Drug Discovery World

NOVEMBER 8, 2022

A team of researchers have identified the specific mutations in the monkeypox virus that contribute to its continued infectiousness. Mutations have enabled the virus to grow stronger and smarter, evading antiviral drugs and vaccines. . Monkeypox has infected more than 77,000 people in more than 100 countries worldwide.

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Drug Discovery World

MAY 1, 2024

This webinar will detail how Oxford Nanopore evaluated long-read nanopore sequencing as a comprehensive and sensitive QC method for rAAVs which is supporting internal research activities at AstraZeneca. Recombinant adeno-associated viruses (rAAVs) are considered a promising delivery system for gene therapy medicines.

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Drug Discovery World

APRIL 24, 2024

This webinar will detail how Oxford Nanopore evaluated long-read nanopore sequencing as a comprehensive and sensitive QC method for rAAVs which is supporting internal research activities at AstraZeneca. Recombinant adeno-associated viruses (rAAVs) are considered a promising delivery system for gene therapy medicines.

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Codon

AUGUST 26, 2024

When COVID-19 emerged in 2019, by contrast, mRNA vaccines developed by Pfizer and Moderna took just 326 days from the initial sequencing of the virus to gaining approval for emergency use. The Coalition for Epidemic Preparedness Innovations (CEPI)—a nonprofit organization that funds vaccine research and development—thinks so.

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SCIENMAG: Medicine & Health

JUNE 16, 2023

As a part of its life cycle, the human immunodeficiency virus-1 (HIV) inserts a copy of its DNA into human immune cells. Some of these newly infected immune cells can then transition into a dormant, latent state for a long period of time, which is referred to as HIV latency. Credit: UNC Division of Infectious […]

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Drug Discovery World

JULY 22, 2022

Two doses of Covid-19 vaccines were sufficient in providing protection against severe cases of the infectious disease, according to new research.? . Junk DNA could lead to cancer, study says . An early-stage clinical trial has been launched in the US investigating a vaccine against Nipah virus infection.? .

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DNA Clinical Trials Vaccine Virus 130

Drug Discovery World

AUGUST 21, 2024

While many different modalities of delivery vectors exist, the two most common viral vectors are lentivirus and adeno-associated virus. Following initial viral vector transduction, treated samples, typically whole blood and/or enriched cell populations, are collected and the genomic DNA is isolated. The enriched DNA is then sequenced.

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Drug Discovery World

OCTOBER 20, 2023

“The acquisition of Olink underscores the profound impact that proteomics is having as our customers continue to advance life science research and precision medicine,” said Marc Casper, Chairman, President and Chief Executive Officer of Thermo Fisher.

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Drug Discovery World

MARCH 26, 2024

More importantly, it also highlighted that significant challenges remain in selecting the right therapies for the right patients despite the progress made through genomic testing and implementation of circulating tumour (ct) DNA analyses. We were there to present the latest findings from our research.

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Drug Discovery World

JANUARY 17, 2023

Researchers developed nanoparticles able to penetrate the neural retina and deliver mRNA to the photoreceptor cells whose proper function makes vision possible. . They showed, in research involving mice and non-human primates, that LNPs equipped with peptides were able to pass through barriers in the eye and reach the neural retina. . “We

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Drug Discovery World

JUNE 7, 2023

Hosted by DDW and sponsored by DNA Script, join us for this free-to-attend roundtable to learn about the biggest opportunities for the future of drug discovery and development. Roundtable panellists include Commercial Research Scientist, Dr Mark Treherne, CEO of Elevation Oncology, Joe Ferra, and CEO of BioXcel Therapeutics, Vimal Mehta.

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DNA Clinical Trials Drugs Vaccine 130

Drug Discovery World

JUNE 27, 2023

Hosted by DDW and supported by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ Roundtable panelists include Commercial Research Scientist Dr Mark Treherne, CEO of Elevation Oncology, Joe Ferra, and CEO of BioXcel Therapeutics, Vimal Mehta. What can we expect from the cell & gene therapy market?

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DNA Drugs Clinical Trials Vaccine 130

Drug Discovery World

JUNE 22, 2023

Hosted by DDW and supported by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ Roundtable panelists include Commercial Research Scientist Dr Mark Treherne, CEO of Elevation Oncology, Joe Ferra, and CEO of BioXcel Therapeutics, Vimal Mehta. What can we expect from the cell & gene therapy market?

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Drug Target Review

JANUARY 26, 2024

Researchers from Columbia University and the US Department of Energy (DOE)’s Brookhaven National Laboratory have elucidated a method to produce large quantities of the receptor that the SARS-CoV-2 spike protein uses to bind to the surface of human cells.

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Drug Discovery World

JUNE 15, 2023

Hosted by DDW and sponsored by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ Roundtable panelists include Commercial Research Scientist, Dr Mark Treherne, CEO of Elevation Oncology, Joe Ferra, and CEO of BioXcel Therapeutics, Vimal Mehta. What can we expect from the cell & gene therapy market?

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DNA Drugs Clinical Trials Vaccine 130

Drug Discovery World

JUNE 8, 2023

Hosted by DDW and sponsored by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ Roundtable panelists include Commercial Research Scientist Dr Mark Treherne, CEO of Elevation Oncology, Joe Ferra, and CEO of BioXcel Therapeutics, Vimal Mehta. What can we expect from the cell & gene therapy market?

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PLOS: DNA Science

JUNE 13, 2024

The virus SARS-CoV-2 emerged in Wuhan, home of a premiere research institute that focuses on viruses. A year before the initial outbreak, Wuhan researchers proposed nurturing a coronavirus with enhanced ability to attach onto, and enter, human cells. An altered virus could have escaped. Her points: 1. Coincidence?

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Drug Target Review

SEPTEMBER 8, 2023

New researched published in the journal Immunity , T cells exhibit an unusual, yet vital behaviour in their battle against pathogens and cancer cells, involving a nuclear receptor. The cell’s nucleus, containing compacted DNA, is centrally positioned within the cell. Could these two isoforms serve disparate functions in T cells?

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Broad Institute

AUGUST 31, 2023

Evolved prime editors are smaller and more efficient for therapeutic applications By Corie Lok August 31, 2023 Breadcrumb Home Evolved prime editors are smaller and more efficient for therapeutic applications Researchers have evolved the editing machine at the heart of the prime editing system, which can make a wide range of changes to the genome.

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Drug Discovery World

MAY 16, 2023

The company’s DNA-based platform is being developed to address manufacturing challenges associated with the production of recombinant adeno-associated virus (rAAV) vectors used to produce advanced therapy medicinal products (ATMPs).

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Drug Discovery World

MAY 5, 2023

In contrast to DNA-based reprogramming and gene editing, the mRNA-based approach does not expose cells to expensive and potentially harmful viruses or DNA vectors. Eterna plans to use Exacis’ platform to develop engineered cell therapies containing genomic edits designed to enhance their performance.

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Drug Discovery World

FEBRUARY 8, 2024

In 2023, DDW hosted a webinar, ‘A comprehensive guide to using adeno-associated virus (AAV) vectors in gene therapy’, supported by Azenta Life Sciences. AAV is optimal for gene therapy due to its efficiency and safety in humans; however, AAV processes can present obstacles for researchers. Why are those important?

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Advarra

MARCH 31, 2023

This trend came to the forefront during the COVID-19 pandemic, as the three most popular vaccines developed in response to the coronavirus contained engineered genetic materials in the form of mRNA or a genetically engineered virus. Either way, occupational exposure to these gene delivery systems bears potential risks to the research staff.

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PLOS: DNA Science

JULY 27, 2023

Genomics applies to all species, revealing evolution in action, because we all use the same genetic code – that is, the correspondence between DNA sequences and the amino acid sequences of proteins. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages. emerged in late 2021.

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Drug Discovery World

OCTOBER 18, 2023

Sara Donnelly, Director of Research Planning and Business Development at PhoenixBio USA explores why the right pre-clinical model is essential for teams wanting to advance adeno-associated virus vector-based gene therapies. However, NHP models cannot fully predict AAV transduction in the human liver.

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The Premier Consulting Blog

MARCH 7, 2024

For gene therapy vectors, this testing encompasses production cell lines, master and working cell banks (MCB, WCB), and virus banks. Depending on the gene therapy vector, microbial systems may be employed to produce vector DNA (such as in adeno associated virus (AAV)), in which case there may be bacterial cell banks and plasmid banks.

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Drug Discovery World

OCTOBER 3, 2023

Earlier this year, DDW hosted a webinar, ‘A comprehensive guide to using adeno-associated virus (AAV) vectors in gene therapy’, supported by Azenta Life Sciences. AAV is optimal for gene therapy due to its efficiency and safety in humans; however, AAV processes can present obstacles for researchers. Why are those important?

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Drug Discovery World

AUGUST 14, 2023

For example, the FDA’s Center for Biologics Evaluation and Research (CBER) 3 , which regulates biological products for human use, differentiates between in vivo gene therapy (new genes are inserted into the body to target cells) and ex vivo gene therapy (cells are modified outside the body and then administered back into the patient).

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Drug Discovery World

FEBRUARY 13, 2023

How can technology help drug discovery research get to market faster and at optimum efficiency? Using AI, researchers at Chalmers University of Technology, Sweden succeeded in designing synthetic DNA that controls the cells’ protein production. What areas of technology will be key in helping maintain this innovation momentum?

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Codon

AUGUST 28, 2024

Tessa Alexanian and Max Langenkamp build computational DNA screening tools for a living. When the CDC contacted Harris to ask about the plague samples, Harris claimed that he was doing research for the CIA to stop an “imminent invasion from Iraq of super-germ-carrying rats.” This article concludes our mini-issue.

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Drug Discovery World

APRIL 15, 2023

The American Association for Cancer Research (AACR) Annual Meeting is taking place at the Orange County Convention Center in Orlando, Florida from April 14-19, 2023. Tuesday, April 18, 2023, 9:00-12:30am ET 7. Tuesday, April 18, 2023, 1:30-5:00pm ET 8.

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Broad Institute

JULY 11, 2024

Targeted drug treatment leads tumor cells to imitate viral infection By Ari Navetta July 11, 2024 Breadcrumb Home Targeted drug treatment leads tumor cells to imitate viral infection Exploiting "viral mimicry," mIDH1 inhibitors trick tumors into thinking they are infected with a virus.

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Drug Target Review

DECEMBER 28, 2023

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell. Our immune system helps us to fight off infections and cancer.

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Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. 1 Adeno-associated virus (AAV) vectors are the leading platform for in vivo gene delivery for the treatment of various human diseases.

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Drug Target Review

DECEMBER 7, 2023

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. Its presence elsewhere would indicate something is wrong.

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PLOS: DNA Science

OCTOBER 12, 2023

million DNA bases. The DMD gene therapy delivers a shortened version of the dystrophin gene, just 4,558 DNA bases. First, adeno-associated virus (AAV) delivers the genes, rather than the adenovirus (AV) that had entered cells in Jesse’s liver that weren’t the targets. Two other design strategies add precision.

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Drug Discovery World

SEPTEMBER 20, 2022

To develop safe and effective gene therapies, researchers need confidence that genomic data is both complete and accurate. This considerable magnitude of difference in read length affords researchers a more complete and accurate view of genomic variation. For years now the UK has been somewhat of a leader in genomic research.

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