Science Daily: Pharmacology News

NOVEMBER 7, 2024

Genes contain instructions for making proteins, and a central dogma of biology is that this information flows from DNA to RNA to proteins. But only two percent of the human genome actually encodes proteins; the function of the remaining 98 percent remains largely unknown.

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BioPharma Drive: Drug Pricing

AUGUST 26, 2024

Imagine the power of combining CTCs, cell-free DNA and cell-free RNA.

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Broad Institute

JUNE 28, 2023

By Leah Eisenstadt June 28, 2023 Credit: Courtesy of the Zhang lab Cryo-EM map of a Fanzor protein in complex with ωRNA and its target DNA. They showed that Fanzor proteins use RNA as a guide to target DNA precisely, and that Fanzors can be reprogrammed to edit the genome of human cells. said Zhang.

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Covalent Modifiers

DECEMBER 23, 2023

3c10581 Helicases, classified into six superfamilies, are mechanoenzymes that utilize energy derived from ATP hydrolysis to remodel DNA and RNA substrates. Kapoor Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.3c10581

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SCIENMAG: Medicine & Health

JULY 19, 2023

Together, they have published dozens of papers on the mechanics of mitochondrial DNA and RNA in a single-celled, disease-causing parasite called Trypanosoma brucei. As molecular biologists at Boston University and as husband and wife, Ruslan Afasizhev and Inna Afasizheva, have worked together for decades.

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Broad Institute

AUGUST 31, 2023

Their new editors are more efficient and specialized than previous versions, and are able to modify DNA in cultured cells and in animals that have been difficult to edit, including in immune system cells and inside the brain. What had not been done until now is improving the reverse transcriptase in a way that’s tailor-made for prime editing.”

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addgene Blog

JULY 2, 2024

We’ll cover the common terminology for the proteins, DNA, and RNA used in CRISPR. CRISPR is an elegant bacterial immune system and an efficient gene editing tool… but boy does it have a lot of parts! If you’re still a bit confused by CRISPR acronyms, this post is for you.

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Broad Institute

NOVEMBER 23, 2023

The scientists found a surprising number and diversity of CRISPR systems, including ones that could make edits to DNA in human cells, others that can target RNA, and many with a variety of other functions. Zhang’s team showed that two of these systems could make short edits in the DNA of human cells.

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Broad Institute

JANUARY 8, 2024

In the new work published today in Nature Biotechnology , the team adapted engineered virus-like particles (eVLPs) that they had previously designed to carry base editors — another type of precision gene editor that makes single-letter changes in DNA.

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PLOS: DNA Science

JUNE 8, 2023

That was so in 1977, when “intervening DNA sequences” – aka “introns” – were discovered to interrupt protein-encoding genes. But some species control genetic responses another way – via RNA editing. Because the edits are in RNA, and not DNA, they are fleeting.

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Chemical Biology and Drug Design

DECEMBER 19, 2023

Tweaking of chemical compositions of natural nucleotide bases could be developed as novel building blocks of DNA/RNA. In the Hachimoji base pairing, synthetic building blocks are formed using eight modified nucleotide (DNA/RNA) letters (hence the name “Hachimoji”). The modified bases (dP, dZ, dS, and dB etc.)

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addgene Blog

JUNE 25, 2024

Prime editing is a versatile genome editing technology that allows precise modifications of DNA (replacements, small insertions, and deletions) without introducing DNA double-strand breaks (Anzalone et al., 2019; Chen & Liu, 2023).

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Drug Target Review

JUNE 28, 2023

When faced with a viral threat, bacterial cells developed an immune response by capturing and copying DNA fragments of viruses. This allowed bacteria to recognise subsequent attacks and cleave the viral DNA to stop the viral infection. It was also discovered that the Cas enzyme was responsible for DNA cleavage.

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Broad Institute

OCTOBER 23, 2024

That is in part because of the ongoing challenge of understanding the DNA switches, called cis-regulatory elements (CREs), that control the expression and repression of genes. CREs themselves are not part of genes, but are separate, regulatory DNA sequences – often located near the genes they control. In a paper published in Oct.

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Fierce BioTech

NOVEMBER 1, 2023

Plasmid DNA Design Considerations for Cell and Gene Therapy Cell and Gene therapy organizations must balance the need for rapid clinical progression and stringent quality expectations throughout development. In this whitepaper, Aldevron provides an in-depth look at the considerations of plasmid manufacturing used in commercial applications.

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Covalent Modifiers

AUGUST 14, 2023

For both cancer and healthy genomes, we find that cysteine acquisition is a ubiquitous consequence of genetic variation that is further elevated in the context of decreased DNA repair.

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Dark Matter Blog

APRIL 4, 2023

Prior to 2015, I had a casual relationship, at best, with targeting RNA. Targeting RNA is a Whole New World Then in 2015, I became smitten and eloped with RNA, setting out to build a company devoted to bringing to bear industrial drug discovery concepts and methods on a new problem of drugging RNA with small molecules.

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KIF1A

JANUARY 20, 2024

Instead, this is what is called a splicing mutation; it occurs at the boundary between coding DNA that is read into RNA and protein, and noncoding DNA that is excluded. These boundaries need to be “spliced” or specifically cut so RNA and proteins only contain coding DNA.

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DrugBank

MAY 22, 2024

Beyond Proteins: DNA and RNA Frontier The story doesn’t end with proteins. DNA and RNA are also key players, each bringing unique challenges. Many cancer treatments target DNA, but often these can cause collateral damage, leading to severe side effects.

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Dark Matter Blog

AUGUST 31, 2020

Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA. Today, we are pleased to announce that our article describing one such platform: “ PEARL-seq, A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions ” was published in ACS Chemical Biology.

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The Pharma Data

JANUARY 5, 2021

Durham, North Carolina-based Ribometrix announced a strategic collaboration deal with Genentech , a Roche company, to identify and advance novel RNA-targeted small molecule therapeutics. Targeting RNA is believed to be a way to develop therapeutics for so-called undruggable proteins. The first identifies the 3D RNA motifs.

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Broad Institute

OCTOBER 23, 2024

By Leah Eisenstadt, Broad Communications October 23, 2024 Credit: Courtesy of the Broadbent family Brian and Julia Broadbent are raising their daughters Claire, top left, and Emma, seated, who is the first person to be diagnosed with a rare genetic disorder caused by the long noncoding RNA CHASERR.

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PLOS: DNA Science

JULY 13, 2023

Although the researchers followed all of these events with color-labeled DNA, the details of how the cells at the injury site are reprogrammed into a state of stemness are still a mystery. Analyzing RNA Revealed the Regeneration The researchers analyzed RNA to reconstruct the steps to regeneration. Do humans have similar genes?

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RNA DNA Research Disease 98

Drug Target Review

JULY 7, 2023

The reasons for this are multifaceted, including concerns over the safety of directly altering DNA sequences and subsequent regulatory restrictions that have arisen as a result. The epigenome (meaning ‘above the genome’) is a system of reversible marks regulating how the DNA is read, translated and used. What is epigenetic editing?

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DNA Engineering Therapies Regulations 105

Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

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DNA Engineering RNA Small Molecule 93

Drug Target Review

SEPTEMBER 28, 2023

After some time in that role and launching several products, I received a call from Bill Banyai and Bill Peck, or ‘The Bills’ as we call them, who were building a company around technology that creates DNA by ‘writing’ it on a silicon chip. Researchers were able to use our synthetic RNA controls as a reference to verify and validate assays.

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DNA Organic Chemistry Science Virus 116

PLOS: DNA Science

MARCH 28, 2024

million DNA bases. The exons are nestled amongst the much longer introns, which are DNA sequences that are not represented in the final protein. It delivers a shortened dystrophin gene, just 4,558 DNA bases. Proteins called histones wrap around DNA at regular intervals, winding the molecule into units that resemble tiny spools.

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Drug Target Review

NOVEMBER 13, 2023

The instructions to form a cell are encoded in DNA strands, wrapped in proteins and RNA, and wound together into a 3D structure called chromatin. Another finding was that regulatory T cells had distinct chromatin architecture features called DNA loops. This indicated other Foxp3 protein-containing complexes may be involved.

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Drug Target Review

DECEMBER 7, 2023

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. The novel, hairpin-shaped molecule was named cabRNA for CBASS-activating bacteriophage RNA.

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RNA Immune Response DNA Molecular Biology 59

Reprocell

AUGUST 8, 2024

In the ever-evolving landscape of drug discovery, the ability to extract and analyze DNA and RNA from clinical biospecimens has become a cornerstone of innovative research. It is critical for downstream applications such as RT-PCR, RNA sequencing, and Next Generation Sequencing (NGS).

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Broad Institute

JUNE 14, 2024

These CRISPR guides are short sequences of RNA that steer the CRISPR Cas9 enzyme to a specific site in the genome to cut DNA and deactivate a targeted gene. The new findings, from scientists at the Broad Institute of MIT and Harvard, show about 2 percent of these guides miss their target.

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Alta Sciences

FEBRUARY 19, 2025

An oligonucleotide is a short strand of nucleotides, the building blocks of DNA or RNA, used in genetic research and therapy. Our experts stay up to date on all new and evolving regulations to guarantee regulatory compliance in your studies.

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Broad Institute

DECEMBER 13, 2023

The team analyzed the full transcriptome of cells from nearly 100 regions across the mouse brain using high-throughput single-nucleus RNA sequencing, the preferred approach for efforts to create a human brain atlas. Related news Researchers map brain cell changes in Alzheimer’s disease Courtesy of the Chen and Macosko labs.

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Drug Target Review

JULY 5, 2023

In terms of targeted gene insertion, we presented data on a new gene-editing endonuclease called UltraSlice nickase, which is a novel protein-based gene editing system that is very different to CRISPR, as it does not involve a guide RNA. Those kinds of mutations are often associated with double-strand breaks in DNA.

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BMG Labtech

OCTOBER 4, 2023

These numbers reflect impressive developments in DNA sequencing technologies but in most cases represent the immediate costs of consumables on the sequencing instrument. 2 DNA sequencing is also reliant on sample processing and DNA library preparation before sequencing as well as bioinformatics and data analysis after sequencing.

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The Pharma Data

NOVEMBER 17, 2021

Mount Sinai researchers have developed a new model that uses DNA and RNA sequencing data from hundreds of patients to identify specific genes and genetic alterations responsible for never-before-defined subtypes of a blood cancer called multiple myeloma.

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Alta Sciences

APRIL 16, 2024

Gene therapy requires DNA and/or RNA delivery and analysis, and while most ongoing research involves therapies being delivered in vivo via adeno-associated viral (AAV) vectors, other in vivo delivery methods are on the rise. Multiple rounds of DNA synthesis will then take place to amplify that section.

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