Drug Discovery World

AUGUST 15, 2024

A Phase IIa clinical trial has begun evaluating the safety and efficacy of Pelage Pharmaceuticals’ PP405, a novel topical small molecule, for the treatment of androgenetic alopecia (pattern baldness). The company is enrolling 60 women and men for the clinical study.

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Dark Matter Blog

AUGUST 27, 2020

A few years ago, at Arrakis Therapeutics, we set out to conquer a strange new territory, drugging RNA structures with small molecules. In fact, it was these early pharmaceutical successes that gave us the confidence that we would ultimately succeed in systematically drugging a wide range of RNA structures.

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Drug Discovery World

NOVEMBER 1, 2022

A new system utilising artificial intelligence (AI), ‘building-block’ chemistry and a molecule-making machine could speed up innovation and drug discovery, as well as make complex chemistry automated and accessible. Burke’s group has pioneered the development of simple chemical building blocks for small molecules.

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Drug Discovery Today

APRIL 20, 2023

Global integrated drug discovery company, Sygnature Discovery and global healthcare group Daewoong Pharmaceutical, have entered into a research collaboration agreement to accelerate the discovery of a novel small molecule to target autoimmune disease.

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Drug Discovery World

OCTOBER 20, 2022

This is the latest episode of the free DDW podcast, “What does the changing drug discovery and development landscape mean for the future?”. They are called “ The potential of small molecules and biologics for new therapeutics ”, “ AE reporting turnarounds and the translation issue ” and “ Why we are on the cusp of a golden age of medicine ”.

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Drug Discovery World

FEBRUARY 19, 2024

Dr Julie Warner is Vice President of Regulatory Affairs at drug development consultancy, Boyds. In this article, she provides her expert insights into the key trends and developments expected to shape the global drug development industry this year. antibody-drug conjugate [ADC] pipelines in some oncology settings).

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Drug Discovery World

DECEMBER 9, 2022

The 18th Annual Drug Discovery Chemistry meeting will be held on April 10-13, 2023 in San Diego, CA, US and also online. . Drug Discovery Chemistry is a conference for medicinal and biophysical chemists working in pharma, biotech, and academia. For more information, visit the Drug Discovery Chemistry website. . .

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Drug Discovery World

DECEMBER 12, 2023

Exonate has now regained full rights to its complete portfolio of ophthalmology assets from Janssen Pharmaceuticals EXN407 is reportedly well placed to be the first topical treatment for retinal vascular diseases, including diabetic retinopathy and diabetic macular oedema. EXN407 is a small molecule inhibitor of splice factor kinase SRPK1.

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Drug Discovery World

DECEMBER 26, 2023

Otsuka Pharmaceutical and Ionis Pharmaceuticals Otsuka Pharmaceutical and RNA therapy company Ionis have entered into a licence agreement for Otsuka to acquire exclusive marketing rights to Ionis’ hereditary angioedema (HAE) drug candidate donidalorsen in Europe.

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Drug Target Review

JULY 4, 2023

Over the last two decades, an increasing number of Antibody Drug Conjugate (ADC) therapeutics have been approved for oncology indications. These therapies have broadened treatment options for patients to expand beyond the more traditional small molecule drug alternatives. 3D rendering of Antibody Drug Conjugate Molecules.

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Drug Patent Watch

DECEMBER 13, 2023

A new lawsuit citing drug patent 7,795,312 has been filed. The small molecule drug covered by this patent is AMITIZA. Takeda Pharmaceutical Company… The post New patent lawsuit: Walgreen CO v. See more details at Walgreen CO v.

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Drug Patent Watch

DECEMBER 13, 2023

A new lawsuit citing drug patent 8,779,187 has been filed. The small molecule drug covered by this patent is AMITIZA. Takeda Pharmaceutical Company… The post New patent lawsuit: Walgreen CO v. See more details at Walgreen CO v.

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Drug Discovery World

FEBRUARY 13, 2024

Often this can be drug approvals, exciting research into hard-to-treat indications, or even regulatory updates that enable players within the sector to utilise the latest technologies and drive therapies to market faster, ultimately benefitting patients. But is AI the answer to the industry’s development challenges?

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Drug Discovery World

JUNE 1, 2023

The independent Data Monitoring Committee (DMC) has recommended the continuation of Algiax Pharmaceuticals’ Phase IIa study with lead candidate AP-325 in chronic neuropathic pain. AP-325 is a small molecule drug candidate that binds and modulates the GABAA receptor, reducing the excitability of the respective neurons.

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The Pharma Data

JANUARY 19, 2021

Precision medicine developer Kura Oncology is positioned to make a meaningful difference in the treatment of cancer in the next few years with its two, wholly-owned, small molecule compounds. Photo courtesy of Kura. It’s in the spotlight, the data is stunning, and it has a lot of promise,” Troy Wilson, Ph.D., CEO, told BioSpace.

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Drug Discovery World

FEBRUARY 12, 2024

DDW’s Megan Thomas spoke to experts from the drug discovery industry about their predictions on what 2024 holds for our sector. Cameron Ross, SVP, Generative AI, Elsevier “AI has the potential to dramatically shorten one of the most costly areas of early drug development – small molecule discovery.

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DrugBank

MAY 15, 2024

The road to developing effective drugs is fraught with both promise and challenge, particularly when it comes to what scientists call "undruggable" targets. The Evolution of Drug Discovery: From Dark Rooms to Precision Targets In the past, drug discovery often felt like a lucky guess.

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Drug Discovery World

MARCH 12, 2024

RA: Biomia is developing drug candidates for pain, addiction and mental health conditions. What are some of the historical challenges with these drugs? RA: What advantages does a plant-based approach bring to drug development? Also, most second- generation antipsychotics have delayed onset, which may influence patient adherence.

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Drug Discovery World

OCTOBER 21, 2022

Enanta Pharmaceuticals, a clinical-stage biotechnology company dedicated to creating small molecule drugs for viral infections and liver diseases, has dosed the first subject in its Phase I clinical trial of EDP-323, a novel, oral L-protein inhibitor in development for the treatment of respiratory syncytial virus (RSV). .

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Drug Discovery World

APRIL 10, 2023

Could India become an important centre of drug discovery innovation? India is traditionally known as ‘the pharmacy of the world’ due to its huge pharmaceuticals manufacturing capacity and high quantity of exports, particularly generic medicines and vaccines. Diana Spencer explores the evolution of the Hyderabad life sciences hub.

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Drug Discovery World

FEBRUARY 5, 2024

Opening keynote Following a change to the schedule, Juliet Williams of Kymera Therapeutics launched the event with a popular keynote talk ‘Solving Big Problems with Small Molecule Degraders’. In the afternoon, Andrea Bortolato, Director of Drug Discovery at SandboxAQ, explored the use of physics-based methods in combination with AI.

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Drug Discovery World

APRIL 12, 2023

This paid-for advertorial by IRBM appeared in DDW Volume 24 – Issue 2, Spring 2023 The landscape for treating rare cancers is changing with advances in molecular genetics, novel drug modalities and patient-derived models. Such insights are helping drug hunters to design novel drug development strategies.

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Drug Discovery World

SEPTEMBER 26, 2022

DDW Editor Reece Armstrong explores the rise of drug repurposing and the benefits and disadvantages it brings to drug discovery and development. . Drug repurposing, the act of finding new clinical targets for both approved and unapproved drugs, has emerged as a viable alternative to traditional drug discovery approaches. .

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Drug Discovery World

JANUARY 12, 2023

X-Chem and Sironax have agreed a research partnership, in which X-Chem will use its DEL platform to support Sironax’s drug discovery pipeline. . Through the collaboration, X-Chem will screen its DNA-encoded libraries (DEL) against difficult-to-drug targets implicated in neurodegenerative disease to discover hits.

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FDA Law Blog: Biosimilars

SEPTEMBER 11, 2024

Claud — Last week, FDA revised one of its two guidances relating to nitrosamines, Control of Nitrosamine Impurities in Human Drugs. Nitrosamines are impurities that can form during drug manufacturing and are considered potentially potent carcinogens. It’s these varied scenarios that give quality managers nightmares.

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Drug Discovery World

AUGUST 29, 2024

Yunovia (a subsidiary of Ildong Pharmaceutical Group) has received permission from the Ministry of Food and Drug Safety (MFDS) of Korea to begin a Phase I study for its small molecule glucagon-like peptide-1 (GLP-1) agonist for obesity and diabetes.

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Drug Discovery World

JANUARY 17, 2023

The study, led by OSU Associate Professor of Pharmaceutical Sciences Gaurav Sahay, Oregon State doctoral student Marco Herrera-Barrera, and Oregon Health & Science University Assistant Professor of Ophthalmology Renee Ryals, was published in Science Advances. . “We Limitations of AAV gene therapy . Sahay and Ryals have received a $3.2

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Zobio

MARCH 12, 2024

In person Every year ZoBio is actively participating in the Drug Discovery Chemistry event hosted by the Cambridge Healthtech Institute. This event serves as a premier gathering for medicinal chemists in the pharmaceutical and biotech industries, focusing on the challenges and advancements in small molecule drug discovery and optimization.

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Zobio

MARCH 12, 2024

In person Every year ZoBio is actively participating in the Drug Discovery Chemistry event hosted by the Cambridge Healthtech Institute. This event serves as a premier gathering for medicinal chemists in the pharmaceutical and biotech industries, focusing on the challenges and advancements in small molecule drug discovery and optimization.

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Drug Hunter

JUNE 11, 2023

Small molecule drugs make up most of the drugs we take conveniently as pills, including painkillers like ibuprofen (Advil), antibiotics like penicillin and amoxicillin, or cholesterol-lowering drugs like atorvastatin (Lipitor). The small molecules drugs of today look nothing like the molecules of the 1970s.

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Zobio

MARCH 12, 2024

In person Every year ZoBio is actively participating in the Drug Discovery Chemistry event hosted by the Cambridge Healthtech Institute. This event serves as a premier gathering for medicinal chemists in the pharmaceutical and biotech industries, focusing on the challenges and advancements in small molecule drug discovery and optimization.

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Drug Discovery World

SEPTEMBER 29, 2022

Challenges in outsourcing drug discovery. In this listicle, SAMDITech outlines the benefits of outsourcing models in the pharmaceutical industry, looking past perceived costs to the value outsourcing can bring. . The goal of drug discovery is clear: Identify the most promising leads in the shortest amount of time.

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Drug Discovery World

JUNE 1, 2023

Antibody-drug conjugates (ADCs) are biopharmaceutical products in which a monoclonal antibody (mAB) is linked to a small molecule drug with a stable linker 1. Financing When it comes to looking to the future in the drug discovery industry, an important question to ask is: Where is the money?

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Drug Target Review

JULY 6, 2023

1 TPD is expected to challenge undruggable proteins, which are highly difficult to target by conventional small molecules. Unlike traditional drug discovery, which focuses on inhibiting or activating proteins, TPD offers a more precise and efficient way to alter cellular pathways. How does TPD work?

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Drug Discovery World

SEPTEMBER 9, 2024

Dr Mutlu Dogruel, Vice President of AI Solutions at Cresset, examines AI’s transformative potential, highlights the current challenges and introduces a series of potential solutions to implement AI in the drug discovery landscape successfully. However, no AI-discovered or designed drugs have yet reached the market.

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The Pharma Data

NOVEMBER 19, 2020

20, 2020 /PRNewswire/ — Sosei Group Corporation (“the Company”) (TSE: 4565) announces a progress update for its R&D program focused on the design and development of novel drugs targeting the SARS-CoV-2 coronavirus and to treat COVID-19. . TOKYO and CAMBRIDGE, England , Nov. The program was initiated in April 2020.

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Drug Discovery World

OCTOBER 16, 2023

The United Kingdom has established itself as a hub for drug discovery expertise worldwide. There is a range of reasons why this area has become focal point for drug discovery, one of which is the fact that it encompasses the University of Oxford and the University of Cambridge, two of the oldest and most prestigious universities in the world.

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