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Scientists have succeeded in controlling the structure and function of biological membranes with the help of 'DNA origami'. The system they developed may facilitate the transportation of large therapeutic loads into cells. This opens up a new way for the targeted administration of medication and other therapeutic interventions.
A tiny, four-fingered 'hand' folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, researchers report.
A new study finds that mitochondria in our brain cells frequently fling their DNA into the cells' nucleus, where the mitochondrial DNA integrates into chromosomes, possibly causing harm.
The science team designed a turbine engineered from DNA that is powered by hydrodynamic flow inside a nanopore, a nanometer-sized hole in a membrane of solid-state silicon nitride. Scientists have created a working nanoscale electomotor.
With their 'T-REX' method, researchers developed a glassy, amber-like polymer that can be used for long-term storage of DNA, such as entire human genomes or digital files such as photos.
With GROVER, a new large language model trained on human DNA, researchers could now attempt to decode the complex information hidden in our genome. GROVER treats human DNA as a text, learning its rules and context to draw functional information about the DNA sequences.
Researchers have demonstrated a technology capable of a suite of data storage and computing functions -- repeatedly storing, retrieving, computing, erasing or rewriting data -- that uses DNA rather than conventional electronics. Previous DNA data storage and computing technologies could complete some but not all of these tasks.
Researchers have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types.
Over half of our genomes consists of thousands of remnants of ancient viral DNA, known as transposable elements, which are widespread across the tree of life. Once dismissed as the 'dark side' of the genome, researchers have now revealed their crucial role in early embryo development.
Waves of human migration across Europe during the first millennium AD have been revealed using a more precise method of analysing ancestry with ancient DNA, in research led by the Francis Crick Institute.
To better understand the timing of this replacement, researchers sequenced mitochondrial DNA from archaeological dogs. Previous scientific studies have indicated that North American dog lineages were replaced with European ones between 1492 and the present day.
New research has found that thousands of DNA sequences originating from ancient viral infections are expressed in the brain, with some contributing to susceptibility for psychiatric disorders such as schizophrenia, bipolar disorder, and depression.
Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies.
Buildup of a protein called filamentous actin, or F-actin, in the brain inhibits the removal of cellular wastes, including DNA, lipids, proteins and organelles. The resulting accumulation of waste diminishes neuronal functions and contributes to cognitive decline.
Leveraging a unique statistical analysis and applying it to ancient DNA extracted from human skeletal remains, a team of researchers has revealed new insights into how ancient Europeans adapted to their environments over 7,000 years of European history.
Ancient DNA has provided spectacular insights into human history, particularly in Europe and Asia, where researchers have reconstructed the genomes of thousands of people.
While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that the damage has multiple chances to generate harmful mutations, which can lead to cancer.
An international consortium of scientists is using an unprecedentedly large database of canine DNA to take an unbiased look at how our furry friends evolved into the various breeds we know and love.
Scientists were able to fabricate a pure form of glass and coat specialized pieces of DNA with it to create a material that was not only stronger than steel, but incredibly lightweight.
New DNA sequencing technologies have identified the historical remains of George Washington's grandnephews, Samuel Walter Washington and George Steptoe Washington Jr., and their mother, Lucy Payne Washington, from unmarked, fragmentary bones left at the Harewood family cemetery in Charles Town, West Virginia, in the mid-1800s.
By analysing ancient DNA, an international team of researchers have uncovered cases of chromosomal disorders, including what could be the first case of Edwards syndrome ever identified from prehistoric remains.
Researchers introduce a pioneering breakthrough in the world of nanomotors -- the DNA origami nanoturbine. The core of this pioneering discovery is the design, construction, and driven motion of a 'DNA origami' turbine, which features three chiral blades, all within a minuscule 25-nanometer frame, operating in a solid-state nanopore.
Researchers have come one step closer to unlocking the potential of synthetic DNA, which could help scientists develop never-before-seen proteins in the lab.
The DNA double helix is composed of two DNA molecules whose sequences are complementary to each other. Fluorescent markers bound to one of the matching DNA strands make the duplex visible, and fluorescence intensity increases with increasing duplex stability.
An international team of scientists has recently developed a novel type of nano engine made of DNA. It is driven by a clever mechanism and can perform pulsing movements. The researchers are now planning to fit it with a coupling and install it as a drive in complex nano machines.
A research team has discovered that cancer, one of the leading causes of death worldwide, can be caused entirely by epigenetic changes, in other words, changes that contribute to how gene expression is regulated, and partly explain why, despite an identical genome, an individual develops very different cells (neurons, skin cells, etc.).
A new study describes how researchers used ancient DNA to corroborate the events of the saga and discover details about the 'Well-man,' blending history and archaeology with science and setting a precedent for future research on historical figures.
A new study unveils a novel methodology to engineer colloidal quasicrystals using DNA-modified building blocks. The implications of this breakthrough are far-reaching, offering a potential blueprint for the controlled synthesis of other complex structures previously considered beyond reach.
Rapa Nui (Easter Island) with its gigantic statues and treeless landscape has fascinated researchers for centuries. A new genetic study disproves the popular theory that the Rapanui population collapsed as a result of an 'ecocide' and shows that the Rapanui admixed with Indigenous Americans centuries before Europeans arrived on the island.
Creating new technologically advanced sensors, scientists have engineered bacteria that detect the presence of tumor DNA in live organisms. Their innovation could pave the way to new biosensors capable of identifying various infections, cancers and other diseases.
A group of scientists now visualized this dynamic process and give novel insights into the physical characteristics of DNA. This allows specific regions to come into contact and thereby activate a gene.
A 'biological camera' bypasses the constraints of current DNA storage methods, harnessing living cells and their inherent biological mechanisms to encode and store data. This represents a significant breakthrough in encoding and storing images directly within DNA, creating a new model for information storage reminiscent of a digital camera.
Despite the Roman Empire's extensive military and cultural influence on the nearby Balkan peninsula, a DNA analysis of individuals who lived in the region between 1 and 1000 CE found no genetic evidence of Iron Age Italian ancestry.
An international research team has assembled the genome and 3D chromosomal structures of a 52,000-year-old woolly mammoth -- the first time such a feat has been achieved for any ancient DNA sample.
They hijack a little-known piece of the cell's DNA repair function to close themselves into a ring-like shape and then create a matching double strand. Like their viral cousins, retrotransposons have been found borrowing the cell's own machinery to achieve their goals.
A newly discovered code within DNA -- coined 'spatial grammar' -- holds a key to understanding how gene activity is encoded in the human genome. This breakthrough finding revealed a long-postulated hidden spatial grammar embedded in DNA.
A new paper describes a significant leap forward in assembling polyhedral nanoparticles. The researchers introduce and demonstrate the power of a novel synthetic strategy that expands possibilities in metamaterial design. These are the unusual materials that underpin 'invisibility cloaks' and ultrahigh-speed optical computing systems.
Researchers describe the steps they took to manipulate DNA and proteins -- essential building blocks of life -- to create cells that look and act like cells from the body. This accomplishment, a first in the field, has implications for efforts in regenerative medicine, drug delivery systems and diagnostic tools.
For the first time, a group of researchers have successfully extracted ancient DNA from a 2,900-year-old clay brick. The analysis provides a fascinating insight into the diversity of plant species cultivated at that time and place, and could open the way to similar studies on clay material from other sites and time periods.
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