Drug Discovery World

APRIL 23, 2024

Traditional drug discovery is time-consuming, and expensive, and numerous industry studies are showing a year-on-year decrease in return on investment from R&D efforts across the board. What evidence is there showing that the AI-AAM method is effective in identifying drug candidates? Secure your free place today.

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Drug Discovery World

APRIL 30, 2024

Traditional drug discovery is time-consuming, and expensive, and numerous industry studies are showing a year-on-year decrease in return on investment from R&D efforts across the board. What evidence is there showing that the AI-AAM method is effective in identifying drug candidates? appeared first on Drug Discovery World (DDW).

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Dark Matter Blog

AUGUST 27, 2020

A few years ago, at Arrakis Therapeutics, we set out to conquer a strange new territory, drugging RNA structures with small molecules. In fact, it was these early pharmaceutical successes that gave us the confidence that we would ultimately succeed in systematically drugging a wide range of RNA structures.

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Drug Discovery World

FEBRUARY 19, 2024

Dr Julie Warner is Vice President of Regulatory Affairs at drug development consultancy, Boyds. In this article, she provides her expert insights into the key trends and developments expected to shape the global drug development industry this year. antibody-drug conjugate [ADC] pipelines in some oncology settings).

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Drug Target Review

JULY 4, 2023

Over the last two decades, an increasing number of Antibody Drug Conjugate (ADC) therapeutics have been approved for oncology indications. These therapies have broadened treatment options for patients to expand beyond the more traditional small molecule drug alternatives. 3D rendering of Antibody Drug Conjugate Molecules.

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Drug Discovery World

DECEMBER 12, 2023

EXN407 is a small molecule inhibitor of splice factor kinase SRPK1. The post Phase Ib/IIa trial in diabetic macular oedema successfully completed appeared first on Drug Discovery World (DDW). Patients in the Phase Ib/IIa trial were treated twice a day for three months, with either EXN407 or placebo. billion, CAGR 6.4%

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Drug Discovery World

FEBRUARY 12, 2024

DDW’s Megan Thomas spoke to experts from the drug discovery industry about their predictions on what 2024 holds for our sector. In the upcoming year, we will see the expansion of new, more complex markets and updated requirements from regulators. This will ultimately save time and money in drug development.

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Drug Discovery World

FEBRUARY 13, 2024

AM1476, a first-in-class, peripheral-acting serotonin receptor antagonist, has been granted US and EU Orphan Drug Designation as an anti-fibrotic treatment for systemic sclerosis. AM1476 is a selective peripheral-acting 5-HT2B receptor small molecule antagonist that can be delivered orally.

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Drug Discovery World

FEBRUARY 13, 2024

Often this can be drug approvals, exciting research into hard-to-treat indications, or even regulatory updates that enable players within the sector to utilise the latest technologies and drive therapies to market faster, ultimately benefitting patients. But is AI the answer to the industry’s development challenges?

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Drug Discovery World

DECEMBER 26, 2023

Otsuka Pharmaceutical and Ionis Pharmaceuticals Otsuka Pharmaceutical and RNA therapy company Ionis have entered into a licence agreement for Otsuka to acquire exclusive marketing rights to Ionis’ hereditary angioedema (HAE) drug candidate donidalorsen in Europe. Ionis is currently conducting two Phase III multicentre studies.

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Drug Discovery World

MARCH 12, 2024

To this end, a grant of $3 million offered in the Bio Studio programme to mature a technology for ‘platform-market-fit’ is a unique opportunity for translational projects. RA: Biomia is developing drug candidates for pain, addiction and mental health conditions. What are some of the historical challenges with these drugs?

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Drug Discovery World

SEPTEMBER 29, 2023

Seven companies have been highlighted in Clarivate’s ‘Companies to Watch Report’ for delivering more effective and safer medicines to market faster by leveraging artificial intelligence (AI) and machine learning (ML) technology. Enveda Biosciences – focuses on the natural world for drug discovery.

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Drug Discovery World

AUGUST 29, 2024

Yunovia (a subsidiary of Ildong Pharmaceutical Group) has received permission from the Ministry of Food and Drug Safety (MFDS) of Korea to begin a Phase I study for its small molecule glucagon-like peptide-1 (GLP-1) agonist for obesity and diabetes.

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Drug Discovery World

OCTOBER 4, 2022

Using its proprietary compound screening platform, Oligomerix discovers and develops differentiated, oral, small molecule inhibitors of tau self-association that are easy to administer and cost-effective. . Erhardt adds that despite the ever-increasing number of people with AD, there has been an erosion of market value (from $4.2

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Drug Discovery World

APRIL 10, 2023

Could India become an important centre of drug discovery innovation? Thanks to a new focus on R&D, increasing digitalisation and government investment, India is establishing itself as a significant player in drug discovery, and the Hyderabad life sciences hub has played a significant role in this.

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Drug Discovery World

DECEMBER 21, 2023

DDW’s top 10 most popular articles for 2023 reflect the key subjects in drug discovery and development. Other biotechnologies coming to the fore this year were antibody-drug conjugates and CRISPR gene editing. DDW Multimedia Editor Megan Thomas explored three trends in the market.

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Drug Discovery World

MARCH 12, 2024

DDW’s Megan Thomas speaks to experts from the drug discovery industry about their predictions on what 2024 holds for our sector. Amanda Halford, President Bioprocess, Cytiva “In 2024, the emphasis will remain on novel mAbs, specifically antibody drug conjugates. This is part of a series of predictions based on different themes.

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Drug Discovery World

APRIL 27, 2023

Megan Thomas takes a snapshot of the US biotech market and some of the ongoing research coming out of the US. The findings also point to potential side effects of drugs that are being developed to boost ferroptosis to kill cancer cells and suggest new strategies for treating blood disorders caused by low levels of HSCs 7.

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Drug Discovery World

NOVEMBER 14, 2022

Early-stage biopharma company Atrogi initiated a Phase I study for its drug candidate ATR-258 targeting type 2 diabetes in Germany, which is expected to announce results at the end of the year. . The post World Diabetes Day: Five important drug discovery developments appeared first on Drug Discovery World (DDW).

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Alta Sciences

AUGUST 29, 2024

Engaging at the outset with a fully integrated and experienced drug development partner can ensure safety, with timely data sharing at every step of the drug development plan, and facilitate agile, flexible decision-making and planning. billion USD in 2023 to $166.53 billion USD by 2028.

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Drug Discovery World

OCTOBER 16, 2023

The United Kingdom has established itself as a hub for drug discovery expertise worldwide. There is a range of reasons why this area has become focal point for drug discovery, one of which is the fact that it encompasses the University of Oxford and the University of Cambridge, two of the oldest and most prestigious universities in the world.

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Drug Discovery World

AUGUST 14, 2023

Research partners in the UK are progressing their orally available small molecule cancer immunotherapy drug into clinical development as a treatment for advanced solid tumours. In cancer, PGE2 acts in the tumour microenvironment to trigger cancer cells to evade the immune system.

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The Pharma Data

NOVEMBER 19, 2020

20, 2020 /PRNewswire/ — Sosei Group Corporation (“the Company”) (TSE: 4565) announces a progress update for its R&D program focused on the design and development of novel drugs targeting the SARS-CoV-2 coronavirus and to treat COVID-19. . TOKYO and CAMBRIDGE, England , Nov. The program was initiated in April 2020.

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Drug Discovery World

OCTOBER 13, 2022

Sekkei Bio, an India-based company dedicated to building technologies for drug and vaccine design with global impact, has implemented CDD Vault as the main platform to house its research data. . The post Sekkei Bio implements system to centralise research data appeared first on Drug Discovery World (DDW).

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Drug Discovery World

FEBRUARY 28, 2023

Based on advances in understanding of how age-associated chemical damage accumulates in cells and tissues, FAB is developing an innovative small molecule approach aimed at boosting our defences as we age, to ultimately extend the healthy lifespan of our bodies. Globally, the anti-ageing therapeutics market is expected to reach $2.01

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Drug Discovery World

MAY 26, 2023

AM1476, a highly selective small molecule, delivered as an orally administered tablet, was found to be safe and well-tolerated at all relevant doses in a trial of approximately 100 healthy subjects. There are currently no treatments on the market that effectively reverse scarring.

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Drug Discovery World

FEBRUARY 27, 2023

What advice do you have for other start-ups hoping to launch into this market? For founders planning to launch their start-ups, specifically drug developers, there needs to be sound, foundational science with promising data that will enable you to push further down the drug discovery pipeline. What is unique about your engine?

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The Pharma Data

NOVEMBER 30, 2020

Biohaven acquires exclusive global rights to a portfolio of novel, small-molecule CGRP antagonists. Chief Executive Officer of Biohaven, said: “We are excited to enter into this agreement with Sosei Heptares, a world leader in GPCR drug discovery. TOKYO and CAMBRIDGE, England , Dec. Vlad Coric , M.D.,

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The Pharma Data

JUNE 22, 2023

Kite Announces Completion of Marketing Authorization Transfer for Yescarta® CAR T-cell Therapy in Japan SANTA MONICA, Calif.–(BUSINESS in December 2022 about changes to their initial 2017 partnership whereby Daiichi Sankyo obtained the Marketing Authorization for Yescarta ®. –(BUSINESS WIRE)– Kite Pharma, Inc.,

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Drug Discovery World

FEBRUARY 22, 2023

Advances in new manufacturing technology accelerate Back in 2019 I wrote a paper about transforming the drug life cycle, which included what I felt were the opportunities and the challenges that were going to affect the pharmaceutical sector over the next few years.

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Drug Discovery World

SEPTEMBER 26, 2022

DDW Editor Reece Armstrong explores the rise of drug repurposing and the benefits and disadvantages it brings to drug discovery and development. . Drug repurposing, the act of finding new clinical targets for both approved and unapproved drugs, has emerged as a viable alternative to traditional drug discovery approaches. .

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DrugBank

AUGUST 15, 2024

Drug development is challenging, including not only the complexities of biomolecular drug mechanisms but also the convolutions of regulatory pathways and commercialization strategies. UCSD, with its world-renowned Center for Microbiome Innovation , provides expertise in microbial genomics and drug discovery platforms.

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Drug Discovery World

MARCH 2, 2023

ABP-671 is a small molecule inhibitor of the urate transporter 1 (URAT1) protein, which is involved in the reabsorption of uric acid by the kidneys. The post URAT1 inhibitor controls chronic gout at low doses appeared first on Drug Discovery World (DDW).

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Drug Discovery World

NOVEMBER 11, 2022

ATO has previously received marketing approvals in the US and Europe for treatment of a rare cancer condition, acute promyelocytic leukaemia (APL). . The properties of ATO as a small molecule are now well established,” said Prof François Rieger, President and CEO of BioSenic. .

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Drug Discovery World

APRIL 4, 2023

The Food and Drug Administration (FDA) in the US has made several key drug decisions over the last few weeks. EA-2353 takes a novel, small-molecule approach and selectively activates endogenous retinal stem and progenitor cells, which differentiate into photoreceptors and can potentially preserve or restore visual function.

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Drug Discovery World

FEBRUARY 16, 2023

There have been a number of significant appointments in the drug discovery sector over the last month. Dr Ouvry will be responsible for managing internal and external resources to advance the company’s pre-clinical pipeline of small molecule assets which inhibit the mitochondrial permeability transition pore (mPTP) through a novel MOA.

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Drug Discovery World

NOVEMBER 1, 2022

Australia’s drug discovery industry shows promise and innovation, as well as business opportunities. Additionally, no drug related serious adverse events have been observed. . In 2020, WEHI expanded its early stage drug discovery capabilitiesto establish the National Drug Discovery Centre (NDDC ) 6.

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