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Large language models reshaping molecular biology and drug development

Chemical Biology and Drug Design

Exploring the transformative impact of large language models (LLMs) in molecular biology and drug development, discussing potential areas of applications and breakthroughs in personalized therapies. While enhancing molecular biology aspects, we also address ethical concerns ensuring responsible application of these models.

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CHARMM-GUI PDB Reader and Manipulator: Covalent Ligand Modeling and Simulation

Covalent Modifiers

Lingyang Kong, Sang-Jun Park Wonpil Im Journal of Molecular Biology , 2024 [link] Molecular modeling and simulation serve an important role in exploring biological functions of proteins at the molecular level, which is complementary to experiments.

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De-risking drug discovery with predictive AI

Broad Institute

Still, more than 90 percent of drug candidates fail in clinical trials, with even more that never make it to the clinical stage. Many drugs fail because they simply aren’t safe. Seal began this work after wondering if more toxicology insights could be gleaned from a drug candidate’s chemical structure. A fourth is in the works.

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Mount Sinai scientists unlock secrets of red blood cell transporter, potentially paving the way for new drugs

SCIENMAG: Medicine & Health

New York, NY (September 7, 2023)—Researchers at the Icahn School of Medicine at Mount Sinai have identified the structure of a special transporter found in red blood cells and how it interacts with drugs.

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Organoids: the versatile platform for discovery and regeneration

Drug Target Review

Imagine being able to create an in vitro replica of a diseased organ to study the molecular mechanism underlying the illness. Now take a step further: envision testing drugs in these organoids to identify the ones that can treat disease safely and effectively without needing to run expensive clinical trials first.

Treatment 105
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Unlocking Undruggable Targets: Shifting Paradigms in Modern Drug Discovery

DrugBank

The road to developing effective drugs is fraught with both promise and challenge, particularly when it comes to what scientists call "undruggable" targets. The Evolution of Drug Discovery: From Dark Rooms to Precision Targets In the past, drug discovery often felt like a lucky guess.

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Logistics in Focus: Orchestrating the Challenges of Cell Therapy

Conversations in Drug Development Trends

These advanced therapeutics harness the power of molecular biology to improve human health. Delivering this cellular drug product into the patient’s body, followed by intensive medical oversight. There are also nuances for operational planning in cell therapy development programs.