Drug Discovery World

NOVEMBER 27, 2023

For instance, the engineering of CHO cells, widely used protein expression system, for various metabolic pathways has resulted in improved expression levels of large molecule drugs and product quality 1,2. After engineering, stable clones are screened, identified, and characterised. Biotechnol Bioeng 2012;118:2326.

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Production Engineering Molecular Biology Drug Development 148

Drug Target Review

MARCH 15, 2024

As discussed above, recent advances in gene editing tools and transposon-based vectors have facilitated targeted and consistent cell line engineering for the development of protein expressing CHO cell lines. Budge JD, Knight TJ, Povey J, et al. Wright C, Alves C, Kshirsagar R, et al. Biotechnol Prog. 2017 Nov;33(6):1468-1475.

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Engineering Molecular Biology Protein Expression Medical Schools 104

Drug Discovery World

NOVEMBER 9, 2023

These include: Samantha Bailey-Bucktrout, PhD, Senior Vice President, Akamis Bio, on: ‘Tumour specific immunogene therapy to deliver protein therapeutics to solid tumour microenvironments’. Jonathan Fisher, PhD, Group Leader, University College London, on: ‘Local secretion of immune active proteins for direct and bystander tumour killing’.

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Engineering Protein Production Therapies Science 130

Drug Discovery World

NOVEMBER 13, 2023

Yuchih Lin, Doctor, Sino Biological Europe, on: ‘Accelerating drug discovery using advanced antibody development platforms’. Lisa Dietel, PhD, Scientist, Pharmaceutical and Processing Department, Novel Formats, F Hoffmann-La Roche, on: ‘Understanding and overcoming surfactant-related stability challenges’.

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Engineering Science Bioinformatics Vaccine 148