Drug Target Review
JANUARY 26, 2024
To find a DNA fragment that contained the intact ACE2 gene, complete with its embedded regulatory information, they searched libraries of cloned DNA fragments generated as part of the Human Genome Project. The team used the intact human ACE2 gene to increase the chances that mouse cells would incorporate and read the gene correctly.
Drug Target Review
MAY 22, 2024
What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context. DNA vectors in mouse models?
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Broad Institute
AUGUST 24, 2022
Louis have identified biological markers in triple negative breast cancer (TNBC) that are associated with resistance to chemotherapy treatment. It is imperative that we develop approaches to predict response so that only effective treatments are given. 33, was associated with resistance to chemotherapy treatment.
Drug Discovery World
APRIL 17, 2024
CAMP4 is the only company modulating gene expression at the transcriptional level to increase mRNA production and thereby increase healthy protein production. DS: You say on your website that your approach is applicable to any disease where increasing protein expression is beneficial. Can you give some examples?
Drug Target Review
SEPTEMBER 4, 2023
10 Reported cAMP as the second messenger signalling molecule conserved from bacteria to humans and modulates several biological processes, including protein expression, gene transcription, and cell development and differentiation. In this assay, active compounds are discovered under physiologically relevant conditions.
Drug Discovery World
FEBRUARY 28, 2023
With only 10% of these conditions indicated for an approved therapy, there is a sizable opportunity for scientists and companies to develop treatments for patients with no other options to turn to. At this stage, qPCR can be used to check for IVT efficiency, residual DNA contamination and adventitious agents such as microbes.
Drug Discovery World
MAY 2, 2023
Steve Wowk , VP, Business Unit and General Management of Integrated DNA Technologies, shared with DDW the value of CRISPR-Cas9 in drug discovery. In an effort to defend themselves against viral infection, bacterial cells capture and copy DNA fragments of bacteriophages into their genome.
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