Drug Discovery World

SEPTEMBER 25, 2024

Additionally, the dynamic nature of tumour biology means that these targets can change over time, or under treatment pressure, necessitating continuous research and adaptation.” Stefan Ries is Chief Scientific Officer at DISCO Pharmaceuticals, a German company specialising in finding targets for targeted therapies such as ADCs.

Therapies 162

Therapies Pharma Companies FDA Approval FDA 162

Drug Discovery World

APRIL 17, 2024

DDW’s Diana Spencer speaks to Josh Mandel-Brehm , CEO of Massachusetts-based biotech CAMP4, to understand the role regulatory RNAs play in gene expression and how the founders overcame the challenge of launching a business based on brand new science. DS: You describe your therapeutics as RNA Amplifiers. How do they work?

Science 147

Science RNA Disease Protein Expression 147

Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context. DNA vectors in mouse models?

Therapies 59

Therapies RNA Protein Expression DNA 59

Drug Target Review

SEPTEMBER 4, 2023

I had earlier proposed the use of Palmatine and Silver Nitrate in the efficacy against the RNA structure of the COVID-19 virus. 3 Sirtuins are a family of seven protein that play a role in aging by controlling cellular health (all activities in the cell) and function in the presence of NAD+.

Drugs 111

Drugs RNA DNA Disease 111

Broad Institute

AUGUST 24, 2022

Louis have identified biological markers in triple negative breast cancer (TNBC) that are associated with resistance to chemotherapy treatment. It is imperative that we develop approaches to predict response so that only effective treatments are given. 33, was associated with resistance to chemotherapy treatment.

DNA 52

DNA Protein Expression Treatment Protein Production 52

DrugBank

JULY 24, 2024

For example, PROTACs targeting STAT3, a protein crucial for tumor growth, have shown promise where conventional therapies have failed. Similarly, PROTACs can target and degrade overexpressed proteins, offering a way to overcome drug resistance, a common issue in cancer treatment.

Small Molecule 82

Small Molecule Drugs Clinical Trials Therapies 82

Drug Discovery World

APRIL 30, 2024

Messenger RNA (mRNA) has come into focus within the drug discovery and development as an exciting tool to deliver genetic information. Its job is to carry coding information that is essential to the translation and processing of functional proteins.

Therapies 130

Therapies RNA Vaccine Small Molecule 130