PLOS: DNA Science

FEBRUARY 8, 2024

DNA Science recently covered perfumes resurrected from extinct plants, but using older and less precise recombinant DNA technology. appeared first on DNA Science. But will it, can it, improve upon nature? Several species of australopithecines, for example, lived in Africa 2 to 4 million years ago. CRISPR Hubris?

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Immune Response DNA Engineering Virus 97

Broad Institute

DECEMBER 13, 2023

The studies are from groups at the Broad, Allen Institute for Brain Science, the Salk Institute for Biological Studies, and other institutions that are part of the National Institutes of Health’s Brain Research Through Advancing Innovative Neurotechnologies ® Initiative, or The BRAIN Initiative — Cell Census Network ( BICCN ).

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DNA Virus Research Engineering 140

NIH Director's Blog: Drug Discovery

MARCH 8, 2016

Instead of the black, printed stripes of the Universal Product Codes (UPCs) that we see on everything from package deliveries to clothing tags, they used short, unique snippets of DNA to label cells. DNA barcoding has already empowered single-cell analysis, including for nerve cells in the brain. PRISM consists of two key components.

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DNA Drugs Small Molecule FDA Approval 52

Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

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DNA Engineering RNA Small Molecule 87

Broad Institute

JULY 11, 2024

Targeted drug treatment leads tumor cells to imitate viral infection By Ari Navetta July 11, 2024 Breadcrumb Home Targeted drug treatment leads tumor cells to imitate viral infection Exploiting "viral mimicry," mIDH1 inhibitors trick tumors into thinking they are infected with a virus. paper cited Wu M, Kondo H, et al. Online July 11, 2024.

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Treatment Immune Response Drugs Virus 72

Drug Target Review

APRIL 17, 2024

This study is published in Science. Dr Samstein’s research interests are focused on understanding the interaction between the patient’s immune system and cancer cells in the tumour, elucidating the role of the DNA damage repair and response pathways in altering the tumour’s ability to be recognized and attacked by the immune system.

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Immune Response Laboratories DNA Virus 106

Codon

OCTOBER 13, 2024

” From their first intrepid steps into the fields, GM crops have become a scapegoat for distrust in science and its overextension into formerly “unadulterated” products. And though it is not engineered, ultrasonically aged spirits are not the stuff of science fiction either. The science is there.

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Engineering Virus Production DNA 101

Drug Target Review

DECEMBER 5, 2024

2 Structure and function of AAV capsids in gene therapy Wild-type AAV is composed of a protein shell (capsid) that contains a single-stranded DNA genome encoding proteins involved in viral replication, structure and assembly. Adeno-associated virus as a delivery vector for gene therapy of human diseases. Labcompare. 2024;9(1):78.

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Drug Target Review

SEPTEMBER 8, 2023

The study’s outcomes are also the fruit of a fruitful collaboration involving scientists from the RIKEN Center for Integrative Medical Sciences in Japan, alongside local research teams from UC San Diego and the Salk Institute. The cell’s nucleus, containing compacted DNA, is centrally positioned within the cell.

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Regulations Research DNA Immune Response 98

PLOS: DNA Science

JUNE 1, 2023

This DNA Science post from 2018 traces the history of the efforts. ” The post Topical Gene Therapy FDA-Approved for Severe Skin Disease, Dystrophic Epidermolysis Bullosa appeared first on DNA Science. A dominant form – DDEB – is less severe, blistering the hands, feet, knees, and elbows.

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FDA Approval Therapies FDA Disease 52

The Pharma Data

OCTOBER 19, 2020

20, 2020 /PRNewswire/ — Caris Life Sciences® , a leading innovator in molecular science focused on fulfilling the promise of precision medicine, announced today that Winship Cancer Institute of Emory University (Winship) has joined Caris’ Precision Oncology Alliance (The Alliance/POA). . IRVING, Texas and ATLANTA , Oct.

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Clinical Trials RNA DNA Science 52

The Pharma Data

OCTOBER 14, 2020

The research is part of an ongoing collaboration between Columbia University and Tonix that focuses on T cell and antibody responses to SARS-CoV-2 (CoV-2), the virus that causes COVID-19. The research encompasses two projects. The study led by Dr. Ilya Trakht, Ph.D., Ilya Trakht, Ph.D., The study led by Dr. Sergei Rudchenko, Ph.D.,

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Vaccine Pharmaceuticals Small Molecule Virus 40

KIF1A

FEBRUARY 4, 2024

In addition to sequencing patients, the researchers looked for antibodies to the HTLV-1 virus in the patients’ spinal fluid. We each have two DNA copies of the KIF1A gene; each copy is called an allele and makes its own RNA, which is then translated into protein.

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RNA DNA Disease Trials 52

The Pharma Data

OCTOBER 21, 2020

The complete regimen combines the integrase strand transfer inhibitor (INSTI) cabotegravir, developed by ViiV Healthcare, with rilpivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) developed by Janssen Sciences Ireland UC, part of the Janssen Pharmaceutical Companies of Johnson & Johnson. About ViiV Healthcare.

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Clinical Development Therapies Clinical Trials Treatment 52

Alta Sciences

MARCH 1, 2024

q: How can Altasciences support sponsors’ Gene Therapy Programs? We have a supply of NHPs to ensure prompt study start. And more importantly, we have the facilities to screen large numbers of subjects and assign those that are negative to the adeno-associated viruses (AAVs) of interest to the study.

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Therapies Laboratories Molecular Biology RNA 52

The Pharma Data

SEPTEMBER 1, 2020

This can help healthcare professionals identify a SARS-CoV-2 infection in people suspected to carry the virus with results typically ready in 15 minutes. About Roche Roche is a global pioneer in pharmaceuticals and diagnostics focused on advancing science to improve people’s lives.

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Virus Laboratories Clinical Trials Treatment 52

Elrig

FEBRUARY 23, 2023

Synthetic biology, the answer to ageing, and more at Research & Innovation 2023 Synthetic biology, the answer to ageing, and more at Research & Innovation 2023 The life sciences and drug discovery landscape continues to advance at pace, delivering innovations with the potential to transform patients’ lives across the world.

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Research Disease Science Drugs 40

Science Daily: Pharmacology News

JANUARY 31, 2024

In the new study, researchers successfully modified DNA from four types of phages to kill a deadly pathogen. Antimicrobial resistance is an urgent and growing global crisis. Researchers are exploring phages, viruses that infect bacteria, as a possible solution.

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Broad Institute

JUNE 27, 2024

Science (2024) Related content New gene delivery vehicle shows promise for human brain gene therapy My Quest to Cure Prion Disease — Before It’s Too Late | Sonia Vallabh | TED Prion diseases lead to rapid neurodegeneration and death and are caused by misshapen versions of the prion protein in the brain.

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Disease Therapies Clinical Trials Engineering 142

Codon

JUNE 25, 2024

However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide. Due to the nearly ubiquitous use of cloning in life science research, this lost time adds up. However, E.

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DNA RNA Laboratories Research 82

PLOS: DNA Science

APRIL 20, 2023

DNA is a sleek double helix, with “rungs” consisting of a purine base paired with a smaller pyrimidine base: adenine (A) with thymine (T) and guanine (G) with cytosine (C). . ” DNA encodes amino acid sequences comprising proteins, which impart traits. Watson and F. As a child, Mendel tended fruit trees.

DNA 52

DNA Virus Science RNA 52

Codon

FEBRUARY 13, 2024

doi: 10.2210/rcsb_pdb/goodsell-gallery-048 The Virus that Cures It’s been over 25 years since the science magazine Discover first ran an extraordinary article about how a long-forgotten medical treatment, used in the former Soviet country of Georgia, could save us from the growing threat of untreatable, drug-resistant infections.

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Therapies Virus DNA Clinical Trials 131

PLOS: DNA Science

JUNE 13, 2024

Ruling Out Alternate Explanations Requires Logic and Science Soon after Fauci’s grilling, Alina Chan, a molecular biologist at the Broad Institute of MIT and Harvard, succinctly explained the converging evidence in a compelling Opinion piece in the June 9 New York Times. An altered virus could have escaped. Her points: 1.

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Virus RNA DNA Science 52

Codon

JUNE 13, 2024

billion bases of DNA which, if unfurled, would extend for more than 100 meters—taller than the Statue of Liberty. billion bases of DNA, the human genome measures just 2 meters in length when stretched end-to-end. Credit: Oriane Hidalgo Per the book Cell Biology by the Numbers , each base pair of DNA occupies 1 nm 3 of space.

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DNA Molecular Biology Virus Cell Biology 62

Drug Target Review

SEPTEMBER 4, 2023

Infectious agent includes bacteria, virus, fungi, and parasites, and they are capable of causing disease in a living organism. I had earlier proposed the use of Palmatine and Silver Nitrate in the efficacy against the RNA structure of the COVID-19 virus. We discovered it is highly effective and environmentally friendly. Sebastian, B.,

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Drugs RNA DNA Disease 111

Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. 1 Adeno-associated virus (AAV) vectors are the leading platform for in vivo gene delivery for the treatment of various human diseases. Engineering adeno-associated virus vectors for gene therapy.

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Engineering Virus Therapies Immune Response 105

PLOS: DNA Science

AUGUST 22, 2024

Not Just a Volcanic Eruption – Sinister Science, Too Spoiler alert! My knowledge of the field is only what I learned in high school earth science and watching Heather barf on the volcano, but I assume his comments are accurate. The tale opens at the Hilo Botanical Gardens in 2016. BUT WAIT!!!

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DNA Virus Organic Chemistry Science 68

Codon

MARCH 20, 2023

Basic Science A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery. Science Advances. Science Advances. Digital nanoreactors to control absolute stoichiometry and spatiotemporal behavior of DNA receptors within lipid bilayers. O’Neill P. Bachman JA. Szymczak P.

Virus 52

Virus Engineering RNA Small Molecule 52

Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. Once it detects DNA, it relocates to the Golgi body, where it begins to activate proteins that turn on genes required for interferon production. Paper Cited Liu B, Carlson R, et al.

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Regulations Clinical Trials Engineering Science 91

Broad Institute

AUGUST 11, 2022

The study appears in Science. Microbial armory In an earlier study, the researchers scanned data on the DNA sequences of hundreds of thousands of bacteria and archaea, which revealed several thousand genes harboring signatures of microbial defense. These bacterial proteins were instead directly sensing key parts of the virus.

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DNA Virus Immune Response Bioinformatics 52

PLOS: DNA Science

MAY 4, 2023

Over time, the mineralized microbes of tooth tartar come to comprise a mouthful of tiny fossils, including snippets of degraded bacterial DNA. The work appears in Science. But recent strides in computing have enabled overlapping tiny DNA fragments to piece together unknown genes and even genomes, from chunks exceeding 100,000 bases.

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DNA Production RNA Science 52

Codon

APRIL 2, 2023

Basic Science *No evidence for a common blood microbiome based on a population study of 9,770 healthy humans. But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression.

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DNA RNA Engineering Licensing 52

The Pharma Data

JANUARY 21, 2021

Food and Drug Administration (FDA) has approved CABENUVA (consisting of Janssen’s rilpivirine and ViiV Healthcare’s cabotegravir), the first and only once-monthly, long-acting regimen for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults.

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FDA Approval Treatment RNA FDA 52

The Pharma Data

SEPTEMBER 28, 2021

Respiratory infections are caused by a good sort of pathogens, like influenza viruses, respiratory syncytial virus, parainfluenza viruses, metapneumovirus, rhinovirus, enterovirus, coronavirus and adenovirus, and other bacteria pathogens.

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Marketing Virus DNA Disease 52

PLOS: DNA Science

JANUARY 4, 2024

” CRISPRs are short DNA sequences, peppered with repeats, that latch onto DNA-cutting enzymes, commandeering and directing them to snip certain parts of a chromosome. Unlike gene therapy as originally-envisioned since the 1950s, which adds a functioning copy of a gene, CRISPR can add, remove, or replace a DNA sequence.

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FDA Approval DNA Therapies Clinical Trials 52

The Pharma Data

AUGUST 4, 2020

Accurate monitoring of Epstein-Barr virus DNA levels is critical, as they are associated with a range of life threatening-diseases including cancer in transplant patients. This is the first quantitative in vitro diagnostic test for Epstein-Barr virus (EBV) DNA in the United States.

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Virus FDA DNA Laboratories 52

PLOS: DNA Science

FEBRUARY 15, 2024

Gee-Whiz Science Jake binges on junk food and sprays weedkiller. “Apparently, they’d had enough science talk for now.” Jake goes on to call Mark’s explanations “a questionable science class. Soil is a rich ecosystem, alive with species as diverse as viruses, bacteria, fungi, worms and grubs.

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Science DNA Laboratories Virus 96