Drug Discovery World

JUNE 22, 2023

Hosted by DDW and supported by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ What changes can we expect from clinical trials? will be free to attend on June 28 at 8AM PT | 11AM ET | 4PM BST | 5PM CET. How important will mRNA-based vaccines be in treating viruses and diseases such as cancer?

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DNA Clinical Trials Drugs Vaccine 130

Drug Discovery World

JUNE 15, 2023

Hosted by DDW and sponsored by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ What changes can we expect from clinical trials? will be free to attend on June 28 at 8AM PT | 11AM ET | 4PM BST | 5PM CET. How important will mRNA-based vaccines be in treating viruses and diseases such as cancer?

DNA 130

DNA Drugs Clinical Trials Vaccine 130

Drug Discovery World

JUNE 8, 2023

Hosted by DDW and sponsored by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ What changes can we expect from clinical trials? will be free to attend on June 28 at 8AM PT | 11AM ET | 4PM BST | 5PM CET. How important will mRNA-based vaccines be in treating viruses and diseases such as cancer?

Drugs 130

Drugs DNA Clinical Trials Vaccine 130

Drug Discovery World

MARCH 26, 2024

More importantly, it also highlighted that significant challenges remain in selecting the right therapies for the right patients despite the progress made through genomic testing and implementation of circulating tumour (ct) DNA analyses. Results of that Phase I trial are expected to be presented later this year.

Therapies 162

Therapies Small Molecule RNA DNA 162

Drug Discovery World

OCTOBER 18, 2023

Sara Donnelly, Director of Research Planning and Business Development at PhoenixBio USA explores why the right pre-clinical model is essential for teams wanting to advance adeno-associated virus vector-based gene therapies. Adeno-associated virus (AAV) vector-based gene therapies hold exceptional promise across a range of disease areas.

Therapies 162

Therapies Clinical Trials FDA Approval Virus 162

Drug Discovery World

AUGUST 14, 2023

For instance, in a trial where patients are selected based on a specific human leukocyte antigen (HLA) type, the FDA requires the use of a fully certified, FDA approved Companion Diagnostic. Despite this step, there remain divergent views on other regulatory aspects. The EMA, however, doesn’t require the use of an agency-approved diagnostic.

Marketing 130

Marketing DNA Therapies FDA 130

Drug Discovery World

FEBRUARY 28, 2024

Using a technique they’ve dubbed ‘cancer shredding’, the researchers at Gladstone Institutes, California, programmed CRISPR to zero-in on repeating DNA sequences present only in recurrent tumour cells – and then obliterate those cells by snipping away at them.

Drug Development 162

Drug Development Research Clinical Trials Drugs 162

The Premier Consulting Blog

MARCH 7, 2024

For gene therapy vectors, this testing encompasses production cell lines, master and working cell banks (MCB, WCB), and virus banks. Depending on the gene therapy vector, microbial systems may be employed to produce vector DNA (such as in adeno associated virus (AAV)), in which case there may be bacterial cell banks and plasmid banks.

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Production Therapies DNA Virus 52

PLOS: DNA Science

JULY 27, 2023

Genomics applies to all species, revealing evolution in action, because we all use the same genetic code – that is, the correspondence between DNA sequences and the amino acid sequences of proteins. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages. emerged in late 2021.

Disease 68

Disease DNA Virus RNA 68

Drug Discovery World

APRIL 15, 2023

VAL-083, is a ‘first-in-class’ small-molecule chemotherapeutic with a novel mechanism of action that targets DNA and crosses the blood brain barrier to inhibit cancer cell replication and cell division. CONV01-α would be the first Ac-225 radioantibody approved for use in cancer treatment.

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Virus Clinical Trials Trials Therapies 130

PLOS: DNA Science

OCTOBER 12, 2023

million DNA bases. The DMD gene therapy delivers a shortened version of the dystrophin gene, just 4,558 DNA bases. First, adeno-associated virus (AAV) delivers the genes, rather than the adenovirus (AV) that had entered cells in Jesse’s liver that weren’t the targets. Two other design strategies add precision.

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Therapies Immune Response DNA Virus 69

PLOS: DNA Science

JANUARY 4, 2024

” CRISPRs are short DNA sequences, peppered with repeats, that latch onto DNA-cutting enzymes, commandeering and directing them to snip certain parts of a chromosome. Unlike gene therapy as originally-envisioned since the 1950s, which adds a functioning copy of a gene, CRISPR can add, remove, or replace a DNA sequence.

FDA Approval 52

FDA Approval DNA Clinical Trials Therapies 52

Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. 1 Adeno-associated virus (AAV) vectors are the leading platform for in vivo gene delivery for the treatment of various human diseases. Engineering adeno-associated virus vectors for gene therapy.

Engineering 105

Engineering Virus Therapies Immune Response 105

Drug Discovery World

AUGUST 13, 2024

In this webinar, Professor Susumu Uchiyama, Department of Biotechnology, Graduate School of Engineering, Osaka University, will present his work around adeno-associated virus (AAV) characterisation using cryo-electron microscopy. Indeed, more than 250 clinical trials have been conducted in the USA and European countries.

Virus 130

Virus Therapies DNA Clinical Trials 130

The Pharma Data

JANUARY 21, 2021

Senhwa’s Silmitasertib is an oral medication, targeting the host protein kinase CK2 (casein kinase 2), where virus mutations are unlikely to affect its anti-viral and anti-inflammatory efficacy. It is thought that Silmitasertib challenges the virus’ ability to replicate quickly and spread to nearby healthy cells.

Trials 52

Trials Treatment Small Molecule Hospitals 52

Codon

MAY 18, 2023

shelves, it’s easy to find DNA in the air , and some weird insect cybernetics. 2/ Your DNA is Everywhere. A study published Monday in Nature Ecology & Evolution shows that tiny amounts of human DNA, shed into the soil or air, can be easily detected using little more than a $1,000 Nanopore MinION. Read more in WIRED.

DNA 52

DNA Engineering Therapies Virus 52

Codon

MAY 18, 2023

shelves, it’s easy to find DNA in the air , and some weird insect cybernetics. 2/ Your DNA is Everywhere. A study published Monday in Nature Ecology & Evolution shows that tiny amounts of human DNA, shed into the soil or air, can be easily detected using little more than a $1,000 Nanopore MinION. Read more in WIRED.

DNA 52

DNA Engineering Therapies Virus 52

Drug Discovery World

FEBRUARY 6, 2024

As AI-designed drugs start to enter large-scale clinical trials, DDW’s Diana Spencer investigates how new digital tools are reinventing and reshaping drug discovery for the future. We are starting to see the visible impact of new technologies on the sector, as drugs discovered through the use of AI start to enter clinical investigations.

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The Pharma Data

NOVEMBER 23, 2021

Approval is for Cytomegalovirus, a Type of Herpes Virus. Livtencity works by preventing the activity of human cytomegalovirus enzyme pUL97, thus blocking virus replication. CMV is a type of herpes virus that commonly causes infection in patients after a stem cell or organ transplant. Today, the U.S.

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FDA Approval Treatment FDA DNA 52

Drug Discovery World

JANUARY 21, 2024

He will also explain the importance of this innovation as a way to mitigate the high failure rates in clinical trials, which historically see 92% of drugs fail despite passing animal tests, leading to significant financial and time losses in the industry (approximately $53 billion for pharma companies annually).

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Vaccine Computational Chemistry Animal Testing Engineering 130

Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. Drugs that activate STING have been developed and tested in clinical trials as cancer immunotherapy drugs that would help stimulate the immune system to destroy tumors.

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Regulations Engineering Clinical Trials DNA 91

Advarra

MARCH 31, 2023

The use of engineered genetic materials in clinical trials is rapidly expanding, with potential applications for genetic vaccines, gene-modified cellular therapies, and gene therapies. Gene Delivery Systems Genetic material, in the form of DNA or RNA, does not easily enter cells without the aid of a delivery system.

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Engineering Clinical Research Research Virus 52

Drug Discovery World

NOVEMBER 17, 2022

It is believed that the term synthetic biology was created in 1970 by geneticist, Waclaw Szybalski 1 as work was being carried out on the development of DNA sequencing and synthesis techniques. Cilagicin is still far from human trials. These factors can significantly contribute to the growth of the synthetic biology market, it adds.

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Engineering Molecular Biology Synthetic Chemistry DNA 130

The Pharma Data

NOVEMBER 5, 2020

5 of its ongoing Phase 2 extension study, Study 211, examining vebicorvir (VBR, or ABI-H0731) in patients with hepatitis B virus infection. The company’s other two Phase 2 trials, Study 201 and 202, showed that the addition of VBR to NrtI therapy achieved a quicker, deeper level of viral suppression than with NrtI alone.

Virus 40

Virus Clinical Trials Therapies Pharmacokinetics 40

PerkinElmer

AUGUST 18, 2020

The time sensitivity of virus research, combined with an increasing complexity of bench tasks, can make it helpful for labs to increase automaticity of experiments. For this reason, it might be necessary for research teams to screen many potential leads before they find one or two with strong potential. Sources Zhang et al.

Virus 52

Virus Vaccine RNA DNA 52

The Pharma Data

OCTOBER 19, 2020

With over 300 active clinical trials, Winship researchers are dedicated to taking new cancer treatments from bench to bedside. cancer centers selected as a Lead Academic Participating Site for the NCI’s National Clinical Trials Network (NCTN). Winship is one of 32 U.S. MBA, FACP, Chairman of the Caris Precision Oncology Alliance.

Clinical Trials 52

Clinical Trials RNA DNA Science 52

Drug Discovery World

AUGUST 26, 2024

In a webinar on 5 September, Professor Susumu Uchiyama, Department of Biotechnology, Graduate School of Engineering, Osaka University, will present his work around adeno-associated virus (AAV) characterisation using cryo-electron microscopy. Indeed, more than 250 clinical trials have been conducted in the USA and European countries.

Virus 162

Virus DNA Clinical Trials Engineering 162

The Pharma Data

SEPTEMBER 1, 2020

This can help healthcare professionals identify a SARS-CoV-2 infection in people suspected to carry the virus with results typically ready in 15 minutes. Roche has an ongoing clinical trial program evaluating the role of Actemra©/RoActemra© (tocilizumab) in COVID-19 pneumonia.

Virus 52

Virus Laboratories Clinical Trials Treatment 52

Drug Discovery World

SEPTEMBER 2, 2024

In a webinar on 5 September, Professor Susumu Uchiyama, Department of Biotechnology, Graduate School of Engineering, Osaka University, will present his work around adeno-associated virus (AAV) characterisation using cryo-electron microscopy. Indeed, more than 250 clinical trials have been conducted in the USA and European countries.

Virus 130

Virus DNA Clinical Trials Engineering 130

Drug Discovery World

AUGUST 19, 2024

In a webinar on 5 September, Professor Susumu Uchiyama, Department of Biotechnology, Graduate School of Engineering, Osaka University, will present his work around adeno-associated virus (AAV) characterisation using cryo-electron microscopy. Indeed, more than 250 clinical trials have been conducted in the USA and European countries.

Virus 130

Virus DNA Clinical Trials Engineering 130

Drug Discovery World

SEPTEMBER 6, 2022

And whilst clinical trials activity decreased by around 15% compared to 2020, last year still saw a number of regenerative medicines reach the bedside. In gene therapy, re-engineered adeno-associated virus (AAV) vectors have been produced using various methods such as machine learning or directed evolution. billion, compared to $19.9

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Therapies Clinical Trials Vaccine Disease 130

Codon

MAY 11, 2023

It is used to prevent respiratory syncytial virus, or RSV, which causes about 60,000 hospitalizations in this age group each year. percent effective in preventing lower respiratory tract illness this age group in a randomized, controlled trial with 250,000 participants. Read more in WIRED. The vaccine was 82.6 Beautiful stuff.

Vaccine 52

Vaccine Engineering Licensing Licensing 52

Codon

MAY 11, 2023

It is used to prevent respiratory syncytial virus, or RSV, which causes about 60,000 hospitalizations in this age group each year. percent effective in preventing lower respiratory tract illness this age group in a randomized, controlled trial with 250,000 participants. Read more in WIRED. The vaccine was 82.6 Beautiful stuff.

Vaccine 52

Vaccine Engineering Licensing Licensing 52

Codon

FEBRUARY 13, 2024

doi: 10.2210/rcsb_pdb/goodsell-gallery-048 The Virus that Cures It’s been over 25 years since the science magazine Discover first ran an extraordinary article about how a long-forgotten medical treatment, used in the former Soviet country of Georgia, could save us from the growing threat of untreatable, drug-resistant infections.

Therapies 121

Therapies Virus DNA Clinical Trials 121

NIH Director's Blog: Drug Development

JANUARY 5, 2016

The RNA is preprogrammed to find a distinct short sequence of DNA and deliver the enzyme, which acts like a scalpel to slice the sequence out of the genome. Even as the epidemic waned, researchers pressed forward with trials of new vaccines that might prevent the next outbreak. It’s fast and pretty precise. Protein Cell.

Vaccine 52

Vaccine Science Engineering Disease 52

Drug Discovery World

AUGUST 10, 2022

And now, with more than 600 CAR T trials recruiting or ongoing, these cells represent a majority of the cellular immunotherapies in development today. CAR T cells are made by transfecting T cells with a transgene that encodes the CAR protein using either a virus, a transposon system, or mRNA. Training T cells to target tumours.

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Therapies Virus Treatment Engineering 246

The Pharma Data

OCTOBER 21, 2020

The pooled analysis examined 1,744 participants across 16 countries currently taking long-acting cabotegravir and rilpivirine as part of the regimen’s ongoing global clinical development programme of six studies, which includes the phase IIb/IIIb LATTE-2, ATLAS, ATLAS-2M, FLAIR, POLAR, and CUSTOMIZE clinical trials.

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Clinical Development Therapies Clinical Trials FDA Approval 52