Codon

MAY 22, 2023

And experiments at Tune Therapeutics showed that CRISPR epigenome editing — which doesn’t cut DNA at all, but merely silences genes by adding chemical groups to them — can curb “bad cholesterol” by more than 50% in monkeys. These tools do not cut or nick DNA, and so they may be safer than other options.

DNA 52

DNA Engineering Science Trials 52

Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. Our machine would make proteins without using any DNA or cells. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein.

RNA 52

RNA DNA Engineering Laboratories 52

Codon

JULY 21, 2024

Rex Burch and William Russell at Sheringham Town Hall for the Sheringham Workshop, 31 May, 1995. And whereas it used to be costly for breeders to select for traits beyond the needs of their industry, the falling costs of advanced genomic selection techniques—breeding using DNA sequence data—make it increasingly fast and feasible.

Research 124

Research Engineering Disease Science 124

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Agency IQ

JULY 21, 2023

The next chapter in the ctDNA story: Still promising, not ready for prime time A recent workshop summed up the state of play for circulating tumor DNA. As dying cancer cells degrade, their cell contents are released into the patient’s circulation, affording the possibility of detecting fragments of DNA that are unique to the cancer.

FDA 40

FDA Clinical Trials Treatment Trials 40

Agency IQ

FEBRUARY 2, 2024

See AgencyIQs analysis of a workshop on novel methodology qualification.] Although the guideline notes that collecting tumor tissue in progressive disease is important, the authors also address collection of circulating tumor DNA (ctDNA) and circulating tumor cells (CTC) as approaches “that allow easy and repeated sampling.”

Clinical Trials 40

Clinical Trials Trials Treatment Disease 40

Agency IQ

AUGUST 11, 2023

Two workshops co-hosted by the FDA this summer addressed nitrosamines in general, and the NDSRI question in particular. This latter category is “not predicted to be metabolically activated via an α-hydroxylation pathway,” or would not be predicted to react with DNA. ng/day for Category 1 NDSRIs to 1500 ng/day for Category 5 NDSRIs.

FDA 40

FDA Science Production Regulations 40

Codon

AUGUST 28, 2024

Tessa Alexanian and Max Langenkamp build computational DNA screening tools for a living. But today, rapid advances in DNA synthesis have made it possible for would-be bioterrorists to make pathogens, rather than buy them. government must order synthetic DNA from providers who publicly state that they follow the U.S.

DNA 95

DNA Bioinformatics Virus Government 95

Perficient: Drug Development

MARCH 8, 2025

This transformation might involve establishing paid consulting opportunities for community experts, creating accessible design workshops in underserved neighborhoods, or forming equitable partnerships where decision-making authority is genuinely shared.

Compliance 72

Compliance Production Marketing Regulations 72