KIF1A

JANUARY 27, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. #ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community.

Therapies 111

Therapies Small Molecule DNA Treatment 111

Drug Target Review

NOVEMBER 6, 2023

Advances in research and development and the utilisation of combination treatment strategies are revolutionising the haematology care landscape, but more must be done to address patients’ individual needs. To bring us closer to curing cancer, a combination of effective drugs with non-overlapping mechanisms of action is required.

Small Molecule 111

Small Molecule Therapies Treatment Disease 111

Drug Target Review

JULY 31, 2023

For my PhD project, I chose an advisor who worked on DNA and I started working with her on the physical properties of DNA. Could you share an example of a specific project or some research that you have worked on and its impact in your field? And that was a very controversial idea. ” And now nobody even asks that question.

DNA 98

DNA Small Molecule Science Cell Biology 98

Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

DNA 83

DNA Laboratories Hospitals Virus 83

Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

DNA 73

DNA Engineering RNA Small Molecule 73

Drug Target Review

JUNE 19, 2024

The other powerful benefit is that our cell lines can become any of the cell types of the human body – these cells have within their DNA the capability to become any of the more than 200 human cell types which you might want to manufacture. Just like small molecules and antibodies, cell therapies are changing how we treat patients.

Therapies 84

Therapies Small Molecule Pharmaceutical Companies Molecular Biology 84

PLOS: DNA Science

SEPTEMBER 5, 2024

Researchers from Harvard Medical School describe a new ChatGPT-like model that can guide clinical decision-making to diagnose, treat, and predict survival for several types of cancer. A name ending in “nib” means a small molecule that inhibits an enzyme called a kinase, and is short for “inhibit.”

Treatment 52

Treatment FDA Approval DNA Small Molecule 52

Dark Matter Blog

AUGUST 31, 2020

The majority of small molecule drugs induce their therapeutic effects by seeking out and binding to their intended target while avoiding most other molecules in the dense milieu of the cell interior. Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA.

RNA 52

RNA Small Molecule Bioinformatics Computational Chemistry 52

Drug Target Review

DECEMBER 7, 2023

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. Its presence elsewhere would indicate something is wrong. But what, exactly?”

RNA 59

RNA Immune Response DNA Molecular Biology 59

Nvidia Developer: Drug Discovery

MARCH 21, 2023

New supercomputing-scale large language models (LLMs) that understand biology and chemistry text are helping scientists understand proteins, small molecules, DNA, and biomedical text. These state-of-the-art AI models help generate de novo proteins and molecules and predict the 3D structures of proteins.

Small Molecule 52

Small Molecule Drugs Clinical Trials DNA 52

Drug Target Review

JULY 18, 2024

We believe liquid biopsy is very helpful for oncology drug development because the reduction and clearance of circulating DNA occurs quickly before radiographic imaging is available. The initial techniques were able to detect circulating tumour DNA in patients who already had metastatic spread. Nat Med 30, 531–542 (2024).

Drug Development 59

Drug Development Clinical Trials Drugs Vaccine 59

Dark Matter Blog

JULY 16, 2021

As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. Growing up in Shrewsbury, Massachusetts, it was natural for me to attempt to get a summer job up the road at the Worcester Foundation for Biomedical Research, where the first oral contraceptive was created. I wanted to use molecular biology to create drugs.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

Codon

DECEMBER 12, 2024

Among the report’s authors are 16 members of national academies, two Nobel Laureates, and several researchers who have previously been frontrunners in the quest to create mirrored life. ” 1 Now, it seems, these researchers have changed their minds. 4 As far as we know, right-handed proteins never occur naturally.

DNA 81

DNA RNA Vaccine Virus 81

DrugBank

OCTOBER 17, 2024

By utilizing high-resolution protein structures obtained through X-ray crystallography, researchers could design small molecules that potently inhibit the SARS-CoV-2 main protease, a key enzyme essential for viral replication.

Drug Development 71

Drug Development Metabolic Stability Clinical Trials Drugs 71

LifeSciVC

AUGUST 5, 2024

The genomic capabilities that were brought online for drug discovery (cheaper & faster next-gen DNA sequencing) did not diminish the need for biologists and translational scientists in target and patient selection, respectively. One final parallel to 2001.

Molecular Biology 85

Molecular Biology Production Small Molecule Drug Development 85

Drug Target Review

JULY 18, 2023

I think it is astonishing that The Human Genome Project was completed exactly 20 years ago and DNA was discovered by Franklin and published by Watson and Crick exactly 70 years ago, yet that 10 percent success rate has still not improved. This means that we are not doing something right.

Drug Development 98

Drug Development Drugs Clinical Development Pharmaceutical Companies 98

LifeSciVC

DECEMBER 6, 2022

But the beauty of working in the world of scientific research and drug discovery is that the status quo rarely ever stays that way for long. These hair clip-like molecules clamp onto DNA, thereby turning many genes on and off.

Small Molecule 40

Small Molecule DNA Regulations Science 40

The Pharma Data

MAY 15, 2023

Through the acquisition, Gilead gains rights to a portfolio of small molecule inhibitors targeting PARP1 for oncology and MK2 for inflammatory diseases that could enter clinical trials later this year. Executive Vice President, Research, Gilead Sciences. “The Executive Vice President, Research, Gilead Sciences.

Small Molecule 40

Small Molecule DNA Immune Response Science 40

Codon

APRIL 2, 2023

This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Nucleic Acids Research. Nucleic Acids Research.

DNA 52

DNA RNA Engineering Licensing 52

The Pharma Data

JUNE 28, 2021

Broadens company’s oncology platform of Targeted Alpha Therapies / Acquisition includes actinium-225 labeled differentiated PSMA small molecule for the treatment of prostate cancer. It has been demonstrated to inflict difficult to repair damage to tumor cells by inducing DNA double strand breaks.

Small Molecule 52

Small Molecule Licensing Licensing Therapies 52

The Pharma Data

APRIL 11, 2023

Bayer is progressing novel research around its prostate cancer treatment darolutamide. Both small molecule inhibitors in Immuno-Oncology are being jointly developed in a strategic research alliance with the German Cancer Research Center (DKFZ) in Heidelberg, Germany.

Research 40

Research Clinical Trials Small Molecule Trials 40

The Pharma Data

MARCH 7, 2022

Researchers from the University of Washington School of Medicine in Seattle describe this finding in the journal Cell Reports. The new technique controls gene activity without altering the DNA sequence of the genome by targeting chemical modifications that help package genes in our chromosomes and regulate their activity.

RNA 52

RNA DNA Packaging Small Molecule 52

PLOS: DNA Science

JUNE 22, 2023

“If you’re an adult with newly diagnosed non-small cell lung cancer that’s spread and tests positive for PDL1 without an abnormal EGFR your first option could be …” announces a TV ad for a pair of targeted cancer drugs, flying by so fast that I doubt many patients can grasp anything.

Drugs 52

Drugs Small Molecule DNA Bioethics 52

Codon

MARCH 19, 2024

Most cells (excluding T-cells and B cells after V(D)J recombination) in our body contain the same DNA but appear and behave in distinct ways: A neuron looks and acts very differently from a hepatocyte. While DNA is relatively stable , the epigenome is not; it has to orchestrate changes in cell state, cell type, and more.

DNA 55

DNA Small Molecule Regulations Laboratories 55

Molecule Blog

AUGUST 13, 2021

Announcing the first biopharma IP-NFT Transaction Funding the first longevity research project by utilizing intellectual property NFTs in the pharmaceutical space Summary The vote has passed, the decision is made: The Scheibye-Knudsen Lab will be the first research organisation to fund their longevity research via an IPNFT.

FDA Approval 52

FDA Approval DNA Small Molecule FDA 52

Codon

MARCH 20, 2023

Nucleic Acids Research. Marine biofilm engineered to produce current in response to small molecules. Digital nanoreactors to control absolute stoichiometry and spatiotemporal behavior of DNA receptors within lipid bilayers. CRISPR-induced DNA reorganization for multiplexed nucleic acid detection. Krypotou E.

Virus 52

Virus Engineering RNA Small Molecule 52

The Pharma Data

DECEMBER 2, 2020

Howard Mayer, Ipsen’s head of research and development, called the Fast Track designation for Onivyde “an extension of Ipsen’s focus and contribution” to the oncology landscape. Results show the protocol demonstrated a 30Gb+ yield of long DNA reads raw data of an E. The drug is a small-molecule inhibitor of the S.

Licensing 52

Licensing Licensing DNA Vaccine 52

LifeSciVC

MARCH 1, 2023

Importantly, they also pointed to something that we at HotSpot Therapeutics and a small group of other researchers and companies recognized several years ago – that scientific advances have made this attractive, but once considered ‘undruggable,’ target druggable.

Small Molecule 52

Small Molecule Immune Response DNA Therapies 52

Codon

MAY 30, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. Please send me your feedback. Thanks for reading.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. Please send me your feedback. Thanks for reading.

DNA 52

DNA RNA Engineering Vaccine 52

The Pharma Data

DECEMBER 14, 2020

. The current standard of care for GBM consists of de-bulking surgery followed by combined treatments with fractionated ionizing radiation (IR) and the DNA alkylating agent temozolomide (TMZ). Over the period of treatment, tumors can evolve and begin to overexpress MGMT and therefore become largely resistant to TMZ.

Clinical Trials 52

Clinical Trials DNA Drugs Therapies 52

The Pharma Data

MARCH 18, 2022

Columbia Engineering researchers report that they have developed a “cloaking” system that temporarily hides therapeutic bacteria from immune systems, enabling them to more effectively deliver drugs to tumors and kill cancer cells in mice. To test efficacy, the researchers then engineered E. coli cell surface. Next Steps.

Engineering 52

Engineering Drugs Small Molecule Therapies 52

KIF1A

MAY 6, 2023

Each week, Dr. Dominique Lessard and Dr. Dylan Verden of KIF1A.ORG summarize newly published KIF1A-related research and highlight progress in rare disease research and therapeutic development. In this week’s article, researchers collected high resolution recordings of the kinesin-1 motor protein as it walked along the microtubule.

Small Molecule 40

Small Molecule DNA Disease Research 40

Drug Target Review

MAY 4, 2023

A new approach developed by researchers at New York University (NYU) and the New York Genome Centre, US, combines genetic association studies, gene editing, and single-cell sequencing to address human genetic challenges and discover causal variants and genetic mechanisms for blood cell traits.

Disease 52

Disease Small Molecule Protein Expression Research 52

The Pharma Data

OCTOBER 14, 2020

The research is part of an ongoing collaboration between Columbia University and Tonix that focuses on T cell and antibody responses to SARS-CoV-2 (CoV-2), the virus that causes COVID-19. The research encompasses two projects. The study led by Dr. Ilya Trakht, Ph.D., The study led by Dr. Sergei Rudchenko, Ph.D., 1 Noyce RS, et al.

Vaccine 40

Vaccine Pharmaceuticals Small Molecule Virus 40

Elrig

APRIL 29, 2024

Srinivasan has led the development of multiple computational pipelines to process data from different next generation sequencing techniques with applications in oncology, genome editing systems including CRISPR-Cas mediated DNA editing, and ADAR-mediated RNA editing. There, I supported AI-enabled DD efforts in their small molecule portfolio.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

KIF1A

MAY 31, 2024

With hope, Angie Fuller, Director KIF1A.ORG Research and Therapeutic Development Until we find treatments and cures, our superheroes will continue to lose their hard-fought skills, abilities and even their lives. Your commitment and collaboration have been instrumental in our shared success. This is the fate of KAND unless we change it.

Treatment 52

Treatment Small Molecule International Research 52