Drug Discovery World

AUGUST 30, 2024

Revolver Therapeutics’ project will involve identifying tiny proteins, known as peptides, that can enter cells to prevent specific cancer-causing proteins from binding to DNA within a child’s brain tumour. It is hoped that by interfering with these DNA-binding proteins, these cancers affecting children can be treated.

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Drug Discovery World

MARCH 26, 2024

More importantly, it also highlighted that significant challenges remain in selecting the right therapies for the right patients despite the progress made through genomic testing and implementation of circulating tumour (ct) DNA analyses. We were there to present the latest findings from our research.

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Drug Discovery World

APRIL 11, 2023

The molecule, known as lissodendoric acid A, appears to counteract other molecules that can damage DNA, RNA and proteins and even destroy whole cells. USP30 inhibition has been proposed as a therapeutic strategy for Parkinson’s disease.

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Drug Research Research Drugs RNA 130

Drug Discovery World

MARCH 2, 2023

Scientists at The Institute of Cancer Research, London have revealed how a key epigenetic signal called H3K4me3 determines when and how DNA should be read and translated into proteins within our cells. But, until now, scientists lacked an understanding of what the chemical tag does, despite many years of research.

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RNA DNA Regulations Drugs 130

Drug Discovery World

SEPTEMBER 27, 2023

Epigenetics, often referred to as the ‘software’ of gene regulation, encompasses chemical modifications to DNA, such as methylation, and modifications of other proteins that organise DNA in the nucleus, known as histones, as well as RNA.

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DNA Regulations Disease RNA 289

Drug Discovery World

OCTOBER 2, 2023

This eBook sponsored by DNA Script explores the advances and breakthroughs taking place within vaccines and virology.

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Vaccine RNA DNA Research 130

Chemical Biology and Drug Design

DECEMBER 19, 2023

Tweaking of chemical compositions of natural nucleotide bases could be developed as novel building blocks of DNA/RNA. In the Hachimoji base pairing, synthetic building blocks are formed using eight modified nucleotide (DNA/RNA) letters (hence the name “Hachimoji”). The modified bases (dP, dZ, dS, and dB etc.)

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RNA DNA Research 100

Science Daily: Pharmacology News

MAY 29, 2024

New research has determined the spatial structure of various processes of a novel gene-editing tool called 'prime editor.' Functional analysis based on these structures also revealed how a 'prime editor' could achieve reverse transcription, synthesizing DNA from RNA, without 'cutting' both strands of the double helix.

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RNA DNA Therapies Treatment 97

Broad Institute

OCTOBER 4, 2023

Related links Merkin Prize Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The inaugural Richard N. Caruthers was announced as the winner in June for his development, in 1981, of an efficient, automated technology for synthesizing DNA.

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DNA RNA Science Protein Expression 52

Drug Discovery World

AUGUST 16, 2023

The study, by researchers at The Institute of Cancer Research, London, shows that certain characteristics within patients’ primary tumours can predict how they will respond to different treatments after their tumours have spread around the body.

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Therapies RNA DNA Clinical Trials 130

Codon

AUGUST 26, 2024

The Coalition for Epidemic Preparedness Innovations (CEPI)—a nonprofit organization that funds vaccine research and development—thinks so. Many research groups are now making broad-spectrum antivirals inspired by the innate immune system, leveraging recent advances in chemistry and biology. This work is already underway.

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Drug Discovery World

MAY 26, 2023

Although Clarivate has reported a recent drop in investment in the industry, it is good to see companies raising money through funding rounds and investing in new facilities, as well as government support coming through to boost research in areas of urgent need.

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Small Molecule DNA Government RNA 130

Science Daily: Pharmacology News

JUNE 8, 2023

Researchers report that two-spot octopuses adapt to seasonal temperature shifts by producing different neural proteins under warm versus cool conditions. The octopuses achieve this by editing their RNA, the messenger molecule between DNA and proteins.

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RNA DNA Research 128

Drug Discovery World

JANUARY 20, 2023

Differences in DNA, RNA, and protein can be identified in individual tissue samples, and even in individual cells. The massive data sets generated from this research have driven advances in data science and are used to inform additional studies and clinical practice.

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RNA DNA Science Research 130

Broad Institute

SEPTEMBER 11, 2024

Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA. High-throughput RNA profiling via up-front sample parallelization. Ultrasensitive measurement of hotspot mutations in tumor DNA in blood using error-suppressed multiplexed deep sequencing. Clin Cancer Res. 2018;24(8):1872-1880. Nat Methods.

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DNA RNA Research Production 52

Drug Discovery World

JANUARY 17, 2023

Oregon State University College of Pharmacy scientists have shown that lipid nanoparticles and messenger RNA could treat blindness associated with a rare genetic condition. . Researchers developed nanoparticles able to penetrate the neural retina and deliver mRNA to the photoreceptor cells whose proper function makes vision possible. .

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Small Molecule Pharmacy RNA Packaging 246

Broad Institute

AUGUST 31, 2023

Evolved prime editors are smaller and more efficient for therapeutic applications By Corie Lok August 31, 2023 Breadcrumb Home Evolved prime editors are smaller and more efficient for therapeutic applications Researchers have evolved the editing machine at the heart of the prime editing system, which can make a wide range of changes to the genome.

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Drug Discovery World

APRIL 17, 2024

DDW’s Diana Spencer speaks to Josh Mandel-Brehm , CEO of Massachusetts-based biotech CAMP4, to understand the role regulatory RNAs play in gene expression and how the founders overcame the challenge of launching a business based on brand new science. DS: How easy was it to transfer theoretical research into a viable business?

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Science RNA Disease Protein Expression 147

Drug Discovery World

AUGUST 22, 2024

Dr Rosenzweig-Lipson says: “We are at the forefront of drug development in an area of research called cellular rejuvenation, which is an approach that has the potential to address many diseases of ageing by restoring aged and injured cells to a more youthful and resilient state.

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Therapies DNA Disease RNA 147

Alta Sciences

APRIL 16, 2024

Inside The Altascientist: The Benefits of PCR for Your Gene Therapy Programs pmjackson Tue, 04/16/2024 - 19:04 The gene therapy landscape continues to accelerate in preclinical and clinical research, with programs constantly in development for targeted, personalized medicines. But how are PCR analysis techniques applied?

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Therapies DNA RNA Laboratories 52

Broad Institute

MARCH 8, 2024

Little is known about what pathogens cause these infections, and so these “non-malarial febrile illnesses” (NMFI) often fly under the radar of infectious disease surveillance programs because researchers don’t know which pathogens to look for. Tags: Infectious Disease DNA sequencing RNA sequencing Nature Communications.

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Research Disease Medical Schools RNA 111

DrugBank

MAY 22, 2024

In the dynamic world of drug discovery, the notion of "undruggable" targets presents both a significant challenge and an intriguing frontier for researchers and pharmaceutical companies. Here, researchers are looking at allosteric modulation—hitting different parts of the molecule to increase selectivity.

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Small Molecule RNA DNA Pharmaceutical Companies 67

PLOS: DNA Science

JULY 13, 2023

From animals like Hydractinia , we can learn about how senescence can be beneficial and expand our understanding of aging and healing,” said Andy Baxevanis, senior scientist at the National Human Genome Research Institute and co-author of a study recently published in Cell Reports. Within 3 days, a new head appears.

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RNA DNA Research Disease 83

Drug Target Review

DECEMBER 7, 2023

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. The novel, hairpin-shaped molecule was named cabRNA for CBASS-activating bacteriophage RNA.

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RNA Immune Response DNA Molecular Biology 59

Drug Discovery World

NOVEMBER 7, 2022

One might argue that this all started getting exciting with the launch of the Human Genome Project, which the National Human Genome Research Institute consider to be one of the greatest scientific feats in history 1. With Revio, researchers will be able to access that same great chemistry, but at a much larger scale.” . The origins

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Therapies DNA Disease Research 246

PLOS: DNA Science

JUNE 13, 2024

The virus SARS-CoV-2 emerged in Wuhan, home of a premiere research institute that focuses on viruses. A year before the initial outbreak, Wuhan researchers proposed nurturing a coronavirus with enhanced ability to attach onto, and enter, human cells. Her points: 1. Shortly thereafter, some workers became sick.

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Virus RNA DNA Science 52

Drug Discovery World

JANUARY 23, 2023

Researchers have discovered a clinical drug that sensitises glioblastoma (GBM) cells to radiotherapy and could replace the current standard of care. Armed with this understanding, the researchers further demonstrated that the genetic inhibition of DGAT1 suppresses radioresistance.

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FDA Approval FDA Drugs Pharmacokinetics 130

Drug Target Review

APRIL 26, 2023

Scientists from the Massachusetts Institute of Technology (MIT) and the University of Massachusetts Medical School (UMass), US, have collaborated to create a novel type of nanoparticle that can deliver messenger RNA that encodes for beneficial proteins to the lungs. The study appears in Nature Biotechnology.

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RNA Medical Schools Engineering DNA 98

Broad Institute

FEBRUARY 27, 2024

Broad-MIT Seminars in Chemical Biology By Rose Circeo February 27, 2024 Breadcrumb Home Research Broad-MIT Seminars in Chemical Biology MIT Chemistry and the Broad Institute host monthly seminars in chemical biology with the intent to hear from the thought-leaders and bring together chemical biologists from both academia and industry in the Boston/Cambridge (..)

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RNA DNA Regulations Disease 52

Broad Institute

JUNE 28, 2023

Merkin Prize in Biomedical Technology for developing an efficient, automated technology for synthesizing DNA. The chemical reactions that he discovered in the early 1980s to accurately and quickly assemble nucleotides into strands of DNA provided an essential element in the development of modern molecular medicine.

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DNA RNA Vaccine Research 52

Drug Target Review

JULY 24, 2023

Researchers from Tokyo Tech’s World Research Hub Initiative conducted a study to investigate the regulation of gene expression in the apicoplast of the malaria parasite Plasmodium falciparum. He has shared his excitement about the study’s implications and how it opens up new avenues in malaria research.

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RNA Regulations Bioinformatics Laboratories 98

Drug Discovery World

AUGUST 29, 2024

For example, multiple RNA helicases are being targeted for cancer and viral infections before their catalytic properties are well understood. The company’s SimpleStep ELISA (SSE) kits are sandwich ELISA assays developed to cover over 900 key targets across research areas, including immunology, immuno-oncology and neuroscience.

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Small Molecule Drugs Protein Expression Assay Development 147

Drug Target Review

NOVEMBER 13, 2023

The instructions to form a cell are encoded in DNA strands, wrapped in proteins and RNA, and wound together into a 3D structure called chromatin. Researchers have long understood that Foxp3 is essential for regulatory T cell development, but only as an on-off switch for regulatory T cell genes.

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Government DNA Regulations RNA 104

Drug Discovery World

JANUARY 26, 2023

The molecule, known as lissodendoric acid A, appears to counteract other molecules that can damage DNA, RNA and proteins and even destroy whole cells.

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Organic Chemistry Laboratories RNA DNA 130

Drug Discovery World

DECEMBER 21, 2023

Five 2023 breakthroughs in drug discovery for rare diseases Rare diseases are often overlooked for funding and research, but with various incentives and priority review programmes now in place, many companies are beginning to explore these unusual but often devastating conditions.

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FDA Approval Therapies Small Molecule Clinical Trials 147

PLOS: DNA Science

MARCH 7, 2024

Now new research published in Nature brings the just-so approach to the loss of tails among apes – including us. The researchers searched the DNA of humans and other primates for clues to how we lost our tails. Retrotransposons increase in number over time as DNA copies are peeled off of RNA templates.

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DNA RNA Research Science 52

PLOS: DNA Science

MARCH 28, 2024

Research also took place in two facilities in Italy, with sponsorship from Italfarmaco S.p.A. million DNA bases. The exons are nestled amongst the much longer introns, which are DNA sequences that are not represented in the final protein. Researchers have been working on developing gene therapy for DMD for decades.

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FDA Approval Treatment FDA DNA 75