The Pharma Data

DECEMBER 2, 2020

She is currently the CEO of Twentyeight-Seven, a biotech company focused on novel RNA biology that she co-founded alongside prominent Harvard investigators. Lisa began her career as Assistant Professor at Washington University School of Medicine, following a post-doctoral cardiovascular fellowship at the University of Chicago.

Pharmaceuticals 52

Pharmaceuticals Synthetic Chemistry RNA Disease 52

Elrig

APRIL 29, 2024

She has played a key role inbuilding the target identification platform and a proprietary database of transcriptome-wide, functional RNA structures. Interactive Q&A session: Pose your questions directly to the experts and get tailored insights to your interests and concerns.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Broad Institute

JUNE 21, 2023

Cell Painting uses six fluorescent dyes to image eight different components of a cell: the nucleus, nucleoli, mitochondria, endoplasmic reticulum (ER), golgi apparatus, cytoplasmic RNA, f-actin cytoskeleton, and plasma membrane.

Small Molecule 52

Small Molecule Cell Based Assays Medical Schools Disease 52

Drug Target Review

AUGUST 29, 2023

I then chose to do my doctoral research at the Perelman School of Medicine at the University of Pennsylvania, which provided me with great scientific training, critical thinking, and communication skills. Author’s note: the mention of women in each instance is meant to include all those that identify as women.

Science 98

Science Disease Molecular Biology Therapies 98

Drug Target Review

SEPTEMBER 28, 2023

I originally wanted to be a doctor but that’s a second-tier track in France. Researchers were able to use our synthetic RNA controls as a reference to verify and validate assays. I grew up in France where students are tracked to certain pathways. I was very good at math, which at the time in France directed me towards STEM studies.

DNA 116

DNA Organic Chemistry Science Virus 116

Elrig

JUNE 18, 2024

Supporting yourself to be compassionate and understanding will help those around you too (and often make you a better researcher too) Question 2 – What measures can be put in place to make therapy more accessible to doctoral and early career researchers?

Science 52

Science Therapies RNA Research 52

The Pharma Data

SEPTEMBER 6, 2021

In CUP, doctors cannot identify the location of the original (primary) tumour and can only find metastases. Fusion and rearrangement (RE) detection using DNA and RNA-based comprehensive genomic profiling (CGP) of sarcomas. Comprehensive genomic profiling. Comprehensive genomic profiling.

Treatment 52

Treatment Therapies DNA Trials 52

Broad Institute

DECEMBER 6, 2023

Using single-cell RNA sequencing to analyze gene expression in individual cells, the researchers have found how 86 major cytokines affect 17 immune cell types in mice. Tags: Cell Circuits Program Immunology RNA sequencing The reference, called the Immune Dictionary , appears today in Nature. Did any results surprise you?

Immune Response 138

Immune Response RNA Disease Medical Schools 138

Codon

JUNE 25, 2024

During my doctoral training, I split my work between wet lab research and programming, two streams that differed radically in terms of productivity. Proteins are colored blue and RNA molecules are colored orange and yellow. RNA and proteins comprise each ribosome, but the cell synthesizes these two biomolecules at different rates.

DNA 90

DNA RNA Laboratories Research 90

Drug Target Review

NOVEMBER 29, 2023

Our primary focus is to design and develop RNA therapies for liver diseases. When combined with our in-house GMP-level RNA chemistry lab, Ochre Bio is able to progress from a new target to generating human data on a lead therapy in days. What does Ochre Bio do, can you give me an overview of your work?

Therapies 102

Therapies Disease RNA Engineering 102

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. What do you like about rowing?

Science 124

Science Medical Schools Disease Hospitals 124

Broad Institute

OCTOBER 4, 2023

Today, scientists use such reactions to produce the customizable DNA and RNA molecules that enable genetic sequencing, drug and vaccine development, pathogen tests, cancer diagnostics, and more. It is because we had the Fellowship that we could buy our very first DNA and RNA synthesizer in the lab.”

DNA 52

DNA RNA Science Protein Expression 52

Broad Institute

FEBRUARY 11, 2025

Mapping mRNA through its life cycle within a cell By Corie Lok February 11, 2025 Breadcrumb Home Mapping mRNA through its life cycle within a cell Xiao Wangs studies of how and where RNA is translated could lead to the development of better RNA therapeutics and vaccines.

RNA 52

RNA DNA Science Vaccine 52

The Pharma Data

AUGUST 16, 2021

The antiviral agent incorporates RNA-like building blocks into the RNA genome of the virus. If this genetic material is further replicated, defective RNA copies are produced and the pathogen can no longer spread. When it enters the cell, it is converted into RNA-like building blocks.

RNA 52

RNA Virus Clinical Trials Drugs 52

Broad Institute

OCTOBER 11, 2023

The method prevents the mouse’s immune system from rejecting the CRISPR machinery while also leaving behind RNA barcodes that can be sequenced to determine which gene had been deactivated in each cell. “I

Research 137

Research Immune Response Clinical Trials Therapies 137

The Pharma Data

MAY 9, 2022

Currently, after surgery, doctors examine a specimen of a tumor under a microscope and grade it one, two or three in its aggressiveness. The new study was conducted by doing DNA methylation profiling and RNA sequencing on 565 meningiomas.

DNA 52

DNA Drugs RNA Clinical Trials 52

Codon

JULY 27, 2023

There’s a TV show where a bunch of doctors are walking through a hospital corridor. Because it turns out that at least half of them , in humans, also bind to RNA molecules. How do transcription factors couple up with the correct RNA molecule? RNA export systems. All the colors had the same brightness. No longer.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

There’s a TV show where a bunch of doctors are walking through a hospital corridor. Because it turns out that at least half of them , in humans, also bind to RNA molecules. How do transcription factors couple up with the correct RNA molecule? RNA export systems. All the colors had the same brightness. No longer.

Therapies 52

Therapies RNA DNA Engineering 52

PLOS: DNA Science

MAY 4, 2023

Extracting information from her dental remains was possible because of the universality of the genetic code – in all organisms (and viruses), the same RNA triplets encode the same amino acids. .” The Red Lady was from a group of hunter-gatherers trapped in a cave. Here’s info from his notebooks.

DNA 52

DNA Production RNA Science 52

Codon

AUGUST 27, 2024

Doctors in training are told that when they hear hoofbeats, they should think horses, not zebras; rare diseases are the exception, not the rule. Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. This is the third essay of four in our pandemic mini-issue.

DNA 106

DNA Laboratories Hospitals Virus 106

The Pharma Data

MAY 13, 2021

WITHOUT doctors, physical therapists or chiropractors. Our Unique Solution Has Been Featured All Over The Media, From Hallmark, The Doctors, Atlanta Live & Arizona Midday…. I Have A Doctorate In Pharmacy, But Everything I Learned About Pain Relief In Pharmacy School Is Dead Wrong! And then got my Doctor of Pharmacy (Pharm.

Pharmacy 52

Pharmacy Doctors Production Therapies 52

Broad Institute

JANUARY 30, 2024

I’d seen more than my share of doctors by the time I graduated high school, but it gave me a lot of respect for them,” he said. “I He frantically learned what he could about the virus and was alarmed by reports from doctors in hard-hit hospitals in Italy who were in tears, overwhelmed by seeing their colleagues becoming desperately ill. “I

Hospitals 137

Hospitals Virus Medical Schools Science 137

Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. Across the tree of life, organisms strictly require exactly one of the two chiral forms of their molecular building blocks — amino acids, nucleotides of RNA and DNA. 4 As far as we know, right-handed proteins never occur naturally.

RNA 103

RNA DNA Vaccine Virus 103

keypoint

JANUARY 8, 2025

Dr. Cheruiyot is a post-doctoral fellow at the Joslin Diabetes Center, Harvard Medical School (HMS) I n the lab of Dr. Jean Schaffer, s he studies molecular mechanisms underlying protein synthesis in pancreatic beta cells, and alterations of such mechanisms in diabetes.

Medical Schools 59

Medical Schools RNA Laboratories Doctors 59

PLOS: DNA Science

OCTOBER 24, 2024

In those early days, politicians and government officials who’d never heard terms like “cytokine storm” and “RNA virus” were suddenly charged with explaining what was happening. But much of it was in the unfamiliar language of virology and immunology, public health and epidemiology.

Science 52

Science Research Vaccine Government 52

Codon

FEBRUARY 19, 2025

ESM is a protein language model that captures certain aspects of protein structure and function, for example, but is blind to DNA or RNA-level features that drive cell behavior. Evo 2 was trained on DNA sequences but can make predictions about myriad aspects of biology, including RNA stability and protein structures.

DNA 103

DNA Laboratories Engineering RNA 103

Elrig

MARCH 10, 2025

The free-to-attend event will bring together scientists, researchers and entrepreneurs from across the drug discovery community working on proteins, RNA, cell and gene therapies, PROTACs, as well as the application of big data to support target identification, biomarkers and the development of big molecules.

Research 52

Research Laboratories Medical Schools Engineering 52

Drug Target Review

APRIL 1, 2025

“Patients often present with symptoms that overlap with more common conditions, and it is a major challenge for primary care doctors to be aware of the 8,000 or so rare diseases that are currently known.” . “One of the biggest challenges for rare disease patients is getting to a diagnosis,” Williams points out.

Disease 52

Disease Therapies Clinical Trials Cell Biology 52

Codon

NOVEMBER 3, 2024

Based on early successes in animal experiments, doctors tested the vaccine on an infant whose mother had died of TB shortly after giving birth. These targeted different bacterial components, including RNA polymerases that control gene expression plus enzymes involved in synthesizing the bacterium’s unique cell wall.

Vaccine 106

Vaccine Trials Therapies Treatment 106

The Pharma Data

NOVEMBER 18, 2020

Both vaccine makers used a synthetic version of coronavirus genetic material called messenger RNA to program a person’s cells to churn out copies of a fragment of the virus, the Times said. Doctors say this reflects India’s younger and leaner population.

FDA Approval 52

FDA Approval FDA Vaccine Virus 52

The Pharma Data

NOVEMBER 17, 2020

Both companies used a synthetic version of coronavirus genetic material called messenger RNA to program a person’s cells to churn out copies of a fragment of the virus, the Times said. Doctors say this reflects India’s younger and leaner population.

Vaccine 52

Vaccine Virus RNA Hospitals 52

PLOS: DNA Science

FEBRUARY 20, 2025

I remember my mother’s joyous comments in my baby book, thanking doctors Salk and Sabin for inventing polio vaccines. An article in The Journal of the American Medical Association confirmed his claim that his 2-year-old was unable to get antitoxin – a treatment that preceded the vaccine – from white doctors in Atlanta.

Vaccine 94

Vaccine Science RNA Disease 94

Broad Institute

NOVEMBER 6, 2024

Doctors currently don’t have effective targeted treatments, so they often have to stop the anti-tumor therapy or give large amounts of steroids, which have their own undesired side effects such as lowering the efficacy of the ICI anti-tumor treatment. Tags: Cancer RNA sequencing Paper Cited Blum S, Zlotoff D, et al.

Immune Response 125

Immune Response Medical Schools Clinical Trials Treatment 125

NIH Director's Blog: Drug Development

JANUARY 5, 2016

This gene-editing system consists of a short segment of RNA that is attached to an enzyme. The RNA is preprogrammed to find a distinct short sequence of DNA and deliver the enzyme, which acts like a scalpel to slice the sequence out of the genome. It’s fast and pretty precise. deaths from unintentional overdoses.

Vaccine 52

Vaccine Science Disease Engineering 52

Codon

JANUARY 26, 2025

RNA polymerase — the enzyme responsible for replicating influenza’s genetic material — lacks proofreading abilities, meaning that mutations aren’t corrected and can rapidly accumulate. But it’s difficult to make accurate predictions so early when viruses mutate every day.

Vaccine 105

Vaccine Immune Response Virus Clinical Trials 105

The Pharma Data

DECEMBER 23, 2020

One person familiar with the list said it included the lipids that encase the RNA material in both the Moderna and Pfizer vaccines, the Times reported. Doctors say this reflects India’s younger and leaner population.

Vaccine 52

Vaccine Government Virus Medical Schools 52

Codon

OCTOBER 27, 2024

But doctors explored numerous uninformed remedies in the interim. ” Doctors physically examined the chests of their sanatorium patients, looking for signs of disease and recovery. Chest X-rays gave doctors additional insight into the inflamed granulomas within the lungs. Left) Robert Koch.

Immune Response 99

Immune Response Doctors Disease Laboratories 99