Drug Discovery World

APRIL 16, 2024

Attendees will hear how library preparation, assessed data quality, and generated important rAAV metrics such as integrity of DNA cargo, truncation events, chimeric transgenes, and levels of co-packaged impurities were performed.

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Packaging DNA Virus International 130

Drug Discovery World

NOVEMBER 8, 2022

A team of researchers have identified the specific mutations in the monkeypox virus that contribute to its continued infectiousness. Mutations have enabled the virus to grow stronger and smarter, evading antiviral drugs and vaccines. . Monkeypox has infected more than 77,000 people in more than 100 countries worldwide.

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Virus DNA Vaccine Drugs 130

Drug Discovery World

MAY 1, 2024

Information will be presented on how they performed library preparation, assessed data quality, and generated important rAAV metrics such as integrity of DNA cargo, truncation events, chimeric transgenes, and levels of co-packaged impurities. The event will take place on 13 May, 4PM BST.

Packaging 130

Packaging DNA Virus International 130

Drug Discovery World

APRIL 24, 2024

Information will be presented on how they performed library preparation, assessed data quality, and generated important rAAV metrics such as integrity of DNA cargo, truncation events, chimeric transgenes, and levels of co-packaged impurities. The event will take place on 13 May, 4PM BST.

DNA 130

DNA Packaging Virus International 130

Codon

AUGUST 26, 2024

When COVID-19 emerged in 2019, by contrast, mRNA vaccines developed by Pfizer and Moderna took just 326 days from the initial sequencing of the virus to gaining approval for emergency use. These drugs would be ideal tools to bridge the wait for a vaccine against a quickly-spreading virus.

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RNA Virus DNA Vaccine 95

Drug Discovery World

AUGUST 7, 2024

The US Food and Drug Administration (FDA) has cleared GigaGen’s application to initiate a Phase I trial of its polyclonal drug for the treatment of hepatitis B virus (HBV) infection, GIGA-2339. In mouse models, GIGA-2339 neutralised and cleared HBV’s viral DNA along with its antigens.

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Drug Trials FDA Trials Immune Response 148

Drug Discovery World

JULY 22, 2022

Junk DNA could lead to cancer, study says . Non-coding or ‘junk’ DNA could contribute to the development of certain cancers due to how it disrupts the replication of the genome, scientists have discovered.?? . An early-stage clinical trial has been launched in the US investigating a vaccine against Nipah virus infection.? .

DNA 130

DNA Clinical Trials Vaccine Virus 130

Drug Discovery World

AUGUST 21, 2024

While many different modalities of delivery vectors exist, the two most common viral vectors are lentivirus and adeno-associated virus. Following initial viral vector transduction, treated samples, typically whole blood and/or enriched cell populations, are collected and the genomic DNA is isolated. The enriched DNA is then sequenced.

Therapies 148

Therapies Bioinformatics DNA FDA 148

Drug Discovery World

OCTOBER 20, 2023

GenomeFrontier partners with BioCina on CAR-T therapy CDMO BioCina and GenomeFrontier Therapeutics will partner on the development of virus-free CAR-T products for cancer treatment. BioCina will provide process development and GMP manufacturing for Minicircle DNA and Plasmid DNA.

DNA 130

DNA Clinical Trials Engineering Bioinformatics 130

Drug Discovery World

MAY 5, 2023

In contrast to DNA-based reprogramming and gene editing, the mRNA-based approach does not expose cells to expensive and potentially harmful viruses or DNA vectors. Eterna plans to use Exacis’ platform to develop engineered cell therapies containing genomic edits designed to enhance their performance.

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Engineering DNA Therapies Licensing 130

PLOS: DNA Science

JUNE 13, 2024

The virus SARS-CoV-2 emerged in Wuhan, home of a premiere research institute that focuses on viruses. Experiments at the Wuhan facility were done at the lowest two of the four standard biosafety levels, which were established at the dawn of recombinant DNA research in the 1970s. An altered virus could have escaped. Coincidence?

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Virus RNA DNA Science 52

Drug Target Review

JUNE 28, 2023

When faced with a viral threat, bacterial cells developed an immune response by capturing and copying DNA fragments of viruses. This allowed bacteria to recognise subsequent attacks and cleave the viral DNA to stop the viral infection. It was also discovered that the Cas enzyme was responsible for DNA cleavage.

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Engineering DNA Immune Response RNA 98

Drug Discovery World

JUNE 7, 2023

Hosted by DDW and sponsored by DNA Script, join us for this free-to-attend roundtable to learn about the biggest opportunities for the future of drug discovery and development. Roundtable panellists include Commercial Research Scientist, Dr Mark Treherne, CEO of Elevation Oncology, Joe Ferra, and CEO of BioXcel Therapeutics, Vimal Mehta.

DNA 130

DNA Clinical Trials Drugs Vaccine 130

Drug Discovery World

MARCH 26, 2024

More importantly, it also highlighted that significant challenges remain in selecting the right therapies for the right patients despite the progress made through genomic testing and implementation of circulating tumour (ct) DNA analyses.

Therapies 163

Therapies Small Molecule RNA DNA 163

SCIENMAG: Medicine & Health

JULY 11, 2023

The immune system is one of the most complex parts of our body. It keeps us healthy by getting rid of parasites, viruses or bacteria, and by destroying damaged or cancer cells. One of its most intriguing abilities is its memory: upon first contact with a foreign component (called “antigens” in scientific jargon) our adaptive […]

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DNA Virus 60

Drug Discovery World

JUNE 27, 2023

Hosted by DDW and supported by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ will be free to attend on June 28 at 8AM PT | 11AM ET | 4PM BST | 5PM CET. Join this free roundtable to learn about the biggest opportunities for the future of drug discovery and development.

DNA 130

DNA Drugs Clinical Trials Vaccine 130

Drug Discovery World

JUNE 22, 2023

Hosted by DDW and supported by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ will be free to attend on June 28 at 8AM PT | 11AM ET | 4PM BST | 5PM CET. Join this free roundtable to learn about the biggest opportunities for the future of drug discovery and development.

DNA 130

DNA Clinical Trials Drugs Vaccine 130

Drug Discovery World

MAY 16, 2023

The company’s DNA-based platform is being developed to address manufacturing challenges associated with the production of recombinant adeno-associated virus (rAAV) vectors used to produce advanced therapy medicinal products (ATMPs).

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Production Bioinformatics Therapies Virus 130

Drug Discovery World

JUNE 15, 2023

Hosted by DDW and sponsored by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ will be free to attend on June 28 at 8AM PT | 11AM ET | 4PM BST | 5PM CET. Join this free roundtable to learn about the biggest opportunities for the future of drug discovery and development.

DNA 130

DNA Drugs Clinical Trials Vaccine 130

Drug Discovery World

JUNE 8, 2023

Hosted by DDW and sponsored by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ will be free to attend on June 28 at 8AM PT | 11AM ET | 4PM BST | 5PM CET. Join this free roundtable to learn about the biggest opportunities for the future of drug discovery and development.

DNA 130

DNA Drugs Clinical Trials Vaccine 130

Drug Target Review

JANUARY 26, 2024

These ACE2-coated particles could be tested as an anti-viral therapeutic, and as sensors for detecting virus particles. To find a DNA fragment that contained the intact ACE2 gene, complete with its embedded regulatory information, they searched libraries of cloned DNA fragments generated as part of the Human Genome Project.

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Production DNA Virus Protein Expression 114

The Premier Consulting Blog

MARCH 7, 2024

For gene therapy vectors, this testing encompasses production cell lines, master and working cell banks (MCB, WCB), and virus banks. Depending on the gene therapy vector, microbial systems may be employed to produce vector DNA (such as in adeno associated virus (AAV)), in which case there may be bacterial cell banks and plasmid banks.

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Production Therapies DNA Virus 52

Drug Discovery World

JANUARY 17, 2023

The research aims to develop solutions for the limitations associated with adeno-associated virus (AAV), the current primary means of delivery for gene editing. . It also doesn’t do fantastically well in continuing to express the enzymes the editing tool uses as molecular scissors to make cuts in the DNA to be edited.

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Small Molecule Pharmacy RNA Packaging 246

Broad Institute

AUGUST 31, 2023

Their new editors are more efficient and specialized than previous versions, and are able to modify DNA in cultured cells and in animals that have been difficult to edit, including in immune system cells and inside the brain. In the new work, they focused on improving the heart of the prime editing system—the reverse transcriptase.

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DNA Engineering RNA Laboratories 145

SCIENMAG: Medicine & Health

JUNE 16, 2023

As a part of its life cycle, the human immunodeficiency virus-1 (HIV) inserts a copy of its DNA into human immune cells. Some of these newly infected immune cells can then transition into a dormant, latent state for a long period of time, which is referred to as HIV latency. Credit: UNC Division of Infectious […]

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DNA Research Virus 82

SCIENMAG: Medicine & Health

AUGUST 7, 2023

Prolonged exposure to UVR is associated with damage to DNA in skin cells, […] Skin, the largest organ of the human body, is home to a vast array of bacteria, fungi, and viruses – microorganisms that compose the skin microbiota.

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DNA Virus 75

PLOS: DNA Science

JULY 27, 2023

Genomics applies to all species, revealing evolution in action, because we all use the same genetic code – that is, the correspondence between DNA sequences and the amino acid sequences of proteins. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages. emerged in late 2021.

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Disease DNA Virus RNA 68

Codon

AUGUST 28, 2024

Tessa Alexanian and Max Langenkamp build computational DNA screening tools for a living. But today, rapid advances in DNA synthesis have made it possible for would-be bioterrorists to make pathogens, rather than buy them. government must order synthetic DNA from providers who publicly state that they follow the U.S.

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DNA Bioinformatics Virus Government 88

Drug Discovery World

FEBRUARY 8, 2024

In 2023, DDW hosted a webinar, ‘A comprehensive guide to using adeno-associated virus (AAV) vectors in gene therapy’, supported by Azenta Life Sciences. Questions were fielded from the audience, which included: What analysis will be performed to evaluate host or other DNA contamination? Why are those important?

Therapies 148

Therapies Bioinformatics Packaging Molecular Biology 148

Drug Discovery World

AUGUST 14, 2023

When working with adeno-associated virus (AAV) vectors – an engineered technology and the most common platform for gene delivery – the FDA requires specific information on the percentage of empty capsids from the AAV or capsids that might have other sequences in them.

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Marketing DNA Therapies FDA 130

SCIENMAG: Medicine & Health

AUGUST 3, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the […] CAMBRIDGE, MA — A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms.

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Regulations DNA Virus 64

Drug Discovery World

OCTOBER 3, 2023

Earlier this year, DDW hosted a webinar, ‘A comprehensive guide to using adeno-associated virus (AAV) vectors in gene therapy’, supported by Azenta Life Sciences. Questions were fielded from the audience, which included: What analysis will be performed to evaluate host or other DNA contamination? Why are those important?

Therapies 130

Therapies Bioinformatics Packaging Molecular Biology 130

Drug Target Review

DECEMBER 7, 2023

In an infected animal, cGAS senses viral DNA in cytoplasm whilst in an uninfected organism, DNA is confined in the nucleus. Bacteria must take a different approach as they do not have nuclei and if CBASS reacted to the presence of DNA, it would cause autoimmunity or the bacterium to attack itself, Banh said.

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RNA Immune Response DNA Molecular Biology 59

Drug Discovery World

OCTOBER 18, 2023

Sara Donnelly, Director of Research Planning and Business Development at PhoenixBio USA explores why the right pre-clinical model is essential for teams wanting to advance adeno-associated virus vector-based gene therapies. Adeno-associated virus (AAV) vector-based gene therapies hold exceptional promise across a range of disease areas.

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Therapies Clinical Trials FDA Approval Virus 163

Covalent Modifiers

DECEMBER 23, 2023

3c10581 Helicases, classified into six superfamilies, are mechanoenzymes that utilize energy derived from ATP hydrolysis to remodel DNA and RNA substrates. Kapoor Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.3c10581 Therefore, helicases are important targets for chemical probes and therapeutics.

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RNA DNA Virus 77

PLOS: DNA Science

OCTOBER 12, 2023

million DNA bases. The DMD gene therapy delivers a shortened version of the dystrophin gene, just 4,558 DNA bases. First, adeno-associated virus (AAV) delivers the genes, rather than the adenovirus (AV) that had entered cells in Jesse’s liver that weren’t the targets. Two other design strategies add precision.

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Therapies Immune Response DNA Virus 69

Broad Institute

JULY 11, 2024

Targeted drug treatment leads tumor cells to imitate viral infection By Ari Navetta July 11, 2024 Breadcrumb Home Targeted drug treatment leads tumor cells to imitate viral infection Exploiting "viral mimicry," mIDH1 inhibitors trick tumors into thinking they are infected with a virus.

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Treatment Immune Response Virus Drugs 72