Drug Discovery World

AUGUST 6, 2024

“Over the past decade, research into circRNAs has emerged as a vital area of study, revealing the crucial role these unique RNA molecules play in cancer biology,” said Professor Conn. “By We’ve also discovered that high levels of circRNAs in certain people can cause mutations in their DNA which results in leukaemia.”

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Fierce BioTech

NOVEMBER 1, 2023

Plasmid DNA Design Considerations for Cell and Gene Therapy Cell and Gene therapy organizations must balance the need for rapid clinical progression and stringent quality expectations throughout development. In this whitepaper, Aldevron provides an in-depth look at the considerations of plasmid manufacturing used in commercial applications.

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Drug Discovery World

AUGUST 30, 2024

Revolver Therapeutics’ project will involve identifying tiny proteins, known as peptides, that can enter cells to prevent specific cancer-causing proteins from binding to DNA within a child’s brain tumour. It is hoped that by interfering with these DNA-binding proteins, these cancers affecting children can be treated.

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Drug Discovery World

OCTOBER 10, 2022

By Dr Dina Finan, PhD, Product Manager at 10x Genomics and Dr Nick Downey, PhD, NGS Collaborations Lead at Integrated DNA Technologies. RNA sequencing has become a widely used tool that can explore the transcriptome in a seemingly endless number of applications.

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Drug Discovery World

MARCH 26, 2024

More importantly, it also highlighted that significant challenges remain in selecting the right therapies for the right patients despite the progress made through genomic testing and implementation of circulating tumour (ct) DNA analyses.

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Drug Discovery World

SEPTEMBER 27, 2023

Epigenetics, often referred to as the ‘software’ of gene regulation, encompasses chemical modifications to DNA, such as methylation, and modifications of other proteins that organise DNA in the nucleus, known as histones, as well as RNA.

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Drug Discovery World

MARCH 5, 2024

The grant will enable the company to invest in new equipment that will increase the rapid creation of a large pool of candidates of RNA/DNA sequences. CatSci has won a Welsh Government SMART Capital Equipment Fund grant to enhance its oligonucleotides capability.

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Drug Discovery World

MARCH 14, 2023

The success of messenger RNA or mRNA vaccines in the fight against the global SARS-CoV-2 crisis brings a new era of vaccine development. In vitro transcription, or IVT, is a complex reaction, requiring key components like an RNA polymerase, nucleotides, and a DNA template to make each mRNA.

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Drug Discovery World

MARCH 2, 2023

Scientists at The Institute of Cancer Research, London have revealed how a key epigenetic signal called H3K4me3 determines when and how DNA should be read and translated into proteins within our cells. When it gives the green light, H3K4me3 allows RNA polymerase II to move along DNA, transcribing it into RNA as it moves.

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Chemical Biology and Drug Design

DECEMBER 19, 2023

Tweaking of chemical compositions of natural nucleotide bases could be developed as novel building blocks of DNA/RNA. In the Hachimoji base pairing, synthetic building blocks are formed using eight modified nucleotide (DNA/RNA) letters (hence the name “Hachimoji”). The modified bases (dP, dZ, dS, and dB etc.)

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Broad Institute

OCTOBER 4, 2023

Related links Merkin Prize Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The inaugural Richard N. Caruthers was announced as the winner in June for his development, in 1981, of an efficient, automated technology for synthesizing DNA.

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Science Daily: Pharmacology News

MAY 29, 2024

Functional analysis based on these structures also revealed how a 'prime editor' could achieve reverse transcription, synthesizing DNA from RNA, without 'cutting' both strands of the double helix. New research has determined the spatial structure of various processes of a novel gene-editing tool called 'prime editor.'

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RNA DNA Therapies Treatment 101

Drugs.com

APRIL 8, 2024

MONDAY, April 8, 2024 -- A blood test appears capable of detecting early-stage pancreatic cancers with up to 97% accuracy, a new study reports.The test looks for eight small RNA particles and eight larger DNA markers shed by pancreatic cancers,

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Drug Discovery World

OCTOBER 2, 2023

This eBook sponsored by DNA Script explores the advances and breakthroughs taking place within vaccines and virology.

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Codon

AUGUST 26, 2024

Remdesivir and other broad-spectrum antivirals work by jamming up RNA-dependent RNA polymerase (RdRp), an enzyme that nearly all RNA viruses use to replicate their genomes. Other efforts to build broad-spectrum antivirals have focused on another conserved feature of viruses: double-stranded RNA.

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BioPharma Drive: Drug Pricing

AUGUST 26, 2024

Imagine the power of combining CTCs, cell-free DNA and cell-free RNA.

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Reprocell

AUGUST 8, 2024

In the ever-evolving landscape of drug discovery, the ability to extract and analyze DNA and RNA from clinical biospecimens has become a cornerstone of innovative research. It is critical for downstream applications such as RT-PCR, RNA sequencing, and Next Generation Sequencing (NGS).

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addgene Blog

JULY 2, 2024

We’ll cover the common terminology for the proteins, DNA, and RNA used in CRISPR. CRISPR is an elegant bacterial immune system and an efficient gene editing tool… but boy does it have a lot of parts! If you’re still a bit confused by CRISPR acronyms, this post is for you.

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addgene Blog

JUNE 25, 2024

Prime editing is a versatile genome editing technology that allows precise modifications of DNA (replacements, small insertions, and deletions) without introducing DNA double-strand breaks (Anzalone et al., 2019; Chen & Liu, 2023).

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Drug Discovery World

OCTOBER 19, 2022

Yapan Bio has expanded its capabilities with a new process development facility at Genome Valley, Hyderabad, India, which has enhanced its ability to support end-to-end development and manufacturing of RNA, DNA and gene therapy products starting from plasmids. .

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Science Daily: Pharmacology News

JUNE 8, 2023

The octopuses achieve this by editing their RNA, the messenger molecule between DNA and proteins. Researchers report that two-spot octopuses adapt to seasonal temperature shifts by producing different neural proteins under warm versus cool conditions.

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Drug Discovery World

MAY 26, 2023

The top stories: Biopharma investment drops by nearly 50% in 2022 Cell therapy, RNA technology, antibody drug conjugates and AI/machine learning are among the key areas of investment for pharma, according to a new report. investment to target cancer and neurological diseases PharmEnable has closed a pre-series A investment round of $7.5

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The Pharma Data

JANUARY 5, 2021

Durham, North Carolina-based Ribometrix announced a strategic collaboration deal with Genentech , a Roche company, to identify and advance novel RNA-targeted small molecule therapeutics. Targeting RNA is believed to be a way to develop therapeutics for so-called undruggable proteins. The first identifies the 3D RNA motifs.

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Drug Discovery World

AUGUST 16, 2023

Additionally, patients whose cancer has spread but who have not yet received chemotherapy, and whose primary tumours have markers of faults in genes linked to DNA repair pathways, tend to respond better to carboplatin. “Our findings paint a complex picture – with many, dynamic factors driving how tumours respond to treatment.”

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Drug Discovery World

JANUARY 6, 2023

Orbit Discovery and start-up SanegeneBio have entered into a Master Service Agreement to identify tissue-specific delivery of a wide range of RNA therapeutics. . Orbit’s technology enables the screening of large libraries of peptides using a combination of DNA encoded libraries and bead-based presentation.

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Drug Target Review

JUNE 28, 2023

When faced with a viral threat, bacterial cells developed an immune response by capturing and copying DNA fragments of viruses. This allowed bacteria to recognise subsequent attacks and cleave the viral DNA to stop the viral infection. It was also discovered that the Cas enzyme was responsible for DNA cleavage.

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Drug Discovery World

JANUARY 20, 2023

Differences in DNA, RNA, and protein can be identified in individual tissue samples, and even in individual cells. Precision medicine uses information about an individual’s genes, proteins, and environment to prevent, diagnose, and treat diseases, including cancer.

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Broad Institute

AUGUST 31, 2023

Their new editors are more efficient and specialized than previous versions, and are able to modify DNA in cultured cells and in animals that have been difficult to edit, including in immune system cells and inside the brain. What had not been done until now is improving the reverse transcriptase in a way that’s tailor-made for prime editing.”

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Drug Discovery World

APRIL 17, 2024

DDW’s Diana Spencer speaks to Josh Mandel-Brehm , CEO of Massachusetts-based biotech CAMP4, to understand the role regulatory RNAs play in gene expression and how the founders overcame the challenge of launching a business based on brand new science. DS: You describe your therapeutics as RNA Amplifiers. How do they work?

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Science RNA Disease Protein Expression 148

Drug Discovery World

JANUARY 17, 2023

Oregon State University College of Pharmacy scientists have shown that lipid nanoparticles and messenger RNA could treat blindness associated with a rare genetic condition. . It also doesn’t do fantastically well in continuing to express the enzymes the editing tool uses as molecular scissors to make cuts in the DNA to be edited.

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Drug Target Review

DECEMBER 7, 2023

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. The novel, hairpin-shaped molecule was named cabRNA for CBASS-activating bacteriophage RNA.

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Alta Sciences

APRIL 16, 2024

Gene therapy requires DNA and/or RNA delivery and analysis, and while most ongoing research involves therapies being delivered in vivo via adeno-associated viral (AAV) vectors, other in vivo delivery methods are on the rise. Multiple rounds of DNA synthesis will then take place to amplify that section.

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Drug Discovery World

AUGUST 22, 2024

Life Biosciences’ gene therapy approach differs from traditional gene replacement and gene editing approaches in that the company are not altering the DNA sequence. Latest technological advancements “Technological advancements in the CGT space that hold a lot of promise include CRISPR and RNA-based therapies.

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Therapies DNA Disease RNA 148

DrugBank

MAY 22, 2024

Beyond Proteins: DNA and RNA Frontier The story doesn’t end with proteins. DNA and RNA are also key players, each bringing unique challenges. Many cancer treatments target DNA, but often these can cause collateral damage, leading to severe side effects.

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Covalent Modifiers

APRIL 25, 2024

Kinsella Nature , 2024 [link] WRN helicase is a promising target for treatment of cancers with microsatellite instability (MSI) due to its essential role in resolving deleterious non-canonical DNA structures that accumulate in cells with faulty mismatch repair mechanisms 1 , 2 , 3 , 4 , 5.

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PLOS: DNA Science

JULY 13, 2023

Although the researchers followed all of these events with color-labeled DNA, the details of how the cells at the injury site are reprogrammed into a state of stemness are still a mystery. Analyzing RNA Revealed the Regeneration The researchers analyzed RNA to reconstruct the steps to regeneration. Do humans have similar genes?

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RNA DNA Research Disease 83

PLOS: DNA Science

JUNE 13, 2024

Experiments at the Wuhan facility were done at the lowest two of the four standard biosafety levels, which were established at the dawn of recombinant DNA research in the 1970s. The Likely Predecessor of SARS-CoV-2 – From my Past Blog Posts I wrote 100+ DNA Science blog posts during the pandemic about the virus.

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