Drug Hunter
AUGUST 21, 2023
Obtaining adequate drug exposure in the brain is key to treating CNS diseases effectively. Recently, Dennis Koester gave us a crash course in CNS drug discovery in a Drug Hunter Flash Talk. Why Kp,uu is the Most Important Parameter in CNS Drug Discovery What Influences the Kp,uu of Drugs?
Drug Target Review
JULY 4, 2023
Over the last two decades, an increasing number of Antibody Drug Conjugate (ADC) therapeutics have been approved for oncology indications. These therapies have broadened treatment options for patients to expand beyond the more traditional small molecule drug alternatives. 3D rendering of Antibody Drug Conjugate Molecules.
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Drug Target Review
APRIL 22, 2024
What are the primary methods used for bioconjugation in antibody drug-conjugate (ADC) development, and how do they influence the stability and efficacy of the resulting ADCs? How does the conjugation chemistry affect the drug-to-antibody ratio (DAR) and why is optimising DAR crucial for ADC performance?
FDA Law Blog: Biosimilars
AUGUST 8, 2023
Failure to detect nitrosamines, failure to notify FDA when nitrosamines appear in finished drug products, failure to identify impurities in drugs that may be nitrosamines, even having a deviation in pH of an Active Pharmaceutical Ingredient that might conceivably contribute to the formation of nitrosamines in a finished drug product.
Drug Target Review
DECEMBER 22, 2023
My secondary school chemistry teacher had a PhD in organic chemistry, and I found her classes and lab experiments to be very interesting, especially those in physical and organic chemistry. Excipients, or inactive ingredients in a drug formulation, are critical components.
Drug Target Review
MAY 1, 2024
How have advancements in antibody-drug conjugates (ADCs) expanded treatment options for different types of cancer? What innovative strategies are being developed to improve drug stability? Intuitively, if the linker is not stable enough, the drug cannot be delivered by the antibody directly to tumour cells expressing the target.
Drug Target Review
JUNE 8, 2023
Our efforts are challenging, setbacks are very common, and success in the form of finding a new drug is inherently unlikely in our industry. 1 Before the discovery of more targeted drugs, a person diagnosed with CLL faced a tough road, with chemotherapy, radiation and bone marrow transplant being the primary treatment options.
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