ASPET

NOVEMBER 17, 2023

Despite a century of research, there are no specific treatments for acute or persistent ocular SM injuries. SM cytotoxicity emerges, in part, through DNA alkylation and double-strand breaks (DSBs). Significance Statement Sulfur Mustard Gas corneal injury currently has no therapeutic treatment.

DNA 100

DNA Treatment Drugs Research 100

Chemical Biology and Drug Design

JANUARY 29, 2024

MGMT mRNA expression was significantly increased in CD138+ myeloma cells compared with their matched CD138-nontumorigenic cells and inhibition of MGMT by its specific inhibitor lomeguatrib in MM cells reduced DNA repair, cell viability, and S phase entry and increased DNA damage and apoptosis.

DNA 100

DNA Treatment Disease Research 100

Chemical Biology and Drug Design

APRIL 24, 2023

Raltegravir, an integrase inhibitor approved for the treatment of HIV infection, led to an increase in DNA damage and apoptosis in multiple myeloma that remains as an incurable malignancy. In addition, the mRNA levels of V(D)J recombination and DNA repair genes were analyzed using qPCR. 01 for U66 and p  ˂ .0001

DNA 100

DNA Treatment Research 100

BioPharma Drive: Drug Pricing

FEBRUARY 15, 2024

The partnership will use Intellia's "DNA writing” technology, and initially focus on people with the lung disease who have limited or no available treatment options.

DNA 189

DNA Treatment Disease 189

Covalent Modifiers

APRIL 25, 2024

Kinsella Nature , 2024 [link] WRN helicase is a promising target for treatment of cancers with microsatellite instability (MSI) due to its essential role in resolving deleterious non-canonical DNA structures that accumulate in cells with faulty mismatch repair mechanisms 1 , 2 , 3 , 4 , 5.

DNA 173

DNA RNA Treatment Drugs 173

DrugBank

MARCH 12, 2025

  The Expanding Role of mRNA in Cancer Therapy One of the most exciting applications of mRNA therapeutics lies in cancer treatment, where leveraging the immune system to target tumors offers a novel approach. This approach can be personalized for each patient by sequencing the tumor's DNA and RNA to identify unique mutations.

Vaccine 97

Vaccine Treatment Clinical Trials Therapies 97

Chemical Biology and Drug Design

FEBRUARY 26, 2024

The mechanism research revealed that cinnamaldehyde activated the Nrf2 pathway to attenuate lipid peroxidation and repair DNA damage to protect cardiomyocytes from ischemia/reperfusion injury in the OGD/R-induced H9C2 cardiomyocyte model. The severity of DNA damage was assessed by tail moment (TM) values using alkaline comet assay.

DNA 100

DNA Treatment Disease Research 100

PLOS: DNA Science

MARCH 28, 2024

FDA classifies it as a “nonsteroidal treatment” – not a gene therapy, but it affects gene expression. A gene-based treatment would have to alter many cells to exert a noticeable effect. million DNA bases. In 2023, two gene-based treatments became available. What’s an HDAC Inhibitor?

FDA Approval 97

FDA Approval Treatment FDA DNA 97

SCIENMAG: Medicine & Health

DECEMBER 13, 2023

The most comprehensive analysis of Indigenous Australians’ genomes collected to date has revealed an “abundance” of DNA variations – some of which have never been reported anywhere else in the world – paving the way for new, personalised treatments that address health inequities for Aboriginal and Torres Strait Islander peoples.

DNA 80

DNA Treatment 80

ASPET

SEPTEMBER 16, 2024

GBM has a poor prognosis despite aggressive treatment, in part due to lack of adequate drug permeability at the BBB. Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Subsequent activation of DNA damage response (DDR) pathways can induce resistance.

Pharmacogenetics 100

Pharmacogenetics DNA Treatment Pharmacokinetics 100

Covalent Modifiers

DECEMBER 22, 2023

Mutations in the TRF2TRFH domain physically impair t-loop formation and prevent the recruitment of several factors that promote efficient telomere replication, causing telomeric DNA damage. We identify APOD53 as our most promising compound, as it consistently induces a telomeric DNA damage response in cancer cell lines.

DNA 162

DNA Regulations Treatment 162

ASPET

JUNE 30, 2023

It was found that combining these drugs with lower doses and for shorter treatment periods induced greater or equal toxicity in cancer cells than using either as a single agent. Here, we develop a mathematical model to investigate the effects of ceralasertib and olaparib, two drugs that target DNA damage response pathways.

DNA 100

DNA Therapies Government Treatment 100

Broad Institute

APRIL 5, 2025

Base editing, which Lius team developed in 2016, is a gene editing technique that directly converts an individual DNA base pair into a different base pair. Liu and other prize recipients were announced on April 5, 2025, at the 11th annual Breakthrough Prize ceremony in Los Angeles.

Science 139

Science Clinical Trials DNA Disease 139

Drug Target Review

JUNE 9, 2023

This exclusive interview with Dr Sharon Benzeno, Chief Commercial Officer, Immune Medicine at Adaptive Biotechnologies, unveils some ground-breaking research on T- cell therapy for cancer , which has seen the first TCR-based therapeutic candidate progress to clinical development, offering promising advancements in innovative cancer treatments.

Treatment 105

Treatment Packaging Clinical Research Therapies 105

SCIENMAG: Medicine & Health

JUNE 16, 2023

• Genomic sequencing panels are tests that analyse the DNA of the patient’s tumour to look for genetic variants for which there are effective drugs. If the tumour has these variants, treatment can be personalised.

Treatment 86

Treatment DNA Drugs 86

ASPET

JUNE 10, 2024

Radiation therapy, a standard treatment option for many cancer patients, induces DNA double strand breaks (DSBs), leading to cell death. This approach will provide critical insights for the clinical translation of WSD0628 for the treatment of primary and secondary brain tumors.

Pharmacokinetics 100

Pharmacokinetics Pharmacogenetics Treatment DNA 100

PLOS: DNA Science

FEBRUARY 1, 2024

Recombinant DNA technology has since provided a pure source of the hormone. This transmission occurred following treatment with a now obsolete form of growth hormone, and involved repeated treatments with contaminated material, often over several years. At least 1,848 patients with short stature developed vCJD, mostly in the UK.

Disease 98

Disease Treatment DNA Research 98

Drug Target Review

JULY 9, 2024

2 DNA repair mechanism disruption is a significant cause of increased cancer risk, with around 20 percent of bowel cancers known as mismatch repair deficient (MMRd) cancers, which have mutations in DNA repair genes. She continued: “The really interesting finding from our research is what happens afterwards.

Regulations 105

Regulations DNA Treatment Research 105

Drug Target Review

DECEMBER 13, 2024

2 Unmet needs in lung cancer treatment Recent decades have seen significant advancements in lung cancer treatment, especially with the introduction of targeted therapies and immunotherapies, which have notably improved survival rates. 7 Recent clinical studies highlight promising developments in c-MET-targeting ADCs for NSCLC.

Therapies 98

Therapies Treatment Clinical Trials Drugs 98

Covalent Modifiers

SEPTEMBER 19, 2023

No dose-limiting toxic effects or treatment-related deaths were reported. Treatment-related adverse events occurred in 127 patients (93%); grade 3 events occurred in 15 patients (11%) and a grade 4 event in 1 patient (1%). Among patients with NSCLC, a confirmed response was observed in 53.4% months (95% CI, 8.8

Pharmacokinetics 147

Pharmacokinetics DNA Treatment 147

PLOS: DNA Science

SEPTEMBER 5, 2024

Diagnosis began to shift from a body-part basis to a molecular one, which I wrote about in “Mutation and location important in cancer treatment” for The Lancet in 2015. These findings can then be used to predict response to treatments as well as survival time. More information enables more treatment choices.

Treatment 70

Treatment FDA Approval DNA Small Molecule 70

Chemical Biology and Drug Design

SEPTEMBER 16, 2024

This study identified MAPK9 as the directly binding target of baicalein by the DNA-programmed affinity labeling method and tested the binding affinity as 89.7 nM However, there are limited effective treatments available for it. The use of natural products in the management and treatment of HCC is gaining more attention.

DNA 100

DNA Therapies Treatment Production 100

Broad Institute

AUGUST 31, 2023

Their new editors are more efficient and specialized than previous versions, and are able to modify DNA in cultured cells and in animals that have been difficult to edit, including in immune system cells and inside the brain. In the new work, they focused on improving the heart of the prime editing system—the reverse transcriptase.

DNA 145

DNA Engineering RNA Laboratories 145

Conversations in Drug Development Trends

AUGUST 14, 2024

By: Simran Padam, Medical Director, Medical Affairs Personalized treatment approaches have emerged as pivotal in improving outcomes for hematological cancers. Hematological cancer cells can also develop resistance to therapies over time, reducing treatment effectiveness.

Treatment 78

Treatment Therapies Disease Protein Expression 78

Broad Institute

NOVEMBER 13, 2023

Liquid biopsies enable clinicians to find and analyze tumor DNA in a patient’s blood sample to detect cancer early, monitor cancer recurrence, assess the patient’s response to treatment, and measure other clinically important features in real time, without invasive procedures.

DNA 116

DNA Medical Schools Treatment Therapies 116

Drug Target Review

AUGUST 3, 2023

Precision medicine , with its focus on personalised treatments tailored to an individual’s genetic makeup, has seen remarkable progress in recent years. What preclinical research methods are commonly employed in precision medicine, and how do they contribute to the development of personalised treatments?

DNA 52

DNA Clinical Trials Trials Disease 52

Broad Institute

OCTOBER 3, 2024

Largest-ever genetic study of epilepsy finds possible therapeutic targets By Ari Navetta October 3, 2024 Breadcrumb Home Largest-ever genetic study of epilepsy finds possible therapeutic targets Scientists have uncovered new genetic links to different types of epilepsy, which could lead to more tailored treatments.

DNA 133

DNA Doctors Treatment Disease 133

Broad Institute

JUNE 10, 2024

The new method uses a combination of prime editing, which can directly make a wide range of edits up to about 100 or 200 base pairs, and newly developed recombinase enzymes that efficiently insert large pieces of DNA thousands of base pairs in length at specific sites in the genome.

DNA 144

DNA Engineering Therapies Disease 144

Drug Target Review

JULY 3, 2023

There is a significant unmet need for effective treatments to alleviate suffering and prevent premature death across the spectrum of genetic diseases. While existing treatments can help manage symptoms, reduce complications, and slow disease progression in certain cases, they do not offer lasting cures for most genetic disorders.

Disease 98

Disease Therapies DNA Treatment 98

Broad Institute

JULY 11, 2024

Targeted drug treatment leads tumor cells to imitate viral infection By Ari Navetta July 11, 2024 Breadcrumb Home Targeted drug treatment leads tumor cells to imitate viral infection Exploiting "viral mimicry," mIDH1 inhibitors trick tumors into thinking they are infected with a virus.

Treatment 72

Treatment Immune Response Drugs Virus 72

Broad Institute

MARCH 26, 2024

The team analyzed ancient DNA and traced the variant all the way back to the first people to enter the Americas about 13,000 years ago. "We The researchers then analyzed ancient DNA samples to understand when the risk variant arose in human history.

DNA 59

DNA Research Disease Treatment 59

Codon

NOVEMBER 3, 2024

In the 1924 novel, The Magic Mountain , Thomas Mann describes a sanatorium patient named Anton Ferge as he undergoes a painful tuberculosis (TB) treatment. Some fluoroquinolones — a class of antibiotics that inhibits DNA replication — may even cause psychosis. million people every year. tuberculosis strains. OK, Computer.

Vaccine 102

Vaccine Trials Therapies Treatment 102

ASPET

AUGUST 21, 2024

Mice were euthanatized 72 hours after cisplatin treatment. The renal protection from oral gavage of PF-04457845 against cisplatin-induced nephrotoxicity was associated with an enhanced AEA tone and reduced levels of DNA damage response biomarkers p53 and p21.

DNA 100

DNA Treatment 100

Chemical Biology and Drug Design

MAY 11, 2023

In our study of AGS cells, nuclear condensation was observed by 4′,6-diamidino-2-phenylindole (DAPI) staining, cell death was confirmed by a cell viability assay, and fragmented DNA was observed at the IC 50 dose by a DNA fragmentation assay. Apoptosis was evaluated by the qPCR technique.

DNA 100

DNA Treatment Research 100

PLOS: DNA Science

JULY 27, 2023

Genomics applies to all species, revealing evolution in action, because we all use the same genetic code – that is, the correspondence between DNA sequences and the amino acid sequences of proteins. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages.

Disease 94

Disease DNA Virus RNA 94

Broad Institute

JUNE 28, 2023

Such large-scale changes in DNA have been difficult to study. The findings, published today in Nature , could lead to new ways of guiding cancer treatment or developing targeted drugs. Many of the regions, they suspect, will point towards new drug targets or ways of screening cancer patients for the most effective treatment. “Our

DNA 122

DNA Medical Schools Treatment Research 122

Chemical Biology and Drug Design

APRIL 3, 2023

Our results show that benzimidazole's broad therapeutic spectrum is due to its structural isosteres with purine, which improves hydrogen bonding, electrostatic interactions with topoisomerase complexes, intercalation with DNA, and other functions.

DNA 100

DNA Therapies FDA Treatment 100