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Not all neoantigens are created equal

Drug Target Review

These neoantigens are identified by T cells of the immune system as foreign proteins and thus trigger an immune response. Neoantigens are recognised as non-self and trigger an immune response.

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Researchers decipher how a gut bacterium influences immunity

Broad Institute

Researchers decipher how a gut bacterium influences immunity By Corie Lok July 26, 2022 Breadcrumb Home News Researchers decipher how a gut bacterium influences immunity Study finds a molecule made by the bacterium that helps moderate immune responses. Adapted from a press release issued by Harvard Medical School.

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New “dictionary” of immune responses reveals far more complexity in the immune system than previously thought

Broad Institute

Using single-cell RNA sequencing to analyze gene expression in individual cells, the researchers have found how 86 major cytokines affect 17 immune cell types in mice. NH: This is the first single-cell resolution dictionary of each major immune cell type responding to each major cytokine in vivo at an unprecedented scale.

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Study reveals how cancer immunotherapy may cause heart inflammation in some patients

Broad Institute

By Leah Eisenstadt November 6, 2024 Credit: Ricardo Job-Reese, Broad Communications Despite being one of the rarer complications from immune checkpoint inhibitors, myocarditis is the most deadly. This study is a game-changer, paving the way to unearthing the roots of these complications.

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Q&A: How a partnership between physicians and researchers aims to make cancer drugs safer

Broad Institute

We don’t have good therapeutic solutions and we often have to stop the antitumor therapy or give large amounts of steroids that will also shut down the very immune response that’s fighting the cancer. The longer patients wait to inform their doctor, the more complex it can become. How did you go about launching this effort?

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