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A Look Back

Dark Matter Blog

As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. Last stops at RNA My last roles in biotech were where my original passion began: DNA and RNA. My last stop at Arrakis Therapeutics is with a company targeting RNA with small molecules. I wanted to use molecular biology to create drugs.

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Global advances in synthetic biology

Drug Discovery World

It is believed that the term synthetic biology was created in 1970 by geneticist, Waclaw Szybalski 1 as work was being carried out on the development of DNA sequencing and synthesis techniques. These factors can significantly contribute to the growth of the synthetic biology market, it adds. . Brady and colleagues turned to algorithms.

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The future outlook for mRNA therapies

Drug Discovery World

“This recognition has led to the development of programs encompassing vaccines, RNAi, and small molecules that span diverse therapeutic areas. It’s worth noting that the approach of small molecules interacting with mRNA biology represents a relatively new and potentially broader and more effective strategy.

Therapies 130
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Gene editing in organoids: accounting for complexity in drug discovery

Drug Discovery World

The genome is the blueprint for life, consisting of genes made up of thousands of pairs of DNA bases. Altering one base pair can drastically change how the gene’s protein product functions, while mutations can lead to the development of a range of genetic disorders. .

Drugs 246
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Codon Digest: Bacteria Resist Every Virus

Codon

Point-of-care peptide hormone production enabled by cell-free protein synthesis. Marine biofilm engineered to produce current in response to small molecules. Digital nanoreactors to control absolute stoichiometry and spatiotemporal behavior of DNA receptors within lipid bilayers. DeWinter MA. ACS Synthetic Biology.

Virus 52
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What to expect from PEGS Europe 2023: Day 3

Drug Discovery World

Michael Traxlmayr, PhD, Group leader, CD Laboratory for Next-Generation CAR T Cells, University of Natural Resources & Life Sciences, on: ‘Novel concepts to regulate CAR T cell activity with small molecule drugs in vivo’. These topics include: High-throughput (HTP) protein production and AI and automation in bioprocess development.

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Codon Digest: Discovering Antibiotics with Deep Learning

Codon

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52