ASPET

FEBRUARY 26, 2024

Panobinostat also showed inter-strain and inter-species differences in the in vitro plasma stability; and was stable in human plasma. Importantly, the plasma stability in various mouse strains was not reflected in the in vivo systemic pharmacokinetic behavior of panobinostat.

Metabolic Stability 100

Metabolic Stability Pharmacokinetics Pharmacogenetics Treatment 100

Covalent Modifiers

OCTOBER 24, 2023

For example, sulfonyl imidazole EM12-SO2Im covalently blocked the CRBN binding site and possessed excellent metabolic stability in human plasma, liver microsomes, and hepatocytes.

Metabolic Stability 173

Metabolic Stability Drug Development Drugs 173

DrugBank

OCTOBER 17, 2024

Data science has emerged as an innovative tool in the biopharmaceutical industry, leveraging the power of machine learning and artificial intelligence to drive innovation and efficiency across the entire drug development lifecycle. These complex molecules require precise engineering to ensure optimal efficacy and safety.

Drug Development 98

Drug Development Metabolic Stability Clinical Trials Drugs 98

Drug Target Review

JANUARY 16, 2025

Cyclic Peptide Design, Chapter 2: Strategies to Enhance Metabolic Stabilities. Cyclic peptides in pipeline: What future for these great molecules? Pharmaceuticals , 16(7):996, 2023. Khatri B, Nuthakki VR, Chatterjee J. Springer, 2019. Jain AN, Cleves AE, Gao Q, et al. Journal of Computer-Aided Molecular Design , 33:531558, 2019.

Drug Development 52

Drug Development Small Molecule Drugs FDA Approval 52