Drug Discovery World

MARCH 7, 2023

For International Women’s Day, DDW’s Diana Spencer celebrates some of the women in leadership making an impact on the drug discovery and life sciences sector. The life sciences sector has traditionally outperformed others when it comes to attracting women to its workforce. Anti-ageing science therefore has huge value.

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International Science Pharmaceuticals DNA 246

Drug Discovery World

AUGUST 16, 2023

Samir Ounzain , PhD, CEO & Co-Founder of HAYA Therapeutics, looks at how a better understanding of our DNA can lead to increased activity for RNA therapeutics. Many scientists are now discovering that this junk DNA plays an essential role in our biology and the epigenetic processes that respond to the environment to drive disease.

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RNA DNA Therapies Small Molecule 130

Science Daily: Pharmacology News

AUGUST 16, 2024

To better understand the timing of this replacement, researchers sequenced mitochondrial DNA from archaeological dogs. Previous scientific studies have indicated that North American dog lineages were replaced with European ones between 1492 and the present day.

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DNA Research 105

Science Daily: Pharmacology News

AUGUST 29, 2024

Innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer.

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DNA Research Treatment Disease 94

Science Daily: Pharmacology News

AUGUST 1, 2024

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies.

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DNA 106

Science Daily: Pharmacology News

MAY 22, 2024

New research has found that thousands of DNA sequences originating from ancient viral infections are expressed in the brain, with some contributing to susceptibility for psychiatric disorders such as schizophrenia, bipolar disorder, and depression.

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DNA Research 122

SCIENMAG: Medicine & Health

AUGUST 10, 2023

Pushing into a new chapter of technologically advanced biological sensors, scientists from the University of California San Diego and their colleagues in Australia have engineered bacteria that can detect the presence of tumor DNA in a live organism.

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DNA Engineering Research Science 86

Drug Discovery World

APRIL 17, 2024

DDW’s Diana Spencer speaks to Josh Mandel-Brehm , CEO of Massachusetts-based biotech CAMP4, to understand the role regulatory RNAs play in gene expression and how the founders overcame the challenge of launching a business based on brand new science. JMB: Since the early days of CAMP4, we have always followed the science.

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Science RNA Disease Protein Expression 148

Science Daily: Pharmacology News

SEPTEMBER 27, 2023

Scientists were able to fabricate a pure form of glass and coat specialized pieces of DNA with it to create a material that was not only stronger than steel, but incredibly lightweight.

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DNA 91

Science Daily: Pharmacology News

FEBRUARY 20, 2024

By analysing ancient DNA, an international team of researchers have uncovered cases of chromosomal disorders, including what could be the first case of Edwards syndrome ever identified from prehistoric remains.

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DNA International Research 90

Broad Institute

JUNE 28, 2023

Merkin Prize in Biomedical Technology for developing an efficient, automated technology for synthesizing DNA. The chemical reactions that he discovered in the early 1980s to accurately and quickly assemble nucleotides into strands of DNA provided an essential element in the development of modern molecular medicine.

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DNA RNA Science Therapies 98

Science Daily: Pharmacology News

SEPTEMBER 7, 2023

An international consortium of scientists is using an unprecedentedly large database of canine DNA to take an unbiased look at how our furry friends evolved into the various breeds we know and love.

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DNA International 97

Science Daily: Pharmacology News

OCTOBER 17, 2023

The DNA double helix is composed of two DNA molecules whose sequences are complementary to each other. Fluorescent markers bound to one of the matching DNA strands make the duplex visible, and fluorescence intensity increases with increasing duplex stability.

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DNA Research 82

Science Daily: Pharmacology News

OCTOBER 26, 2023

Researchers introduce a pioneering breakthrough in the world of nanomotors -- the DNA origami nanoturbine. The core of this pioneering discovery is the design, construction, and driven motion of a 'DNA origami' turbine, which features three chiral blades, all within a minuscule 25-nanometer frame, operating in a solid-state nanopore.

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DNA Research 78

Science Daily: Pharmacology News

DECEMBER 13, 2023

Researchers have come one step closer to unlocking the potential of synthetic DNA, which could help scientists develop never-before-seen proteins in the lab.

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DNA Research 86

Science Daily: Pharmacology News

SEPTEMBER 28, 2023

Paleontologists discover possible DNA remains in fossil turtle that lived 6 million years ago in Panama, where continents collide.

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DNA 95

SCIENMAG: Medicine & Health

JUNE 29, 2023

Performing cutting-edge science requires thinking outside the box and bringing together different scientific disciplines. Sometimes this even means being in the right place at the right time.

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DNA Science Research Engineering 87

Science Daily: Pharmacology News

MARCH 28, 2024

New DNA sequencing technologies have identified the historical remains of George Washington's grandnephews, Samuel Walter Washington and George Steptoe Washington Jr., and their mother, Lucy Payne Washington, from unmarked, fragmentary bones left at the Harewood family cemetery in Charles Town, West Virginia, in the mid-1800s.

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DNA 109

Science Daily: Pharmacology News

AUGUST 28, 2023

The stakes of their findings are high: a ruptured nucleus can lead to elevated DNA damage that is characteristic of many diseases, including cancer.

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DNA Regulations Disease Research 73

Science Daily: Pharmacology News

OCTOBER 19, 2023

An international team of scientists has recently developed a novel type of nano engine made of DNA. It is driven by a clever mechanism and can perform pulsing movements. The researchers are now planning to fit it with a coupling and install it as a drive in complex nano machines.

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DNA Engineering International Research 65

Drug Discovery World

AUGUST 30, 2024

Revolver Therapeutics’ project will involve identifying tiny proteins, known as peptides, that can enter cells to prevent specific cancer-causing proteins from binding to DNA within a child’s brain tumour. It is hoped that by interfering with these DNA-binding proteins, these cancers affecting children can be treated.

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DNA Drugs RNA Therapies 148

Science Daily: Pharmacology News

AUGUST 10, 2023

Creating new technologically advanced sensors, scientists have engineered bacteria that detect the presence of tumor DNA in live organisms. Their innovation could pave the way to new biosensors capable of identifying various infections, cancers and other diseases.

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DNA Engineering Research Disease 72

Science Daily: Pharmacology News

JULY 26, 2023

DNA analysis of 34 individuals buried at Machu Picchu revealed that many traveled alone from throughout the Inca Empire.

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DNA 94

Drug Discovery World

DECEMBER 29, 2023

A new technique to clone and reassemble DNA could simplify and lower the cost of making synthetic chromosomes, according to its creators at University of Southern California (USC) Dornsife. This is a ton of work and extremely expensive.”

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DNA Science Pharmaceuticals Therapies 130

Broad Institute

OCTOBER 4, 2023

Related links Merkin Prize Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The inaugural Richard N. Caruthers was announced as the winner in June for his development, in 1981, of an efficient, automated technology for synthesizing DNA.

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DNA RNA Science Protein Expression 52

Science Daily: Pharmacology News

JUNE 29, 2023

A group of scientists now visualized this dynamic process and give novel insights into the physical characteristics of DNA. This allows specific regions to come into contact and thereby activate a gene.

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DNA 68

Science Daily: Pharmacology News

JULY 11, 2023

A 'biological camera' bypasses the constraints of current DNA storage methods, harnessing living cells and their inherent biological mechanisms to encode and store data. This represents a significant breakthrough in encoding and storing images directly within DNA, creating a new model for information storage reminiscent of a digital camera.

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DNA Engineering 68

Science Daily: Pharmacology News

JUNE 21, 2023

DNA can mimic protein functions by folding into elaborate, three-dimensional structures, according to a new study.

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DNA 86

Science Daily: Pharmacology News

NOVEMBER 2, 2023

A new study unveils a novel methodology to engineer colloidal quasicrystals using DNA-modified building blocks. The implications of this breakthrough are far-reaching, offering a potential blueprint for the controlled synthesis of other complex structures previously considered beyond reach.

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DNA Engineering Research 58

Drug Target Review

JANUARY 8, 2024

Modifications to the epigenome, such as DNA hypermethylation, modify the expression of genes by increasing or decreasing their expression without altering the genes themselves. One way we are doing this at Life Biosciences is through partial epigenetic reprogramming. The epigenome drifts with age, leading to dysregulated gene expression.

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Science Disease FDA Approval Pharmaceutical Companies 145

Drug Discovery World

AUGUST 21, 2024

Dr Andrea O’Hara, Senior Product Manager at Azenta Life Sciences asks why integration site analysis (ISA) is critical for the safety and efficacy of viral vectors for gene therapy. The enriched DNA is then sequenced.

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Therapies Bioinformatics DNA FDA 148

Science Daily: Pharmacology News

JULY 12, 2023

They hijack a little-known piece of the cell's DNA repair function to close themselves into a ring-like shape and then create a matching double strand. Like their viral cousins, retrotransposons have been found borrowing the cell's own machinery to achieve their goals.

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DNA Immune Response 73

Science Daily: Pharmacology News

DECEMBER 7, 2023

Despite the Roman Empire's extensive military and cultural influence on the nearby Balkan peninsula, a DNA analysis of individuals who lived in the region between 1 and 1000 CE found no genetic evidence of Iron Age Italian ancestry.

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DNA 83

Science Daily: Pharmacology News

APRIL 24, 2024

A research team has discovered that cancer, one of the leading causes of death worldwide, can be caused entirely by epigenetic changes, in other words, changes that contribute to how gene expression is regulated, and partly explain why, despite an identical genome, an individual develops very different cells (neurons, skin cells, etc.).

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DNA Regulations Research 107

Drug Discovery World

MAY 25, 2023

Several new products for the life sciences sector have been launched over the last month, from miniature semiconductor chip (MSC) technology to a new inhalation testing service. DDW provides an update.

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Production DNA Assay Development Drugs 130

Science Daily: Pharmacology News

AUGUST 20, 2024

A newly discovered code within DNA -- coined 'spatial grammar' -- holds a key to understanding how gene activity is encoded in the human genome. This breakthrough finding revealed a long-postulated hidden spatial grammar embedded in DNA.

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Government DNA Regulations Disease 124

PLOS: DNA Science

MAY 18, 2023

Perhaps more telling, I recently discovered a previously unknown branch of my own family tree that includes a dozen half-siblings that I know of, from a DNA test that I didn’t even remember taking. It was eerily like forensic scientists using familial DNA to track down serial killers. Which one was our biodad?

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DNA Doctors Research Science 65