Drugs - Drug Discovery Digest

Drug Discovery Informatics for Big Pharma: Key Webinar Insights

Collaborative Drug

MARCH 21, 2025

Our recent Q1 2025 scientific webinar brought together industry veterans Dr. Chris Waller and Dr. Dimitris Agrafiotis to discuss the current state and future directions of drug discovery informatics in large pharmaceutical organizations led by CDD's Founder and CEO, Dr. Barry Bunin.

Drugs

Drugs Pharmaceuticals

Agility with Complex Data Sets – Integration of Predicted and Empirical Data for Drug Discovery

Collaborative Drug

DECEMBER 6, 2024

We recently hosted an insightful webinar featuring the team from Congruence Therapeutics , who shared how they're using CDD Vault alongside their proprietary systems to manage complex drug discovery data.

Computational Chemistry

Computational Chemistry Drugs

Synthesis and Investigation of Peptide–Drug Conjugates Comprising Camptothecin and a Human Protein‐Derived Cell‐Penetrating Peptide

Chemical Biology and Drug Design

JANUARY 20, 2025

ABSTRACT Drug targeting strategies, such as peptidedrug conjugates (PDCs), have arisen to combat the issue of off-target toxicity that is commonly associated with chemotherapeutic small molecule drugs. The PDCs crossed membranes and cleavable PDCs killed melanoma cells with nanomolar potency.

Small Molecule

Small Molecule Drugs International Therapies

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

MORE WEBINARS

New drug triggers rapid cell death in cancer models

Broad Institute

OCTOBER 29, 2024

New drug triggers rapid cell death in cancer models By Karen Zusi-Tran October 29, 2024 Breadcrumb Home New drug triggers rapid cell death in cancer models BRD-810 inhibits the MCL1 protein and reactivates apoptosis in tumor cells, displaying therapeutic potential in animal models. The result was the compound named BRD-810.

Drugs

Drugs Small Molecule Pharmacokinetics Clinical Trials

Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes.

Clinical Trials

Drug candidate eliminates breast cancer tumors in mice in a single dose

Science Daily: Pharmacology News

JANUARY 22, 2025

Despite significant therapeutic advances, breast cancer remains a leading cause of cancer-related death in women. Treatment typically involves surgery and follow-up hormone therapy, but late effects of these treatments include osteoporosis, sexual dysfunction and blood clots.

Treatment

Treatment Therapies Drugs Research

New drug shows promise in clearing HIV from brain

Science Daily: Pharmacology News

JULY 25, 2024

An experimental drug originally developed to treat cancer may help clear HIV from infected cells in the brain, according to a new study. By targeting infected cells in the brain, drug may clear virus from hidden areas that have been a major challenge in HIV treatment.

Virus

Virus Drugs Treatment

GLP-1 Drugs Improve Outlook For Kidney Transplants

Drugs.com

MARCH 6, 2025

THURSDAY, March 6, 2025 -- GLP-1 drugs like Ozempic can help kidney transplant patients avoid organ failure and live longer, a new study suggests.The drugs help manage patients type 2 diabetes and promote weight loss, both of which improve the c.

Drugs

Stroke rehabilitation drug repairs brain damage

Science Daily: Pharmacology News

MARCH 18, 2025

A new study has discovered what researchers say is the first drug to fully reproduce the effects of physical stroke rehabilitation in model mice, following from human studies.

Drugs

Drugs Research

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Investors put $400M into biotech licensing obesity drugs from China

BioPharma Drive: Drug Pricing

MAY 16, 2024

The biotech, tentatively named Hercules CM Newco, has rights to three incretin drugs discovered by Jiangsu Hengrui Pharmaceuticals, two of which are in clinical testing.

Licensing

Licensing Licensing Drugs Pharmaceuticals

After rejections, AbbVie secures approval for Parkinson’s drug

BioPharma Drive: Drug Pricing

OCTOBER 17, 2024

Vyalev’s clearance is the second victory for AbbVie in Parkinson’s this year, following an April readout for a drug acquired through its Cerevel buyout.

Drugs

Summit lung cancer drug shows ‘striking’ benefit over Keytruda

BioPharma Drive: Drug Pricing

SEPTEMBER 8, 2024

Study results provide much-anticipated details to Summit’s claim earlier this year that its drug “decisively beat” Merck’s dominant immunotherapy.

Drugs

No Suicide Risk Associated With GLP-1 Drugs

Drugs.com

FEBRUARY 28, 2025

28, 2025 -- GLP-1 drugs like Ozempic/Wegovy dont increase a persons risk of suicidal actions or thoughts, a new study has concluded.Earlier research had potentially linked these drugs -- which are used to treat type 2 diabetes and obe. FRIDAY, Feb.

Drugs

Drugs Research

Analyzing Oxygen Atom Distribution in FDA‐Approved Drugs to Enhance Drug Discovery Strategies

Chemical Biology and Drug Design

FEBRUARY 6, 2025

Analysis of prevalence of ring, nonring, sp 3 -, and sp 2 -hybridized oxygen in approved drugs. This work presents a comprehensive analysis of oxygen atoms in approved drugs, aiming to streamline drug design and discovery efforts. In approved drugs, majority of oxygen atoms are present within 4 from the COM of the molecule.

FDA Approval

FDA Approval FDA Small Molecule Pharmacokinetics

Vertex’s non-opioid pain drug gets FDA approval in milestone for company and research

BioPharma Drive: Drug Pricing

JANUARY 30, 2025

Despite high demand for an option like Journavx, doctors fear the drug’s price could be a major hangup for insurers, potentially limiting patients’ ability to access it.

FDA Approval

FDA Approval Doctors Research FDA

Anti-amyloid drug shows signs of preventing Alzheimer's dementia

Science Daily: Pharmacology News

MARCH 19, 2025

An experimental drug appears to reduce the risk of Alzheimer's-related dementia in people destined to develop the disease in their 30s, 40s or 50s, according to the results of a new study.

Clinical Trials

Clinical Trials Drugs Trials Treatment

A decade of cancer immunotherapy: Keytruda, Opdivo and the drugs that changed oncology

BioPharma Drive: Drug Pricing

SEPTEMBER 4, 2024

But the steady expansion of their use has slowed and, despite much trying, pharmaceutical companies have largely failed to top the drugs’ successes. Over the past 10 years, PD1-blocking medicines have transformed cancer care.

Pharmaceutical Companies

Pharmaceutical Companies Drugs Pharmaceuticals

So, Who Benefits From New Cancer Drugs?

Drugs.com

JANUARY 16, 2025

16, 2025 -- Cutting-edge targeted therapies are pushing back the line between life and death for cancer patients.However, these targeted cancer drugs frequently arent benefitting members of ethnic and racial minorities in the U.S., THURSDAY, Jan.

Drugs

Drugs Therapies

An innovative antibiotic for drug-resistant bacteria

Science Daily: Pharmacology News

NOVEMBER 20, 2024

Antibacterial drugs are important for treating infections. But increasingly, bacterial resistance to current drugs -- so they don't work well, or even at all -- means new ones are urgently needed. coli, that are known to develop drug resistance. coli, that are known to develop drug resistance.

Drugs

Drugs Trials Treatment Research

Novo Nordisk To Pay $2 Billion for New Weight Loss Drug

Drugs.com

MARCH 25, 2025

TUESDAY, March 25, 2025 -- Novo Nordisk, a Danish pharmaceutical company, has signed a major deal worth up to $2 billion for the rights to a new obesity and diabetes drug, the company announced March 24. The drug, called UBT251, is being developed.

Pharmaceutical Companies

Pharmaceutical Companies Drugs Pharmaceuticals

The Nature of Nanodisc Lipids Influences Fragment‐Based Drug Discovery Results

Chemical Biology and Drug Design

MARCH 14, 2025

Fragment-based drug discovery (FBDD) was applied to cytochrome P450 3A4 reconstituted in Nanodiscs (NDs) with various lipid compositions. The choice of ND lipid influenced drug membrane interactions and fragment hit rates, demonstrating the critical role of the membrane environment in fragment screening for membrane proteins.

Fragment Screening

Fragment Screening Pharmacokinetics Drugs Marketing

Bristol Myers schizophrenia drug, the first of its kind, approved by FDA

BioPharma Drive: Drug Pricing

SEPTEMBER 26, 2024

In testing, Cobenfy eased schizophrenia symptoms without some of the disruptive side effects typical of existing drugs. The results have been met with excitement, as well as caution.

FDA

FDA Drugs

Drug-resistant hookworms put pets and people at risk

Science Daily: Pharmacology News

JANUARY 6, 2025

Canine hookworms are becoming increasingly resistant to drugs across Australia, according to new research. Scientists have identified widespread resistance to benzimidazole-based dewormers which are commonly used to treat gastrointestinal parasites in dogs.

Drugs

Drugs Research

Eisai wins over European regulators on Alzheimer’s drug Leqembi

BioPharma Drive: Drug Pricing

NOVEMBER 14, 2024

A key regulatory committee sided against the drug this summer. But an appeal from Eisai appears to have worked, teeing Leqembi up for authorization in a major market.

Regulations

Regulations Drugs Marketing

Injectable Drug, Xolair, Resolves Dangerous Food Allergies In One-Third Of Kids

Drugs.com

MARCH 3, 2025

MONDAY, March 3, 2025 -- More than a third of food-allergic kids were able to eat full servings of their trigger foods after treatment with an injectable asthma drug, new clinical trial findings report. In all, 36% of children treated with.

Clinical Trials

Clinical Trials Drugs Trials Treatment

Scientists discover how aspirin could prevent some cancers from spreading

Science Daily: Pharmacology News

MARCH 5, 2025

The scientists say that discovering the mechanism will support ongoing clinical trials, and could lead to the targeted use of aspirin to prevent the spread of susceptible types of cancer, and to the development of more effective drugs to prevent cancer metastasis.

Clinical Trials

Clinical Trials Trials Drugs

New research demonstrates potential for increasing effectiveness of popular diabetes, weight-loss drugs

Science Daily: Pharmacology News

JULY 15, 2024

A network of proteins found in the central nervous system could be harnessed to increase the effectiveness and reduce the side effects of popular diabetes and weight-loss drugs, according to new research.

Research

Research Drugs

Anti-Amyloid Drug Shows Promise In Preventing Alzheimer's

Drugs.com

MARCH 24, 2025

MONDAY, March 24, 2025 -- The best evidence yet that cutting-edge Alzheimers disease drugs might indeed ward off the degenerative brain disease has emerged from a small-scale study.An experimental drug that clears amyloid beta from the brain cut t.

Drugs

Drugs Disease

On Wall Street, ‘flat out’ failure of AbbVie schizophrenia drug leaves analysts stunned

BioPharma Drive: Drug Pricing

NOVEMBER 11, 2024

Negative drug results cost AbbVie billions of dollars in market value and convinced analysts that Bristol Myers had placed a better bet in buying Karuna Therapeutics.

Drugs

Drugs Marketing

GLP-1 Zepbound Is Approved As First Drug For Sleep Apnea

Drugs.com

DECEMBER 23, 2024

Food and Drug Administration (FDA) has approved the first prescription medication specifically for treating obstructive sleep apnea (OSA): the weight-loss drug Zepbound. MONDAY, Dec. 23, 2024 -- The U.S. In a news release published Dec. 20, the FDA.

FDA

FDA Drugs

Ozempic-Type Drug Fails To Slow Parkinson’s, Study Finds

Drugs.com

FEBRUARY 5, 2025

5, 2025 -- Hopes that GLP-1 drugs such as Ozempic and Wegovy could help slow Parkinson's disease have taken an hit.A new study found that a drug in the same class called exenatide, marketed as Byetta, had no effect on slowing the. WEDNESDAY, Feb.

Drugs

Drugs Disease Marketing

Scientists develop grain-sized soft robots controlled by magnetic fields for targeted drug delivery

Science Daily: Pharmacology News

OCTOBER 24, 2024

A team of scientists has developed grain-sized soft robots that can be controlled using magnetic fields for targeted drug delivery, paving the way to possible improved therapies in future.

Therapies

Therapies Drugs

Diabetes advocacy group discourages use of compounded GLP-1 drugs

BioPharma Drive: Drug Pricing

DECEMBER 2, 2024

The ADA recommended doctors avoid prescribing unapproved, off-brand versions of drugs like Wegovy, wading into a dispute that has gripped the FDA and compounding pharmacies over the past few months.

Compounding Pharmacies

Compounding Pharmacies Pharmacy Doctors FDA

ALS drugs from Denali, Calico come up short, marking more failures for Healey trial

BioPharma Drive: Drug Pricing

JANUARY 7, 2025

Denali’s medicine and a similar one from Calico Life Sciences and AbbVie were not much different than a placebo, bringing the tally of failed drugs in the innovative “Healey platform trial” to seven.

Trials

Trials Science Drugs

New research could ease concerns over suicide risk of obesity drugs

BioPharma Drive: Drug Pricing

SEPTEMBER 3, 2024

While results from two after-the-fact analyses were “reassuring,” outside experts urged “continued vigilance” to ensure GLP-1 drugs don’t worsen problems in people with preexisting mental health conditions.

Research

Research Drugs

Diabetes Drug Metformin Might Help Fight Lung Cancer

Drugs.com

NOVEMBER 27, 2024

27, 2024 -- Already the go-to drug of choice for millions with type 2 diabetes, metformin might also fight lung cancer if those patients have it as well, new research shows.Metformin appears to help boost the benefits of. WEDNESDAY, Nov.

Drugs

Drugs Research

Accelerate oncology drug development: A data-driven approach to clinical decisions

BioPharma Drive: Drug Pricing

MARCH 24, 2025

Speed vs. success in oncology trials: Discover data-driven strategies to accelerate drug development.

Drug Development

Drug Development Drugs Trials

Versant startup sets out to make a new type of obesity drug

BioPharma Drive: Drug Pricing

NOVEMBER 21, 2024

The startup, Pep2Tango, is combining four methods of accelerating weight loss into one medicine in the hopes of developing a treatment that can improve upon drugs like Wegovy and Zepbound.

Drugs

Drugs Treatment

Researchers make breakthrough in bioprinting functional human heart tissue

Science Daily: Pharmacology News

JANUARY 22, 2025

The breakthrough science focused on replicating heart tissues, bringing research closer to generating functional, bioprinted organs, which would have broad applications in disease modelling, drug screening and regenerative medicine.

Research

Research Science Disease Drugs

Alector turns to layoffs as Alzheimer’s drug fails

BioPharma Drive: Drug Pricing

NOVEMBER 26, 2024

The brain drug developer is letting go of around 41 of its 238 employees, in a move the company says will help “align resources” with its strategic priorities.

Drugs

Drugs Drug Development

Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Science Daily: Pharmacology News

NOVEMBER 27, 2024

Dubbed the NanoGripper, the nanorobotic hand also could be programmed to interact with other viruses or to recognize cell surface markers for targeted drug delivery, such as for cancer treatment.

DNA

DNA Virus Treatment Research

IGM’s autoimmune pivot backfires as top drug disappoints in testing

BioPharma Drive: Drug Pricing

JANUARY 9, 2025

The biotech will stop developing two drugs and lay off nearly three-quarters of its staff after its lead therapy wasn’t as potent in early testing as the company expected.

Drugs

Drugs Therapies

Novo, with new results, to seek approval for obesity drug in MASH

BioPharma Drive: Drug Pricing

NOVEMBER 1, 2024

The Phase 3 findings position semaglutide to become the first drug of its kind for the liver disease. But they also confirm GLP-1s aren't a "silver bullet" for MASH, one analyst argued.

Drugs

Drugs Disease

Drug Discovery Informatics for Big Pharma: Key Webinar Insights

Agility with Complex Data Sets – Integration of Predicted and Empirical Data for Drug Discovery

Webinars

Trending Sources

Synthesis and Investigation of Peptide–Drug Conjugates Comprising Camptothecin and a Human Protein‐Derived Cell‐Penetrating Peptide

Webinars

New drug triggers rapid cell death in cancer models

Bridging Innovation & Patient Care: The Growing Role of AI

Drug candidate eliminates breast cancer tumors in mice in a single dose

New drug shows promise in clearing HIV from brain

GLP-1 Drugs Improve Outlook For Kidney Transplants

Stroke rehabilitation drug repairs brain damage

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Investors put $400M into biotech licensing obesity drugs from China

After rejections, AbbVie secures approval for Parkinson’s drug

Summit lung cancer drug shows ‘striking’ benefit over Keytruda

No Suicide Risk Associated With GLP-1 Drugs

Analyzing Oxygen Atom Distribution in FDA‐Approved Drugs to Enhance Drug Discovery Strategies

Vertex’s non-opioid pain drug gets FDA approval in milestone for company and research

Anti-amyloid drug shows signs of preventing Alzheimer's dementia

A decade of cancer immunotherapy: Keytruda, Opdivo and the drugs that changed oncology

So, Who Benefits From New Cancer Drugs?

An innovative antibiotic for drug-resistant bacteria

Novo Nordisk To Pay $2 Billion for New Weight Loss Drug

The Nature of Nanodisc Lipids Influences Fragment‐Based Drug Discovery Results

Bristol Myers schizophrenia drug, the first of its kind, approved by FDA

Drug-resistant hookworms put pets and people at risk

Eisai wins over European regulators on Alzheimer’s drug Leqembi

Injectable Drug, Xolair, Resolves Dangerous Food Allergies In One-Third Of Kids

Scientists discover how aspirin could prevent some cancers from spreading

New research demonstrates potential for increasing effectiveness of popular diabetes, weight-loss drugs

Anti-Amyloid Drug Shows Promise In Preventing Alzheimer's

On Wall Street, ‘flat out’ failure of AbbVie schizophrenia drug leaves analysts stunned

GLP-1 Zepbound Is Approved As First Drug For Sleep Apnea

Ozempic-Type Drug Fails To Slow Parkinson’s, Study Finds

Scientists develop grain-sized soft robots controlled by magnetic fields for targeted drug delivery

Diabetes advocacy group discourages use of compounded GLP-1 drugs

ALS drugs from Denali, Calico come up short, marking more failures for Healey trial

New research could ease concerns over suicide risk of obesity drugs

Diabetes Drug Metformin Might Help Fight Lung Cancer

Accelerate oncology drug development: A data-driven approach to clinical decisions

Versant startup sets out to make a new type of obesity drug

Researchers make breakthrough in bioprinting functional human heart tissue

Alector turns to layoffs as Alzheimer’s drug fails

Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

IGM’s autoimmune pivot backfires as top drug disappoints in testing

Novo, with new results, to seek approval for obesity drug in MASH

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