Conversations in Drug Development Trends

AUGUST 14, 2024

The analysis of circulating tumor DNA (ctDNA) in a liquid biopsy can also permit genotyping and help monitor the effectiveness of chemotherapy. Proteomics Proteomics involves studying the entire set of proteins expressed in a cell or tissue.

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Treatment Therapies Disease Protein Expression 78

The Pharma Data

MARCH 30, 2021

Fibroblast activation protein (FAP) is a cell-surface protein expressed at low levels in most normal adult tissues, but over-expressed in common cancers, particularly on cancer-associated fibroblasts that form the tumor stroma, which is essential for growth 1 ,2 ,3 ,4.

Therapies 52

Therapies Licensing Licensing Protein Expression 52

Drug Target Review

MAY 4, 2023

The researchers turned to CRISPR —a gene editing tool that uses “molecular scissors to cut DNA ,” according to Sanjana—to edit the regions identified by GWAS. The researchers then use CRISPR to target each of the regions of the genomes implicated by GWAS and conduct single-cell sequencing to evaluate gene and protein expression.

Disease 52

Disease Small Molecule Protein Expression Research 52

Drug Target Review

SEPTEMBER 10, 2024

The current landscape of protein drug development is characterised by accelerated timelines where new drugs are approved in months rather than years. For example, advances in media and feeds have contributed to higher cell protein expression by optimising nutrient availability and reducing accumulation of waste products within a culture.

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Drug Development Clinical Supply Production FDA 65

Alta Sciences

APRIL 17, 2024

Several viral vectors are being used currently, in addition to non-viral vectors, such as oligonucleotides, naked DNA, and lipoplexes and polyplexes. They work by binding to specific sequences of nucleotides present within the mRNA structure and can induce mechanisms that either decrease, restore, or modify protein expression.

Drug Development 52

Drug Development Treatment FDA Approval Drugs 52

Broad Institute

JUNE 27, 2024

By Greta Friar, Whitehead Institute June 27, 2024 Images of a mouse brain show the effect of a technology called CHARM in turning off the expression of a gene in the brain. Like Cas9, ZFPs can serve as guide proteins to direct the tool to a target site in DNA. Credit: Neumann EN, Bertozzi TM, et al.

Disease 142

Disease Therapies Clinical Trials Engineering 142

Drug Target Review

JANUARY 26, 2024

To find a DNA fragment that contained the intact ACE2 gene, complete with its embedded regulatory information, they searched libraries of cloned DNA fragments generated as part of the Human Genome Project. The team used the intact human ACE2 gene to increase the chances that mouse cells would incorporate and read the gene correctly.

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Production DNA Virus Protein Expression 115

Broad Institute

OCTOBER 4, 2023

Related links Merkin Prize Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The inaugural Richard N. Caruthers was announced as the winner in June for his development, in 1981, of an efficient, automated technology for synthesizing DNA.

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DNA RNA Science Protein Expression 52

Drug Target Review

SEPTEMBER 4, 2023

10 Reported cAMP as the second messenger signalling molecule conserved from bacteria to humans and modulates several biological processes, including protein expression, gene transcription, and cell development and differentiation. In this assay, active compounds are discovered under physiologically relevant conditions.

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Drugs RNA DNA Disease 111

Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context. DNA vectors in mouse models?

Therapies 59

Therapies RNA Protein Expression DNA 59

Codon

APRIL 9, 2023

.” This technology could be used to design protein therapeutics that can bind to, and “shut down,” harmful or misfolded proteins in living cells. Thousands of transcription factors — proteins that bind DNA and control gene expression — were studied in human cells. Bergs A.C.F.

Therapies 52

Therapies RNA Engineering Vaccine 52

Codon

FEBRUARY 16, 2025

Building a Circuit Much like electronic circuits, which use wires and transistors to create or process signals, a synthetic gene circuit is a network of biological parts — DNA, RNA, and proteins — that process inputs and generate outputs. Elowitz inserted his assembled DNA into E. 3 Subscribe to Asimov Press.

DNA 84

DNA RNA Engineering Small Molecule 84

Drug Target Review

JANUARY 20, 2025

Genetic factors Mutations or alterations in tumour DNA (eg, EGFR mutations in lung cancer or HER2 amplification in breast cancer) are key targets of precision medicine. Molecular factors Molecular markers, such as protein expression and signalling pathway activation, also guide therapy choices.

Clinical Trials 52

Clinical Trials Trials Drugs Drug Development 52

Conversations in Drug Development Trends

APRIL 7, 2025

Making strategic decisions when designing the protocol, such as including biomarkers like programmed death ligand-1 protein expression to guide the use of immune checkpoint inhibitors during treatment, can better assure safety and efficacy.

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Research Clinical Trials Trials Clinical Research 40