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My Attendance at the 2024 Boston Society Cell and Gene Therapy Conference

Alta Sciences

Attendees were encouraged to engage in several talks and presentations throughout the day, and the event organizers had done a fantastic job assembling an outstanding lineup of speakers/key industry leaders to spark extensive discussions. Of all the high-quality presentations I attended, two in particular caught my attention.

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How organoids can redefine pre-clinical research

Drug Target Review

This heterogeneity, present within the same structure or between various organoids, could complicate our understanding of specific mechanisms of action when testing novel drugs in vitro. Prior to joining Beckman Coulter Life Sciences, she worked as a Research Associate and Postdoctoral Fellow at Indiana University School of Medicine.

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Mediating BRAF-mutant melanoma resistance

Drug Target Review

Dr Alani also directs a clinical program at Boston Medical Center focused on patients with melanoma and other high-risk skin cancers and has been recognized as a 2024 Boston Magazine and Castle Connolly Top Doctor. Dr Alani further developed her research interests as a research fellow at Memorial Sloan-Kettering Cancer Center.

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Alzheimer’s disease: driving advancements with precision medicine

Drug Target Review

Progress in molecular biology and translational science. References Juganavar, A., Joshi, A., & Shegekar, T. 2023, September 9). Changes in Alzheimer Disease Blood Biomarkers and Associations With Incident All-Cause Dementia. link] Pugazhenthi, S. 2017, February 4). Metabolic syndrome and the cellular phase of alzheimer’s disease.

Disease 59
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Driving efficiency across upstream bioprocess workflow

Drug Target Review

3 The use of transposon-based systems significantly reduces risks of integrating bacterial elements present on the transposon vector, since integration of the gene is catalysed by the transposase only upon recognition of the inverted terminal repeats (ITRs) flanking the gene of interest and the selection cassette.

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Breaking the Speed Limit on Cell Division

Codon

During my doctoral training, I split my work between wet lab research and programming, two streams that differed radically in terms of productivity. One could speculate that placing these cell-splitting genes near the origin might ensure they are always present at an adequate concentration to split cells and thus speed up cell division.

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Scaling Phage Therapy

Codon

coli in urinary tract infections, Garofolo says they achieved a 6-log reduction in bacterial numbers in patients (meaning the number of bacterial cells present has been reduced a million-fold), leading to “100 percent clinical cure” of all 31 patients. In a trial of their most advanced asset, a phage mixture targeting E.

Therapies 130