DNA Protein Expression Therapies Treatment 
Drug Discovery World
SEPTEMBER 25, 2024
Getting new targets for ADCs is a high priority as it could lead to therapies that are more likely to hit cancer cells, allowing for higher doses and greater efficacy with fewer trade-offs needed to ensure an acceptable safety profile.
Drug Target Review
MAY 22, 2024
What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context.
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DrugBank
JULY 24, 2024
For example, PROTACs targeting STAT3, a protein crucial for tumor growth, have shown promise where conventional therapies have failed. Similarly, PROTACs can target and degrade overexpressed proteins, offering a way to overcome drug resistance, a common issue in cancer treatment.
Drug Discovery World
APRIL 17, 2024
Increasing gene expression via protein replacement or gene therapy has been shown to have limitations and drawbacks. CAMP4 is the only company modulating gene expression at the transcriptional level to increase mRNA production and thereby increase healthy protein production. Can you give some examples?
Drug Target Review
SEPTEMBER 4, 2023
10 Reported cAMP as the second messenger signalling molecule conserved from bacteria to humans and modulates several biological processes, including protein expression, gene transcription, and cell development and differentiation. In this assay, active compounds are discovered under physiologically relevant conditions.
Drug Discovery World
APRIL 30, 2024
Reece Armstrong explores the potential and future opportunities for mRNA-based therapies. For instance, consider how at the end of 2018, the mRNA therapies market was valued at $3.43 mRNA-based approaches can produce proteins / peptides by using protein synthesis which is processed in a transfected cell 1.
Broad Institute
JUNE 27, 2024
Science (2024) Related content New gene delivery vehicle shows promise for human brain gene therapy My Quest to Cure Prion Disease — Before It’s Too Late | Sonia Vallabh | TED Prion diseases lead to rapid neurodegeneration and death and are caused by misshapen versions of the prion protein in the brain.
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