Drug Discovery World

AUGUST 19, 2024

Chief Investigator Richard Wilson, Professor of Gastrointestinal Oncology at the University of Glasgow, said: “What sets CV6-168 apart is that the DNA uracilation mechanism selectively damages cancer cell DNA but also triggers signals to the immune system opening up the potential to unleash our natural immunity against the cancer cells.

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Trials Therapies DNA Small Molecule 148

Covalent Modifiers

MAY 21, 2024

A DNA-encoded chemical library (DEL) screen against Bfl-1 identified the first known reversible covalent small-molecule ligand for Bfl-1. Rivers ACS Medicinal Chemistry Letters 2024 DOI: 10.1021/acsmedchemlett.4c00113

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DNA Small Molecule Drugs 65

Drug Discovery World

MARCH 26, 2024

More importantly, it also highlighted that significant challenges remain in selecting the right therapies for the right patients despite the progress made through genomic testing and implementation of circulating tumour (ct) DNA analyses. We were there to present the latest findings from our research.

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Therapies Small Molecule RNA DNA 163

Drug Discovery World

AUGUST 21, 2023

Transcription factors are proteins that control every gene in a person’s genome by binding to DNA and flipping the on/off switches that govern gene expression. Talus Bio was also awarded a $2.0M When they go awry, they often drive cancer and other disease processes like diabetes, inflammatory diseases, and neurological conditions.

Small Molecule 245

Small Molecule DNA Drugs Licensing 245

Drug Discovery World

NOVEMBER 1, 2022

Automated synthesis machines for proteins and nucleic acids such as DNA have revolutionised research and chemical manufacturing in those fields, but many chemicals of importance are small molecules with complex structures, the researchers say.

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Small Molecule DNA Drugs Doctors 130

Drug Discovery World

AUGUST 29, 2024

Now, with HT-SPR, researchers have the ability to screen entire antibody and small molecule libraries, along with characterising epitopes, so there is way more data available at the earliest stages of drug discovery than ever before.”

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Small Molecule Drugs Protein Expression Assay Development 148

Drug Discovery World

MAY 26, 2023

million to develop the next generation of small molecule drugs against disease areas of high clinical need. New London facility exceeds global plasmid DNA demand Touchlight, a company providing DNA services and manufacturing enzymes, has completed the redevelopment and expansion of its UK manufacturing facility in London, UK.

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Small Molecule DNA Government RNA 130

Drug Discovery World

FEBRUARY 21, 2023

Charles River Laboratories and Pioneering Medicines have entered a multi-programme agreement that gives Pioneering Medicines access to artificial intelligence (AI) model Logica.

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Small Molecule DNA Drugs Laboratories 130

Drug Discovery World

SEPTEMBER 29, 2022

The company has narrowed down their decision to three options: Option #1: Company Z performs the project internally and screens their in-house collection of 250,000 small molecules using a traditional fluorescence-based biochemical assay. protein-protein or small molecule-target interactions). Conclusion.

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Small Molecule Assay Development DNA Biochemical Assays 130

Drug Discovery World

JANUARY 12, 2023

Through the collaboration, X-Chem will screen its DNA-encoded libraries (DEL) against difficult-to-drug targets implicated in neurodegenerative disease to discover hits. Its DEL platform is designed to discover novel small molecule leads against challenging, high-value therapeutic targets. .

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Disease Screening Hits Research Small Molecule 130

Drug Discovery World

JANUARY 17, 2023

The peptides that we have discovered can be used as targeting ligands directly conjugated to silencing RNAs, small molecules for therapeutics or as imaging probes,” Herrera-Barrera added. . “We used these peptides to act as zip codes to deliver nanoparticles carrying genetic materials to the intended address within the eye.” .

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Small Molecule Pharmacy RNA Packaging 246

DrugBank

JULY 24, 2024

These multifunctional small molecules are like tiny spies, hijacking the body’s natural protein degradation system to remove unwanted proteins. Multifunctional Small Molecules and Peptides Beyond PROTACs, there are other exciting tools in the new drug discovery toolbox.

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Small Molecule Clinical Trials Drugs Therapies 84

Drug Discovery World

JULY 17, 2023

IRBM, Rainwater Charitable Foundation and Weill Cornell Medicine will start of a multi-year drug discovery collaboration to identify small molecule cGAS (cyclic GMP-AMP synthase) inhibitors for the treatment of tauopathies and other neurodegenerative diseases.

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Therapies Small Molecule DNA Clinical Trials 130

DrugBank

MAY 22, 2024

Molecular dynamics (MD) simulations and other computational methods are vital tools in our arsenal , helping us peek into the atomic-level interactions and movements within the protein, helping reveal potential new binding sites induced by small molecule interactions. DNA and RNA are also key players, each bringing unique challenges.

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Small Molecule RNA DNA Pharmaceutical Companies 67

Covalent Modifiers

MAY 25, 2024

Complementary to genetic approaches, small-molecule probes have emerged as useful tools for modulating caspase activity. However, due to the high sequence and structure homology of all 12 human caspases, achieving selectivity remains a central challenge for caspase-directed small-molecule inhibitor development efforts.

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Small Molecule DNA Virus Regulations 59

DrugBank

MAY 15, 2024

One approach is to look beyond the traditional drug molecule. Researchers are experimenting with biologics—larger biological molecules that can do things small molecules can't, like targeting larger, more complex structures on cell surfaces or even inside cells.

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Small Molecule Molecular Biology Drugs Disease 83

Covalent Modifiers

DECEMBER 11, 2023

Covalent ligands are a promising strategy to pharmacologically target nuclear proteins, such as transcription factors, which lack ordered small-molecule binding pockets. To identify nuclear cysteines that are susceptible to covalent liganding, we couple proximity labeling (PL), using a histone H3.3-TurboID

Small Molecule 59

Small Molecule DNA Regulations Disease 59

Drug Hunter

MAY 18, 2023

researching DNA photoproducts related to skin cancer. As the ADC team moved toward a greater emphasis on development, Dian felt the pull to return to her “research mindset” and switched paths again, this time delving into DMPK, particularly small molecules and peptides. “I Proteomics!

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Small Molecule DNA Pharmacokinetics Engineering 131

Drug Discovery World

APRIL 8, 2024

Bold Therapeutics’ BOLD-100, a ruthenium-based small molecule, acts by targeting GRP78 to modulate the unfolded protein response (UPR) and by generating reactive oxygen species (ROS) leading to DNA damage and cell cycle arrest.

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DNA Small Molecule Science Treatment 130

Covalent Modifiers

MAY 29, 2023

We further show that members of our nucleophilic fragment library can impair functional protein–protein interactions involved in nuclear oncoprotein transport and DNA damage repair.

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Small Molecule DNA 52

Drug Discovery World

DECEMBER 21, 2023

Three trends in the antibody-drug conjugate (ADC) market Antibody-drug conjugates are biopharmaceutical products in which a monoclonal antibody (mAB) is linked to a small molecule drug with a stable linker.

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FDA Approval Therapies Small Molecule Clinical Trials 148

Drug Target Review

APRIL 16, 2024

By delivering radiation directly to the tumour cells, RLT can induce DNA damage, leading to cell death and tumour regression. Peptides are relatively small molecules compared to mAbs, making them easier and less costly to produce and modulate. In contrast, development of mAbs is typically resource intensive.

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Small Molecule Therapies Treatment Pharmaceutical Companies 59

DrugBaron

FEBRUARY 7, 2022

Finding small molecule drugs is much harder than finding a needle in a haystack – discovering the right arrangement of atoms to bind precisely to a protein target to elicit a particular response is a problem of vast dimensionality. Yet the situation with small molecules is even worse.

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Small Molecule Synthetic Chemistry Pharma Companies Pharmacokinetics 100

Drug Target Review

JULY 18, 2024

We believe liquid biopsy is very helpful for oncology drug development because the reduction and clearance of circulating DNA occurs quickly before radiographic imaging is available. The initial techniques were able to detect circulating tumour DNA in patients who already had metastatic spread.

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Drug Development Clinical Trials Small Molecule Vaccine 59

Drug Target Review

DECEMBER 7, 2023

In an infected animal, cGAS senses viral DNA in cytoplasm whilst in an uninfected organism, DNA is confined in the nucleus. Bacteria must take a different approach as they do not have nuclei and if CBASS reacted to the presence of DNA, it would cause autoimmunity or the bacterium to attack itself, Banh said. But what, exactly?”

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RNA Immune Response DNA Molecular Biology 59

Covalent Modifiers

AUGUST 14, 2023

For both cancer and healthy genomes, we find that cysteine acquisition is a ubiquitous consequence of genetic variation that is further elevated in the context of decreased DNA repair.

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Small Molecule RNA DNA Therapies 52

The Pharma Data

JANUARY 5, 2021

Durham, North Carolina-based Ribometrix announced a strategic collaboration deal with Genentech , a Roche company, to identify and advance novel RNA-targeted small molecule therapeutics. This is because many proteins do not have small-molecule binding sites. This is not the first deal for RNA therapeutics for Genentech.

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RNA Small Molecule DNA Licensing 52

Drug Discovery World

JANUARY 3, 2023

Matthew Clark , CEO of X-Chem, looks at what the future could hold for DNA-encoded library (DEL) technology. In the 13 years since it was first described, DNA-encoded library (DEL) technology has become a firmly established approach to small molecule hit generation in drug discovery. Artificial intelligence. Wu Z, et al.

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DNA Targeted Protein Degradation Small Molecule Pharma Companies 130

The Premier Consulting Blog

JULY 9, 2023

During the development of new small molecule drug products, developers must conduct impurity and degradant evaluation at several points in the program and to varying degrees. In addition, this guidance focuses on DNA reactive substances that could potentially cause cancer. Global regulatory agencies, including the U.S.

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Small Molecule DNA Drugs Clinical Development 52

The Pharma Data

MAY 15, 2023

Through the acquisition, Gilead gains rights to a portfolio of small molecule inhibitors targeting PARP1 for oncology and MK2 for inflammatory diseases that could enter clinical trials later this year. Executive Vice President, Research, Gilead Sciences. The company was founded in 2021 by Stephen Kaldor, Ph.D., Qing Dong, Ph.D.,

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Small Molecule DNA Immune Response Science 40

Metabolite Tales Blog

OCTOBER 5, 2023

Trapping agents are described for reactive metabolites that could ordinarily be overlooked due to quenching with endogenous small molecules and protein nucleophiles.

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Small Molecule DNA Drug Development Drugs 52

Drug Target Review

JUNE 19, 2024

The other powerful benefit is that our cell lines can become any of the cell types of the human body – these cells have within their DNA the capability to become any of the more than 200 human cell types which you might want to manufacture. Just like small molecules and antibodies, cell therapies are changing how we treat patients.

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Therapies Small Molecule Pharmaceutical Companies Molecular Biology 84

LifeSciVC

DECEMBER 6, 2022

These hair clip-like molecules clamp onto DNA, thereby turning many genes on and off. As Darnell observed, the prospect of being able to regulate Transcription Factor function holds the potential to reframe the way we treat disease but achieving that goal with traditional small molecule screening approaches is impossible.

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Small Molecule DNA Regulations Science 40

Drug Target Review

NOVEMBER 6, 2023

These regimens frequently include one or two small molecule inhibitors and immuno-oncology (IO) therapies, such as monoclonal antibodies and T-cell engagers. To bring us closer to curing cancer, a combination of effective drugs with non-overlapping mechanisms of action is required.

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Small Molecule Therapies Treatment Immune Response 111

DrugBaron

JULY 19, 2022

Despite the current hype around so called “advanced therapies”, which range from gene editing to cell therapies, and the inexorable advance of biologic therapeutics such as monoclonal antibodies, even in 2022 the majority of drugs in development and reaching patients are still small organic molecules.

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Small Molecule Drugs DNA Pharma Companies 100

Drug Discovery World

AUGUST 10, 2023

ND : Totus has innovated three interdependent and fundamental technologies in chemistry, biology, and AI to enable screening of billions of candidate molecules against hundreds of targets in parallel. Second, we have created a novel DNA-tracking technology to analyse billions of molecular interaction in a cellular setting.

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Small Molecule Clinical Trials Cell Biology Disease 130

Drug Discovery World

NOVEMBER 8, 2023

AI-enabled tumour profiling Furthermore, scientists from Harvard Medical School 8 have pioneered an AI tool named CHARM (Cryosection Histopathology Assessment and Review Machine), which deciphers the DNA of brain tumours in real-time during surgery. Psychology Today 25 January 2023. Ren F, Ding X, Zheng M, et al. Chem Sci 2023;14:1443-145.

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Clinical Trials Trials Disease Medical Schools 183