Drug Discovery World

JUNE 24, 2024

Drugs developed to treat HIV and AIDS are being trialled for the first time in patients with multiple brain tumours. The rare inherited genetic condition causes tumours such as schwannoma (which include acoustic neuroma), ependymoma and meningioma which develop on the membrane surrounding the brain.

Clinical Trials 147

Clinical Trials Trials Drugs DNA 147

Drug Discovery World

OCTOBER 6, 2022

A new Alzheimer’s disease (AD) treatment has been shown to reduce clinical decline in mild cognitive impairment (MCI) due to AD and mild AD with confirmed presence of amyloid pathology in the brain. . protofibril antibody lecanemab met the primary endpoint and all key secondary endpoints in the global Phase III Clarity AD clinical trial. .

Trials 130

Trials Treatment Clinical Trials Disease 130

Drug Discovery World

APRIL 20, 2023

Dr Paula Moran, Dr Kiri Granger, Dr J Mark Treherne , and Dr Jenny Barnett explore the effects of long Covid-19 symptoms and what the opportunities are for drug developers working to treat post-Covid-19 cognitive impairment. These may provide an opportunity for treatment for post-Covid-19 cognitive impairment.

Drug Development 246

Drug Development Clinical Trials Drugs Virus 246

Drug Discovery World

NOVEMBER 29, 2023

Researchers have created a mathematical model that can accurately depict Alzheimer’s disease progression in individual patients, paving the way for personalised treatment and faster development of therapies. These findings closely matched the results of the corresponding real-life clinical trials.

Drug Development 130

Drug Development Pharmaceutical Companies Drugs FDA Approval 130

Drug Discovery World

OCTOBER 10, 2023

The National Institutes of Health has awarded the first phase of a roughly $40m grant to Yale University to advance a novel CRISPR-based gene-editing delivery platform for the targeted treatment of neurogenetic diseases. The post NIH awards ‘bench-to-bedside’ grant for CRISPR drug development appeared first on Drug Discovery World (DDW).

Drug Development 130

Drug Development Clinical Trials Engineering Drugs 130

Drug Discovery World

OCTOBER 31, 2023

Professor Andy Whiting and Dr Tony Lockett discuss how specific levels of a protein could be used to advance drug development in neurodegenerative diseases. They can predict which drugs might clinically benefit patients in personalised medicine, thereby reducing the length and size of trials needed to screen for effective medication.

Drug Development 147

Drug Development Disease Drugs Clinical Trials 147

Drug Discovery World

JUNE 8, 2023

Grown in vitro, these cells can provide patient specific human brain models from a large cohort of AD patients – to create a ‘clinical trial in a dish’. The recent US Federal Food and Drug Administration Agency (FDA) Modernization Act 2.0

Clinical Trials 243

Clinical Trials Trials Cell Based Assays Disease 243

Drug Discovery World

NOVEMBER 8, 2023

Deepika Khedekar , Associate Centralized Clinical Lead at IQVIA, explains how artificial intelligence could make clinical trials more accurate, accessible and standardised. Tapping into the capabilities of AI One reason AI may accelerate clinical trials is its ability to rapidly process and analyse vast amounts of data.

Clinical Trials 182

Clinical Trials Trials Disease Medical Schools 182

Drug Discovery World

OCTOBER 9, 2023

Despite the size of the market and the global impact, there are currently no effective treatments. The reported MOD framework advances the mechanistic rationale of the clinical benefits on fatigue observed in our clinical trial with AXA1125 in the context of the combination’s mechanism of action. Can you explain how it works?

Drug Development 147

Drug Development Clinical Trials Virus Drugs 147

Drug Discovery World

MARCH 2, 2023

This has left many living with rare diseases without available or approved treatments and support for their conditions. ” The role of AI in rare disease clinical trials might hold the key to helping the UK achieve this vision. Changing the business model behind drug development is the first step.

Drug Development 130

Drug Development Disease Clinical Trials Drugs 130

Drug Discovery World

MAY 8, 2024

Fiona Maini , Senior Director Global Compliance & Strategy, at Medidata looks at the rise of artificial intelligence (AI) and machine learning (ML) within life sciences and the applications for the technology in clinical trials.

Clinical Trials 162

Clinical Trials Trials Regulations Compliance 162

DrugBank

AUGUST 15, 2024

Drug development is challenging, including not only the complexities of biomolecular drug mechanisms but also the convolutions of regulatory pathways and commercialization strategies. This includes funding large-scale clinical trials and establishing robust manufacturing/distribution networks.

Drug Development 82

Drug Development Clinical Trials Drugs Therapies 82

Drug Discovery World

DECEMBER 23, 2022

A study by Ellipses Pharma, a global drug development company focused on accelerating the development of new oncology treatments, has presented preliminary data from the first in human Phase I/II trial of EP0042, a dual FLT-3 an Aurora kinase inhibitor, in patients with acute myeloid leukaemia (AML). . The data

Treatment 130

Treatment Clinical Trials Drug Development Trials 130

Drug Discovery World

JULY 25, 2023

Justin Hay , Senior Director, Amy Cheung Senior Director of Integrated Drug Development, and Patrick Loebs Director, at Certara, examine recent changes in paediatric guidelines and how they affect drug development projects. The guidance mentions PBPK four times regarding renal function and DDIs.

Drug Development 130

Drug Development Clinical Pharmacology Pharmacokinetics Drugs 130

PPD

SEPTEMBER 25, 2023

As the clinical trial landscape evolves, drug developers are faced with novel challenges and changes in study recruitment, trial size and structure, and more. The adoption of new innovations, strategies and technologies offers opportunities to address persistent challenges and develop suitable approaches for the future.

Drug Development 104

Drug Development Clinical Trials Drugs Trials 104

Drug Discovery World

JANUARY 24, 2023

By combining human movement data gathered from wearable tech with a powerful new medical AI technology, the team were able to significantly increase the efficiency of clinical trials in two very different rare disorders, Duchenne muscular dystrophy (DMD) and Friedreich’s ataxia (FA).

Drug Development 130

Drug Development Clinical Trials Trials Disease 130

Drug Discovery World

MAY 9, 2023

Jantzen Sperry , PhD, Director of Scientific Operations at Certis Oncology looks at how the adoption of orthotopic PDX models can elevate the impact of cancer research and improve translation in oncology drug development. Fewer than 5% of oncology drugs that enter clinical trials in the US receive US FDA approval.

Drug Development 130

Drug Development Clinical Trials Animal Testing Cell Based Assays 130

Drug Discovery World

AUGUST 14, 2023

Research partners in the UK are progressing their orally available small molecule cancer immunotherapy drug into clinical development as a treatment for advanced solid tumours. Chief Investigator Dr Bristi Basu, University of Cambridge, and Co-Chief Investigator Dr Debashis Sarker, King’s College London, are leading the trial.

Trials 130

Trials Small Molecule Pharmacokinetics Clinical Trials 130

Drug Discovery World

DECEMBER 5, 2022

A recent study revealed that traditional research sources are missing evidence for up to 70% of clinically encountered variants, information that is essential to developing treatments for genetic disorders. This lack of comprehensive data increases the risk of program failure in clinical trials. .

Drug Development 130

Drug Development Clinical Trials Drugs Disease 130

Conversations in Drug Development Trends

MAY 10, 2024

By: Christine Moore, PhD, Vice President, Neuroscience, Scientific Solutions Patients with borderline personality disorder (BPD) face a heightened risk of substance abuse and suicide, as well as substantial delays in receiving treatment.

Clinical Trials 95

Clinical Trials Trials Treatment Drug Development 95

Drug Discovery World

AUGUST 9, 2023

The UK Medicines and Healthcare products Regulatory Agency (MHRA) has granted Aleta Biotherapeutics a clinical trial authorisation (CTA) to evaluate biologic ALETA-001 in a Phase I/II clinical trial in patients with B-cell malignancies who are relapsed/refractory to CD19 CAR T cell therapy.

Clinical Trials 130

Clinical Trials Trials Therapies Licensing 130

Drug Target Review

AUGUST 7, 2024

The pharmaceutical industry is undergoing a major shift towards the development of breakthrough medicines and advanced therapies. This continued innovation highlights the complexity of the drug development process, particularly as the field is highly regulated by health authorities around the world.

Drug Development 59

Drug Development Clinical Pharmacology Clinical Trials Packaging 59

Alta Sciences

AUGUST 29, 2024

Engaging at the outset with a fully integrated and experienced drug development partner can ensure safety, with timely data sharing at every step of the drug development plan, and facilitate agile, flexible decision-making and planning. billion USD in 2023 to $166.53 billion USD by 2028.

Drug Development 52

Drug Development Small Molecule Clinical Trials Drugs 52

Drug Discovery World

APRIL 14, 2023

By Lucy Radley , Senior Vice President, Head of European Regulatory Development at ProPharma Group. Clinical trials are, undoubtedly, an essential part of the drug development process, providing us with valuable information about the safety and efficacy of new treatments and therapies.

Clinical Trials 130

Clinical Trials Trials Pharmaceuticals Vaccine 130

Drug Discovery World

MARCH 16, 2023

Overcoming Resistance to FLT3 Inhibitors in the Treatment of FLT3-Mutated AML. Therapeutic targeting of FLT3 and associated drug resistance in acute myeloid leukemia. Around one third of patients with AML are diagnosed with FLT3-mutations, which are associated with a higher risk of relapse and poor clinical outcome. and Leung, A.

Treatment 130

Treatment FDA FDA Approval Drug Development 130

DrugBank

JUNE 6, 2024

In the rapidly evolving landscape of oncology drug development, artificial intelligence (AI) has emerged as a revolutionary force, altering not just the pace but the very methodology of discovery and development.   What sets RADR ® apart is its robust data-driven approach.

Drug Development 75

Drug Development Clinical Trials Drugs Therapies 75

Drug Discovery World

DECEMBER 5, 2023

Cancer Research UK (CRUK), Cancer Research Horizons, and precision oncology company Guardant Health have launched a collaboration to advance cancer treatment. This includes the DETERMINE trial – the first UK national precision medicine trial in rare cancers, and other CRUK and Cancer Research Horizons research collaborations.

Clinical Trials 286

Clinical Trials Drugs Trials Clinical Development 286

Drug Discovery World

OCTOBER 4, 2022

The US Food and Drug Administration (FDA) has granted approval to AMX0035, a new treatment for people living with amyotrophic lateral sclerosis (ALS). Development of the drug was funded by $2.2 We still have a lot of work to do to cure ALS, but this new treatment is a significant step in that fight.” .

FDA Approval 130

FDA Approval FDA Treatment Clinical Trials 130

Drug Discovery World

FEBRUARY 9, 2023

Launched in 2020, the Oxford-based business hopes the designation will “open regulatory discussions, supplement funding, increase the viability of drug development and enable quick access to market a treatment.” SynaptixBio CEO and co-founder Dr Dan Williams said the designation was a “monumental step forward” in its bid to treat the disease.

Treatment 130

Treatment Disease Clinical Trials FDA 130

Drug Discovery World

JULY 1, 2024

The same spatial mapping will also enable Nucleai’s applications to serve as companion diagnostics that match patients to the most effective treatment. “Today’s advanced therapies require advanced diagnostics,” said David West, Proscia’s CEO.

Clinical Trials 162

Clinical Trials Laboratories Trials Treatment 162

Alta Sciences

SEPTEMBER 13, 2023

Four Pain Models Altasciences Uses to Assess Treatments During Clinical Trials pmjackson Wed, 09/13/2023 - 17:01 September is pain awareness month, and the importance of pain management and continued research into effective analgesics is integral to helping patients suffering from various pain conditions.

Clinical Trials 52

Clinical Trials Treatment Trials Drug Development 52

Drug Discovery World

AUGUST 16, 2024

The chosen news highlights this week all feature advances in drug development in oncology indications and reflect the breadth of therapeutic approaches to cancer treatment. News round-up for 12-16 August by DDW Senior Digital Content Editor Diana Spencer. First claudin 18.2 monoclonal antibody.

Licensing 147

Licensing Licensing Drugs Clinical Trials 147

PPD

JUNE 27, 2024

Our expertise in alopecia areata studies As of July 2023, there were more than 60 planned or ongoing clinical trials for alopecia areata, involving nearly 20 pharmaceutical or biotech organizations. CorEvitas will be deploying AA focus groups among physicians and patients to provide insights for pragmatic clinical trial designs.

Treatment 52

Treatment Clinical Trials Small Molecule Clinical Research 52

Conversations in Drug Development Trends

JANUARY 24, 2024

Written By: Derek Ansel, MS, CCRA, Executive Director, Therapeutic Strategy Lead, Rare Disease Given that 80% of rare diseases have a genetic etiology, genetic implications should be addressed at the onset of a clinical program to support trial enrollment. One diagnostic example that I discussed in my presentation is autism.

Trials 75

Trials Disease Clinical Trials Clinical Research 75

Drug Discovery World

FEBRUARY 2, 2024

Head of clinical trials at the University College London (UCL) Dementia Research Centre, Dr Cath Mummery, has been announced as the Director of a new network of dementia trial sites across the country. million of new funding to improve access to clinical trials and help accelerate the development of new treatments.

Research 250

Research Clinical Trials Trials Science 250

Conversations in Drug Development Trends

MARCH 20, 2024

In the increasingly advancing world of medicine, personalized care is a key factor that can progress your drug development efforts. One way to ensure customized disease management is to utilize pharmacogenomics (PGx) in your clinical trial. Reduces Trial Failures Oftentimes, clinical trials may fail due to a lack of efficacy.

Clinical Trials 52

Clinical Trials Trials Compliance Treatment 52

Conversations in Drug Development Trends

AUGUST 9, 2024

Authors: Matt Cooper, PhD, Executive Director, Therapeutic Strategy Lead, Oncology; Megan Morrison, Vice President, Asia Pacific Strategy Lead Adaptive trial designs have become essential in oncology, offering a flexible and efficient approach for conducting clinical trials.

Trials 80

Trials Clinical Trials Regulations FDA 80