Science Daily: Pharmacology News

JUNE 13, 2024

With their 'T-REX' method, researchers developed a glassy, amber-like polymer that can be used for long-term storage of DNA, such as entire human genomes or digital files such as photos.

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Science Daily: Pharmacology News

AUGUST 16, 2024

To better understand the timing of this replacement, researchers sequenced mitochondrial DNA from archaeological dogs. Previous scientific studies have indicated that North American dog lineages were replaced with European ones between 1492 and the present day.

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Drug Discovery World

JULY 19, 2022

Non-coding or ‘junk’ DNA could contribute to the development of certain cancers due to how it disrupts the replication of the genome, scientists have discovered. . A team from The Institute of Cancer Research (ICR), London reconstituted the entire process of DNA replication in a test tube in order to understand it more completely. .

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Drug Discovery World

AUGUST 16, 2023

Samir Ounzain , PhD, CEO & Co-Founder of HAYA Therapeutics, looks at how a better understanding of our DNA can lead to increased activity for RNA therapeutics. Many scientists are now discovering that this junk DNA plays an essential role in our biology and the epigenetic processes that respond to the environment to drive disease.

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SCIENMAG: Medicine & Health

AUGUST 10, 2023

Pushing into a new chapter of technologically advanced biological sensors, scientists from the University of California San Diego and their colleagues in Australia have engineered bacteria that can detect the presence of tumor DNA in a live organism.

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Science Daily: Pharmacology News

MAY 22, 2024

New research has found that thousands of DNA sequences originating from ancient viral infections are expressed in the brain, with some contributing to susceptibility for psychiatric disorders such as schizophrenia, bipolar disorder, and depression.

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Drug Discovery World

OCTOBER 25, 2022

Recombinant production is a field in which Sino Biological has extensive expertise – the company boasts several platforms to use recombinant DNA technology for the manufacturing of a variety of proteins and antibodies to expedite the process of novel drug identification and validation, for example. . Listen here.

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Drug Discovery World

OCTOBER 25, 2022

Recombinant production is a field in which Sino Biological has extensive expertise – the company boasts several platforms to use recombinant DNA technology for the manufacturing of a variety of proteins and antibodies to expedite the process of novel drug identification and validation, for example. .

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Chemical Biology and Drug Design

JANUARY 29, 2024

MGMT mRNA expression was significantly increased in CD138+ myeloma cells compared with their matched CD138-nontumorigenic cells and inhibition of MGMT by its specific inhibitor lomeguatrib in MM cells reduced DNA repair, cell viability, and S phase entry and increased DNA damage and apoptosis.

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Science Daily: Pharmacology News

JANUARY 19, 2024

The science team designed a turbine engineered from DNA that is powered by hydrodynamic flow inside a nanopore, a nanometer-sized hole in a membrane of solid-state silicon nitride. Scientists have created a working nanoscale electomotor.

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Drug Discovery World

JUNE 22, 2023

In a new paper published in Nature , researchers at the Francis Crick Institute in the UK have outlined the structure and function of a protein complex which is required to repair damaged DNA and protect against cancer. The research could help inform the best line of treatment for people living with cancer.

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Drug Discovery World

JULY 25, 2024

UK researchers have mapped the exact variants in a gene that dramatically increase a person’s risk of developing cancer, paving the way for targeted treatment across diverse populations. The research team tested all 18,108 possible DNA changes in the BAP1 gene using ‘saturation genome editing’.

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Science Daily: Pharmacology News

AUGUST 10, 2023

Creating new technologically advanced sensors, scientists have engineered bacteria that detect the presence of tumor DNA in live organisms. Their innovation could pave the way to new biosensors capable of identifying various infections, cancers and other diseases.

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SCIENMAG: Medicine & Health

JUNE 19, 2023

Aleksandra Radenovic, head of the Laboratory of Nanoscale Biology in the School of Engineering, has worked for years to improve nanopore technology, which involves passing a molecule like DNA through a tiny pore in a membrane to measure an ionic current.

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Drug Discovery World

OCTOBER 4, 2023

Scientists have discovered the link between gene expression, DNA methylation, and brain structural changes in depression, revealing new potential therapeutic targets. The post Researchers uncover molecular pathways underlying depression appeared first on Drug Discovery World (DDW).

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Drug Discovery World

JUNE 11, 2024

Researchers have discovered a new biological pathway in inflammatory bowel disease (IBD) and related conditions that can be targeted using existing drugs. The researchers are now working with LifeArc to find ways to deliver MEK inhibitors directly to macrophages.

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Science Daily: Pharmacology News

FEBRUARY 20, 2024

By analysing ancient DNA, an international team of researchers have uncovered cases of chromosomal disorders, including what could be the first case of Edwards syndrome ever identified from prehistoric remains.

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Chemical Biology and Drug Design

FEBRUARY 26, 2024

The mechanism research revealed that cinnamaldehyde activated the Nrf2 pathway to attenuate lipid peroxidation and repair DNA damage to protect cardiomyocytes from ischemia/reperfusion injury in the OGD/R-induced H9C2 cardiomyocyte model. The severity of DNA damage was assessed by tail moment (TM) values using alkaline comet assay.

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Chemical Biology and Drug Design

AUGUST 6, 2023

Radiotherapy induced DNA damage in rat lymphocytes. DNA damage was significantly reduced by 4 mg/kg/day Astaxanthin for 7 days. Astaxanthin may be a promising agent against radiotherapy induced DNA damage. Abstract Astaxanthin, a carotenoid pigment, is believed to be effective in the repair of DNA damage.

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Science Daily: Pharmacology News

APRIL 23, 2024

Researchers describe the steps they took to manipulate DNA and proteins -- essential building blocks of life -- to create cells that look and act like cells from the body. This accomplishment, a first in the field, has implications for efforts in regenerative medicine, drug delivery systems and diagnostic tools.

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Drug Discovery World

MARCH 18, 2024

Landmark genetic research could allow doctors to accurately predict whether a patient is at risk of developing common diseases, decades before any symptoms would become evident. Snow Medical Research Foundation chair Tom Snow congratulated Dr Yengo, the first Snow Fellow from UQ: “Loic Yengo is a serious talent who we are proud to support.

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Science Daily: Pharmacology News

NOVEMBER 2, 2023

A new study unveils a novel methodology to engineer colloidal quasicrystals using DNA-modified building blocks. The implications of this breakthrough are far-reaching, offering a potential blueprint for the controlled synthesis of other complex structures previously considered beyond reach.

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Science Daily: Pharmacology News

DECEMBER 13, 2023

Researchers have come one step closer to unlocking the potential of synthetic DNA, which could help scientists develop never-before-seen proteins in the lab.

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Drug Discovery World

JANUARY 19, 2023

The post Key acquisition for next generation sequencing research assays appeared first on Drug Discovery World (DDW). The products, tools, talent and licensed technology will enable us to grow our NGS platform and unlock new market opportunities for IDT.”

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Science Daily: Pharmacology News

OCTOBER 26, 2023

Researchers introduce a pioneering breakthrough in the world of nanomotors -- the DNA origami nanoturbine. The core of this pioneering discovery is the design, construction, and driven motion of a 'DNA origami' turbine, which features three chiral blades, all within a minuscule 25-nanometer frame, operating in a solid-state nanopore.

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Science Daily: Pharmacology News

OCTOBER 17, 2023

The DNA double helix is composed of two DNA molecules whose sequences are complementary to each other. Fluorescent markers bound to one of the matching DNA strands make the duplex visible, and fluorescence intensity increases with increasing duplex stability.

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SCIENMAG: Medicine & Health

MARCH 4, 2024

FOR IMMEDIATE RELEASE People with cancer have different amounts of a type of repetitive DNA — called Alu elements — than people without cancer. Researchers at the Johns Hopkins Kimmel Cancer Center have used this finding to improve a test that detects cancer early, […] Now, machine learning can measure that from a blood draw.

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Chemical Biology and Drug Design

APRIL 24, 2023

Raltegravir, an integrase inhibitor approved for the treatment of HIV infection, led to an increase in DNA damage and apoptosis in multiple myeloma that remains as an incurable malignancy. In addition, the mRNA levels of V(D)J recombination and DNA repair genes were analyzed using qPCR. 01 for U66 and p  ˂ .0001

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Drug Discovery World

FEBRUARY 28, 2024

Lu Rahman selects some of the year’s interesting and noteworthy advances in cancer research drug discovery and development. In the UK, according to Cancer Research UK, around 167,000 people die from cancer in the UK each year. Research into new drugs and therapeutics is on-going and is helping drive mortality rates down.

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Drug Discovery World

APRIL 19, 2023

Scientists at The Institute of Cancer Research, London, are teaming up with small molecule neoantigen immuno-oncology company NeoPhore to develop new potential cancer drugs. Under a new strategic research collaboration, an ICR team led by Professor Chris Lord will investigate the effect of NeoPhore’s inhibitors on tumours in the laboratory.

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Science Daily: Pharmacology News

AUGUST 28, 2023

The stakes of their findings are high: a ruptured nucleus can lead to elevated DNA damage that is characteristic of many diseases, including cancer.

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Drugs.com

AUGUST 13, 2024

13, 2024 -- New research suggests that switching from smoking to vaping won't prevent some dangerous changes to a person's genome.A TUESDAY, Aug. new study conducted in young adults shows similar cancer-linked gene changes in both vapers and.

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Science Daily: Pharmacology News

OCTOBER 19, 2023

An international team of scientists has recently developed a novel type of nano engine made of DNA. The researchers are now planning to fit it with a coupling and install it as a drive in complex nano machines. It is driven by a clever mechanism and can perform pulsing movements.

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SCIENMAG: Medicine & Health

AUGUST 3, 2023

Combining ancient DNA (aDNA) with data from the 23andMe genetic database, researchers have uncovered the lineage and legacy – including more than 40,000 living relatives – of free and enslaved African Americans who labored at the Catoctin Iron Furnace in Maryland, between 1774 and 1850.

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Drug Discovery World

JANUARY 12, 2023

X-Chem and Sironax have agreed a research partnership, in which X-Chem will use its DEL platform to support Sironax’s drug discovery pipeline. . Through the collaboration, X-Chem will screen its DNA-encoded libraries (DEL) against difficult-to-drug targets implicated in neurodegenerative disease to discover hits.

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Drug Discovery World

APRIL 17, 2024

This webinar will detail how Oxford Nanopore evaluated long-read nanopore sequencing as a comprehensive and sensitive QC method for rAAVs which is supporting internal research activities at AstraZeneca. The post DDW event focusses on rAAVs and long-read nanopore sequencing appeared first on Drug Discovery World (DDW).

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Science Daily: Pharmacology News

AUGUST 22, 2023

For the first time, a group of researchers have successfully extracted ancient DNA from a 2,900-year-old clay brick. The analysis provides a fascinating insight into the diversity of plant species cultivated at that time and place, and could open the way to similar studies on clay material from other sites and time periods.

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