Science Daily: Pharmacology News

AUGUST 16, 2024

To better understand the timing of this replacement, researchers sequenced mitochondrial DNA from archaeological dogs. Previous scientific studies have indicated that North American dog lineages were replaced with European ones between 1492 and the present day.

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Science Daily: Pharmacology News

MAY 22, 2024

New research has found that thousands of DNA sequences originating from ancient viral infections are expressed in the brain, with some contributing to susceptibility for psychiatric disorders such as schizophrenia, bipolar disorder, and depression.

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Broad Institute

AUGUST 16, 2023

Nuclear DNA influences variation in mitochondrial DNA By Allessandra DiCorato August 16, 2023 Breadcrumb Home Nuclear DNA influences variation in mitochondrial DNA Whole genomes from hundreds of thousands of people reveal new complexity in how the nuclear and mitochondrial genomes interact, which may influence how cells produce energy.

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Science Daily: Pharmacology News

NOVEMBER 19, 2024

Leveraging a unique statistical analysis and applying it to ancient DNA extracted from human skeletal remains, a team of researchers has revealed new insights into how ancient Europeans adapted to their environments over 7,000 years of European history.

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Science Daily: Pharmacology News

APRIL 23, 2024

Researchers describe the steps they took to manipulate DNA and proteins -- essential building blocks of life -- to create cells that look and act like cells from the body. This accomplishment, a first in the field, has implications for efforts in regenerative medicine, drug delivery systems and diagnostic tools.

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Science Daily: Pharmacology News

SEPTEMBER 19, 2024

Ancient DNA has provided spectacular insights into human history, particularly in Europe and Asia, where researchers have reconstructed the genomes of thousands of people.

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Broad Institute

OCTOBER 23, 2024

Machine learning guides researchers to new synthetic genetic switches By Tom Ulrich October 23, 2024 Breadcrumb Home Machine learning guides researchers to new synthetic genetic switches A new method allows precise activation or repression of genes in specific cells and tissues. By Sarah C.P. In a paper published in Oct.

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SCIENMAG: Medicine & Health

AUGUST 10, 2023

Pushing into a new chapter of technologically advanced biological sensors, scientists from the University of California San Diego and their colleagues in Australia have engineered bacteria that can detect the presence of tumor DNA in a live organism.

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Science Daily: Pharmacology News

FEBRUARY 20, 2024

By analysing ancient DNA, an international team of researchers have uncovered cases of chromosomal disorders, including what could be the first case of Edwards syndrome ever identified from prehistoric remains.

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Chemical Biology and Drug Design

JANUARY 29, 2024

MGMT mRNA expression was significantly increased in CD138+ myeloma cells compared with their matched CD138-nontumorigenic cells and inhibition of MGMT by its specific inhibitor lomeguatrib in MM cells reduced DNA repair, cell viability, and S phase entry and increased DNA damage and apoptosis.

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DNA Treatment Disease Research 100

PLOS: DNA Science

AUGUST 17, 2023

The Maui firestorm was so vast and fast that most identification of human remains will come from bits of persisting DNA from mitochondria. MtDNA in Forensics and Genealogy Mitochondrial DNA (mtDNA) is used in forensics to match the tiniest bits of human remains to families. Mitochondrial DNA is also far more abundant than nuclear DNA.

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PLOS: DNA Science

DECEMBER 14, 2023

“Meet Invisible Woods: a clean, refreshing scent revived from extinct flower DNA ,” beneath an image of “origin flower” Wendlandia angustifolia. • compare the DNA sequence to similar genes in other species. • tweak a lab-made copy of the DNA sequence using clues from other plant species.

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Broad Institute

JUNE 28, 2023

By Leah Eisenstadt June 28, 2023 Credit: Courtesy of the Zhang lab Cryo-EM map of a Fanzor protein in complex with ωRNA and its target DNA. They showed that Fanzor proteins use RNA as a guide to target DNA precisely, and that Fanzors can be reprogrammed to edit the genome of human cells.

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Science Daily: Pharmacology News

MARCH 8, 2024

For the first time, scientists have developed artificial nucleotides, the building blocks of DNA, with several additional properties in the laboratory.

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Broad Institute

JANUARY 8, 2024

Williams January 8, 2024 Credit: Susanna Hamilton, Broad Communications Researchers have developed virus-like particles that can deliver gene-editing cargo to cells, including those in the mouse brain. Prime editing, described in 2019 by Liu’s group, can make longer and more diverse types of DNA changes than other types of editing.

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Broad Institute

NOVEMBER 21, 2024

Researchers identify source of a brain cancer’s deadly transformation By Corie Lok November 21, 2024 Breadcrumb Home Researchers identify source of a brain cancer’s deadly transformation Slow-growing glioma tumors become more aggressive when their cells shift identities and acquire new genetic mutations.

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addgene Blog

SEPTEMBER 12, 2023

DNA sequence analysis. Primer design. Plasmid mapping. We all have our favorite tools for tackling these particular tasks, but they tend to be scattered about the internet. To help you keep your virtual molecular biology toolbox organized, today’s post features a list of free online molecular biology tools all in one place.

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Science Daily: Pharmacology News

OCTOBER 26, 2023

Researchers introduce a pioneering breakthrough in the world of nanomotors -- the DNA origami nanoturbine. The core of this pioneering discovery is the design, construction, and driven motion of a 'DNA origami' turbine, which features three chiral blades, all within a minuscule 25-nanometer frame, operating in a solid-state nanopore.

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Science Daily: Pharmacology News

DECEMBER 13, 2023

Researchers have come one step closer to unlocking the potential of synthetic DNA, which could help scientists develop never-before-seen proteins in the lab.

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Science Daily: Pharmacology News

AUGUST 10, 2023

Creating new technologically advanced sensors, scientists have engineered bacteria that detect the presence of tumor DNA in live organisms. Their innovation could pave the way to new biosensors capable of identifying various infections, cancers and other diseases.

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Chemical Biology and Drug Design

AUGUST 6, 2023

Radiotherapy induced DNA damage in rat lymphocytes. DNA damage was significantly reduced by 4 mg/kg/day Astaxanthin for 7 days. Astaxanthin may be a promising agent against radiotherapy induced DNA damage. Abstract Astaxanthin, a carotenoid pigment, is believed to be effective in the repair of DNA damage.

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Chemical Biology and Drug Design

FEBRUARY 26, 2024

The mechanism research revealed that cinnamaldehyde activated the Nrf2 pathway to attenuate lipid peroxidation and repair DNA damage to protect cardiomyocytes from ischemia/reperfusion injury in the OGD/R-induced H9C2 cardiomyocyte model. The severity of DNA damage was assessed by tail moment (TM) values using alkaline comet assay.

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Science Daily: Pharmacology News

OCTOBER 17, 2023

The DNA double helix is composed of two DNA molecules whose sequences are complementary to each other. Fluorescent markers bound to one of the matching DNA strands make the duplex visible, and fluorescence intensity increases with increasing duplex stability.

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Science Daily: Pharmacology News

NOVEMBER 2, 2023

A new study unveils a novel methodology to engineer colloidal quasicrystals using DNA-modified building blocks. The implications of this breakthrough are far-reaching, offering a potential blueprint for the controlled synthesis of other complex structures previously considered beyond reach.

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Science Daily: Pharmacology News

APRIL 24, 2024

A research team has discovered that cancer, one of the leading causes of death worldwide, can be caused entirely by epigenetic changes, in other words, changes that contribute to how gene expression is regulated, and partly explain why, despite an identical genome, an individual develops very different cells (neurons, skin cells, etc.).

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Chemical Biology and Drug Design

APRIL 24, 2023

Raltegravir, an integrase inhibitor approved for the treatment of HIV infection, led to an increase in DNA damage and apoptosis in multiple myeloma that remains as an incurable malignancy. In addition, the mRNA levels of V(D)J recombination and DNA repair genes were analyzed using qPCR. 01 for U66 and p  ˂ .0001

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Science Daily: Pharmacology News

OCTOBER 19, 2023

An international team of scientists has recently developed a novel type of nano engine made of DNA. The researchers are now planning to fit it with a coupling and install it as a drive in complex nano machines. It is driven by a clever mechanism and can perform pulsing movements.

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Broad Institute

JUNE 28, 2023

Merkin Prize in Biomedical Technology for developing an efficient, automated technology for synthesizing DNA. The chemical reactions that he discovered in the early 1980s to accurately and quickly assemble nucleotides into strands of DNA provided an essential element in the development of modern molecular medicine.

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Rapa Nui (Easter Island) with its gigantic statues and treeless landscape has fascinated researchers for centuries. A new genetic study disproves the popular theory that the Rapanui population collapsed as a result of an 'ecocide' and shows that the Rapanui admixed with Indigenous Americans centuries before Europeans arrived on the island.

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Broad Institute

OCTOBER 23, 2023

Researchers still do not fully understand why, in part because people of South Asian descent are largely underrepresented in genomic and cardiometabolic research. Researchers still do not fully understand why, in part because people of South Asian descent are largely underrepresented in genomic and cardiometabolic research.

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Science Daily: Pharmacology News

AUGUST 28, 2023

The stakes of their findings are high: a ruptured nucleus can lead to elevated DNA damage that is characteristic of many diseases, including cancer.

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Science Daily: Pharmacology News

AUGUST 22, 2023

For the first time, a group of researchers have successfully extracted ancient DNA from a 2,900-year-old clay brick. The analysis provides a fascinating insight into the diversity of plant species cultivated at that time and place, and could open the way to similar studies on clay material from other sites and time periods.

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ASPET

NOVEMBER 17, 2023

Despite a century of research, there are no specific treatments for acute or persistent ocular SM injuries. SM cytotoxicity emerges, in part, through DNA alkylation and double-strand breaks (DSBs). Exposure to higher doses can elicit persistent secondary keratopathies that cause reduced quality of life and impaired or lost vision.

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Chemical Biology and Drug Design

APRIL 15, 2023

The chemosensitive effects of miR-34 is mediated through increasing DNA damage and apoptosis in a p53 depended manner. The present study aimed to evaluate the effects of miR-34 restoration in OECM-1 oral cancer resistant to paclitaxel (OECM-1/PTX) and its underlying mechanisms through p53-mediated DNA damage and apoptosis.

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SCIENMAG: Medicine & Health

AUGUST 3, 2023

Combining ancient DNA (aDNA) with data from the 23andMe genetic database, researchers have uncovered the lineage and legacy – including more than 40,000 living relatives – of free and enslaved African Americans who labored at the Catoctin Iron Furnace in Maryland, between 1774 and 1850.

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SCIENMAG: Medicine & Health

MARCH 4, 2024

FOR IMMEDIATE RELEASE People with cancer have different amounts of a type of repetitive DNA — called Alu elements — than people without cancer. Researchers at the Johns Hopkins Kimmel Cancer Center have used this finding to improve a test that detects cancer early, […] Now, machine learning can measure that from a blood draw.

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DNA Research 73

Broad Institute

JANUARY 18, 2024

McAlpine January 18, 2024 Credit: Susanna Hamilton, Broad Communications One of the new "priming agents" works by preventing immune cells from engulfing tumor DNA circulating in the bloodstream. Liquid biopsies promise to transform how cancers are diagnosed, monitored, and treated by detecting DNA that tumors shed into the blood.

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