Drug Development, Pharmaceuticals and Screening Hits

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Drug Development

Pharmaceuticals

Screening Hits

Target-directed cancer: protein-ligand interactions

Drug Target Review

NOVEMBER 1, 2023

We can look at the detailed binding modes of our compounds bound to their protein targets in X-ray crystallography, and for drug targets or complexes that are difficult to crystallise we can use cryo-electron microscopy (cryoEM) as well. In 2019 he became Reader in Structural Biology and Cancer Drug Discovery.

Fragment Screening

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays

A PAINful itch

Molecular Design

OCTOBER 14, 2018

The distinction between Type 1 and and Type 2 behaviors is an important and useful one to make from the perspective of drug discovery scientists who are making decisions as to which screening hits to take forward. For example, it has been claimed that "Most PAINS function as reactive chemicals rather than discriminating drugs."

Screening Hits

Screening Hits FDA Approval Drugs FDA

Drug Discovery Digest

Target-directed cancer: protein-ligand interactions

A PAINful itch

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