Common Sense for Drug Policy Blog

AUGUST 28, 2024

Laboratory Evaluation of Nitazene Test Strips "This study presents an independent, laboratory-based assessment of the potential of the first commercially available NTS for drug checking applications. The test strips consistently detected the presence of a nitazene analogue in 6 authentic drug samples. Stove, C.P.

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Conversations in Drug Development Trends

JANUARY 21, 2025

Jayaprakash Kotha, MBBS, PhD, ASCP (SH), Vice President, Bioanalytical Laboratory Satish Kumar, MBB, Head of Process Improvement Continuous Innovation is a Cornerstone of Bioanalysis Approximately 80% of drugs that begin the research process fail to reach approval. Rigorous procedures to ensure that drugs are effective and safe.

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Drug Discovery Today

DECEMBER 3, 2021

Alderley Park, Cheshire – One of the UK’s leading infectious disease biotech companies has announced a breakthrough in laboratory trials of a new drug to treat COVID-19 and new variants of the disease, such as the Omicron variant.

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Collaborative Drug

AUGUST 15, 2023

Company Named as a Sample Vendor for SaaS Electronic Lab Notebook San Francisco, CA - August 15, 2023 - Collaborative Drug Discovery (CDD) is proud to announce its recent recognition as a Sample Vendor for Software-as-a-Service (SaaS) Electronic Laboratory Notebook (ELN) in the Gartner Hype Cycle for Life Science Discovery Research, 2023 report.

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PPD

JANUARY 15, 2025

As a result, drug developers make better decisions more quickly (removing 50% of study timeline whitespace) to bring new therapies to market faster. Accelerate customer speed to market With a modern and integrated user experience, AI solutions put the right data and insights into the right hands in real time.

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PPD

OCTOBER 31, 2024

As the pharmaceutical industry continues to evolve, drug developers encounter new challenges and opportunities in their pursuit of innovation. In response, the PPD clinical research business of Thermo Fisher Scientific conducted its third global survey of 150 drug developers to capture a comprehensive view of these evolving trends.

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Collaborative Drug

AUGUST 15, 2023

Company Named as a Sample Vendor for SaaS Electronic Lab Notebook San Francisco, CA - August 15, 2023 - Collaborative Drug Discovery (CDD) is proud to announce its recent recognition as a Sample Vendor for Software-as-a-Service (SaaS) Electronic Laboratory Notebook (ELN) in the Gartner Hype Cycle for Life Science Discovery Research, 2023 report.

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Codon

NOVEMBER 3, 2024

As an undergraduate biology student, I spent some time in a TB lab working on antibiotic resistance — a growing concern for drug developers. Antibiotics From the Ground Up Researchers unearthed the first TB drug from the ground. To feed bacterial growth, they used potato extracts rich in sugar and other nutrients.

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Broad Institute

JULY 17, 2024

Still, more than 90 percent of drug candidates fail in clinical trials, with even more that never make it to the clinical stage. Many drugs fail because they simply aren’t safe. Seal began this work after wondering if more toxicology insights could be gleaned from a drug candidate’s chemical structure.

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PPD

OCTOBER 18, 2023

1 With this growth comes increased demands for laboratory services at all steps across the development process. Access to a laboratory partner that already possesses the equipment, knowledge and personnel can save time and money. Stay ahead of the curve with a great GMP/CMC contract laboratory partner.

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Alta Sciences

OCTOBER 31, 2023

Altasciences Completes Expansion of New State-Of-The-Art Laboratory in Columbia, Missouri pmjackson Tue, 10/31/2023 - 16:08 Laval, Québec, October 31, 2023 – Altasciences is pleased to announce the completion of its laboratory facilities in Columbia, MO. This is Altasciences’ third purpose-built laboratory.

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NIH Director's Blog: Drug Discovery

NOVEMBER 5, 2020

In work published in the journal ACS Nano , a team that included Kirill Gorshkov, NIH’s National Center for Advancing Translational Sciences (NCATS), Rockville, MD, along with Eunkeu Oh and Mason Wolak, Naval Research Laboratory, Washington, D.C., Naval Research Laboratory (Washington, D.C.) That’s not science fiction. That’s now.

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Research Laboratories Laboratories Science Drugs 85

DrugBank

JUNE 27, 2024

Drug repurposing is an approach that, while not new, has become popular in the last decade.   One of the most exciting prospects of drug repurposing is its potential to tackle "undruggable" targets—proteins or molecules that traditional drugs can't easily bind to.

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Drug Target Review

DECEMBER 11, 2024

This shift in focus is especially critical in toxicology, where accurate target analysis plays a vital role in identifying toxic effects and ensuring patient safety, particularly as the field transitions from traditional drugs to the promising realm of biotherapeutics, especially for rare diseases.

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KIF1A

MARCH 2, 2024

Read the Article Rare Roundup The Jackson Laboratory offers “Exploring Rare Disease Through Translational Research” MiniCourse Human health is incredibly complex; developing safe, effective treatments requires knowledge of molecular mechanisms, cell biology, and drug administration.

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Laboratories Cell Biology Disease Research 119

Elrig

MARCH 25, 2025

Prof Rory Johnson, Associate Professor, University College Dublin, and Dr Shalini Andersson, Vice President Nucleic Acid Therapeutics, AstraZeneca will lead this years event focussed on drugging the undruggable.

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Alta Sciences

NOVEMBER 13, 2024

Altasciences’ Commitment to Supporting Pharma and Biotech With Comprehensive Bioanalytical Services pmjackson Wed, 11/13/2024 - 14:50 Greater Montréal, Québec, 11/13, 2024 — Altasciences , a trusted drug development research partner for over 30 years, continues its commitment to providing world-class bioanalytical services.

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Conversations in Drug Development Trends

DECEMBER 19, 2024

At the recent World Orphan Drug Congresses (WODC) in Europe and the United States, Worldwide Clinical Trials Derek Ansel , Vice President, Therapeutic Strategy Lead, Rare Disease, facilitated roundtable discussions to explore the operational challenges and ethical barriers surrounding genetic testing.

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Drug Target Review

SEPTEMBER 4, 2023

There have been several studies that have reported the ability of infectious disease agents to be drug resistant. Studies have shown that targeting some expression gene sites could lead to the production of new drugs as indicated. 7,13 The use of Plants extract is important in drug discovery.

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Practical Cheminformatics

JANUARY 8, 2024

Picking up where we left off in Part I , this post covers several other ML in drug discovery topics that interested me in 2023. Most of the LLM activity in the drug discovery space in 2023 was reported as preprints from academic groups. Most of the drug discovery examples were underwhelming. Here’s the structure of Part II.

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Broad Institute

OCTOBER 21, 2024

Current methods for determining which drugs might work for each patient rely on growing bacteria from the patient in the lab and take days to yield results. In the meantime, patients are often given broad-spectrum antibiotics, which encourage drug-resistant infections, a significant public health threat.

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Drug Target Review

AUGUST 30, 2023

Advancing drug discovery for pain disorders: human iPSC-based approach Drug discovery relies on the use of relevant model systems. Therefore, to advance drug discovery in the field, screens on human cellular models such as such as specialised sensory neurons (nociceptors) are necessary.

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PPD

SEPTEMBER 25, 2023

As the clinical trial landscape evolves, drug developers are faced with novel challenges and changes in study recruitment, trial size and structure, and more. Decentralized Trials Digital and decentralized clinical trials  (DCTs) continue to expand and have become a standard solution for drug developers.

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SCIENMAG: Medicine & Health

AUGUST 14, 2023

After a highly lauded research campaign that successfully redesigned a hepatitis C drug into one of the leading drug treatments for COVID-19, scientists at the Department of Energy’s Oak Ridge National Laboratory are now turning their drug design approach toward cancer. Credit: Credit: Jill Hemman/ORNL, U.S.

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Laboratories Treatment Research Drugs 89

ASPET

SEPTEMBER 12, 2023

Opioid addiction is a chronic relapsing disorder in which drug-seeking behavior during abstinence can be provoked by exposure to a µ-opioid receptor (MOR) agonist or opioid-associated cues.

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DrugBaron

JULY 19, 2022

Despite the current hype around so called “advanced therapies”, which range from gene editing to cell therapies, and the inexorable advance of biologic therapeutics such as monoclonal antibodies, even in 2022 the majority of drugs in development and reaching patients are still small organic molecules. But it has its limitations too.

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Drug Target Review

JULY 13, 2023

Drug discovery is a complex and vital field that continually seeks to identify new therapeutic targets and develop effective treatments. In recent years, a novel approach known as condensate biology has emerged, revolutionising the way researchers think about drug discovery and development.

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NIOSH Science Blog: Drugs

SEPTEMBER 6, 2023

NIOSH’s National Personal Protective Technology Laboratory (NPPTL) mission is to prevent disease, injury, and death for the millions of workers who rely on personal protective technology. occupational settings. One of NPPTL’s main responsibilities is

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Conversations in Drug Development Trends

NOVEMBER 12, 2024

Modifying and expanding the cells in a GMP laboratory. Delivering this cellular drug product into the patient’s body, followed by intensive medical oversight. At a high level, the process involves: Collecting cells from the patient (autologous) or processing healthy donor cells (allogeneic).

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FDA Law Blog: Biosimilars

JUNE 10, 2024

This draft guidance, titled “ Processes and Practices Applicable to Bioresearch Monitoring Inspections ,” was prompted by a congressional directive under the Food and Drug Omnibus Reform Act and is intended to provide recommendations that are not otherwise specified in existing publicly available guides and manuals for such inspections (see pgs.

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DrugBank

MARCH 28, 2024

Their focus spans a wide range of potential solutions, from drug repurposing to the creation of nutrient-dense products tailored to counteract the omics-level changes.  Vector Space Biosciences is pioneering this effort by devising countermeasures against the detrimental impacts of space travel on human physiology.

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FDA Law Blog: Biosimilars

NOVEMBER 1, 2023

Gibbs — For more than three decades, FDA has claimed that the Federal Food, Drug & Cosmetic (FD&C Act) gives the agency legal authority to regulate laboratory developed tests (LDTs) as medical devices (see our prior post here ). Lenz, Principal Medical Device Regulation Expert & Sophia R. Gaulkin & Jeffrey N.

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BMG Labtech

MARCH 11, 2024

Enzyme-Linked Immunosorbent Assays (ELISAs) are an essential technique in today’s laboratory with many applications in the life sciences. They are often the method of choice to detect or measure specific biological molecules (analytes) for diagnostics, drug discovery or fundamental research.

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DS in Pharmatics

JANUARY 6, 2025

In the pharmaceutical industry, the successful transition of a drug substance from the controlled environment of the laboratory to large-scale production at a manufacturing plant is critical.

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Drug Target Review

MARCH 19, 2024

This is also important considering that too much of the vitamin can also be harmful, particularly to the developing foetus and therefore supplements and retinoid drugs should only be given under medical supervision, especially in women of childbearing age. This study by Reay and colleagues was published in Nature Communications.

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ASPET

MARCH 20, 2024

TOP2β/180 can be a target for DNA damage-stabilizing anticancer drugs, whose efficacy is often limited by chemoresistance. Our laboratory previously demonstrated reduced levels of TOP2β/180 (and the paralog TOP2α/170) in an acquired etoposide-resistant K562 clonal cell line, K/VP.5

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KIF1A

MARCH 9, 2024

She also once interned at Wenzhou Institute, University of Chinese Academy of Sciences and participated in the research of photocurable protein-based hydrogels for developing an in vitro liver model for hepatitis drug screening. Mayo Clinic laboratories has also developed next-generation sequencing (NGS) to detect HSPs.

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