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Multi-ancestry study reveals genetic risk factors for two common pregnancy complications

Broad Institute

The scores could help doctors identify and treat at-risk individuals earlier in pregnancy with existing but underutilized strategies such as low-dose aspirin. They also developed polygenic risk scores, which distill a person’s likelihood of developing a condition down to a single number based on their genes.

Doctors 133
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New “dictionary” of immune responses reveals far more complexity in the immune system than previously thought

Broad Institute

In the future, when doctors give patients cytokine therapies targeting the immune system, they could potentially look in the Immune Dictionary for expected cell-level immune responses. There are many open questions, and having this foundational reference can significantly improve our understanding of the immune system.

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Not all neoantigens are created equal

Drug Target Review

In most cancers, the tumour evolves by acquiring mutations that confer growth advantages or resistance to therapies. However, if the therapy targets only the subclonal (branch) mutations, this will result in the mere ‘pruning’ of specific branches rather than elimination of the whole cancer.

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With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks

Broad Institute

“We’ve come to realize recently that there is a lot more information that we can get from our retina images than we thought was possible,” says senior author Nazlee Zebardast, director of glaucoma imaging at Mass Eye and Ear and an assistant professor of ophthalmology at Harvard Medical School.

Disease 124
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Zebrafish for Disease Modeling and Drug Screening in Pediatric Cancers

biobide

Children and adolescents lack robust preclinical models to replicate the pathologies and provide precise and targeted therapies. This is why not many Pharma companies specifically specialize in discovering and developing pediatric cancer treatments; a great example of advancing new therapies for childhood cancer is the biotech Oncoheroes.

Disease 59
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Women in Stem with Dr Amber D. Van Laar

Drug Target Review

Through further research and work as a principal investigator on clinical studies for several central nervous system indications, I laid the groundwork for a career in gene therapy drug development. AskBio) I continue to work to bring innovative gene therapies to patients in need. In my current role at Asklepios BioPharmaceutical, Inc.

Therapies 111
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Battling antibiotic resistance in the lab and the clinic

Broad Institute

Patients with possible undiagnosed infections kept him up at night as he ran through their medical histories, occupations, and personal life details in his mind, searching for clues to the identity of the microscopic invaders. I couldn’t fathom what it was going to be like,” he said.

Hospitals 137