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An Evolving Regulatory Environment for Rare and Orphan Diseases

Advarra

The Orphan Drug Act of 1983 was instrumental in changing the number of orphan drugs approved in the U.S. The law established the Office of Orphan Products Development , providing financial incentives for pharmaceutical companies to develop orphan drugs and making it more viable to invest in orphan drug research and development.

Disease 52
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Deliberate Dysentery

Codon

People are hesitant to do this because it's not a particularly flashy disease to research, nor is this population the focus of major pharmaceutical companies. So if you're a researcher, you can pour your heart and soul into a hepatitis C vaccine, and it probably won't ever get tested. So you have to do a field study.

Vaccine 108