Drug Discovery World

NOVEMBER 29, 2023

Researchers have created a mathematical model that can accurately depict Alzheimer’s disease progression in individual patients, paving the way for personalised treatment and faster development of therapies. The post Mathematical model can speed up Alzheimer’s drug development appeared first on Drug Discovery World (DDW).

Drug Development 130

Drug Development Pharmaceutical Companies Drugs FDA Approval 130

Drug Discovery World

OCTOBER 31, 2023

Professor Andy Whiting and Dr Tony Lockett discuss how specific levels of a protein could be used to advance drug development in neurodegenerative diseases. They can predict which drugs might clinically benefit patients in personalised medicine, thereby reducing the length and size of trials needed to screen for effective medication.

Drug Development 147

Drug Development Disease Drugs Clinical Trials 147

Drug Discovery World

JULY 25, 2023

Justin Hay , Senior Director, Amy Cheung Senior Director of Integrated Drug Development, and Patrick Loebs Director, at Certara, examine recent changes in paediatric guidelines and how they affect drug development projects. In addition to describing the ethical framework (eg.

Drug Development 130

Drug Development Clinical Pharmacology Pharmacokinetics Drugs 130

Drug Discovery World

OCTOBER 10, 2023

The National Institutes of Health has awarded the first phase of a roughly $40m grant to Yale University to advance a novel CRISPR-based gene-editing delivery platform for the targeted treatment of neurogenetic diseases. The post NIH awards ‘bench-to-bedside’ grant for CRISPR drug development appeared first on Drug Discovery World (DDW).

Drug Development 130

Drug Development Clinical Trials Engineering Drugs 130

DrugBank

AUGUST 15, 2024

Drug development is challenging, including not only the complexities of biomolecular drug mechanisms but also the convolutions of regulatory pathways and commercialization strategies. UCSD, with its world-renowned Center for Microbiome Innovation , provides expertise in microbial genomics and drug discovery platforms.

Drug Development 82

Drug Development Clinical Trials Drugs Therapies 82

Drug Discovery World

SEPTEMBER 1, 2022

These sequence-defined, recombinant antibodies are suitable for developing highly selective and sensitive pharmacokinetic (PK) and anti-drug antibody (ADA) assays for evolocumab and its biosimilars. Evolocumab is a monoclonal antibody used for the treatment of hyperlipidemia, or elevated levels of cholesterol and other lipoproteins.

Drug Development 130

Drug Development Biosimilars Pharmacokinetics Drugs 130

Quanticate

SEPTEMBER 13, 2024

With the implementation of technology rapidly increasing, stricter regulatory standards, and growing demand for innovative treatments, the trends within the industry continue to evolve, impacting the future of clinical trials both positively and negatively.

Clinical Trials 95

Clinical Trials Trials Drug Development Treatment 95

Drug Discovery World

MARCH 2, 2023

Rare disease drugs can be complicated and expensive to produce, with a limited patient pool their development is often slow and their cost price to the UK’s health service high. This has left many living with rare diseases without available or approved treatments and support for their conditions. This needs to change.

Drug Development 130

Drug Development Disease Clinical Trials Drugs 130

Drug Discovery World

OCTOBER 9, 2023

Despite the size of the market and the global impact, there are currently no effective treatments. DS: As new variants begin circulating, what impact could this finding have on our understanding and the potential treatment of long Covid? DS: Why do you think we are no closer to treatments for long Covid?

Drug Development 147

Drug Development Clinical Trials Virus Drugs 147

Drug Discovery World

SEPTEMBER 12, 2024

In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Dr Friso Postma, Vice President of AI Drug Discovery at BioXcel Therapeutics.

FDA Approval 162

FDA Approval Drugs FDA Science 162

Drug Discovery World

MAY 9, 2023

Jantzen Sperry , PhD, Director of Scientific Operations at Certis Oncology looks at how the adoption of orthotopic PDX models can elevate the impact of cancer research and improve translation in oncology drug development. Fewer than 5% of oncology drugs that enter clinical trials in the US receive US FDA approval.

Drug Development 130

Drug Development Clinical Trials Animal Testing Cell Based Assays 130

PPD

SEPTEMBER 25, 2023

As the clinical trial landscape evolves, drug developers are faced with novel challenges and changes in study recruitment, trial size and structure, and more. The adoption of new innovations, strategies and technologies offers opportunities to address persistent challenges and develop suitable approaches for the future.

Drug Development 104

Drug Development Clinical Trials Drugs Trials 104

Drug Discovery World

NOVEMBER 23, 2022

The CoE aims to develop best practices and guidelines to use social media analysis as RWD for patient-focused drug development. While there is a concise regulatory framework on many sources of RWE for drug approval and Health Technology Assessments (HTA), this guidance is lacking for social media. .

Drug Development 130

Drug Development Drugs Government Science 130

Drug Discovery World

DECEMBER 5, 2022

A new partnership between industry and three rare disease foundations has formed with the goal of accelerating the development of precision drugs to treat rare neurodevelopmental disorders. . The post Partnership takes on mission to advance precision drug development appeared first on Drug Discovery World (DDW).

Drug Development 130

Drug Development Clinical Trials Drugs Disease 130

Drug Target Review

AUGUST 7, 2024

The pharmaceutical industry is undergoing a major shift towards the development of breakthrough medicines and advanced therapies. This continued innovation highlights the complexity of the drug development process, particularly as the field is highly regulated by health authorities around the world.

Drug Development 59

Drug Development Clinical Pharmacology Clinical Trials Packaging 59

Drug Discovery World

JANUARY 17, 2023

Genoscience Pharma, a clinical-stage biotech company developing lysosomotropic drug candidates for the treatment of cancer, fibrosis and auto-immune diseases through autophagy modulation has launched the ABE-LIVER study, along with trial sponsor Grenoble University Hospital. . The trial . The primary criteria is PFS.

Clinical Trials 130

Clinical Trials Trials Drug Development Hospitals 130

Alta Sciences

AUGUST 29, 2024

Engaging at the outset with a fully integrated and experienced drug development partner can ensure safety, with timely data sharing at every step of the drug development plan, and facilitate agile, flexible decision-making and planning.

Drug Development 52

Drug Development Small Molecule Clinical Trials Drugs 52

Drug Discovery World

JANUARY 24, 2023

There are currently no cures for either disease, but researchers hope that these results will significantly speed up the search for new treatments. Tracking the progression of FA and DMD is normally done through intensive testing in a clinical setting. Image shows: Luchen Li, wearing the sensor suit, and Professor Aldo Faisal.

Drug Development 130

Drug Development Clinical Trials Trials Disease 130

Drug Discovery World

SEPTEMBER 12, 2024

In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Dr Friso Postma, Vice President of AI Drug Discovery at BioXcel Therapeutics.

FDA Approval 130

FDA Approval Drugs FDA Science 130

Drug Discovery World

DECEMBER 23, 2022

A study by Ellipses Pharma, a global drug development company focused on accelerating the development of new oncology treatments, has presented preliminary data from the first in human Phase I/II trial of EP0042, a dual FLT-3 an Aurora kinase inhibitor, in patients with acute myeloid leukaemia (AML). . The data .

Treatment 130

Treatment Clinical Trials Drug Development Trials 130

Drug Discovery World

AUGUST 16, 2024

The chosen news highlights this week all feature advances in drug development in oncology indications and reflect the breadth of therapeutic approaches to cancer treatment. The post This week in drug discovery (12-16 August) appeared first on Drug Discovery World (DDW). First claudin 18.2 monoclonal antibody.

Licensing 147

Licensing Licensing Drugs Clinical Trials 147

DrugBank

JUNE 6, 2024

In the rapidly evolving landscape of oncology drug development, artificial intelligence (AI) has emerged as a revolutionary force, altering not just the pace but the very methodology of discovery and development.   What sets RADR ® apart is its robust data-driven approach.

Drug Development 75

Drug Development Clinical Trials Drugs Therapies 75

Drug Discovery World

JULY 5, 2024

The Division of Clinical Neuroscience at Oslo University Hospital (OUS) and the Swedish drug development company TikoMed have signed a research collaboration agreement focused on amyotrophic lateral sclerosis (ALS).

Drug Research 204

Drug Research Research Hospitals Drugs 204

Drug Discovery World

DECEMBER 5, 2023

Cancer Research UK (CRUK), Cancer Research Horizons, and precision oncology company Guardant Health have launched a collaboration to advance cancer treatment. The post CRUK and Guardant Health collaborate on precision cancer drugs appeared first on Drug Discovery World (DDW).

Clinical Trials 286

Clinical Trials Drugs Trials Clinical Development 286

Drug Discovery World

JANUARY 30, 2023

The event will cover aspects affecting growth of the CGT market, including how manufacturing technologies are enabling drug development, what these therapies mean for the healthcare market, and the opportunities for developers. As research progresses it is hoped that cell and gene therapies will offer innovation for the future.

Disease 130

Disease Treatment Therapies Drug Development 130

Drug Discovery World

MARCH 16, 2023

2 EP0042’s ongoing clinical-stage study follows earlier drug discovery and development work led by The Institute of Cancer Research, London, which was funded by organisations including The Institute of Cancer Research, Breast Cancer Now and Cancer Research UK. and Leung, A. International Journal of Molecular Science, 21(4): 1537.

Treatment 130

Treatment FDA FDA Approval Drug Development 130

Drug Discovery World

FEBRUARY 9, 2023

The US Food and Drug Administration (FDA) has granted Rare Paediatric Disease (RPD) Designation to SynaptixBio’s drug candidate for TUBB4a leukodystrophy – a genetic and debilitating condition which mainly affects babies and young children. This is a key part of our overall strategy,” he said. “To

Treatment 130

Treatment Disease Clinical Trials FDA 130

Drug Discovery World

NOVEMBER 16, 2023

A new digital article is now available to download entitled ‘ A comprehensive approach to immunophenotyping for targeted drug discovery and development’ With high costs of therapeutic development, success relies on optimising preclinical and early clinical studies.

Drugs 130

Drugs Drug Development Treatment 130

Drug Discovery World

NOVEMBER 16, 2023

Download this content-rich digital article to read about considerations for implementing and standardising high-dimensional immune profiling methods into drug development programs.

Drug Development 130

Drug Development Drugs Treatment 130

Fierce BioTech

APRIL 3, 2024

Mini-Organs, Major Breakthroughs: How Hub Organoids Are Accelerating Oncology Drug Development dwunderlin Wed, 04/03/2024 - 17:28 Tue, 05/14/2024 - 09:30 Resource Type Webinar Dr. Sylvia F. png Listing Introduction Predict patient response to treatment with patient-derived organoids. Click here to login.

Drug Development 52

Drug Development Drugs Therapies Treatment 52

Drug Discovery World

OCTOBER 4, 2022

The US Food and Drug Administration (FDA) has granted approval to AMX0035, a new treatment for people living with amyotrophic lateral sclerosis (ALS). Development of the drug was funded by $2.2 Development of the drug was funded by $2.2 A years-long advocacy campaign .

FDA Approval 130

FDA Approval FDA Treatment Clinical Trials 130

Drug Discovery World

JUNE 28, 2024

This week has seen some exciting advances in neuroscience drug discovery, including Phase II clinical trials for two potentially game-changing treatments, a synapse-regenerating drug for Alzheimer’s and a gene therapy for Parkinson’s, as well as the launch of DDW’s latest In Focus report.

Clinical Trials 130

Clinical Trials Drugs Trials Virus 130

BioPharma Drive: Drug Pricing

MAY 29, 2024

An acquisition of EyeBio will hand Merck a treatment for diabetic macular edema and age-related macular degeneration that’s ready for pivotal testing.

Drug Development 76

Drug Development Treatment Drugs 76

Drug Discovery World

JUNE 24, 2024

Drugs developed to treat HIV and AIDS are being trialled for the first time in patients with multiple brain tumours. The rare inherited genetic condition causes tumours such as schwannoma (which include acoustic neuroma), ependymoma and meningioma which develop on the membrane surrounding the brain.

Clinical Trials 147

Clinical Trials Trials Drugs DNA 147

Drug Discovery World

MARCH 14, 2023

Teitur Trophics, a biotech company developing new treatments for patients suffering from neurodegenerative diseases, has complete a €28M Series A financing. The financing was co-led by Sunstone Life Science Ventures and Sound Bioventures, with participation from new investors, Industrifonden, Innovestor’s Life Science Fund and P53 Invest.

Disease 130

Disease Treatment Science Clinical Development 130

Drug Discovery World

JUNE 5, 2024

The new partnership, which will involve scientists from both organisations working closely together, is part of LifeArc’s MND Translational Challenge, aimed at discovering innovative and potentially disease-modifying treatments for MND, a key component of the new UK MND Research Institute. Drug development is inherently risky and expensive.

Bioinformatics 173

Bioinformatics Research Drugs Clinical Trials 173

Drug Discovery World

JUNE 14, 2024

Flagship Pioneering and ProFound Therapeutics have announced a collaboration to conduct foundational research to identify potential next-generation first-in-class therapies for the treatment of obesity. Charlotte Allerton, Head of Discovery and Early Development, Pfizer, said: “With obesity expected to impact 1.9

Research 147

Research Drugs Therapies Drug Development 147