Drug Discovery World

AUGUST 28, 2023

DS: Samsara’s autophagy inducing candidate SAM001 will be the first agent of its class to enter clinical trials. And we’ve shown that, at least in animal models of these diseases, our drug molecules work really well. DS: Your research has so far focused on Parkinson’s disease and Amyotrophic Lateral Sclerosis (ALS).

Disease 130

Disease Science Clinical Trials Therapies 130

Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. Consequently, an increasing number of academic researchers and companies are entering this field. Molecular Therapy 20 , 1831-1832 (2012). Russell S, et al. The Lancet 390 , 849-860 (2017).

Engineering 105

Engineering Virus Therapies Immune Response 105

Advarra

AUGUST 16, 2022

Orphan drugs have historically faced a number of barriers, such as limited research and development (R&D) investment due to an expected lack of profitability as well as challenges in clinical trial design and recruitment. Before 1983, only 38 orphan drugs had received U.S. Food and Drug Administration (FDA) approval.

Disease 52

Disease Clinical Trials FDA Approval FDA 52

Drug Discovery World

MARCH 13, 2023

The cell and gene therapy (CGT) landscape has grown significantly in the past year. Between the 24 therapies already approved by the FDA 1 and a marked increase in clinical trials, widespread accessibility to precision medicine feels within reach.

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Therapies Drug Development Clinical Trials Cell Based Assays 130

Codon

JANUARY 21, 2024

Human challenge trials were an indispensable part of the development of the malaria vaccine, R21/Matrix-M, endorsed by the World Health Organization last October. But for all of their benefits, human challenge trials have their drawbacks. Jake himself has participated in both Zika and Shigella challenge trials.

Vaccine 117

Vaccine Trials Disease Virus 117

NIH Director's Blog: Drug Development

FEBRUARY 16, 2021

This improvement stems from several factors, including the FDA’s emergency use authorization (EUA) of a number of therapies found to be safe and effective for COVID-19. ACTIV was founded last April to accelerate drug research that typically requires more than a decade of clinical ups and downs to develop a safe, effective therapy.

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Clinical Trials Hospitals Vaccine Trials 52

Drug Discovery World

NOVEMBER 16, 2022

There’s data that show if you use organoids [in a clinical trial] the drug that works nine out of 10 times on the organoids will work nine out of 10 times on the patients and vice versa.” . The benefits to drug development are obvious then. Current research .

Pharma Companies 243

Pharma Companies Science Research Drugs 243

Drug Discovery World

JULY 22, 2022

But while psychedelic drug research has witnessed a relative roller-coaster ride of effort since the mid-20th century, more recent interest in the use of psychedelics for treating mental health and psychiatric disorders has spurred a raft of clinical trials 1.

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Computational Chemistry Drugs Clinical Trials Packaging 246

Drug Discovery World

FEBRUARY 6, 2023

Johannes Goll, Global Head of Emmes’ Biomedical Data Science and Bioinformatics department, explains how big data analytics can deliver improved therapies and bring clinical research one step close to realising the potential of personalised care. It also helps to quickly address unplanned changes.

Bioinformatics 130

Bioinformatics RNA Vaccine Clinical Trials 130

The Pharma Data

JANUARY 26, 2021

percent) in patients taking therapy and 36 events (7.0 Bamlanivimab and etesevimab together also demonstrated statistically significant improvements on all key secondary endpoints, providing strong evidence that the therapy reduced viral load and accelerated symptom resolution. INDIANAPOLIS, Jan.

Hospitals 52

Hospitals Treatment Long-Term Care Facilities Trials 52

Drug Discovery World

AUGUST 8, 2023

India will make its mark as a growing market, potential competitor or partner in manufacturing and R&D, and as a location for clinical trials.” Outside of academia, there are institutions such as the CSIR- Central Drug Research Institute (CDRI), a multidisciplinary research laboratory in Lucknow 11.

Research 130

Research Pharmacy Pharmaceuticals Government 130

The Pharma Data

APRIL 24, 2021

In 1999, Novartis launched the first fixed-dose Artemisinin-based Combination Therapy (ACT) and in 2009, the first dispersible pediatric ACT developed in partnership with Medicines for Malaria Venture (MMV). R&D partnerships to combat drug-resistant malaria in Africa. Follow us on social media at #MalariaFuture. 50-51) (PDF 6.3

Clinical Trials 52

Clinical Trials Treatment Trials Disease 52

Agency IQ

JUNE 9, 2023

The problems: Although the current regulation stimulated orphan drug research, it didn’t do enough The regulation fostered development of medicines for rare diseases since implementation, but not enough. Additionally, the smaller potential customer base may provide an insufficient return on the investment into research.

Marketing 40

Marketing Biosimilars Regulations Drugs 40

Drug Discovery World

JULY 3, 2024

The AI revolution Artificial intelligence (AI) is becoming an integral tool in drug discovery, and Swiss researchers have been some of the first to capitalise on and progress this new resource. Swiss companies are also applying AI beyond preclinical drug discovery, to clinical trials and upskilling staff.

Drugs 130

Drugs Clinical Trials Science Therapies 130

Codon

JUNE 2, 2024

Without mouse models, we may never have developed polio and meningitis vaccines, organ transplants, GLP-1 drugs, gene therapies , or any other number of transformative treatments. Today, somewhere on the order of 30 million rodents are used yearly in biomedical research in the U.S.

Laboratories 120

Laboratories Research Disease Science 120