Drugs - Drug Discovery Digest

Agility with Complex Data Sets – Integration of Predicted and Empirical Data for Drug Discovery

Collaborative Drug

DECEMBER 6, 2024

We recently hosted an insightful webinar featuring the team from Congruence Therapeutics , who shared how they're using CDD Vault alongside their proprietary systems to manage complex drug discovery data.

Computational Chemistry

Computational Chemistry Drugs

Drug candidate eliminates breast cancer tumors in mice in a single dose

Science Daily: Pharmacology News

JANUARY 22, 2025

Despite significant therapeutic advances, breast cancer remains a leading cause of cancer-related death in women. Treatment typically involves surgery and follow-up hormone therapy, but late effects of these treatments include osteoporosis, sexual dysfunction and blood clots.

Treatment

Treatment Therapies Drugs Research

New drug shows promise in clearing HIV from brain

Science Daily: Pharmacology News

JULY 25, 2024

An experimental drug originally developed to treat cancer may help clear HIV from infected cells in the brain, according to a new study. By targeting infected cells in the brain, drug may clear virus from hidden areas that have been a major challenge in HIV treatment.

Virus

Virus Drugs Treatment

Lilly drug for Alzheimer’s approved by FDA

BioPharma Drive: Drug Pricing

JULY 2, 2024

The drug, which Lilly will sell as Kinsunla, carries a warning for the risk of a certain kind of imaging abnormality that can be serious in rare cases.

FDA

FDA Drugs

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

After rejections, AbbVie secures approval for Parkinson’s drug

BioPharma Drive: Drug Pricing

OCTOBER 17, 2024

Vyalev’s clearance is the second victory for AbbVie in Parkinson’s this year, following an April readout for a drug acquired through its Cerevel buyout.

Drugs

Investors put $400M into biotech licensing obesity drugs from China

BioPharma Drive: Drug Pricing

MAY 16, 2024

The biotech, tentatively named Hercules CM Newco, has rights to three incretin drugs discovered by Jiangsu Hengrui Pharmaceuticals, two of which are in clinical testing.

Licensing

Licensing Licensing Drugs Pharmaceuticals

Summit lung cancer drug shows ‘striking’ benefit over Keytruda

BioPharma Drive: Drug Pricing

SEPTEMBER 8, 2024

Study results provide much-anticipated details to Summit’s claim earlier this year that its drug “decisively beat” Merck’s dominant immunotherapy.

Drugs

Use of acid reflux drugs linked to higher risk of migraine

Science Daily: Pharmacology News

APRIL 24, 2024

People who take acid-reducing drugs may have a higher risk of migraine and other severe headache than people who do not take these medications, according to a new study.

Drugs

Stomach Paralysis Risk May Rise in People Taking Ozempic and Similar Drugs

Drugs.com

MAY 20, 2024

MONDAY, May 20, 2024 -- New, real-world research confirms that the blockbuster weight-loss drugs that millions of Americans have been taking to shed pounds can trigger stomach paralysis in some patients.“Although Although these drugs do work and should be.

Drugs

Drugs Research

Biogen, Ionis shelve ALS drug following study failure

BioPharma Drive: Drug Pricing

MAY 16, 2024

While results indicated the drug works as intended, it didn’t have enough of an effect on a protein that’s become integral to many ALS research programs.

Drugs

Drugs Research

Drug patents protect pharma profits. Track when they’ll expire here.

BioPharma Drive: Drug Pricing

MAY 8, 2024

Intellectual property is the foundation of the drug industry’s business model. This database will track key patent expiry dates for 30 top-selling medicines.

Drugs

Vertex’s non-opioid pain drug gets FDA approval in milestone for company and research

BioPharma Drive: Drug Pricing

JANUARY 30, 2025

Despite high demand for an option like Journavx, doctors fear the drug’s price could be a major hangup for insurers, potentially limiting patients’ ability to access it.

FDA Approval

FDA Approval Doctors Research FDA

Medicare reveals results of drug price negotiations

BioPharma Drive: Drug Pricing

AUGUST 15, 2024

The agency said the first round of pricing talks, which involved drugs like the blood thinners Eliquis and Xarelto, will result in $6 billion in savings for taxpayers.

Drugs

A decade of cancer immunotherapy: Keytruda, Opdivo and the drugs that changed oncology

BioPharma Drive: Drug Pricing

SEPTEMBER 4, 2024

But the steady expansion of their use has slowed and, despite much trying, pharmaceutical companies have largely failed to top the drugs’ successes. Over the past 10 years, PD1-blocking medicines have transformed cancer care.

Pharmaceutical Companies

Pharmaceutical Companies Drugs Pharmaceuticals

FDA Expands Use of Breast Cancer Drug Kisqali

Drugs.com

SEPTEMBER 18, 2024

Food and Drug Administration's expanded approval of the treatment, drug maker Novartis. WEDNESDAY, Sept. 18, 2024 -- Women with early stage breast cancer may now take Kisquali, a medication already approved for advanced disease, following the U.S.

FDA

FDA Drugs Treatment Disease

So, Who Benefits From New Cancer Drugs?

Drugs.com

JANUARY 16, 2025

16, 2025 -- Cutting-edge targeted therapies are pushing back the line between life and death for cancer patients.However, these targeted cancer drugs frequently arent benefitting members of ethnic and racial minorities in the U.S., THURSDAY, Jan.

Drugs

Drugs Therapies

An innovative antibiotic for drug-resistant bacteria

Science Daily: Pharmacology News

NOVEMBER 20, 2024

Antibacterial drugs are important for treating infections. But increasingly, bacterial resistance to current drugs -- so they don't work well, or even at all -- means new ones are urgently needed. coli, that are known to develop drug resistance. coli, that are known to develop drug resistance.

Drugs

Drugs Trials Treatment Research

Bristol Myers schizophrenia drug, the first of its kind, approved by FDA

BioPharma Drive: Drug Pricing

SEPTEMBER 26, 2024

In testing, Cobenfy eased schizophrenia symptoms without some of the disruptive side effects typical of existing drugs. The results have been met with excitement, as well as caution.

FDA

FDA Drugs

Eisai wins over European regulators on Alzheimer’s drug Leqembi

BioPharma Drive: Drug Pricing

NOVEMBER 14, 2024

A key regulatory committee sided against the drug this summer. But an appeal from Eisai appears to have worked, teeing Leqembi up for authorization in a major market.

Regulations

Regulations Drugs Marketing

Drug-resistant hookworms put pets and people at risk

Science Daily: Pharmacology News

JANUARY 6, 2025

Canine hookworms are becoming increasingly resistant to drugs across Australia, according to new research. Scientists have identified widespread resistance to benzimidazole-based dewormers which are commonly used to treat gastrointestinal parasites in dogs.

Drugs

Drugs Research

Lilly obesity drug shows heart benefit in late-stage trial

BioPharma Drive: Drug Pricing

AUGUST 1, 2024

The drug led to a 38% reduction in the risk of death or complications from a type of heart failure, a finding that compared favorably to available treatments.

Trials

Trials Drugs Treatment

Scientists discover how aspirin could prevent some cancers from spreading

Science Daily: Pharmacology News

MARCH 5, 2025

The scientists say that discovering the mechanism will support ongoing clinical trials, and could lead to the targeted use of aspirin to prevent the spread of susceptible types of cancer, and to the development of more effective drugs to prevent cancer metastasis.

Clinical Trials

Clinical Trials Trials Drugs

On Wall Street, ‘flat out’ failure of AbbVie schizophrenia drug leaves analysts stunned

BioPharma Drive: Drug Pricing

NOVEMBER 11, 2024

Negative drug results cost AbbVie billions of dollars in market value and convinced analysts that Bristol Myers had placed a better bet in buying Karuna Therapeutics.

Drugs

Drugs Marketing

Drug may stop migraines before headache starts

Science Daily: Pharmacology News

AUGUST 28, 2024

When taken at the first signs of a migraine, before headache pain begins, a drug called ubrogepant may be effective in helping people with migraine go about their daily lives with little or no symptoms, according to a new study.

Drugs

Diabetes advocacy group discourages use of compounded GLP-1 drugs

BioPharma Drive: Drug Pricing

DECEMBER 2, 2024

The ADA recommended doctors avoid prescribing unapproved, off-brand versions of drugs like Wegovy, wading into a dispute that has gripped the FDA and compounding pharmacies over the past few months.

Compounding Pharmacies

Compounding Pharmacies Pharmacy Doctors FDA

Ionis plots next steps for Angelman drug Biogen passed on

BioPharma Drive: Drug Pricing

JULY 22, 2024

The company plans to start a late-stage study next year, after a smaller trial found its drug offered “robust and consistent” benefits on communication, cognition and motor function.

Drugs

Drugs Trials

New research demonstrates potential for increasing effectiveness of popular diabetes, weight-loss drugs

Science Daily: Pharmacology News

JULY 15, 2024

A network of proteins found in the central nervous system could be harnessed to increase the effectiveness and reduce the side effects of popular diabetes and weight-loss drugs, according to new research.

Research

Research Drugs

New research could ease concerns over suicide risk of obesity drugs

BioPharma Drive: Drug Pricing

SEPTEMBER 3, 2024

While results from two after-the-fact analyses were “reassuring,” outside experts urged “continued vigilance” to ensure GLP-1 drugs don’t worsen problems in people with preexisting mental health conditions.

Research

Research Drugs

GLP-1 Zepbound Is Approved As First Drug For Sleep Apnea

Drugs.com

DECEMBER 23, 2024

Food and Drug Administration (FDA) has approved the first prescription medication specifically for treating obstructive sleep apnea (OSA): the weight-loss drug Zepbound. MONDAY, Dec. 23, 2024 -- The U.S. In a news release published Dec. 20, the FDA.

FDA

FDA Drugs

FDA Says Drug Makers Will Stop Producing Fentanyl 'Lollipops'

Drugs.com

SEPTEMBER 20, 2024

20, 2024 -- Controversial fentanyl lollipops and similar products will no longer be made by drug makers, the U.S. Food and Drug Administration has announced.Known as TIRF medications, these products contain fentanyl and are used to. FRIDAY, Sept.

FDA

FDA Drugs Production

Lessons from Monte Carlo Models: Why Drug Development is Hard

DrugBaron

FEBRUARY 16, 2024

But not everyone in drug development is playing this game. No wonder investing in drug development is so hard! The single most important skill for investing in drug development, or managing a portfolio of assets in a company, is recognizing when the “switch point” comes for each asset. And that is easier said than done.

Drug Development

Drug Development Pharma Companies Drugs Science

Ozempic-Type Drug Fails To Slow Parkinson’s, Study Finds

Drugs.com

FEBRUARY 5, 2025

5, 2025 -- Hopes that GLP-1 drugs such as Ozempic and Wegovy could help slow Parkinson's disease have taken an hit.A new study found that a drug in the same class called exenatide, marketed as Byetta, had no effect on slowing the. WEDNESDAY, Feb.

Drugs

Drugs Disease Marketing

ALS drugs from Denali, Calico come up short, marking more failures for Healey trial

BioPharma Drive: Drug Pricing

JANUARY 7, 2025

Denali’s medicine and a similar one from Calico Life Sciences and AbbVie were not much different than a placebo, bringing the tally of failed drugs in the innovative “Healey platform trial” to seven.

Trials

Trials Science Drugs

Scientists develop grain-sized soft robots controlled by magnetic fields for targeted drug delivery

Science Daily: Pharmacology News

OCTOBER 24, 2024

A team of scientists has developed grain-sized soft robots that can be controlled using magnetic fields for targeted drug delivery, paving the way to possible improved therapies in future.

Therapies

Therapies Drugs

Versant startup sets out to make a new type of obesity drug

BioPharma Drive: Drug Pricing

NOVEMBER 21, 2024

The startup, Pep2Tango, is combining four methods of accelerating weight loss into one medicine in the hopes of developing a treatment that can improve upon drugs like Wegovy and Zepbound.

Drugs

Drugs Treatment

An Alzheimer's Drug May Also Slow Lewy Body Dementia

Drugs.com

AUGUST 26, 2024

24, 2024 -- A type of drug used to treat Alzheimer’s disease appears to slow the progression of Lewy body dementia, the brain disease that afflicted comedian Robin Williams prior to his suicide.Cholinesterase inhibitors prevent the b. MONDAY, Aug.

Drugs

Drugs Disease

Nura Bio gets another $68M, new CEO to advance ‘neuroprotective’ brain drugs

BioPharma Drive: Drug Pricing

SEPTEMBER 17, 2024

The funding will support mid-stage testing of a drug the company believes to have the potential to treat a range of neurodegenerative conditions.

Drugs

Diabetes Drug Metformin Might Help Fight Lung Cancer

Drugs.com

NOVEMBER 27, 2024

27, 2024 -- Already the go-to drug of choice for millions with type 2 diabetes, metformin might also fight lung cancer if those patients have it as well, new research shows.Metformin appears to help boost the benefits of. WEDNESDAY, Nov.

Drugs

Drugs Research

Alector turns to layoffs as Alzheimer’s drug fails

BioPharma Drive: Drug Pricing

NOVEMBER 26, 2024

The brain drug developer is letting go of around 41 of its 238 employees, in a move the company says will help “align resources” with its strategic priorities.

Drugs

Drugs Drug Development

IGM’s autoimmune pivot backfires as top drug disappoints in testing

BioPharma Drive: Drug Pricing

JANUARY 9, 2025

The biotech will stop developing two drugs and lay off nearly three-quarters of its staff after its lead therapy wasn’t as potent in early testing as the company expected.

Drugs

Drugs Therapies

Novo, with new results, to seek approval for obesity drug in MASH

BioPharma Drive: Drug Pricing

NOVEMBER 1, 2024

The Phase 3 findings position semaglutide to become the first drug of its kind for the liver disease. But they also confirm GLP-1s aren't a "silver bullet" for MASH, one analyst argued.

Drugs

Drugs Disease

Sarepta scraps a Duchenne drug as gene therapy sales rise

BioPharma Drive: Drug Pricing

NOVEMBER 7, 2024

Now, Sarepta is abandoning a successor to its drug Exondys 51, citing an “evolving" treatment landscape. Elevidys sales have increased since the FDA made a controversial choice to expand the therapy's use.

Therapies

Therapies Drugs FDA Treatment

Researchers make breakthrough in bioprinting functional human heart tissue

Science Daily: Pharmacology News

JANUARY 22, 2025

The breakthrough science focused on replicating heart tissues, bringing research closer to generating functional, bioprinted organs, which would have broad applications in disease modelling, drug screening and regenerative medicine.

Research

Research Science Disease Drugs

Agility with Complex Data Sets – Integration of Predicted and Empirical Data for Drug Discovery

Drug candidate eliminates breast cancer tumors in mice in a single dose

Trending Sources

New drug shows promise in clearing HIV from brain

Lilly drug for Alzheimer’s approved by FDA

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

After rejections, AbbVie secures approval for Parkinson’s drug

Investors put $400M into biotech licensing obesity drugs from China

Summit lung cancer drug shows ‘striking’ benefit over Keytruda

Use of acid reflux drugs linked to higher risk of migraine

Stomach Paralysis Risk May Rise in People Taking Ozempic and Similar Drugs

Biogen, Ionis shelve ALS drug following study failure

Drug patents protect pharma profits. Track when they’ll expire here.

Vertex’s non-opioid pain drug gets FDA approval in milestone for company and research

Medicare reveals results of drug price negotiations

A decade of cancer immunotherapy: Keytruda, Opdivo and the drugs that changed oncology

FDA Expands Use of Breast Cancer Drug Kisqali

So, Who Benefits From New Cancer Drugs?

An innovative antibiotic for drug-resistant bacteria

Bristol Myers schizophrenia drug, the first of its kind, approved by FDA

Eisai wins over European regulators on Alzheimer’s drug Leqembi

Drug-resistant hookworms put pets and people at risk

Lilly obesity drug shows heart benefit in late-stage trial

Scientists discover how aspirin could prevent some cancers from spreading

On Wall Street, ‘flat out’ failure of AbbVie schizophrenia drug leaves analysts stunned

Drug may stop migraines before headache starts

Diabetes advocacy group discourages use of compounded GLP-1 drugs

Ionis plots next steps for Angelman drug Biogen passed on

New research demonstrates potential for increasing effectiveness of popular diabetes, weight-loss drugs

New research could ease concerns over suicide risk of obesity drugs

GLP-1 Zepbound Is Approved As First Drug For Sleep Apnea

FDA Says Drug Makers Will Stop Producing Fentanyl 'Lollipops'

Lessons from Monte Carlo Models: Why Drug Development is Hard

Ozempic-Type Drug Fails To Slow Parkinson’s, Study Finds

ALS drugs from Denali, Calico come up short, marking more failures for Healey trial

Scientists develop grain-sized soft robots controlled by magnetic fields for targeted drug delivery

Versant startup sets out to make a new type of obesity drug

An Alzheimer's Drug May Also Slow Lewy Body Dementia

Nura Bio gets another $68M, new CEO to advance ‘neuroprotective’ brain drugs

Diabetes Drug Metformin Might Help Fight Lung Cancer

Alector turns to layoffs as Alzheimer’s drug fails

IGM’s autoimmune pivot backfires as top drug disappoints in testing

Novo, with new results, to seek approval for obesity drug in MASH

Sarepta scraps a Duchenne drug as gene therapy sales rise

Researchers make breakthrough in bioprinting functional human heart tissue

Stay Connected