digital nanoreactors to control absolute stoichiometry and spatiotemporal behavior of DNA receptors within lipid bilayers. DeWinter MA. ACS Synthetic Biology.

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DrugBank

FEBRUARY 26, 2025

Targeting Novel Bacterial Pathways Traditional antibiotics often target essential bacterial processes such as cell wall synthesis or DNA replication. In 2020, MIT researchers demonstrated the potential of AI by discovering salicin , a novel antibiotic that targets bacterial energy production.

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Agency IQ

APRIL 19, 2024

Over time, as more products have been approved for MM, the list of potential combinations has also grown. Products granted accelerated approval are required to conduct confirmatory studies to verify their clinical benefit and convert the accelerated approval to a traditional approval.

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The Pharma Data

DECEMBER 21, 2020

The UK Medicines and Healthcare products Regulatory Agency participated in the review as an observer. These included Health Canada, the Australian Therapeutic Goods Administration, the Brazilian Health Regulatory Agency (Anvisa), Swissmedic, and Singapore Health Sciences Authority.

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Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

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Drug Target Review

OCTOBER 4, 2023

2 In response, DNA-damaging agents that could target the entire cell cycle received renewed attention as ADC payloads. Groundbreaking strategies like proteolysis-targeting chimeric molecules (PROTACs) are also being explored. DNA damaging agent-based antibody-drug conjugates for cancer therapy. Florian S, Mitchison TJ.

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The Pharma Data

OCTOBER 26, 2020

Demand for our products remains robust, and production, supply and distribution of our medicines, vaccines and animal health products are moving forward with minimal disruption,” said Kenneth C. The following table reflects sales of the company’s top pharmaceutical products, as well as sales of animal health products.

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PLOS: DNA Science

AUGUST 8, 2024

This part of chromosome 15 is especially unstable because highly repetitive DNA sequences bracket the genes associated with the symptoms. Repeats can cause slippage as DNA replicates. The researchers scrutinized a “chemogenetic library ,” which is a collection of chemical compounds that bind to specific DNA sequences.

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