Drug Target Review

SEPTEMBER 28, 2023

After some time in that role and launching several products, I received a call from Bill Banyai and Bill Peck, or ‘The Bills’ as we call them, who were building a company around technology that creates DNA by ‘writing’ it on a silicon chip. They had the science and the technology but not the business model. It was right after synbio 1.0

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DNA Organic Chemistry Science Virus 116

PLOS: DNA Science

JULY 27, 2023

Genomics applies to all species, revealing evolution in action, because we all use the same genetic code – that is, the correspondence between DNA sequences and the amino acid sequences of proteins. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages. emerged in late 2021.

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Disease DNA Virus RNA 98

PLOS: DNA Science

FEBRUARY 8, 2024

DNA Science recently covered perfumes resurrected from extinct plants, but using older and less precise recombinant DNA technology. appeared first on DNA Science. But will it, can it, improve upon nature? Several species of australopithecines, for example, lived in Africa 2 to 4 million years ago. CRISPR Hubris?

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Immune Response DNA Engineering Virus 98

Broad Institute

JUNE 27, 2024

Science (2024) Related content New gene delivery vehicle shows promise for human brain gene therapy My Quest to Cure Prion Disease — Before It’s Too Late | Sonia Vallabh | TED Prion diseases lead to rapid neurodegeneration and death and are caused by misshapen versions of the prion protein in the brain.

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Disease Therapies Engineering Clinical Trials 142

Codon

FEBRUARY 13, 2024

doi: 10.2210/rcsb_pdb/goodsell-gallery-048 The Virus that Cures It’s been over 25 years since the science magazine Discover first ran an extraordinary article about how a long-forgotten medical treatment, used in the former Soviet country of Georgia, could save us from the growing threat of untreatable, drug-resistant infections.

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Therapies DNA Virus Clinical Trials 117

PLOS: DNA Science

APRIL 20, 2023

DNA is a sleek double helix, with “rungs” consisting of a purine base paired with a smaller pyrimidine base: adenine (A) with thymine (T) and guanine (G) with cytosine (C). . ” DNA encodes amino acid sequences comprising proteins, which impart traits. Watson and F. As a child, Mendel tended fruit trees.

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DNA Virus Science RNA 52

Broad Institute

DECEMBER 13, 2023

The studies are from groups at the Broad, Allen Institute for Brain Science, the Salk Institute for Biological Studies, and other institutions that are part of the National Institutes of Health’s Brain Research Through Advancing Innovative Neurotechnologies ® Initiative, or The BRAIN Initiative — Cell Census Network ( BICCN ).

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DNA Virus Research Engineering 140

NIH Director's Blog: Drug Discovery

MARCH 8, 2016

Instead of the black, printed stripes of the Universal Product Codes (UPCs) that we see on everything from package deliveries to clothing tags, they used short, unique snippets of DNA to label cells. DNA barcoding has already empowered single-cell analysis, including for nerve cells in the brain. PRISM consists of two key components.

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DNA Drugs Small Molecule FDA Approval 52

PLOS: DNA Science

SEPTEMBER 7, 2023

My Career I’ve been writing life science tomes for a long time. As genetics morphed into genomics, artificial intelligence stepped in, layering the combinatorial information of comparative genomics onto DNA sequences. AI may quickly assemble a table listing DNA replication enzymes or compile technology timelines.

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DNA Science Therapies Licensing 98

Codon

MARCH 20, 2023

Basic Science A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery. Science Advances. Science Advances. Digital nanoreactors to control absolute stoichiometry and spatiotemporal behavior of DNA receptors within lipid bilayers. O’Neill P. Bachman JA. Szymczak P.

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Virus Engineering RNA Small Molecule 52

PLOS: DNA Science

OCTOBER 24, 2024

In those early days, politicians and government officials who’d never heard terms like “cytokine storm” and “RNA virus” were suddenly charged with explaining what was happening. “Do Your Own Research” Fuels Science Illiteracy COVID reawakened the mantra DYOR: do your own research.

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Science Research Vaccine Government 57

Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. 1 Adeno-associated virus (AAV) vectors are the leading platform for in vivo gene delivery for the treatment of various human diseases. Engineering adeno-associated virus vectors for gene therapy.

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Engineering Virus Therapies Immune Response 105

Broad Institute

MARCH 22, 2024

Staying power The mRNA in today’s COVID vaccines is so effective because very little is needed – once injected into the body, it stimulates the production of proteins that resemble parts of the COVID virus. Funding This research was funded in part by the Searle Scholars Program, Thomas D. and Virginia W. Cabot Professorship, E.

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Engineering Protein Production RNA Vaccine 140

Codon

SEPTEMBER 29, 2024

mRNA was the intermediate stage between DNA and protein, a dynamic entity that shifted depending on the second-to-second needs of the cell, able to point out if a cell was cancerous or stressed, what kind of cell it was, and so on. While mRNA data was often illuminating, their interpretation was tricky; more akin to art than science.

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Engineering Virus DNA Therapies 132

PLOS: DNA Science

JUNE 13, 2024

Ruling Out Alternate Explanations Requires Logic and Science Soon after Fauci’s grilling, Alina Chan, a molecular biologist at the Broad Institute of MIT and Harvard, succinctly explained the converging evidence in a compelling Opinion piece in the June 9 New York Times. An altered virus could have escaped. Her points: 1.

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Virus RNA DNA Science 52

Codon

DECEMBER 12, 2024

” The report accompanies an article in Science , also released today, entitled “Confronting Risks of Mirror Life.” For the article in Science , more than 30 scientists from ten countries are calling on the broader community to confront the risks of mirrored life. ” But what, exactly, is a mirrored organism?

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DNA RNA Vaccine Virus 81

Drug Target Review

SEPTEMBER 4, 2023

Infectious agent includes bacteria, virus, fungi, and parasites, and they are capable of causing disease in a living organism. I had earlier proposed the use of Palmatine and Silver Nitrate in the efficacy against the RNA structure of the COVID-19 virus. We discovered it is highly effective and environmentally friendly. Sebastian, B.,

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Drugs RNA DNA Disease 111

Broad Institute

MAY 14, 2024

Then, during graduate school at the California Institute of Technology in the early 1960s, he was introduced to bacteriophage T7, a virus that infects Escherichia coli bacteria. If a gene was tagged with a special DNA sequence, known as the T7 promoter, then the T7 RNA polymerase would latch on and begin copying it. “His

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RNA Production Molecular Biology Laboratories 84

Broad Institute

JULY 11, 2024

Targeted drug treatment leads tumor cells to imitate viral infection By Ari Navetta July 11, 2024 Breadcrumb Home Targeted drug treatment leads tumor cells to imitate viral infection Exploiting "viral mimicry," mIDH1 inhibitors trick tumors into thinking they are infected with a virus. paper cited Wu M, Kondo H, et al. Online July 11, 2024.

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Treatment Immune Response Virus Drugs 72

PLOS: DNA Science

AUGUST 22, 2024

Not Just a Volcanic Eruption – Sinister Science, Too Spoiler alert! My knowledge of the field is only what I learned in high school earth science and watching Heather barf on the volcano, but I assume his comments are accurate. The tale opens at the Hilo Botanical Gardens in 2016. BUT WAIT!!!

DNA 52

DNA Virus Organic Chemistry Science 52

Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. Once it detects DNA, it relocates to the Golgi body, where it begins to activate proteins that turn on genes required for interferon production. Paper Cited Liu B, Carlson R, et al.

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Regulations Clinical Trials Engineering DNA 91

Drug Target Review

APRIL 17, 2024

This study is published in Science. Dr Samstein’s research interests are focused on understanding the interaction between the patient’s immune system and cancer cells in the tumour, elucidating the role of the DNA damage repair and response pathways in altering the tumour’s ability to be recognized and attacked by the immune system.

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Immune Response Laboratories DNA Virus 105

Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

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DNA Engineering RNA Small Molecule 73

Broad Institute

AUGUST 11, 2022

The study appears in Science. Microbial armory In an earlier study, the researchers scanned data on the DNA sequences of hundreds of thousands of bacteria and archaea, which revealed several thousand genes harboring signatures of microbial defense. These bacterial proteins were instead directly sensing key parts of the virus.

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DNA Virus Immune Response Bioinformatics 52

PLOS: DNA Science

FEBRUARY 15, 2024

Gee-Whiz Science Jake binges on junk food and sprays weedkiller. “Apparently, they’d had enough science talk for now.” Jake goes on to call Mark’s explanations “a questionable science class. Soil is a rich ecosystem, alive with species as diverse as viruses, bacteria, fungi, worms and grubs.

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Science DNA Laboratories Virus 98

PLOS: DNA Science

OCTOBER 12, 2023

million DNA bases. The DMD gene therapy delivers a shortened version of the dystrophin gene, just 4,558 DNA bases. First, adeno-associated virus (AAV) delivers the genes, rather than the adenovirus (AV) that had entered cells in Jesse’s liver that weren’t the targets. Two other design strategies add precision.

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Therapies Immune Response DNA Virus 69

Drug Target Review

DECEMBER 5, 2024

2 Structure and function of AAV capsids in gene therapy Wild-type AAV is composed of a protein shell (capsid) that contains a single-stranded DNA genome encoding proteins involved in viral replication, structure and assembly. Adeno-associated virus as a delivery vector for gene therapy of human diseases. Labcompare. 2024;9(1):78.

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Therapies Virus DNA Compliance 52

PerkinElmer

JULY 13, 2020

From this data, scientists have begun to try to classify different subtypes and create phylogenetic trees of the virus to understand how the viral genome is evolving as it spreads across the globe. The question as to whether these genome variations lead to different strains of the novel virus (i.e. Why and how do viruses evolve?

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Treatment DNA Virus RNA 52

Codon

JUNE 25, 2024

However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide. Due to the nearly ubiquitous use of cloning in life science research, this lost time adds up. However, E.

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DNA RNA Laboratories Engineering 70

Codon

JUNE 13, 2024

billion bases of DNA which, if unfurled, would extend for more than 100 meters—taller than the Statue of Liberty. billion bases of DNA, the human genome measures just 2 meters in length when stretched end-to-end. Credit: Oriane Hidalgo Per the book Cell Biology by the Numbers , each base pair of DNA occupies 1 nm 3 of space.

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DNA Molecular Biology Virus Cell Biology 59

Codon

OCTOBER 13, 2024

” From their first intrepid steps into the fields, GM crops have become a scapegoat for distrust in science and its overextension into formerly “unadulterated” products. And though it is not engineered, ultrasonically aged spirits are not the stuff of science fiction either. The science is there.

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Engineering Virus Production DNA 85

PLOS: DNA Science

JANUARY 4, 2024

” CRISPRs are short DNA sequences, peppered with repeats, that latch onto DNA-cutting enzymes, commandeering and directing them to snip certain parts of a chromosome. Unlike gene therapy as originally-envisioned since the 1950s, which adds a functioning copy of a gene, CRISPR can add, remove, or replace a DNA sequence.

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FDA Approval DNA Therapies Clinical Trials 52

Codon

MAY 22, 2023

And experiments at Tune Therapeutics showed that CRISPR epigenome editing — which doesn’t cut DNA at all, but merely silences genes by adding chemical groups to them — can curb “bad cholesterol” by more than 50% in monkeys. These tools do not cut or nick DNA, and so they may be safer than other options.

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DNA Engineering Science Trials 55

Drug Target Review

SEPTEMBER 8, 2023

The study’s outcomes are also the fruit of a fruitful collaboration involving scientists from the RIKEN Center for Integrative Medical Sciences in Japan, alongside local research teams from UC San Diego and the Salk Institute. The cell’s nucleus, containing compacted DNA, is centrally positioned within the cell.

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Regulations Research DNA Immune Response 98

Codon

APRIL 2, 2023

Basic Science *No evidence for a common blood microbiome based on a population study of 9,770 healthy humans. But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression.

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DNA RNA Engineering Licensing 52

PLOS: DNA Science

MAY 4, 2023

Over time, the mineralized microbes of tooth tartar come to comprise a mouthful of tiny fossils, including snippets of degraded bacterial DNA. The work appears in Science. But recent strides in computing have enabled overlapping tiny DNA fragments to piece together unknown genes and even genomes, from chunks exceeding 100,000 bases.

DNA 52

DNA Production RNA Science 52

Codon

MAY 22, 2023

And experiments at Tune Therapeutics showed that CRISPR epigenome editing — which doesn’t cut DNA at all, but merely silences genes by adding chemical groups to them — can curb “bad cholesterol” by more than 50% in monkeys. These tools do not cut or nick DNA, and so they may be safer than other options.

DNA 52

DNA Engineering Science Trials 52