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Not all neoantigens are created equal

Drug Target Review

In most cancers, the tumour evolves by acquiring mutations that confer growth advantages or resistance to therapies. Involving more than 250 investigators based at 19 hospital sites across the UK, the study has analysed genetic signatures in lung tumours, tracking how they have evolved over the past nine years in more than 815 patients.

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Grifols begins clinical trial of a new treatment that would provide immediate immunity against COVID-19

The Pharma Data

The treatment could be administered in primary care centers to people who test positive for COVID-19, avoiding hospitalization due to the progression of the disease and complementing the vaccine in the early phase after vaccination. BARCELONA, Spain , Jan. 18, 2021 /PRNewswire/ — Grifols (MCE: GRF, MCE: GRF.P,

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Damage to Vocal Cords Could Cause Long-Term COVID Symptoms

The Pharma Data

But, in some patients, COVID-19 appears to damage the nerve that regulates speech, causing their vocal cords to impede breathing even when they aren’t talking, said Dr. Jonathan Aviv, an ear, nose and throat specialist at Mount Sinai Hospital in New York City. “Think about when you’re chit-chatting.

Doctors 52
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Women May Transmit Cancer to Infants in Childbirth, Reports Suggest

The Pharma Data

. “In our cases, we think that tumors arose from mother-to-infant vaginal transmission through aspiration of tumor-contaminated vaginal fluids during birth,” said lead researcher Dr. Ayumu Arakawa, a pediatric oncologist with the National Cancer Center Hospital in Tokyo. The findings were reported Jan.

Vaccine 52
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Annaliesa Anderson, Ph.D., Will Lead Pfizer’s Vaccine Research & Development 

The Pharma Data

With more than two decades of biopharmaceutical R&D experience, Dr. Anderson most recently served as Vice President and Chief Scientific Officer for Bacterial Research and Hospital within the Vaccine R&D organization.

Vaccine 40
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Scaling Phage Therapy

Codon

Tom Ireland writes about the companies and technologies that are reimagining phage therapy. Soon after its publication, scientists, journalists, and investors were revisiting ‘phage therapy’ as a promising alternative to our failing antibiotics. Read it on our website here. Illustration by David S. Fast forward to 2023.

Therapies 138
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Bringing Needed Structure to COVID-19 Drug Development

NIH Director's Blog: Drug Development

ACE2 is the receptor that the virus uses to gain entry. This is of particular concern to doctors whose patients are already taking the medications to control hypertension. Solomon (Brigham and Women’s Hospital, Boston) NIH Support: National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute