Drug Discovery World

DECEMBER 12, 2022

The targeted programme aims to identify and accelerate novel oncology innovations into commercially-attractive assets by offering support to academics and early-stage companies. . ODP2 is seeking applications from academics and early-stage companies with a defined oncology-focused innovation.

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H1 Blog

JULY 30, 2024

Increasing diversity in clinical trials not only makes the findings more relevant to various patient groups, but also enhances knowledge about the disease or medical product being studied. We’re curious to see what will happen over the next 12 months and how pharma companies will respond.” billion and taking upwards of 15 years.

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Drug Discovery World

JANUARY 24, 2023

DDW Multimedia Editor Megan Thomas observes the 2023 drug discovery landscape, speaking to industry experts and looking at the foundations of 2022 on which next year will lean. Virtual clinical trials ‘Virtual’ and ‘technology’ are concepts which are readily exchanged in this industry, but these are more than just buzzwords.

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Drug Discovery World

NOVEMBER 11, 2022

BioSenic’s arsenic trioxide (ATO) autoimmune disease platform has completed a successful Phase IIb trial in chronic Graft vs Host Disease (cGVHD) and is preparing to move to a Phase III trial. . Pharma companies team-up to reduce emissions . Phase II success for autoimmune disease platform in GVHD .

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Drug Discovery World

AUGUST 22, 2023

Originator pharma companies are developing ever more complex products, which are transforming the medical landscape, but their cost places an increasing burden on healthcare budgets worldwide. Opportunities Originator pharma companies are developing more and more complex products these days.

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PPD

JULY 13, 2023

Site and patient recruitment vendors are vital in supporting clinical trial operations across all phases and therapeutic areas. Their services help engage a suitable participant pool, facilitate clinical trial participation, ensure that selected sites have the resources to support clinical trial activities and more.

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Reprocell

NOVEMBER 1, 2022

Pharma companies are legally required to test novel drugs in animal models before beginning human trials. And while animal testing has progressed thousands of therapeutics that we use today, it is not without its experimental and ethical downfalls.

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Drug Discovery World

MARCH 29, 2023

For rare disease drugs, a variable RDP period of five, nine, or ten years, depending on the novelty of the drug. Moreover, an extra six months of RDP for drugs with full comparator clinical trials (rather than showing only that a drug is no worse than the standard of care).

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biobide

FEBRUARY 2, 2024

This is why not many Pharma companies specifically specialize in discovering and developing pediatric cancer treatments; a great example of advancing new therapies for childhood cancer is the biotech Oncoheroes. This treatment was developed by performing a chemical screening on zebrafish.

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Drug Discovery World

SEPTEMBER 28, 2022

Its application in pharma, most commonly in drug discovery, has been steadily growing with global partnerships between tech vendors and pharma companies becoming more commonplace. According to Hampleton Patners’ latest Healthtech M&A market report2, digital health companies raised a total of $57.2

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Drug Discovery World

MAY 6, 2024

billion on R&D during 2021, with Germany and Switzerland being the biggest contributors, and around one fourth of clinical trials worldwide were performed in Europe 1. Even before this, however, Amsterdam was established as an important centre for drug development. The CDD will sponsor and manage KWF-supported trials.

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H1 Blog

JULY 5, 2023

The success of drug development and approval relies heavily on the ability to identify diverse patient populations for clinical trials. From trial site feasibility to successful trial recruitment, diversity within a trial population helps ensure the safety and efficacy of drugs that reach the market.

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Drug Discovery World

OCTOBER 16, 2023

From the Beatson Institute for Cancer Research in Glasgow, to Edinburgh Drug Discovery in the University of Edinburgh’s Institute for Genetics and Cancer (IGC). At ELRIG’s Scottish Research and Drug Development Forum meeting, DDW’s Diana Spencer provided a snapshot of drug discovery in Scotland.

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The Pharma Data

OCTOBER 16, 2020

As pharma companies search for solutions to avoid cancelling or delaying clinical trials, virtualizing trials are fast becoming commonplace during the Covid-19 pandemic. With many nationwide and regional lockdowns coming into force, virtual clinical trials are proving to be an effective way to monitor patients remotely.

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Drug Target Review

MARCH 15, 2024

Cultural differences between the UK and mainland Europe were still quite different then but we settled in Southampton and I later went to University in Brighton, studied for a D.Phil, and found a job at a Pharma company. She has held leadership positions in Project Management, Technical Operations, and Business Development.

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Drug Discovery World

JANUARY 21, 2024

Bushell will discuss the history and technological underpinnings of induced proximity, the lessons learned from the PROTAC (proteolysis-targeting chimeric) example, and how technology can create enhancement-targeting chimeric, or ENTAC, drugs and fully realise the potential of targeted protein enhancement. Is pharma’s commercial model dying?

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Vial

MARCH 1, 2024

Growth factors for this market included the growing size of the pharmaceutical industry, the increasing number of clinical trials , substantial funds dedicated to pharma and biotech R&D, and the growing biosimilars and generics market. By geographical region, the global CRO services market in 2023 was dominated by North America.

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Drug Discovery World

JULY 18, 2022

Troy Groetken of intellectual property and technology law firm McAndrews, Held & Malloy tells Lu Rahman how pharma companies can take this data from where it currently stands (drug design and development) to a more clinical level. Groetken sees many opportunities to utilise big data and AI in pharma.

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Drug Discovery World

NOVEMBER 16, 2022

It’s hoped that through this, scientists will be able to better predict how drug molecules perform in the body, leading to expedited drug development and better outcomes for patients. . That means if two pharma companies are trying to grow say a cardiac organoid, they won’t be consistent across the board,” he says. .

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DrugBaron

JANUARY 31, 2024

Billions of dollars have been invested in companies promising to “revolutionise pharma R&D” through the application of artificial intelligence – but it is now clear that global pharma companies, and not just tech bro’s, are buying into the claims. And there is no doubt that there is plenty of room for improvement.

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Drug Discovery World

OCTOBER 4, 2022

million from the National Institute on Aging of the National Institutes of Health, the company plans to begin a Phase Ia clinical trial evaluating its lead tau self- association small molecule inhibitor OLX-07010. . Several of the large pharma companies have recently re-entered the dementia field.

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Drug Discovery World

AUGUST 5, 2022

Ian Hollingsworth, Associate Director of product development at Boyds, the global drug development consultancy, explains the benefits to the drug development lifecycle of building strong partnerships with external consultants, and when and how to get the best from them. Why sponsors use external consultants.

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Drug Discovery World

OCTOBER 25, 2023

MT: How does AI and ML accelerate the drug discovery process? JV: A key bottleneck in the research and development of a drug is the lengthy experimentation that is required to gain the confidence to run clinical trials. MT: Has the company enabled any recent breakthroughs with its technology?

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Drug Discovery World

DECEMBER 14, 2023

As well as the Cancer Research UK Scotland Institute, Cancer Research UK awards grants to research groups at universities and funds Experimental Cancer Medicine Centres (ECMCs) in Glasgow and Edinburgh, which deliver clinical trials of new experimental treatments.

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The Pharma Data

OCTOBER 20, 2020

In hopes to advance the best and brightest, MD Anderson, in partnership with The Focus Fund GP, has launched the Cancer Focus Fund to propel compelling investigational cancer therapies from preclinical development through Phase II clinical trials. The fund is already starting off with more than $50 million in initial capital. .

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Predictive Oncology

FEBRUARY 7, 2023

“We’re providing that richness of tumor diversity and the population diversity that normally the companies will not be able to see until they are in a clinical trial and [the drug is] challenged against a multitude of different patients.”

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Drug Discovery World

FEBRUARY 10, 2023

For life sciences companies across Sweden and the Nordics in general, generating funding equal to international partners in places like the US has proven difficult. He is now a founding partner of EIR Ventures, a venture capital firm investing in innovative companies across the Nordics. A good part of half of those are within pharma.

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Drug Discovery World

AUGUST 7, 2024

Pharma R&D has been heading in the wrong direction, becoming progressively less efficient over the last few decades. Large pharma companies now spend more than $6 billion 4 on R&D per approved drug, compared to just $40 million 5 (in today’s dollars) in the 1950s, with approximately 85% of that spending coming after discovery.

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Drug Discovery World

JANUARY 26, 2023

As such, 2022 saw a marked fall in ROI for global pharmaceutical companies and their research and development activities. According to research from Deloitte 1 , the average ROI in R&D for global pharma companies fell to just 1.2% in 2022, a steep decline compared to the record 6.8% the industry experienced in 2021.

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Drug Discovery World

APRIL 19, 2023

Breaking the barrier Earlier this year, two drugs demonstrated slowed disease progression in large-scale clinical trials for ALS and Alzheimer’s. The drug met primary and secondary endpoints perfectly and has a manageable safety profile.” In an interview in Tokyo, Naito claimed: “The data is indisputable.

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Drug Discovery World

JANUARY 24, 2024

Fibrocor is on track to complete all IND-enabling work to support IND filing and initiation of clinical trials in 2024. Phase I of the clinical program will dose healthy volunteers with single ascending doses of FIB992 before proceeding to a multiple ascending dose study where the drug is administered for a two-week period.

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DrugBank

JUNE 27, 2024

  The benefits of drug repurposing are clear: development times and costs are significantly reduced due to existing knowledge about the drug's properties. These include matching molecular signatures, virtual screening, and analyzing large datasets from health records and clinical trials.

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Drug Discovery World

MAY 7, 2024

It’s doing this by collaborating with companies and providing access to expertise and facilities across 11 specialist research platforms that include things like organoid development, human challenge models, diagnostics, randomised controlled trials, hits to leads and more. They don’t see it.

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Metabolite Tales Blog

DECEMBER 19, 2023

Metabolite Bioanalysis in Drug Development: Recommendations from the IQ Consortium Metabolite Bioanalysis Working Group A Metabolite Bioanalysis Working Group comprised of experts from 14 different pharma companies have proposed recommendations around best practice in metabolite bioanalysis during drug development.

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Drug Discovery World

OCTOBER 7, 2022

Response-mode funding for drug discovery is being administered from the therapeutic division of the organisation for the first time, allowing for strategic build of a fully aligned portfolio stemming from the earliest stages of translational activity. . RA: How can the integration of industry and academia help streamline drug development?

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Drug Discovery World

AUGUST 16, 2022

These observations may come to light in the clinic, but these disparities can be attributed to every phase of the drug development pipeline – clinical trials, translational research and, ultimately, drug discovery. . This imparts significant variability from one trial to another, further widening the disparity.

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DrugBaron

OCTOBER 17, 2022

Buoyed by the string of successes in early discovery delivered by this approach, attention inevitably turned to how we might leverage the same insights to improve return on capital in the rest of the long path through drug development. Examples, such as post-hoc analyses of failed trials, are today too numerous to even be notorious.

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