Drug Discovery World

NOVEMBER 29, 2023

Researchers have created a mathematical model that can accurately depict Alzheimer’s disease progression in individual patients, paving the way for personalised treatment and faster development of therapies. These findings closely matched the results of the corresponding real-life clinical trials.

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Drug Discovery World

NOVEMBER 3, 2023

News round-up for 30 October – 3 November by DDW Editor Reece Armstrong My news highlights this week feature a variety of exciting clinical trial results and launches that are examining therapies for much-needed disease areas, new drug approvals and even a space mission with a pharma twist.

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Drug Discovery World

JUNE 9, 2023

Novel glycan-coated nanoparticle enters trials for geographic atrophy Aviceda Therapeutics has dosed the first patient in its Phase II SIGLEC trial investigating AVD-104 as a treatment for geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

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Drug Discovery World

MAY 21, 2024

This remarkable progress in antibody modalities for disease treatment is a testament to the effectiveness of these methods, and they remain key for many use cases. These targets, along with many others, are universally deemed as ‘difficult-to-drug’ targets.

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Drug Discovery World

FEBRUARY 10, 2023

Clinical drug trials have made the headlines this week, as it was revealed that breast cancer still tops the bill for number of clinical studies and the shortcomings in current methods to ensure representation of patient populations in trials were exposed.

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Drug Discovery World

MAY 3, 2023

Official comments “Measuring endothelial dysfunction with the EndoPAT technology in drug trials is a cost-effective and robust method for early documentation of proof-of-concept in pulmonary, renal and vascular diseases” says Elin Rosendahl, VP Clinical Operations, Vicore Pharma.

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The Pharma Data

DECEMBER 8, 2020

The FDA has issued a clinical hold on Bellicum Pharmaceuticals for its ongoing phase 1/2 trial evaluating CAR-T therapy BPX-601 in patients who received prior treatment for metastatic pancreatic or prostate cancer, following the death of a trial participant. The Houston, Tex.,

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Drug Discovery World

OCTOBER 2, 2023

Independent central reads: AI-assisted image assessment Image assessment is critically important as it provides data for evaluating the safety and efficacy of new treatments. This can lead to generation of more objective endpoints that might lead to a better assessment of treatment efficacy. Frontiers in Oncology.

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Drug Discovery World

FEBRUARY 20, 2023

Capivasertib could offer a completely new treatment option for these patients. This is great news for men, and we hope that this temporary approval leads to the treatment being rolled out permanently across the UK.” 4. The data showed a complete response in all 14 patients who received dostarlimab as a first-line treatment.

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Drug Discovery World

NOVEMBER 3, 2023

The efficacy demonstrated at that dosage showed an unprecedented reduction in depressive symptoms compared to currently available treatments,” said Doug Drysdale, Chief Executive Officer of Cybin. The post Psychedelic depression drug trial shows rapid and robust response appeared first on Drug Discovery World (DDW).

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Advarra

JUNE 27, 2023

Most modern medicines were developed from clinical trials , and clinical trials remain essential for drug development. Without clinical studies, our global understanding of medicine would likely stagnate, and novel treatments would cease to emerge.

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Drug Discovery World

JULY 20, 2023

What are benefits of drug repurposing and why do clinical drug trials so often fail? Diana Spencer summarises the key messages from the ‘Drug Repurposing: Challenges and Opportunities’ Symposium held at the 19th World Congress of Basic & Clinical Pharmacology (WCP) 2023.

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Codon

JANUARY 21, 2024

yellow fever, malaria, and dengue), evaluating new drugs or treatments, and studying pathogenesis, the process by which a disease develops. Scientists studied black men infected with syphilis for several decades while withholding known treatments. Now, we have upwards of 98 or 99 percent cure rates in some cases.

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The Open Targets Blog

OCTOBER 31, 2023

[ Deanne Taylor , lead Principal Investigator of MTP] In the US, formal clinical trials are required to establish the safety and utility of those treatments in pediatric cancers. Despite the evidence that pediatric cancers could benefit from the same drugs used to treat adult cancers, drug trials are much rarer in children than adults. To

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Advarra

AUGUST 16, 2022

That is part of the responsibility of the Center for Biologics Evaluation and Research (CBER) and the Center for Drug Evaluation and Research (CDER). Department for Health and Human Services (DHHS), prepared guidance on expedited programs for sponsors of orphan drug trials. These centers, in conjunction with the FDA and U.S.

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Conversations in Drug Development Trends

NOVEMBER 3, 2022

So while Ansel said he’s seen many sponsors of orphan drugs successfully diversify U.S. Expanding abroad could help sponsors recruit more ethnicities within certain populations while also increasing treatment access to more people. Looking to diversify the reach of your orphan drug trial? enrollment by diversifying U.S.

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Drug Discovery World

MARCH 7, 2023

She has managed multinational projects for charities and not-for-profits to find new treatments for Malaria and led Innovate UK grants through to successful completion. She founded Neuroute in 2019, with the aim of empowering patients from diverse backgrounds to participate in drug trials.

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The Pharma Data

NOVEMBER 10, 2020

This is encouraging as a pharmacodynamic biomarker in larger trials,” Dage said. The assay is being explored for applications in clinical research, including new drug trials, based on its capability to identify patients with Alzheimer’s disease and also to predict their risk of progression. As Takeshi Iwatsubo, M.D.

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Agency IQ

MARCH 29, 2024

Andrews, Oxford, the British Medical Journal Medicine products pending European Commission decision following CHMP opinion Below are the drug or biologic products for which decisions are expected to occur within the next two months, according to AgencyIQ’s review of opinions from the EMA’s Committee for Medicinal Products for Human Use (CHMP).

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PPD

MARCH 28, 2024

Additionally, biomarkers identify patients who are most likely to benefit from a particular treatment, enabling companies to tailor their trials to those most likely to respond positively. By leveraging digital tools and platforms, sponsors often reach a broader range of patients, including those in underserved communities.

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The Pharma Data

AUGUST 16, 2020

Exploring the fact that drug trials predominantly involve white, male participants, and looking at how this may lead to inaccurate and harmful prescribing for other patients. Teaching on the history of medicine, including the exploitation of people of colour in scientific research. ” Experiments without consent.

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Drug Discovery World

JANUARY 17, 2024

With oncology accounting for a third of pharma’s product pipeline, significant challenges include fierce competition, high research and development costs over, 10-15 years for clinical development, and pressures to rapidly meet the demand for new treatments 2-4.

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Drug Target Review

NOVEMBER 30, 2023

We are the only company in the world including this population in any Alzheimer’s drug trial, and we are very proud of this! The recent positive clinical data from two new Alzheimer’s disease treatments – lecanemab from Eisai and Biogen and donanemab from Eli Lilly – bring real hope to patients and families.

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Drug Discovery World

OCTOBER 6, 2022

Precision medicine promises a paradigm shift to confidently match the right patients to the right treatment at the right time. In the cancer space alone over the last five years, clinical trials have increased 500% for new drugs and new drug combinations. Through testing and diagnostics.

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Agency IQ

MAY 3, 2024

and 2 mg [EMA] Product-specific bioequivalence guidance 6/30/2024 Pharmeuropa 36.2 and 2 mg [EMA] Product-specific bioequivalence guidance 6/30/2024 Pharmeuropa 36.2

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The Pharma Data

MAY 17, 2021

Regeneron resumes enrollment in lymphoma drug trials ( Reuters ). Incyte’s vitiligo treatment meets main goal in late-stage trial ( Reuters ). Desperate for treatment, Covid ‘long haulers’ push for 9/11-style health registry ( Politico ). BioPharmaDive ).

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