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Simple test for flu could improve diagnosis and surveillance

Broad Institute

By Allessandra DiCorato June 18, 2024 Credit: Jon Arizti-Sanz SHINE, a rapid diagnostic test developed by Pardis Sabeti's lab in 2020, uses paper strips and CRISPR enzymes to identify specific sequences of viral RNA in samples. Then, in 2022, they began adapting the assay to detect other viruses they knew were always circulating: influenzas.

Virus 144
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Battling antibiotic resistance in the lab and the clinic

Broad Institute

I’d seen more than my share of doctors by the time I graduated high school, but it gave me a lot of respect for them,” he said. “I For his medical residency, he moved to Massachusetts General Hospital, where he was enthralled with seeing patients, especially the ones with perplexing infections.

Hospitals 137
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To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives

Broad Institute

By Leah Eisenstadt, Broad Communications October 23, 2024 Credit: Courtesy of the Broadbent family Brian and Julia Broadbent are raising their daughters Claire, top left, and Emma, seated, who is the first person to be diagnosed with a rare genetic disorder caused by the long noncoding RNA CHASERR.

DNA 128
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Defense-Forward Biosecurity

Codon

Doctors in training are told that when they hear hoofbeats, they should think horses, not zebras; rare diseases are the exception, not the rule. Consider Alice, a 49-year-old woman (and hypothetical patient) who walked into a hospital in Puerto Rico with joint pain, a headache, nausea, and a low fever.

DNA 84
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A close research partnership with African scientists helps solve the mystery of malaria-like illnesses

Broad Institute

Senegal has a very strong clinical infrastructure, including a strong hospital network with incredible resources like West Africa’s Reference Center for Infectious Disease Diagnostics. Tags: Infectious Disease DNA sequencing RNA sequencing Nature Communications. Online January 25, 2024. DOI: 10.1038/s41467-024-44800-7.

Research 111
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F. William Studier receives the 2024 Merkin Prize in ceremony at the Broad Institute for developing technology used to produce millions of doses of COVID-19 vaccines

Broad Institute

William Studier receives the 2024 Merkin Prize in ceremony at the Broad Institute for developing technology used to produce millions of doses of COVID-19 vaccines The groundbreaking, scalable technology is widely used in laboratories around the world today to efficiently produce large amounts of protein and RNA. Merkin (left) and F.

Vaccine 64
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#WhyIScience Q&A: How a computational biologist balances work with life as an elite rower

Broad Institute

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. When your code runs perfectly or you fix a bug, it feels very rewarding.

Science 124