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2 In response, DNA-damaging agents that could target the entire cell cycle received renewed attention as ADC payloads. Dual payload ADCs As effective as therapies have been in treating solid and haematological cancers, tumour heterogeneity and resistance remain major clinical challenges. Fu Y, Ho M. 1 , 33–43 (2018).
While the successful therapeutic targeting of transcription factors is a relatively new undertaking by industry, these proteins themselves are nothing new. One area of interest is that of oncology, where growing evidence has shown the role that transcription factors play in driving various cancers.
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