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DNA Analysis Finds New Target for Diabetes Drugs

NIH Director's Blog: Drug Development

Credit: Jane Ades, National Human Genome Research Institute, NIH Type 2 diabetes (T2D) tends to run in families, and over the last five years the application of genomic technologies has led to discovery of more than 60 specific DNA variants that contribute to risk.

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The First Patented G.M.O.

Codon

Modern biotechnology began in 1972 when biochemists at Stanford University spliced together DNA from two different organisms. The race to exploit recombinant DNA technology was on. General Electric Research Laboratory in Schenectady, New York. Credit: Matt H.

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What Biology Can Learn from Physics

Codon

Predictive Models A “ sequence-to-function ” predictive model – an algorithm that determines a protein’s likely function solely by looking at the DNA sequence encoding it – is the natural successor to AlphaFold2. The biggest challenge will be to acquire DNA that encodes millions of different proteins.

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Meet the Flower Designer Who Built a Laboratory In His Home

Codon

In a quiet New York town, an amateur scientist has constructed a fully equipped research laboratory in which to advance plant biology research. ” Earlier this year, we sent a photographer to Sebastian’s home laboratory. I use it to transform—or push DNA into—plant cells.

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What Biology Can Learn from Physics

Codon

Predictive Models A “ sequence-to-function ” predictive model – an algorithm that determines a protein’s likely function solely by looking at the DNA sequence encoding it – is the natural successor to AlphaFold2. The biggest challenge will be to acquire DNA that encodes millions of different proteins.

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Could Fluoride be the Solution to Antibiotic Resistance? A New Study Weighs In

The Pharma Data

. “Essentially, what Justin did was to create a series of DNA instructions you can give to cells that will enable them to survive when fluoride is around,” said O’Malley. ” This method may also provide significant cost-savings, particularly in relation to antibiotic-driven selection in research laboratories.

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LYNPARZA® (olaparib) in Patients with Metastatic Castration-Resistant Prostate Cancer to Stop for Futility

The Pharma Data

“There remains a significant unmet need for patients diagnosed with advanced prostate cancer, who have a poor prognosis after not responding to initial therapy,” said Dr. Roy Baynes, senior vice president and head of global clinical development, chief medical officer, Merck Research Laboratories.

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