Broad Institute

OCTOBER 11, 2023

The drugs work by blocking a protein, PD-1 — which helps keep immune responses in check — and stimulating the immune system to attack tumors. The team studied the immune response to CRISPR and designed a new technology that they published in 2021 — a way of removing immune-triggering molecules from CRISPR-edited cells.

Research 137

Research Immune Response Clinical Trials Therapies 137

Codon

NOVEMBER 3, 2024

As an undergraduate biology student, I spent some time in a TB lab working on antibiotic resistance — a growing concern for drug developers. The researchers were left with 40 drug candidates. tuberculosis. A Peace Corps Volunteer administers the BCG vaccine to a six-year-old Korean boy. However, hope prevails.

Vaccine 92

Vaccine Trials Therapies Clinical Trials 92

DrugBank

MAY 15, 2024

Its structure makes it incredibly difficult for drugs to bind effectively, which has stymied drug development for decades. The binding pockets on KRAS are shallow and polar , not ideal for the kinds of interactions needed for strong, effective drug binding.

Small Molecule 81

Small Molecule Molecular Biology Drugs Disease 81

The Pharma Data

DECEMBER 3, 2020

Strong Th1 cell-mediated immune responses were also observed for the vaccine candidates with either adjuvant. We and our collaborators are steadfast in our commitment to the development of safe, effective and accessible COVID-19 vaccines for the global population.”.

Vaccine 52

Vaccine Immune Response Virus RNA 52

Codon

SEPTEMBER 29, 2024

But, regardless of which was first, they all operated with the same core data as their mechanism for understanding life: messenger RNA ( mRNA ). It wasn’t a silver bullet to the hard problem of drug development, but it wasn’t too far off either. There was scFormer in 2022, scGPT in 2023, and plenty of others.

Engineering 137

Engineering Virus DNA Therapies 137

The Pharma Data

OCTOBER 25, 2020

The Phase 1 interim analysis showed that mRNA-1273 was generally well-tolerated across all age groups and induced rapid and strong immune responses against SARS-CoV-2. Moderna is advancing messenger RNA (mRNA) science to create a new class of transformative medicines for patients. 26, 2020 11:00 UTC. CAMBRIDGE, Mass.–(

Vaccine 52

Vaccine Clinical Development RNA Clinical Trials 52

SugarCone Biotech

MAY 28, 2019

Importantly, these papers fit into a new contextual framework and cap a series of studies that have come out over the last year or so that have enriched our understanding of how the immune system and tumor cell populations interact. is focused on the response of sarcomas to immunotherapy ( [link] ). The paper by Cabrita et al.

Immune Response 52

Immune Response Therapies Production Vaccine 52