DNA and Science - Drug Discovery Digest

DNA origami folded into tiny motor

Science Daily: Pharmacology News

JANUARY 19, 2024

The science team designed a turbine engineered from DNA that is powered by hydrodynamic flow inside a nanopore, a nanometer-sized hole in a membrane of solid-state silicon nitride. Scientists have created a working nanoscale electomotor.

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DNA Engineering Science Research

Mitochondria are flinging their DNA into our brain cells

Science Daily: Pharmacology News

AUGUST 22, 2024

A new study finds that mitochondria in our brain cells frequently fling their DNA into the cells' nucleus, where the mitochondrial DNA integrates into chromosomes, possibly causing harm.

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Scientists preserve DNA in an amber-like polymer

Science Daily: Pharmacology News

JUNE 13, 2024

With their 'T-REX' method, researchers developed a glassy, amber-like polymer that can be used for long-term storage of DNA, such as entire human genomes or digital files such as photos.

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DNA Research

Cracking the code of life: new AI model learns DNA's hidden language

Science Daily: Pharmacology News

AUGUST 5, 2024

With GROVER, a new large language model trained on human DNA, researchers could now attempt to decode the complex information hidden in our genome. GROVER treats human DNA as a text, learning its rules and context to draw functional information about the DNA sequences.

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DNA Research

DNA tech offers both data storage and computing functions

Science Daily: Pharmacology News

AUGUST 22, 2024

Researchers have demonstrated a technology capable of a suite of data storage and computing functions -- repeatedly storing, retrieving, computing, erasing or rewriting data -- that uses DNA rather than conventional electronics. Previous DNA data storage and computing technologies could complete some but not all of these tasks.

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DNA Research

Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Science Daily: Pharmacology News

NOVEMBER 27, 2024

A tiny, four-fingered 'hand' folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, researchers report.

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DNA Virus Treatment Research

Researchers flip genes on and off with AI-designed DNA switches

Science Daily: Pharmacology News

OCTOBER 23, 2024

Researchers have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types.

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DNA Research

Nuclear DNA influences variation in mitochondrial DNA

Broad Institute

AUGUST 16, 2023

Nuclear DNA influences variation in mitochondrial DNA By Allessandra DiCorato August 16, 2023 Breadcrumb Home Nuclear DNA influences variation in mitochondrial DNA Whole genomes from hundreds of thousands of people reveal new complexity in how the nuclear and mitochondrial genomes interact, which may influence how cells produce energy.

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DNA Molecular Biology Disease Regulations

Ancient DNA reveals Indigenous dog lineages found at Jamestown, Virginia

Science Daily: Pharmacology News

AUGUST 16, 2024

To better understand the timing of this replacement, researchers sequenced mitochondrial DNA from archaeological dogs. Previous scientific studies have indicated that North American dog lineages were replaced with European ones between 1492 and the present day.

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DNA Research

Perfume from Extinct Flowers, Thanks to Ancient DNA and Synthetic Biology

PLOS: DNA Science

DECEMBER 14, 2023

“Meet Invisible Woods: a clean, refreshing scent revived from extinct flower DNA ,” beneath an image of “origin flower” Wendlandia angustifolia. Before I dig into the science, I’ll relate taking a quiz on the Future Society website that would help me choose a product. On to the science.

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DNA Production Science Disease

Ancient viral DNA in the human genome linked to major psychiatric disorders

Science Daily: Pharmacology News

MAY 22, 2024

New research has found that thousands of DNA sequences originating from ancient viral infections are expressed in the brain, with some contributing to susceptibility for psychiatric disorders such as schizophrenia, bipolar disorder, and depression.

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DNA Research

When it comes to DNA replication, humans and baker's yeast are more alike than different

Science Daily: Pharmacology News

AUGUST 1, 2024

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies.

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Researchers map 50,000 of DNA's mysterious 'knots' in the human genome

Science Daily: Pharmacology News

AUGUST 29, 2024

Innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer.

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DNA Research Treatment Disease

Maui Fires: How Mitochondrial DNA Will Identify Human Remains

PLOS: DNA Science

AUGUST 17, 2023

The Maui firestorm was so vast and fast that most identification of human remains will come from bits of persisting DNA from mitochondria. MtDNA in Forensics and Genealogy Mitochondrial DNA (mtDNA) is used in forensics to match the tiniest bits of human remains to families. Mitochondrial DNA is also far more abundant than nuclear DNA.

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Scientists use ancient DNA to shed light on adaptation of early Europeans

Science Daily: Pharmacology News

NOVEMBER 19, 2024

Leveraging a unique statistical analysis and applying it to ancient DNA extracted from human skeletal remains, a team of researchers has revealed new insights into how ancient Europeans adapted to their environments over 7,000 years of European history.

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DNA Research

Insights into South African population history from 10,000-year-old human DNA

Science Daily: Pharmacology News

SEPTEMBER 19, 2024

Ancient DNA has provided spectacular insights into human history, particularly in Europe and Asia, where researchers have reconstructed the genomes of thousands of people.

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DNA Research

Researchers engineer bacteria that can detect tumor DNA

SCIENMAG: Medicine & Health

AUGUST 10, 2023

Pushing into a new chapter of technologically advanced biological sensors, scientists from the University of California San Diego and their colleagues in Australia have engineered bacteria that can detect the presence of tumor DNA in a live organism.

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DNA Engineering Research Science

DNA study IDs descendants of George Washington from unmarked remains, findings to aid service member IDs going back to World War II

Science Daily: Pharmacology News

MARCH 28, 2024

New DNA sequencing technologies have identified the historical remains of George Washington's grandnephews, Samuel Walter Washington and George Steptoe Washington Jr., and their mother, Lucy Payne Washington, from unmarked, fragmentary bones left at the Harewood family cemetery in Charles Town, West Virginia, in the mid-1800s.

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A turtle time capsule: DNA found in ancient shell

Science Daily: Pharmacology News

SEPTEMBER 28, 2023

Paleontologists discover possible DNA remains in fossil turtle that lived 6 million years ago in Panama, where continents collide.

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Ancient DNA reveals Down syndrome in past human societies

Science Daily: Pharmacology News

FEBRUARY 20, 2024

By analysing ancient DNA, an international team of researchers have uncovered cases of chromosomal disorders, including what could be the first case of Edwards syndrome ever identified from prehistoric remains.

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Dog diversity unveiled by international DNA database

Science Daily: Pharmacology News

SEPTEMBER 7, 2023

An international consortium of scientists is using an unprecedentedly large database of canine DNA to take an unbiased look at how our furry friends evolved into the various breeds we know and love.

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DNA International

Strength is in this glass's DNA

Science Daily: Pharmacology News

SEPTEMBER 27, 2023

Scientists were able to fabricate a pure form of glass and coat specialized pieces of DNA with it to create a material that was not only stronger than steel, but incredibly lightweight.

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Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA

Broad Institute

JUNE 28, 2023

Merkin Prize in Biomedical Technology for developing an efficient, automated technology for synthesizing DNA. The chemical reactions that he discovered in the early 1980s to accurately and quickly assemble nucleotides into strands of DNA provided an essential element in the development of modern molecular medicine.

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DNA RNA Science Therapies

The science of ageing and restoring healthspan

Drug Target Review

JANUARY 8, 2024

Modifications to the epigenome, such as DNA hypermethylation, modify the expression of genes by increasing or decreasing their expression without altering the genes themselves. One way we are doing this at Life Biosciences is through partial epigenetic reprogramming. The epigenome drifts with age, leading to dysregulated gene expression.

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DNA Origami nanoturbine sets new horizon for nanomotors

Science Daily: Pharmacology News

OCTOBER 26, 2023

Researchers introduce a pioneering breakthrough in the world of nanomotors -- the DNA origami nanoturbine. The core of this pioneering discovery is the design, construction, and driven motion of a 'DNA origami' turbine, which features three chiral blades, all within a minuscule 25-nanometer frame, operating in a solid-state nanopore.

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DNA Research

Enzymes can't tell artificial DNA from the real thing

Science Daily: Pharmacology News

DECEMBER 13, 2023

Researchers have come one step closer to unlocking the potential of synthetic DNA, which could help scientists develop never-before-seen proteins in the lab.

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DNA Research

Art with DNA -- Digitally creating 16 million colors by chemistry

Science Daily: Pharmacology News

OCTOBER 17, 2023

The DNA double helix is composed of two DNA molecules whose sequences are complementary to each other. Fluorescent markers bound to one of the matching DNA strands make the duplex visible, and fluorescence intensity increases with increasing duplex stability.

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DNA Research

Ancient DNA reveals diverse community in 'Lost City of the Incas'

Science Daily: Pharmacology News

JULY 26, 2023

DNA analysis of 34 individuals buried at Machu Picchu revealed that many traveled alone from throughout the Inca Empire.

DNA

Injectable agents could improve liquid biopsy for cancer detection and monitoring

Broad Institute

JANUARY 18, 2024

McAlpine January 18, 2024 Credit: Susanna Hamilton, Broad Communications One of the new "priming agents" works by preventing immune cells from engulfing tumor DNA circulating in the bloodstream. Liquid biopsies promise to transform how cancers are diagnosed, monitored, and treated by detecting DNA that tumors shed into the blood.

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DNA Engineering Science Disease

DNA can fold into complex shapes to execute new functions

Science Daily: Pharmacology News

JUNE 21, 2023

DNA can mimic protein functions by folding into elaborate, three-dimensional structures, according to a new study.

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International team develops novel DNA nano engine

Science Daily: Pharmacology News

OCTOBER 19, 2023

An international team of scientists has recently developed a novel type of nano engine made of DNA. It is driven by a clever mechanism and can perform pulsing movements. The researchers are now planning to fit it with a coupling and install it as a drive in complex nano machines.

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DNA Engineering International Research

DNA organization in real-time

SCIENMAG: Medicine & Health

JUNE 29, 2023

Performing cutting-edge science requires thinking outside the box and bringing together different scientific disciplines. Sometimes this even means being in the right place at the right time.

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DNA Science Research Engineering

Discovering cancers of epigenetic origin without DNA mutation

Science Daily: Pharmacology News

APRIL 24, 2024

A research team has discovered that cancer, one of the leading causes of death worldwide, can be caused entirely by epigenetic changes, in other words, changes that contribute to how gene expression is regulated, and partly explain why, despite an identical genome, an individual develops very different cells (neurons, skin cells, etc.).

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DNA Regulations Research

The Love Songs of W. E. B. Du Bois Celebrates Afro-Indigenous History with Genealogy – No DNA Needed

PLOS: DNA Science

MAY 18, 2023

Perhaps more telling, I recently discovered a previously unknown branch of my own family tree that includes a dozen half-siblings that I know of, from a DNA test that I didn’t even remember taking. It was eerily like forensic scientists using familial DNA to track down serial killers. Which one was our biodad?

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DNA Doctors Research Science

The physics of fat droplets reveal DNA danger

Science Daily: Pharmacology News

AUGUST 28, 2023

The stakes of their findings are high: a ruptured nucleus can lead to elevated DNA damage that is characteristic of many diseases, including cancer.

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DNA Regulations Disease Research

'Well-man' thrown from castle identified from 800-year-old Norse saga

Science Daily: Pharmacology News

OCTOBER 25, 2024

A new study describes how researchers used ancient DNA to corroborate the events of the saga and discover details about the 'Well-man,' blending history and archaeology with science and setting a precedent for future research on historical figures.

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DNA Science Research

Ancient DNA from Rapa Nui (Easter Island) refutes best-selling population collapse theory

Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Rapa Nui (Easter Island) with its gigantic statues and treeless landscape has fascinated researchers for centuries. A new genetic study disproves the popular theory that the Rapanui population collapsed as a result of an 'ecocide' and shows that the Rapanui admixed with Indigenous Americans centuries before Europeans arrived on the island.

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DNA Research

Chewing Gum Reveals Stone Age Diet and Disease

PLOS: DNA Science

JANUARY 25, 2024

We can learn about life, past and present, anywhere we find DNA and determine its sequence. DNA Science has described intriguing sources of environmental DNA, aka eDNA: DNA in Strange Places: Hippo Poop, Zoo Air, and Cave Dirt and A Glimpse of the Ocean’s Twilight Zone Through Environmental DNA.

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Disease DNA Science Virus

Researchers engineer bacteria that can detect tumor DNA

Science Daily: Pharmacology News

AUGUST 10, 2023

Creating new technologically advanced sensors, scientists have engineered bacteria that detect the presence of tumor DNA in live organisms. Their innovation could pave the way to new biosensors capable of identifying various infections, cancers and other diseases.

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DNA Engineering Research Disease

How the motion of DNA controls gene activity

Science Daily: Pharmacology News

JUNE 29, 2023

A group of scientists now visualized this dynamic process and give novel insights into the physical characteristics of DNA. This allows specific regions to come into contact and thereby activate a gene.

DNA

Capturing the immense potential of microscopic DNA for data storage

Science Daily: Pharmacology News

JULY 11, 2023

A 'biological camera' bypasses the constraints of current DNA storage methods, harnessing living cells and their inherent biological mechanisms to encode and store data. This represents a significant breakthrough in encoding and storing images directly within DNA, creating a new model for information storage reminiscent of a digital camera.

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DNA Engineering

Researchers engineer colloidal quasicrystals using DNA-modified building blocks

Science Daily: Pharmacology News

NOVEMBER 2, 2023

A new study unveils a novel methodology to engineer colloidal quasicrystals using DNA-modified building blocks. The implications of this breakthrough are far-reaching, offering a potential blueprint for the controlled synthesis of other complex structures previously considered beyond reach.

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DNA Engineering Research

Ancient DNA analysis reveals how the rise and fall of the Roman Empire shifted populations in the Balkans

Science Daily: Pharmacology News

DECEMBER 7, 2023

Despite the Roman Empire's extensive military and cultural influence on the nearby Balkan peninsula, a DNA analysis of individuals who lived in the region between 1 and 1000 CE found no genetic evidence of Iron Age Italian ancestry.

DNA

First ever 3D reconstruction of 52,000-year-old woolly mammoth chromosomes thanks to serendipitously freeze-dried skin

Science Daily: Pharmacology News

JULY 11, 2024

An international research team has assembled the genome and 3D chromosomal structures of a 52,000-year-old woolly mammoth -- the first time such a feat has been achieved for any ancient DNA sample.

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DNA International Research

DNA origami folded into tiny motor

Mitochondria are flinging their DNA into our brain cells

Trending Sources

Scientists preserve DNA in an amber-like polymer

Cracking the code of life: new AI model learns DNA's hidden language

DNA tech offers both data storage and computing functions

Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Researchers flip genes on and off with AI-designed DNA switches

Nuclear DNA influences variation in mitochondrial DNA

Ancient DNA reveals Indigenous dog lineages found at Jamestown, Virginia

Perfume from Extinct Flowers, Thanks to Ancient DNA and Synthetic Biology

Ancient viral DNA in the human genome linked to major psychiatric disorders

When it comes to DNA replication, humans and baker's yeast are more alike than different

Researchers map 50,000 of DNA's mysterious 'knots' in the human genome

Maui Fires: How Mitochondrial DNA Will Identify Human Remains

Scientists use ancient DNA to shed light on adaptation of early Europeans

Insights into South African population history from 10,000-year-old human DNA

Researchers engineer bacteria that can detect tumor DNA

DNA study IDs descendants of George Washington from unmarked remains, findings to aid service member IDs going back to World War II

A turtle time capsule: DNA found in ancient shell

Ancient DNA reveals Down syndrome in past human societies

Dog diversity unveiled by international DNA database

Strength is in this glass's DNA

Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA

The science of ageing and restoring healthspan

DNA Origami nanoturbine sets new horizon for nanomotors

Enzymes can't tell artificial DNA from the real thing

Art with DNA -- Digitally creating 16 million colors by chemistry

Ancient DNA reveals diverse community in 'Lost City of the Incas'

Injectable agents could improve liquid biopsy for cancer detection and monitoring

DNA can fold into complex shapes to execute new functions

International team develops novel DNA nano engine

DNA organization in real-time

Discovering cancers of epigenetic origin without DNA mutation

The Love Songs of W. E. B. Du Bois Celebrates Afro-Indigenous History with Genealogy – No DNA Needed

The physics of fat droplets reveal DNA danger

'Well-man' thrown from castle identified from 800-year-old Norse saga

Ancient DNA from Rapa Nui (Easter Island) refutes best-selling population collapse theory

Chewing Gum Reveals Stone Age Diet and Disease

Researchers engineer bacteria that can detect tumor DNA

How the motion of DNA controls gene activity

Capturing the immense potential of microscopic DNA for data storage

Researchers engineer colloidal quasicrystals using DNA-modified building blocks

Ancient DNA analysis reveals how the rise and fall of the Roman Empire shifted populations in the Balkans

First ever 3D reconstruction of 52,000-year-old woolly mammoth chromosomes thanks to serendipitously freeze-dried skin

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